MSH/VIP education source

[Guest guest]

The best text is by Dr. Cone on MSH. It is not light reading.

In two new books we try to expand on Cone's material and some new studies on the

20 plus roles of MSH.

Dr. Shoemaker was right that MSH (and VIP) are two powerful hormones to watch.

That is not only him saying this, it is just he reads--plug either into PubMed

and be prepared for a year of light reading.

JS

Re: [] Re: Potentially Life-Threatening Bloodstream

Infection

Hi Barb,

I am assuming they would use MSH analogues (synthetic Alpha MSH). Here's an

article from Pubmed.

J Med Chem. 2003 Feb 27;46(5):850-5. Related Articles,

Links

Novel alpha-melanocyte stimulating hormone peptide analogues with high

candidacidal activity.

Grieco P, Rossi C, Colombo G, Gatti S, Novellino E, Lipton JM, Catania A.

Department of Pharmaceutical Chemistry and Toxicology, University of Naples,

80131 Naples, Italy.

alpha-Melanocyte stimulating hormone (alpha-MSH) is an endogenous linear

tridecapeptide with potent antiinflammatory effects. We recently demonstrated

that alpha-MSH and its C-terminal sequence Lys-Pro-Val (alpha-MSH (11-13)) have

antimicrobial effects against two major and representative pathogens:

Staphylococcus aureus and Candida albicans. In an attempt to improve the

candidacidal activity of alpha-MSH and to better understand the peptide

structure-antifungal activity relations, we designed and synthesized novel

peptide analogues. Because previous data suggested that antimicrobial effects of

alpha-MSH were receptor-mediated, we chose to focus on the sequence alpha-MSH

(6-13), which contains the invariant core sequence His-Phe-Arg-Trp (6-9) that is

important for binding to the known melanocortin receptors and also contains the

sequence Lys-Pro-Val (11-13) that is known to be important for antimicrobial

activity. In this structure-activity study, we discovered several compounds that

have greater candidacidal activity than alpha-MSH. The peptide

[d-Nal-7,Phe-12]-alpha-MSH (6-13) was the most potent of the analogues tested.

The present results are very encouraging because they show the great potential

of these peptides as a truly novel class of candidacidal compounds.

barb1283 <barb1283@...> wrote: Hi Jay, I'm interested in your post but

how would a doctor use Alpha

Melanocyte Stimulating Hormone to treat Candida?? Perhaps you are

just reporting what was said and don't know how they would, just

asking just in case you do understand. barb

>

> Alpha MSH is Alpha Melanocyte Stimulating Hormone.

>

> I agree with what you say on systemic candida.

>

> Jay

>

FAIR USE NOTICE:

[Guest guest]

From: jschaller

Sent: Tuesday, February 28, 2006 8:03 PM

Subject: [] MSH/VIP education source

The best text is by Dr. Cone on MSH. It is not light reading.

* Would you please provide the full name of Dr Cone and/or the title of the

book. Thanks.

In two new books we try to expand on Cone's material and some new studies on

the 20 plus roles of MSH.

* Are these books available now? If so, would you please provide the titles

and authors? Thanks.

[Guest guest]

Can anyone tell me What VIP is? I know that mine is abnormal (and

not improving) but I am not sure what it is, or what it does.

Thanks.

--- In , " Bjerring " <jamesbj@...>

wrote:

>

> From: jschaller

>

> Sent: Tuesday, February 28, 2006 8:03 PM

> Subject: [] MSH/VIP education source

>

>

> The best text is by Dr. Cone on MSH. It is not light reading.

> * Would you please provide the full name of Dr Cone and/or the

title of the book. Thanks.

>

> In two new books we try to expand on Cone's material and some

new studies on the 20 plus roles of MSH.

>

> * Are these books available now? If so, would you please

provide the titles and authors? Thanks.

>

>

>

>

>

[Guest guest]

Here is some research I've done on VIP. Mine is very low also, along with

MSH.

I hope this helps.

Kathy

http://arbl.cvmbs.colostate.edu/hbooks/pathphys/endocrine/gi/vip.html

VIP is a 28-amino acid peptide structurally related to secretin. It was

originally isolated from intestinal extracts and shown to be a potent

vasodilator. Subsequent work demonstrated that VIP is very widely distributed in

the peripheral and central nervous systems, and probably should not be

considered a true GI hormone.

A huge number of biological effects have been attributed to VIP. With respect

to the digestive system, VIP seems to induce smooth muscle relaxation (lower

esophageal sphincter, stomach, gallbladder), stimulate secretion of water into

pancreatic juice and bile, and cause inhibition of gastric acid secretion and

absorption from the intestinal lumen.

Certain tumors arising from the pancreatic islets or nervous tissue (called

VIPomas) secrete excessive quantities of VIP, and are associated with chronic,

watery diarrhea.

--------------------------------------------------------------------------------\

--------

http://www.medhelp.org/glossary/new/gls_4350.htm

VASOACTIVE INTESTINAL PEPTIDE - is found in highest concentration in the

nervous system and gut. or VIP, may be a type of or neuromodulator. VIP

increases the and water secretion from the pancreas and intestines. It also

increases the release of hormones from the pancreas, gut, and hypothalamus. VIP

stimulates the breakdown of fat and glycogen; stimulates bile flow, and inhibits

gastrin and gastric acid secretion. Greater than normal values of VIP in the

bloodstream can indicate a VIP-secreting tumor

--------------------------------------------------------------------------------\

------------------------------------------

http://pharmrev.aspetjournals.org/cgi/content/full/56/2/249

Abstract

First identified by Said and Mutt some 30 years ago, the vasoactive intestinal

peptide (VIP) was originally isolated as a vasodilator peptide. Subsequently,

its biochemistry was elucidated, and within the 1st decade, their signature

features as a neuropeptide became consolidated. It did not take long for these

insights to permeate the field of immunology, out of which surprising new

attributes for VIP were found in the last years. VIP is rapidly transforming

into something more than a mere hormone. In evolving scientifically from a

hormone to a novel agent for modifying immune function and possibly a

cytokine-like molecule, VIP research has engaged many physiologists, molecular

biologists, biochemists, endocrinologists, and pharmacologists and it is a

paradigm to explore mutual interactions between neural and neuroendocrine links

in health and disease. The aim of this review is firstly to update our knowledge

of the cellular and molecular events relevant to VIP function on the

immune system and secondly to gather together recent data that support its role

as a type 2 cytokine. Recognition of the central functions VIP plays in cellular

processes is focusing our attention on this " very important peptide " as exciting

new candidates for therapeutic intervention and drug development.

-I. Introduction

Optimal host defense is the result of interactions between the two systems

implicated in homeostasis: the neuroendocrine and immune systems. For many

years, the neuroendocrine system and the immune system have been viewed as being

two autonomous networks functioning to maintain a balance between host and

environment. The neuroendocrine system responds to external stimuli such as

temperature, pain, and stress, whereas the immune system responds to exposure to

bacteria, viruses, and trauma. Within the last 30 years, a direct link between

the functions of these two systems has been pointed out by evidence presented in

four distinct areas: 1) psychoneuroimmunology, the interaction between stress,

behavior, and immune responses to diseases; 2) immunopsychiatry, abnormalities

of the immune system that may be associated with mental illness; 3)

immunoneurology, the actions of secreted immune factors and immunologically

competent cells on the central nervous system (CNS1); and 4)

neuroimmunomodulation, the effects of the CNS on immune function (for review,

see Weigent and Blalock, 1987

moldcankill <moldcankill@...> wrote: Can anyone tell me What VIP is? I

know that mine is abnormal (and

not improving) but I am not sure what it is, or what it does.

Thanks.

--- In , " Bjerring " <jamesbj@...>

wrote:

>

> From: jschaller

>

> Sent: Tuesday, February 28, 2006 8:03 PM

> Subject: [] MSH/VIP education source

>

>

> The best text is by Dr. Cone on MSH. It is not light reading.

> * Would you please provide the full name of Dr Cone and/or the

title of the book. Thanks.

>

> In two new books we try to expand on Cone's material and some

new studies on the 20 plus roles of MSH.

>

> * Are these books available now? If so, would you please

provide the titles and authors? Thanks.

>

>

>

>

>

[Guest guest]

Does anyone know if any dietary supplements or US-available,

affordable prescription drugs can improve synthesis of MSH or VIP?

I am taking cholestyramine and I live in a very moldy building and its

proving very difficult to deal with the situation.. My wife and I are

struggling to move out of my moldy home (don't know where we are

moving to yet, but we do have to go, as the mold is getting worse

rapidly, our basement is flooded and there is no escape from the mold

anymore...it seems, all our management strategies are not working like

they would need to..) and the big problem is overwhelming nausea and

fatigue when we stir it up.. but I have to pack...and clean.. (how do

you clean things when you can't get away from the mold.. anywhere?)

I am taking CSM, four times a day (and it is helping, especially when

I am successful in not stirring up mold.. but the problem is that I

HAVE to pack and with so much of our stuff covered with mold dust, the

problem is that I get sick almost immediately..)

The LL pretends not to understand containment or the need to clean -

it may be intentional, they want to terrify us, and its working.. we

are scared.. Even though we have not figured out where to move to we

need to get packed up and get out of here, but its taking FOREVER

because I get ill and my wife works full time and she's exhausted when

she gets home, so it falls on me.

And as I typed this.. I just felt a little earthquake.. I DON'T want

to be here in one of those..

[Guest guest]

-Thank you for this, I have allways suspected that my mold exposure

had something to do with loosing my gall bladder- after reading this-I

believe it must have- no one else on either side of my family ever had

gall bladder problems. recovering in Fl for 5 weeks after my operation-

which nearly killed me- I resolved alot of my symptoms- like

migraines-- which started up after being home a month- I said to my

nuero- that I thought my headaches were from a bad gall bladder and I

was surprised that they started up again--now if he had been on the

ball- he might have suspected mold illness, and given me a VCS test

then- I have been meaning to write him a letter explaining how he

missed the diagnosis- since then I heard that his brother had mold

illness- and a friend of mine he recommended seeing Dr Shoe-so

hopefully in the future people won't have to suffer 14 years

, Kathy <kathywnb@...> wrote:

>

> Here is some research I've done on VIP. Mine is very low also,

along with MSH.

> I hope this helps.

>

> Kathy

>

>

[Guest guest]

Dr Shoe recommends lots of fish body oil to raise VIP_

>

> Does anyone know if any dietary supplements or US-available,

> affordable prescription drugs can improve synthesis of MSH or VIP?

>

> I am taking cholestyramine and I live in a very moldy building and

its

> proving very difficult to deal with the situation.. My wife and I

are

> struggling to move out of my moldy home (don't know where we are

> moving to yet, but we do have to go, as the mold is getting worse

> rapidly, our basement is flooded and there is no escape from the

mold

> anymore...it seems, all our management strategies are not working

like

> they would need to..) and the big problem is overwhelming nausea

and

> fatigue when we stir it up.. but I have to pack...and clean.. (how

do

> you clean things when you can't get away from the mold.. anywhere?)

>

> I am taking CSM, four times a day (and it is helping, especially

when

> I am successful in not stirring up mold.. but the problem is that I

> HAVE to pack and with so much of our stuff covered with mold dust,

the

> problem is that I get sick almost immediately..)

>

> The LL pretends not to understand containment or the need to

clean -

> it may be intentional, they want to terrify us, and its working..

we

> are scared.. Even though we have not figured out where to move to

we

> need to get packed up and get out of here, but its taking FOREVER

> because I get ill and my wife works full time and she's exhausted

when

> she gets home, so it falls on me.

>

> And as I typed this.. I just felt a little earthquake.. I DON'T

want

> to be here in one of those..

>

[Guest guest]

>>>Dr Shoe recommends lots of fish body oil to raise VIP_

>

> Does anyone know if any dietary supplements or US-available,

> affordable prescription drugs can improve synthesis of MSH or VIP?>>

Take a look at:

http://www.personalconsult.com/articles/moldandbiotoxins/moldandnutritionalt

reatments.html

Dr. Schaller's website is extraordinary for those of you who haven't

visited. He has a searchable data base, just type in what you are looking

for and click on the links. I'm learning so much from his generous web

site; could spend days reading and never finish.

Rosie

[Guest guest]

hope this helps, if you can stand the smell of ammonia, mix half

and half in a spray bottle and spray down the air in your home. it

doesn't kill mold, but nutralizes it temperarily, also wash your

cloths, blankets exc. with it. do not mix with bleach. and you can

wipe down some belongings. anything that is not washable, throw away

or put in air tight containers. try not to take the mold with you, or

it well still make you sick. throw away your bed mattresses. wash

your pillows. I did have a antique chase lounge that I refused to

part with, I left it out in the sunshine, put on my mask and beated

the crap out of it with a broom(good therepy,lol) it seamed to have

worked.

>

> Dr Shoe recommends lots of fish body oil to raise VIP_

> >

> > Does anyone know if any dietary supplements or US-available,

> > affordable prescription drugs can improve synthesis of MSH or VIP?

> >

> > I am taking cholestyramine and I live in a very moldy building

and

> its

> > proving very difficult to deal with the situation.. My wife and I

> are

> > struggling to move out of my moldy home (don't know where we are

> > moving to yet, but we do have to go, as the mold is getting worse

> > rapidly, our basement is flooded and there is no escape from the

> mold

> > anymore...it seems, all our management strategies are not working

> like

> > they would need to..) and the big problem is overwhelming nausea

> and

> > fatigue when we stir it up.. but I have to pack...and clean..

(how

> do

> > you clean things when you can't get away from the mold..

anywhere?)

> >

> > I am taking CSM, four times a day (and it is helping, especially

> when

> > I am successful in not stirring up mold.. but the problem is that

I

> > HAVE to pack and with so much of our stuff covered with mold

dust,

> the

> > problem is that I get sick almost immediately..)

> >

> > The LL pretends not to understand containment or the need to

> clean -

> > it may be intentional, they want to terrify us, and its working..

> we

> > are scared.. Even though we have not figured out where to move to

> we

> > need to get packed up and get out of here, but its taking FOREVER

> > because I get ill and my wife works full time and she's exhausted

> when

> > she gets home, so it falls on me.

> >

> > And as I typed this.. I just felt a little earthquake.. I DON'T

> want

> > to be here in one of those..

> >

>