Guest guest Posted March 22, 2008 Report Share Posted March 22, 2008 PCOS is not PA. I use up to 400 mg for PA. I recommend you ask her to read about the treatment of PA with spiro and Inspra. Dr. Young at the Mayo clinic has written the most recently about this. On Mar 22, 2008, at 2:23 PM, Valarie wrote: > 2nd day on 50 mg spiro. Nothing's changed. Still sweating, still > anxiety, > still swelling. BP up from 152 to 164 (where I started before > Inspra). I > think the Inspra may have been starting to kick in. I had taken it 9 > days, > but only 25 mg most days. Wt has increased 2 lbs since stopping > Triam/HCTZ. > I need to give it more time. I am NOT eating salt, probably no more > than > 600 - 800 mg/day. > > The blips of 135 - 145 I had for one day had to have been Mutka Vati. > I've > stopped that. > > My doc uses 50 mg spiro for her PCOS patients. I'm not sure she's ever > treated PA. Seriously doubt 50 mg is enough. > > She really wants me to take the Ativan. Could it be that once an > anxiety > state starts, it needs something to stop it? For a couple of days, > I've > been taking 1 mg at night and 1/2 mg in day if needed. > > Lord, give me patience! > > Val > > From: hyperaldosteronism > [mailto:hyperaldosteronism ] On Behalf Of Clarence Grim > > Swelling almost always requires excess salt in the diet. Has your > weight increased? > > I recommend looking at EVERYTHING you are eating or drinking and > taking > to see where the Na is coming from. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 22, 2008 Report Share Posted March 22, 2008 I guess I will call her to double it if I'm not seeing any change. Chances are, I won't get a call back until next Thursday anyway. She's only in my office on Thursday and Friday. I'm getting a little resentful. It shouldn't have taken seven days to even get started on Inspra and then another week to get a change off of it. Every day this goes on is a day out of my life. Gives me the weepies, sometimes. Should spiro be taken 2x/day or is once enough? I ordered 300 - 25 mg spiro for myself so I can titrate. I'm good enough, I'm smart enough, and damn, I could get myself well faster! I check BP twice a day. Problem is, it won't be here for two weeks. I have a double whammy with the swelling. Non-pitting edema is common in low thyroid. The only time it totally leaves me is when I take some T3 but that, of course, sets off an episode. Anyway, I dropped my T4 dose for a few days to see if that helped the racing/anxiety. No change (except cold feet) so I bumped it back up today. I've been reading old posts from the archives. I am seeing sweating and racing/anxiety. It help me to see I'm not alone with these crazy symptoms. I'll go see if I can find Dr. Young's writing on the drugs for treating. Val From: hyperaldosteronism [mailto:hyperaldosteronism ] On Behalf Of Clarence Grim PCOS is not PA. I use up to 400 mg for PA. I recommend you ask her to read about the treatment of PA with spiro and Inspra. Dr. Young at the Mayo clinic has written the most recently about this. On Mar 22, 2008, at 2:23 PM, Valarie wrote: > 2nd day on 50 mg spiro. Nothing's changed. Still sweating, still > anxiety, > still swelling. BP up from 152 to 164 (where I started before > Inspra). I > think the Inspra may have been starting to kick in. I had taken it 9 > days, > but only 25 mg most days. Wt has increased 2 lbs since stopping > Triam/HCTZ. > I need to give it more time. I am NOT eating salt, probably no more > than > 600 - 800 mg/day. > > The blips of 135 - 145 I had for one day had to have been Mutka Vati. > I've > stopped that. > > My doc uses 50 mg spiro for her PCOS patients. I'm not sure she's ever > treated PA. Seriously doubt 50 mg is enough. > > She really wants me to take the Ativan. Could it be that once an > anxiety > state starts, it needs something to stop it? For a couple of days, > I've > been taking 1 mg at night and 1/2 mg in day if needed. > > Lord, give me patience! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 22, 2008 Report Share Posted March 22, 2008 BRITISH MEDICAL JOURNAL 24 JUNE 1972 All 67 patients received oral spironolactone in a dose of 50-400 mg daily (mean 254 mg daily) for a minimum period of four weeks As shown in the Table, spironolactone treatment was accompanied by significant reductions in body weight, total body water, extracellular fluid volume, and plasma volume. My copy of Guyton and Hall's book came today. I will be busy learning everything I couldn't comprehend in college. Val From: hyperaldosteronism [mailto:hyperaldosteronism ] On Behalf Of Clarence Grim PCOS is not PA. I use up to 400 mg for PA. I recommend you ask her to read about the treatment of PA with spiro and Inspra. Dr. Young at the Mayo clinic has written the most recently about this. On Mar 22, 2008, at 2:23 PM, Valarie wrote: > 2nd day on 50 mg spiro. Nothing's changed. Still sweating, still > anxiety, > still swelling. BP up from 152 to 164 (where I started before > Inspra). I > think the Inspra may have been starting to kick in. I had taken it 9 > days, > but only 25 mg most days. Wt has increased 2 lbs since stopping > Triam/HCTZ. > I need to give it more time. I am NOT eating salt, probably no more > than > 600 - 800 mg/day. > > The blips of 135 - 145 I had for one day had to have been Mutka Vati. > I've > stopped that. > > My doc uses 50 mg spiro for her PCOS patients. I'm not sure she's ever > treated PA. Seriously doubt 50 mg is enough. > > She really wants me to take the Ativan. Could it be that once an > anxiety > state starts, it needs something to stop it? For a couple of days, > I've > been taking 1 mg at night and 1/2 mg in day if needed. > > Lord, give me patience! > > Val > > From: hyperaldosteronism <mailto:hyperaldosteronism%40> > [mailto:hyperaldosteronism <mailto:hyperaldosteronism%40> ] On Behalf Of Clarence Grim > > Swelling almost always requires excess salt in the diet. Has your > weight increased? > > I recommend looking at EVERYTHING you are eating or drinking and > taking > to see where the Na is coming from. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 23, 2008 Report Share Posted March 23, 2008 Spiron can be taken once a day but with your GI upsets with Inspra I would do bid till you are stable. You can increase dose every 4-5 days by 25 mg. On Mar 22, 2008, at 9:58 PM, Valarie wrote: > I guess I will call her to double it if I'm not seeing any change. > Chances > are, I won't get a call back until next Thursday anyway. She's only > in my > office on Thursday and Friday. I'm getting a little resentful. It > shouldn't have taken seven days to even get started on Inspra and then > another week to get a change off of it. Every day this goes on is a > day out > of my life. Gives me the weepies, sometimes. > > Should spiro be taken 2x/day or is once enough? > > I ordered 300 - 25 mg spiro for myself so I can titrate. I'm good > enough, > I'm smart enough, and damn, I could get myself well faster! I check BP > twice a day. Problem is, it won't be here for two weeks. > > I have a double whammy with the swelling. Non-pitting edema is common > in > low thyroid. The only time it totally leaves me is when I take some > T3 but > that, of course, sets off an episode. Anyway, I dropped my T4 dose > for a > few days to see if that helped the racing/anxiety. No change (except > cold > feet) so I bumped it back up today. > > I've been reading old posts from the archives. I am seeing sweating > and > racing/anxiety. It help me to see I'm not alone with these crazy > symptoms. > > I'll go see if I can find Dr. Young's writing on the drugs for > treating. > > Val > > From: hyperaldosteronism > [mailto:hyperaldosteronism ] On Behalf Of Clarence Grim > > PCOS is not PA. I use up to 400 mg for PA. > > I recommend you ask her to read about the treatment of PA with spiro > and Inspra. > > Dr. Young at the Mayo clinic has written the most recently about this. > > On Mar 22, 2008, at 2:23 PM, Valarie wrote: > > > 2nd day on 50 mg spiro. Nothing's changed. Still sweating, still > > anxiety, > > still swelling. BP up from 152 to 164 (where I started before > > Inspra). I > > think the Inspra may have been starting to kick in. I had taken it 9 > > days, > > but only 25 mg most days. Wt has increased 2 lbs since stopping > > Triam/HCTZ. > > I need to give it more time. I am NOT eating salt, probably no more > > than > > 600 - 800 mg/day. > > > > The blips of 135 - 145 I had for one day had to have been Mutka > Vati. > > I've > > stopped that. > > > > My doc uses 50 mg spiro for her PCOS patients. I'm not sure she's > ever > > treated PA. Seriously doubt 50 mg is enough. > > > > She really wants me to take the Ativan. Could it be that once an > > anxiety > > state starts, it needs something to stop it? For a couple of days, > > I've > > been taking 1 mg at night and 1/2 mg in day if needed. > > > > Lord, give me patience! > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 23, 2008 Report Share Posted March 23, 2008 Note the date of the publication. Good data is good data. On Mar 22, 2008, at 11:13 PM, Valarie wrote: > > May your pressure be low! CE Grim BS, MS, MD High Blood Pressure Consulting Specializing in Difficult to Manage High Blood Pressure Consult the following at for details bloodpressureline hyperaldosteronism Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 23, 2008 Report Share Posted March 23, 2008 I have a new computer and when I click on a *.pdf, it opens but the URL is not displayed. I've uploaded this particular article in case you're interested. I found it fascinating in that it's a 35-year-old report. hyperaldosteronism/files/-MedlineArticl es/ I apologize if it is in the wrong folder. Couldn't quite determine where to put it. Val From: hyperaldosteronism [mailto:hyperaldosteronism ] On Behalf Of Clarence Grim Note the date of the publication. Good data is good data. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 23, 2008 Report Share Posted March 23, 2008 Was still 5 years after I trained with Dr. Conn. On Mar 23, 2008, at 6:38 PM, Valarie wrote: > I have a new computer and when I click on a *.pdf, it opens but the > URL is > not displayed. I've uploaded this particular article in case you're > interested. I found it fascinating in that it's a 35-year-old report. > > hyperaldosteronism/files/- > MedlineArticl > es/ > > I apologize if it is in the wrong folder. Couldn't quite determine > where to > put it. > > Val > > From: hyperaldosteronism > [mailto:hyperaldosteronism ] On Behalf Of Clarence Grim > > Note the date of the publication. Good data is good data. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 23, 2008 Report Share Posted March 23, 2008 I know. I don't know what I did to deserve finding you. You have been a Godsend to all of us, and I thank you. Val Cohen EL, Grim CE, Conn JW, Blough WM Jr, Guyer RB, Kem DC, Lucas CP. Accurate and rapid measurement of plasma renin activity by radioimmunoassay. Results in normal and hypertensive people. J Lab Clin Med. 1971 Jun;77(6):1025-38. No abstract available. PMID: 4327019 [PubMed - indexed for MEDLINE] Gunnells JC Jr, McGuffin WL Jr, RR, Grim CE, Wells S, Silver D, Glenn JF. Hypertension, adrenal abnormalities, and alterations in plasma renin activity. Ann Intern Med. 1970 Dec;73(6):901-11. No abstract available. PMID: 5525542 [PubMed - indexed for MEDLINE] Grim CE, Glenn JF, Wynn JO, Gunnells JC Jr. Bilateral pheochromocytoma: the application of a plasma catecholamine bioassay for tumor localization. Am Heart J. 1967 Dec;74(6):809-15. No abstract available. PMID: 6073359 [PubMed - indexed for MEDLINE] Gunnells JC Jr, Grim CE. Hematuria and A-D hemoglobinopathy. Arch Intern Med. 1967 Sep;120(3):337-40. No abstract available. PMID: 6038293 [PubMed - indexed for MEDLINE] Grim CE, McBryde AC, Glenn JF, Gunnells JC Jr. Childhood primary aldosteronism with bilateral adrenocortical hyperplasia: plasma renin activity as an aid to diagnosis. J Pediatr. 1967 Sep;71(3):377-83. No abstract available. PMID: 6034788 [PubMed - indexed for MEDLINE] Gunnells JC Jr, Grim CE, RR, Wildermann NM. Plasma renin activity in healthy subjects and patients with hypertension. Preliminary experience with a rapid and quantitative bio-assay. Arch Intern Med. 1967 Mar;119(3):232-40. No abstract available. PMID: 6019940 [PubMed - indexed for MEDLINE] From: hyperaldosteronism [mailto:hyperaldosteronism ] On Behalf Of Clarence Grim Was still 5 years after I trained with Dr. Conn. On Mar 23, 2008, at 6:38 PM, Valarie wrote: I've uploaded this particular article in case you're > interested. I found it fascinating in that it's a 35-year-old report. > > hyperaldosteronism/files/-MedlineArticl es/ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 23, 2008 Report Share Posted March 23, 2008 Did I send you my CV for your files? On Mar 23, 2008, at 10:40 PM, Valarie wrote: > I know. I don't know what I did to deserve finding you. You have been a > Godsend to all of us, and I thank you. > > Val > > Cohen EL, Grim CE, Conn JW, Blough WM Jr, Guyer RB, Kem DC, Lucas CP. > > Accurate and rapid measurement of plasma renin activity by > radioimmunoassay. > Results in normal and hypertensive people. > J Lab Clin Med. 1971 Jun;77(6):1025-38. No abstract available. > PMID: 4327019 [PubMed - indexed for MEDLINE] > > Gunnells JC Jr, McGuffin WL Jr, RR, Grim CE, Wells S, Silver > D, > Glenn JF. > > Hypertension, adrenal abnormalities, and alterations in plasma renin > activity. > Ann Intern Med. 1970 Dec;73(6):901-11. No abstract available. > PMID: 5525542 [PubMed - indexed for MEDLINE] > > Grim CE, Glenn JF, Wynn JO, Gunnells JC Jr. > > Bilateral pheochromocytoma: the application of a plasma catecholamine > bioassay for tumor localization. > Am Heart J. 1967 Dec;74(6):809-15. No abstract available. > PMID: 6073359 [PubMed - indexed for MEDLINE] > > Gunnells JC Jr, Grim CE. > > Hematuria and A-D hemoglobinopathy. > Arch Intern Med. 1967 Sep;120(3):337-40. No abstract available. > PMID: 6038293 [PubMed - indexed for MEDLINE] > > Grim CE, McBryde AC, Glenn JF, Gunnells JC Jr. > > Childhood primary aldosteronism with bilateral adrenocortical > hyperplasia: > plasma renin activity as an aid to diagnosis. > J Pediatr. 1967 Sep;71(3):377-83. No abstract available. > PMID: 6034788 [PubMed - indexed for MEDLINE] > > Gunnells JC Jr, Grim CE, RR, Wildermann NM. > > Plasma renin activity in healthy subjects and patients with > hypertension. > Preliminary experience with a rapid and quantitative bio-assay. > Arch Intern Med. 1967 Mar;119(3):232-40. No abstract available. > PMID: 6019940 [PubMed - indexed for MEDLINE] > > From: hyperaldosteronism > [mailto:hyperaldosteronism ] On Behalf Of Clarence Grim > > Was still 5 years after I trained with Dr. Conn. > > On Mar 23, 2008, at 6:38 PM, Valarie wrote: > > I've uploaded this particular article in case you're > > interested. I found it fascinating in that it's a 35-year-old > report. > > > > > hyperaldosteronism/files/- > MedlineArticl > es/ > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 23, 2008 Report Share Posted March 23, 2008 CV? I thought I knew most of the words by now. I don't know CV. Val From: hyperaldosteronism [mailto:hyperaldosteronism ] On Behalf Of Clarence Grim Did I send you my CV for your files? On Mar 23, 2008, at 10:40 PM, Valarie wrote: > I know. I don't know what I did to deserve finding you. You have been a > Godsend to all of us, and I thank you. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 23, 2008 Report Share Posted March 23, 2008 Oh, now I know what it is. No, you didn't. I would like that please. Val From: hyperaldosteronism [mailto:hyperaldosteronism ] On Behalf Of Clarence Grim Sent: Sunday, March 23, 2008 9:57 PM hyperaldosteronism Subject: Re: Spiro experience Did I send you my CV for your files? On Mar 23, 2008, at 10:40 PM, Valarie wrote: > I know. I don't know what I did to deserve finding you. You have been a > Godsend to all of us, and I thank you. > > Val Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 23, 2008 Report Share Posted March 23, 2008 Curriculum Vitae with all my references etc. On Mar 24, 2008, at 12:00 AM, Valarie wrote: > CV? I thought I knew most of the words by now. I don't know CV. > > Val > > From: hyperaldosteronism > [mailto:hyperaldosteronism ] On Behalf Of Clarence Grim > > Did I send you my CV for your files? > > On Mar 23, 2008, at 10:40 PM, Valarie wrote: > > > I know. I don't know what I did to deserve finding you. You have > been a > > Godsend to all of us, and I thank you. > > Quote Link to comment Share on other sites More sharing options...
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