PubMed: chronic sinusitis

[Guest guest]

Note this sentence " Systemic symptoms associated with fungal exposure, which

resolved

when fungus was removed from the patient and the environmental air and

reappeared with

recurrent environmental fungal exposure....

reappeared with recurrent environmental exposure......

also note the genetic component in the last couple of sentences

*************************************************

Arch Environ Health. 2003 Jul;58(7):433-41.

Related Articles, Links

Chronic sinusitis: defective T-cells responding to superantigens, treated by

reduction of

fungi in the nose and air.

Dennis DP.

Atlanta Center for ENT and Facial Plastic Surgery, Atlanta, Georgia 30327, USA.

ddennis@...

In this study, the author used endoscopic sinus photography to study the effects

of

reduction of fungi in the nose, and in environmental air, on the sinus mucosa of

639

patients diagnosed with chronic rhinosinusitis. Sinus mucosal photographs were

taken

before and after reduction of fungal load in the nose and air, to determine if

there was an

optimum environmental air fungal load associated with sinus mucosal recovery to

normal

appearance. Systemic symptoms associated with fungal exposure, which resolved

when

fungus was removed from the patient and the environmental air and reappeared

with

recurrent environmental fungal exposure, are also discussed and are termed

systemic

fungal symptoms. Interventions consisted of nasal fungal load reduction with

normal

saline nasal irrigations and antimicrobial nasal sprays, and environmental air

fungal load

reduction with high-efficiency particulate air (HEPA) filtration in combination

with ionizers

or evaporation of a solution of botanical extract. Main outcome measures were

obtained

with environmental air 1-hr gravity-plate fungal colony counts, laser air

particle counts,

and endoscopic sinus photography. Blood levels of immunoglobulins IgG and IgE

for 7

common molds were also determined. After intervention, 94% of patients who used

antimicrobial nasal sprays and who reduced their environmental fungal air count

to 0-4

colonies per 1-hr agar gravity-plate exposure (n = 365) exhibited normal sinus

mucosa by

endoscopic exam. Environmental air fungal counts that exceeded 4 colonies

resulted in

sinus mucosal abnormalities ranging from edema, to pus and/or nasal polyps at

higher

counts. Neutralization of allergy, and/or surgery, were used as appropriate

following

implementation of environmental measures. On the basis of these observations, as

well as

detailed clinical experience and a review of the current literature, the author

hypothesizes

that the pathogenesis of chronic rhinosinusitis, allergic fungal sinusitis, and

systemic

fungal symptoms is a genetic defect at the variable beta chain helper T-cell

receptor (TCR

Vbeta) site which requires the presence of an antigen (fungus). Chronic

sinusitis patients

who have recurring exposure to environmental air that contains fungal

concentrations in

excess of 4 colonies per 1-hr agar plate exposure appear to have an increased

risk of

persistent chronic sinusitis and/or systemic symptoms, regardless of the medical

treatment provided.

PMID: 15143856 [PubMed - indexed for MEDLINE]

[Guest guest]

What would be an 'antimicrobial nasal spray'?

--- In , " kl_clayton " <kl_clayton@...>

wrote:

Interventions consisted of nasal fungal load reduction with normal

> saline nasal irrigations and antimicrobial nasal sprays, and

environmental air fungal load

> reduction with high-efficiency particulate air (HEPA) filtration in

combination with ionizers

> or evaporation of a solution of botanical extract.

[Guest guest]

Post below mentions evaporating a botanical product. Do you think tha

is referring to CitriSafe, as in link below?

http://www.natlallergy.com/allergy_relief/1626/citrisafe-air-treatment-

solution-for-airborne-mold-control.html

OR TINY URL: http://tinyurl.com/h35tc

--- In , " kl_clayton " <kl_clayton@...>

wrote:

.... environmental air fungal load

> reduction with high-efficiency particulate air (HEPA) filtration in

combination with ionizers

> or evaporation of a solution of botanical extract.

[Guest guest]

I remember reading about the guy who discovered this, how he had some nasal

spray

compounded at a compounding pharmacy with one or another antifungal agent. I

guess it

could be done with an antibiotic too. I have been prescribed nasal sprays with

steroids,

and cromylyn sodium (is that a leukotrine inhibitor? I forget), and it seems

they can put

anything in it. Nasal spray is a delivery method. Probably you could use

medication in a

nasal irrigation also, it would not be as convenient as a spray, though.

> Interventions consisted of nasal fungal load reduction with normal

> > saline nasal irrigations and antimicrobial nasal sprays, and

> environmental air fungal load

> > reduction with high-efficiency particulate air (HEPA) filtration in

> combination with ionizers

> > or evaporation of a solution of botanical extract.

>

[Guest guest]

I really don't know.

But I remember Dr Graham saying some time back about using grapefruit seed

extract to

kill mold, and one of those products is called CitriSolve. Maybe it is based on

GSE.

It says it is safe for those with MCS, but I would test it on myself before I

spent too much

money on it. People with chemical sensitivities can be sensitive to almost

anything.

If it is tolerated, maybe it would work- for airborne spores, but NOT in place

of

remediation. It looks a little fishy to me.

> ... environmental air fungal load

> > reduction with high-efficiency particulate air (HEPA) filtration in

> combination with ionizers

> > or evaporation of a solution of botanical extract.

>