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Chronic Fatigue Syndrome (CFS).

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ProHealth - Research News Alert

http://www.immunesupport.com/ep_promotions/EP050206/index.cfm

Recent newspaper reports have commented on studies by the Center for

Disease Control (CDC) and reported in the April issue of

Phamacogenomics concerning the discovery of a genetic basis for

Chronic Fatigue Syndrome (CFS). ProHealth is now offering you a link

to the full transcript of the press conference announcing these

findings.

The studies used multiple research technologies and extensive

clinical testing to identify unique aspects of genetic expression

among individuals suffering CFS relative to the general healthy

population. There is no single gene responsible for CFS. However,

three specific gene sequences were found that are associated with

the brain activities that mediate the reaction to stress and are

highly correlated with the expression of symptoms of CFS. The

activity level of these gene sequences are also stronger among

individuals with CFS. These gene sequences involve gluco-corticoid

receptors, serotonin signaling and the sympathetic nervous system.

Researchers stated that " For the first time ever, we have documented

that people with CFS have certain genes that are related to those

parts of brain activity that mediate the stress response.Why is it

important? Well, knowing that there is now a biologic basis for CFS

will help us identify better ways to more effectively diagnose the

illness and to come up with more effective treatments, including

cognitive behavioral therapy, medications or a combination of both. "

Individuals with CFS have significantly higher Allostatic Load

(stress) indexes. Different gene expressions of the three key

genetic sequences seem to differentiate between the sudden or the

gradual onset of CFS symptoms. Early life stresses are associated

with the later outbreak of CFS.

Researchers concluded by saying " The working hypothesis is that the

HPA axis and the brain is a plastic organ which changes its actual

physical architecture depending on stresses that are accumulated

over the lifetime. ...all the stresses that we experience ...

throughout the lifespan, to some extent the genetics determine how

you are going to react to them, they determine how your allostatic

load may accumulate, and more importantly, they actually determine

your subsequent reaction to stress applied at a later time during

the lifespan... "

Read the entire interview

Facts about the impact of CFS:

One million people in America suffer from CFS.

Only 16% of the CFS patients identified in the study have been

diagnosed and treated.

One-quarter of CFS patients are on disability or out of work.

Having a family member with CFS reduces family income by $20,000 per

year.

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