Guest guest Posted July 6, 2001 Report Share Posted July 6, 2001 Collagen becomes excessively cross-linked with age, resulting in loss of tissue elasticity, wrinkles, and aging. This was demonstrated conclusively by Bjorksten, Verzar, and other early researchers. Bjorksten spent his life searching for the crosslinkage inhibitor and breaker that he believed would retard the aging process. He demonstrated that EDTA could reverse crosslinkages to a limited degree. However, it now appears that we have other crosslinkage inhibitors (aminoguanadine, Metformin, carnosine) and crosslinkage breakers (ALT 711 and others), as recently presented by Dr. Don Kleinsek (a former associate of Bjorksten) at the the 2d annual Monte Carlo Anti-Aging Conference in Monaco. DMSO is probably one of these anti-crosslinkage agents that Bjorksten was searching for. Its long-term safety has been well-established in topical, IV and oral use. Ward Dean, M.D. Re: DMSO > > Hi Trish, > > Isn't it disconcerting that DMSO breaks down the collagen of scleroderma > patients? I wonder what it would do with our (normal) collagen? Anyone out > there with some ideas? It'd be a great transporter even if it does 'spice' > one up like a head of garlic... > > MM Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 6, 2001 Report Share Posted July 6, 2001 Dear Dr Dean, Thanks for your interesting reply! You mention the following: " DMSO is probably one of these anti-crosslinkage agents that Bjorksten was searching for. Its long-term safety has been well-established in topical, IV and oral use. " I'd love to read some abstracts and/or research about the anti-crosslinkage effects of DMSO on collagen. I understood that DMSO breaks down the collagen matrix in scleroderma patients. Why wouldn't that be the case in normal collagen? Also the safety studies of DMSO are of interest!. I found very little on Medline. Also, have you read Rae's warning on Aminoguanidine? I saved it (in case you haven't seen it yet.) critiques, contrasts? comments? Thank You! MM _________________________________________________________________ Get your FREE download of MSN Explorer at http://explorer.msn.com Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 6, 2001 Report Share Posted July 6, 2001 MM, I'm away from home and don't have access to my library here. However, Dr. Stanley s (I think he's at the U of Oregon) has done a great deal of the clinical work with DMSO. Use his name to start your search. I don't think DMSO causes collagen matrix to break down, but does, I believe, reverse some of the crosslinking. I have not seen Rae's comments on aminoguanadine. I'd appreciate your sending them. Thanks, Ward Re: DMSO and crosslinking > Dear Dr Dean, > Thanks for your interesting reply! You mention the following: > > " DMSO is probably one of these anti-crosslinkage agents that Bjorksten was > searching for. Its long-term safety has been well-established in topical, > IV and oral use. " > > I'd love to read some abstracts and/or research about the anti-crosslinkage > effects of DMSO on collagen. I understood that DMSO breaks down the collagen > matrix in scleroderma patients. Why wouldn't that be the case in normal > collagen? > Also the safety studies of DMSO are of interest!. I found very little on > Medline. > > Also, have you read Rae's warning on Aminoguanidine? > I saved it (in case you haven't seen it yet.) > critiques, contrasts? comments? > > Thank You! > MM Quote Link to comment Share on other sites More sharing options...
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