[csda] The capsaicin cough reflex in eczema patients elicited by perfume, 2006 (fwd)

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Subject: [csda] The capsaicin cough reflex in eczema patients elicited by

perfume, 2006

The capsaicin cough reflex in eczema patients with respiratory

symptoms elicited by perfume.

Elberling J, Dirksen A, Johansen JD, Mosbech H.

The National Allergy Research Centre, Gentofte, Denmark.

Contact Dermatitis. 2006 Mar;54(3):158-64.

Respiratory symptoms elicited by perfume are common in the population

but have unclear pathophysiology. Increased capsaicin cough

responsiveness has been associated with the symptoms, but it is

unknown whether the site of the symptoms in the airways influences

this association. The aim of this study was to investigate the

association between the site of airway symptoms elicited by perfume

and cough responsiveness to bronchial challenge with capsaicin. 21

eczema patients with respiratory symptoms elicited by perfume were

compared with 21 healthy volunteers in a sex- and age-matched case

control study.

The participants completed a symptom questionnaire and underwent a

bronchial challenge with capsaicin. Lower, but not upper, respiratory

symptoms elicited by perfume were associated with increased capsaicin

cough responsiveness. Having severe symptoms to perfume (n = 11) did

not relate to the site of the symptoms in the airways and was not

associated with increased capsaicin cough responsiveness. In

conclusion, respiratory symptoms elicited by perfume may reflect

local hyperreactivity related to defensive reflexes in the airways,

and measurements of the capsaicin cough reflex are relevant when

patients with lower respiratory symptoms related to environmental

perfume exposures are investigated.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

cmd=Retrieve & db=pubmed & dopt=Abstract & list_uids=16524439 & query_hl=50 & it

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PMID: 16524439 [PubMed - in process]