Dr.Schaller - Re: MSH/VIP education source

[Guest guest]

Thanks, Dr.Schaller. Is there a book (or a link) by Dr. Cone on MSH ? Where can

I find the text you mention ?

Thanks

Jay

jschaller <jschaller@...> wrote:

The best text is by Dr. Cone on MSH. It is not light reading.

In two new books we try to expand on Cone's material and some new studies on the

20 plus roles of MSH.

Dr. Shoemaker was right that MSH (and VIP) are two powerful hormones to watch.

That is not only him saying this, it is just he reads--plug either into PubMed

and be prepared for a year of light reading.

JS

Re: [] Re: Potentially Life-Threatening Bloodstream

Infection

Hi Barb,

I am assuming they would use MSH analogues (synthetic Alpha MSH). Here's an

article from Pubmed.

J Med Chem. 2003 Feb 27;46(5):850-5. Related Articles,

Links

Novel alpha-melanocyte stimulating hormone peptide analogues with high

candidacidal activity.

Grieco P, Rossi C, Colombo G, Gatti S, Novellino E, Lipton JM, Catania A.

Department of Pharmaceutical Chemistry and Toxicology, University of Naples,

80131 Naples, Italy.

alpha-Melanocyte stimulating hormone (alpha-MSH) is an endogenous linear

tridecapeptide with potent antiinflammatory effects. We recently demonstrated

that alpha-MSH and its C-terminal sequence Lys-Pro-Val (alpha-MSH (11-13)) have

antimicrobial effects against two major and representative pathogens:

Staphylococcus aureus and Candida albicans. In an attempt to improve the

candidacidal activity of alpha-MSH and to better understand the peptide

structure-antifungal activity relations, we designed and synthesized novel

peptide analogues. Because previous data suggested that antimicrobial effects of

alpha-MSH were receptor-mediated, we chose to focus on the sequence alpha-MSH

(6-13), which contains the invariant core sequence His-Phe-Arg-Trp (6-9) that is

important for binding to the known melanocortin receptors and also contains the

sequence Lys-Pro-Val (11-13) that is known to be important for antimicrobial

activity. In this structure-activity study, we discovered several compounds

that have greater candidacidal activity than alpha-MSH. The peptide

[d-Nal-7,Phe-12]-alpha-MSH (6-13) was the most potent of the analogues tested.

The present results are very encouraging because they show the great potential

of these peptides as a truly novel class of candidacidal compounds.

barb1283 <barb1283@...> wrote: Hi Jay, I'm interested in your post but

how would a doctor use Alpha

Melanocyte Stimulating Hormone to treat Candida?? Perhaps you are

just reporting what was said and don't know how they would, just

asking just in case you do understand. barb

>

> Alpha MSH is Alpha Melanocyte Stimulating Hormone.

>

> I agree with what you say on systemic candida.

>

> Jay

>

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