Re: Some Laboratory Definitions of Tests Ordered

[Guest guest]

" IT'S LIKE JUMPING OFF A CLIFF - THE POINT OF NO RETURN IS PASSED! "

___________________________________________________________________

" Lorrie was severely affected. She had 34 symptoms, mold susceptible

genotypes, antibodies to gliadin and myelin basic protein. low MSH,

high MMP9 and the typical screwed up levels of pituitary hormones we

see in low MSH patients. Lorrie's brain was full of plaque -

everywhere the radiologist looked, there was another non-specific "

plaque.

I tried the standard approach: " You must leave the workplace NOW.

You can't afford any more brain damage. The job isn't worth the

illnesss. Let's get you treated and out into a new job or you'll

destroy more brain tissue. "

" Look, Dr Shoemaker, you don't understand, " she said. " Those

officers in the buildings are long time friends. This is my family.

I can't just walk out and leave them to fight this alone. I don't

care what it takes to prove the building is making people ill. If

you need me to go back in there to prove I get sick again, you got

it. How many times do I need to do it? But I'm telling you; I

won't stop working, not as long as my fellow officers are getting

sick. I know it's too late for me. And even if your treatment

lowers my MBP - and I'm glad it has so far - those plaques aren't

going away. I'll be damned if I'm going to sit back and let what

happened to me happen to anyon else. You got it now, doc?

" If I need to drive the thre hours to see you every week and have

all the blood tests and everything else done, that's what I'll do.

What the Hell, I'll drag the entire station down to you with me.

I'm not going to let this disaster happen to anyone else! "

" Lorrie, I hear you and believe me, I'm not going to argue with

you. I respect you and your loyalty, " I told her. " But you should

work here with me for a week or two and just look at the illnesses

my patients have. Once a person goes over the MSH line, it's like

jumping off a cliff - the point of no return is passed.

You're on the edge right now. What good are you to the other

officers if you can't spell cat correctly three times in a row? "

Chapt 18. Mold Warriors

" WHAT GOOD ARE YOU TO THE OTHER OFFICERS IF YOU CAN'T SPELL CAT

CORRECTLY THREE TIMES IN A ROW? "

[Guest guest]

Rosie,

Thank you ever so much for taking the time to do this

list. It is absolutely fabulous and I really

appreciate it.

Barb

--- healthier4all <Healthier4All@...>

wrote:

> Thought you all might like a small list of some

> tests along with definitions

> ordered by Dr. Schoemaker.

> Rosie

>

__________________________________________________

[Guest guest]

thanks Rosie, this is good info.--- In

, " healthier4all " <Healthier4All@...>

wrote:

>

> Thought you all might like a small list of some tests along with

definitions

> ordered by Dr. Schoemaker.

> Rosie

>

>

> Laboratory:

> LabCorp, Inc., Quest Diagnostics, and Specialty Laboratories, Inc.,

each

> CLIA approved,high complexity, national laboratory facilities.

>

> MSH: alpha melanocyte stimulating hormone (MSH) is a 13 amino acid

compound

> formed in the ventromedial nucleus (VMN) of the hypothalamus,

solitary

> nucleus and arcuate nucleus by cleavage of proopiomelanocortin

(POMC) to

> yield beta-endorphin and MSH.

>

> MSH exerts inductive regulatory effects on production of

hypothalamic

> endorphins and melatonin. MSH has multiple anti-inflammatory and

> neurohormonal regulatory functions,

>

> exerting regulatory control on peripheral cytokine release as well

as on

> both anterior and posterior pituitary function. Deficiency of MSH,

commonly

> seen in biotoxin-associated

>

> illnesses, is associated with impairment of multiple regulatory

functions

> and dysregulation of pituitary hormone release. Symptoms associated

with MSH

> deficiency include chronic fatigue and chronic, unusual pain

syndromes.

> Normal values of MSH in commercial labs (Esoterix and LabCorp) are

35-81

> pg/ml.

>

> Leptin: leptin is a 146 amino acid adipocytokine produced by fat

cells in

> response to rising levels of fatty acids. Leptin has peripheral

metabolic

> effects, promoting storage of fatty acids, as well as central

effects in the

> hypothalamus. Following binding by leptin to a long isoform of the

leptin

> receptor in the VMN, a primordial gp-130 cytokine receptor, a JAK

signal

> causes transcription of the gene for POMC, which is in turned

cleaved to

> make MSH. Peripheral cytokine responses can cause phosphorylation

of a

> serine moiety (instead of threonine) on the leptin receptor,

creating leptin

> resistance and relative deficiency of MSH production. Normal values

in

> commercial labs show differences between males (5-8 ng/ml) and

females (8-18

> ng/ml), with levels of leptin correlated with BMI.

>

> ADH/osmolality: abnormalities in ADH/osmolality are recorded as

absolute if

> ADH is < 1.3 or > 8 pg/ml; or if osmolality is >295 or <275 mOsm/kg.

> Abnormalities are recorded as relative if simultaneous osmolality

is 292-295

> and ADH < 2.3; or if osmo is 275-278 and ADH> 4.0. Symptoms

associated with

> dysregulation of ADH include dehydration, frequent urination, with

urine

> showing low specific gravity; excessive thirst and sensitivity to

static

> electrical shocks; as well as edema and rapid weight gain due to

fluid

> retention during initial correction of ADH deficits.

>

> ACTH/cortisol: abnormalities in ACTH/cortisol are absolute if AM

cortisol >

> 19 ug/ml or < 8 ug/ml; or if AMACTH is >60 pg/ml or < 10 pg/ml.

> Abnormalities are recorded as

>

> dysregulation if simultaneous cortisol is > 15 and ACTH is > 15, or

if

> cortisol is < 8 and ACTH <40. Early in the illness, as MSH begins

to fall,

> high ACTH is associated with few symptoms; amarked increase in

symptoms is

> associated with a fall in ACTH. Finding simultaneous high cortisol

and high

> ACTH may prompt consideration of ACTH secreting tumors, but the

reality is

> that the dysregulation usually corrects with therapy.

>

> Androgens: total testosterone, androstenedione and DHEA-S provide

> measurements regarding the effectiveness of gonadotrophin secretion

as

> influenced adversely by MSH

>

> deficiency. Normal ranges of these hormones in males are 75-205

ng/ml for

> androstenedione, 350-1030 ng/ml for testosterone and 70-218 ug/ml

for

> DHEA-S. Normal values for pre-menopausal women are 60-245, 10-55

and 48-247,

> respectively. Postmenopausal normal ranges are 30-120, 7-40 and 48-

247,

> respectively.

>

> HLA DR by PCR: LabCorp offers a standard HLA DR typing assay of 10

alleles

> using a PCR sequence specific chain reaction technique. As opposed

to

> serologic assays for the

>

> HLA DR genotypes, the PCR gives far greater specificity in

distinguishing

> individual allele polymorphisms. Linkage disequilibrium is strong

in these

> genotypes, with multiple

>

> associations made to inflammatory and autoimmune disease. These

genes are

> part of the human major histocompatibility complex (MHC), also

called the

> HLA complex, located on the short arm of chromosome 6. Relative

risk was

> calculated, susceptible genotypes identified, compared within each

group to

> location and exposure.

>

> MMP9: matrix metalloproteinase 9 (gelatinase is an extracellular

> zinc-dependent enzyme produced by cytokine-stimulated neutrophils

and

> macrophages. MMP9 is involved in degradation of extracellular

matrix; it has

> been implicated in the pathogenesis COPD by destruction of lung

elastin, in

> rheumatoid arthritis, atherosclerosis, cardiomyopathy, and

abdominal aortic

> aneurysm. Cytokines that stimulate MMP9 production include IL-1, IL-

2, TNF,

> IL-1B, interferons alpha and gamma. MMP9 is felt to play a role in

central

> nervous system disease including demyelination, by generation of

myelin

> peptides, as it can break down myelin basic protein. MMP9 " delivers "

> inflammatory elements out of blood into subintimal spaces, where

further

> delivery into solid organs (brain, lung, muscle, peripheral nerve

and joint)

> is initiated. Normal ranges of MMP9 have a mean of 150, with range

of 85-322

> ng/ml.

>

> C3a and C4a: Split products of complement activation, often called

> anaphylatoxins. Each activates inflammatory responses, with

spillover of

> effect from innate immune response to acquired immune responses and

> hematologic parameters. These short-lived products are

remanufactured

> rapidly, such that an initial rise of plasma levels is seen within

12 hours

> of exposure and sustained elevation is seen until definitive

therapy is

> initiated. The components increase vascular permeability, release

> inflammatory elements from macrophages, neutrophils and monocytes,

stimulate

> smooth muscle spasm in small blood vessels and disrupt normal

apoptosis.

>

> Anticardiolipins IgA, IgM and IgG: autoantibodies often identified

in

> collagen vascular diseases such as lupus and scleroderma; often

called

> anti-phospholipids. These antibodies in high titers are associated

with

> increased intravascular coagulation requiring treatment with

heparin and

> coumadin. Lower levels titers are associated with

hypercoagulability. An

> increased risk of spontaneous fetal loss in the first trimester of

> pregnancy is not uncommonly seen in women with presence of

cardiolipin

> antibodies. This problem does not have the same " dose-response "

relationship

> seen with levels of autoantibodies and illness as does the

antiphospholipid

> syndrome. Anticardiolipins are found in over 33% of children with

biotoxins

> associated illnesses.

>

> Antigliadin IgA and IgG: Antibodies thought at one time to be

specific for

> celiac disease. With the advent of testing for IgA antibodies to

tissue

> transglutaminase (TTG-IgA), gliadin antibodies are most often seen

in

> patients with low levels of MSH. Ingestion of gliadin, the 22-amino

acid

> protein found in gluten (found in wheat, oats, barley and rye;

often added

> to processed foods) will initiate a release of pro-inflammatory

cytokines in

> the tissues lining the intestinal tract. This cytokine effect will

often

> cause symptoms within 30 minutes of ingestion that mimic attention

deficit

> disorder, often leading to an incorrect diagnosis. Antigliadin

antibodies

> are found in over 58% of children with biotoxin-associated

illnesses.

>

> Vasoactive intestinal polypeptide (VIP): neuroregulatory hormone

with

> receptors in suprachiasmatic nucleus of hypothalamus. This

hormone/cytokine

> regulates peripheral

>

> cytokine responses, pulmonary artery pressures and inflammatory

responses

> throughout the body. Deficiency is commonly seen in mold illness

patients,

> particularly those with dyspnea on exertion.

>

> http://newsroom.eworldwire.com/media_uploads/2.%

20Dr.Shoemaker_toxins_report

> .pdf

>

> KIDSWITHMCS/

>

>

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