A.V. Constantini reference

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Could this reference be posted?

A.V. Constantini of the WHO with comments on_____

Stachybotrys Chartarum & CFS

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> I'm one of the '85 Incline Village epidemic. I've been saying since

> day one with this illness that mold is primary in my illness. Drs.

> Cheney & disagreed and would not help me research it. I

> decided to trustmy perceptions and conduct my life as if my symptoms

> of anxiety and depression and fatigue represented an exposure to

> toxic mold. In the 2 years since I've applied my mold avoidance

> strategy I have eliminated almost all of my long standing CFS

> symptoms. My recovery continues but at present I am finally able to

> work full time, have no headaches or cognitive dysfunction, no

> fatigue and if it weren't for the reactivity I have to people and

> objects who come into my presence from contaminated buildings, I

> could live a completely normal life. I have been trying to tell

> doctors and CFS patients about this but despite seeing my recovery,

> nobody thinks it could possibly apply to them. While they tell me

> this, I'm shaking with the reaction I get to their clothes. I see

> know after the 48 Hours special that some people want to look into

> this but find little information and so far, no feedback from CFS

> patients with this experience. I have been diagnosed by the famous

> doctors Cheney and as the perfect case of CFS and yet I

> have told them about this mold and my recovery and they are

> completely uninterested. Even if Stachybotrys is not the primary

> cause of CFS, I believe that there must be a connection between the

> illness and an extreme reactivity to mold.

> -

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> Science News Online

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> Week of March 25, 2006; Vol. 169, No. 12

> Moldy whiff kills brain cells

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> Janet Raloff

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> From San Diego, at a meeting of the Society of Toxicology

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> Watch out, Hurricane Katrina and Rita cleanup crews. A common black

> mold that blooms on moist cellulose-based materials-from wallboard

> and ceiling tiles to cardboard- creates a toxin that can kill

> certain brain cells. In an experiment with mice, the chemical,

> satratoxin, targeted neurons running from the inside of the nose to

> the brain's smell center.

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> " This is the first demonstration that a neuron can be killed by

> satratoxin, " notes Jack R. Harkema of Michigan State University in

> East Lansing.

> The fungal toxin's " specificity is what's really unique, " notes

> Harkema's Michigan State colleague J. Pestka. Among the

> exposed nasal cells, the toxin proved lethal only to those that

> sense odors.

> The black mold Stachybotrys chartarum, commonly found in water-

> damaged buildings, had already been linked to people's respiratory

> irritation and asthma. To identify nasal effects, Harkema, Pestka,

> and Zahidul Islam, also of Michigan State, made mice inhale a

> single dose of satratoxin and then monitored tissue changes over the

> next month.

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> Within a day of exposure, 75 to 80 percent of the olfactory neurons

> in the animals' noses had died, Harkema notes. Although these cells

> can regenerate, he says, even after a month, many had still not been

> replaced.

> As little as 25 micrograms of toxin per kilogram of mouse-body

> weight elicited this neural toxicity. The scientists now plan to

> evaluate whether prolonged exposure to even lower doses-as could be

> assaulting hurricane-cleanup crews-might trigger similar changes.

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> A full report of the findings will appear in an upcoming

> Environmental Health Perspectives.

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>> References:

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>> Islam, Z., J.R. Harkema, and J.J. Pestka. In press. Satratoxin G

> from the black mold

>> Stachybotrys chartarum evokes olfactory sensory neuron loss and

> inflammation in the

>> murine nose and brain. Environmental Health Perspectives.

> Available at http://dx.doi.org/

>> 10.1289/ehp.8854.

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>> ______. 2006. Satratoxin G from the black mold Stachybotrys

> chartarum evokes olfactory

>> sensory neuron loss and inflammation in the murine nose and brain.

> Society of Toxicology

>> meeting. March 6-9. San Diego.

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>> Sources:

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>> Jack R. Harkema

>> Michigan State University

>> Department of Pathobiology and Diagnostic Investigation

>> East Lansing, MI 48824

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>> J. Pestka

>> Michigan State University

>> Department of Pathobiology and Diagnostic Investigation

>> East Lansing, MI 48824

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>> http://www.sciencenews.org/articles/20060325/note14.asp

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>> From Science News, Vol. 169, No. 12, March 25, 2006, p. 190.

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>> Copyright © 2006 Science Service. All rights reserved.

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> FAIR USE NOTICE:

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