Re: Rest Easy: MIT Study Confirms Melatonin's Value As Sleep Aid

March 17, 2005

On reading the label on a bottle of 3 mg Melatonin I noticed a warning about

taking it if on HBP medication or if you have HBP. Anyone know why that

might be?? I take 80 mg a day of Diovan. I find the Melatonin helpful with

my sleep and have noticed no particular problem with regard to the HBP.

Bill

Rest Easy: MIT Study Confirms Melatonin's Value As

Sleep Aid

>

> Rest Easy: MIT Study Confirms Melatonin's Value As Sleep Aid

> A new study by MIT scientists and colleagues confirms that melatonin

> is an

> effective sleep aid for older insomniacs and others. Misuse of the hormone

> had

> led some to question its efficacy, but the latest work (published in the

> February issue of Sleep Medicine Reviews) could jump-start interest in the

> dietary supplement and help more people get a good night's sleep.

>

March 17, 2005

Melatonin may raise high blood pressure.

You may want to monitor your blood pressure at various times of the day.

A blood pressure of 120/80 seems to be the consensus for BP. ALLHAT found

that 77% of people being treated for HBP did not have their blood pressure

adequately under control.

Re: Rest Easy: MIT Study Confirms Melatonin's Value As

Sleep Aid

On reading the label on a bottle of 3 mg Melatonin I noticed a warning about

taking it if on HBP medication or if you have HBP. Anyone know why that

might be?? I take 80 mg a day of Diovan. I find the Melatonin helpful with

my sleep and have noticed no particular problem with regard to the HBP.

Bill

Rest Easy: MIT Study Confirms Melatonin's Value As

Sleep Aid

>

> Rest Easy: MIT Study Confirms Melatonin's Value As Sleep Aid

> A new study by MIT scientists and colleagues confirms that melatonin

> is an

> effective sleep aid for older insomniacs and others. Misuse of the hormone

> had

> led some to question its efficacy, but the latest work (published in the

> February issue of Sleep Medicine Reviews) could jump-start interest in the

> dietary supplement and help more people get a good night's sleep.

>

March 23, 2005

I take 9 mg each night and it's not that effective. An additional sleep aid

like Ambien helps but doesn't have much of an effect without the Melatonin.

As to blood pressure, it never had an effect one way or the other. I take

medication for that and typically about 2 hours after taking the melatonin my

BP runs about between 115/70 and 107/65.

--

Steve - dudescholar@...

On Thursday 17 March 2005 12:04 pm, best bad example wrote:

> I take a very low dose, like half a 1 MG tablet.

> More seems to bring on a sluggish morning

> headache.

> BuddyRay

>

> --- Sharon <sharon-anderson@...>

>

> wrote:

> > Melatonin may raise high blood pressure.

> > You may want to monitor your blood pressure at

> > various times of the day.

> > A blood pressure of 120/80 seems to be the

> > consensus for BP. ALLHAT found

> > that 77% of people being treated for HBP did

> > not have their blood pressure

> > adequately under control.

> >

> > Re: Rest Easy: MIT Study

> > Confirms Melatonin's Value As

> > Sleep Aid

> >

> > On reading the label on a bottle of 3 mg

> > Melatonin I noticed a warning about

> >

> > taking it if on HBP medication or if you have

> > HBP. Anyone know why that

> > might be?? I take 80 mg a day of Diovan. I

> > find the Melatonin helpful with

> >

> > my sleep and have noticed no particular problem

> > with regard to the HBP.

> >

> > Bill

> > Rest Easy: MIT Study

> > Confirms Melatonin's Value As

> > Sleep Aid

> >

> > > Rest Easy: MIT Study Confirms Melatonin's

> >

> > Value As Sleep Aid

> >

> > > A new study by MIT scientists and

> >

> > colleagues confirms that melatonin

> >

> > > is an

> > > effective sleep aid for older insomniacs and

> >

> > others. Misuse of the hormone

> >

> > > had

> > > led some to question its efficacy, but the

> >

> > latest work (published in the

> >

> > > February issue of Sleep Medicine Reviews)

> >

> > could jump-start interest in the

> >

> > > dietary supplement and help more people get a

> >

> > good night's sleep.

> >

> > > [Non-text portions of this message have been

> >

> > removed]

> >

> > > Note: This forum is for discussion of health

> >

> > related subjects but under no

> >

> > > circumstances should any information

> >

> > published here be considered a

> >

> > > substitute for personal medical advice from a

> >

> > qualified physician. -the

> >

> > > owner

> > >

March 24, 2005

I was told that the BP medication thing is only if the medication is a Beta

Blocker. It has something to do with the Melatonin/Seratonin relationship.

Rest Easy: MIT Study

>> > Confirms Melatonin's Value As

>> > Sleep Aid

>> >

>> > > Rest Easy: MIT Study Confirms Melatonin's

>> >

>> > Value As Sleep Aid

>> >

>> > > A new study by MIT scientists and

>> >

>> > colleagues confirms that melatonin

>> >

>> > > is an

>> > > effective sleep aid for older insomniacs and

>> >

>> > others. Misuse of the hormone

>> >

>> > > had

>> > > led some to question its efficacy, but the

>> >

>> > latest work (published in the

>> >

>> > > February issue of Sleep Medicine Reviews)

>> >

>> > could jump-start interest in the

>> >

>> > > dietary supplement and help more people get a

>> >

>> > good night's sleep.

>> >

>> > > [Non-text portions of this message have been

>> >

>> > removed]

>> >

>> > > Note: This forum is for discussion of health

>> >

>> > related subjects but under no

>> >

>> > > circumstances should any information

>> >

>> > published here be considered a

>> >

>> > > substitute for personal medical advice from a

>> >

>> > qualified physician. -the

>> >

>> > > owner

>> > >

March 24, 2005

> I take 9 mg each night and it's not that effective.

Sounds like you're taking way too much...

Rest Easy: MIT Study Confirms Melatonin's Value As Sleep Aid

CAMBRIDGE, Mass. -- A new study by MIT scientists and colleagues

confirms that melatonin is an effective sleep aid for older insomniacs

and others. Misuse of the hormone had led some to question its

efficacy, but the latest work (published in the February issue of

Sleep Medicine Reviews) could jump-start interest in the dietary

supplement and help more people get a good night's sleep.

In earlier research, scientists led by Professor Wurtman,

principal investigator for the current study, showed that only a small

dose of melatonin (about 0.3 milligrams) is necessary for a restful

effect. Taken in that quantity, it not only helps people fall asleep,

but also makes it easier for them to return to sleep after waking up

during the night--a problem for many older adults.

The researchers also found, however, that commercially available

melatonin pills contain 10 times the effective amount. And at that

dose, " after a few days it stops working, " said Wurtman, director of

MIT's Clinical Research Center and the Cecil H. Green Distinguished

Professor. When the melatonin receptors in the brain are exposed to

too much of the hormone, they become unresponsive.

As a result of these inadvertent overdoses, " many people don't think

melatonin works at all, " said Wurtman, who is also affiliated with the

Department of Brain and Cognitive Sciences. This belief, coupled with

potentially serious side effects related to high doses such as

hypothermia, has earned the hormone a bad reputation in some

quarters-- " and something that could be very useful to a lot of people

isn't, " said Wurtman, who said that he and his wife have been taking

melatonin every night for about a year now.

To determine conclusively whether melatonin works or not, the

scientists in the current study analyzed 17 peer-reviewed scientific

papers about the hormone. To be included in this study, or

meta-analysis, the experiments reported in each paper had to satisfy

specific criteria. For example, each had to be placebo-controlled and

include objective measurements on at least six adult subjects.

" A meta-analysis essentially tells 'yes' or 'no'--that a treatment

does or does not have a significant effect, " Wurtman said. " When a

meta-analysis says 'yes,' there should no longer be any controversy

about whether the treatment works. "

The melatonin meta-analysis delivered a definitive " yes. "

Wurtman notes that some of the 17 studies included in the analysis

involved very high doses of the hormone over long periods, a

" situation where we know it's not going to work. " Yet the

meta-analysis still showed that the hormone's positive effects on

sleep " are statistically significant. "

When Wurtman first discovered the efficacy of small doses of

melatonin, he and MIT patented its use for dosages up to one

milligram. Because the FDA defined the hormone as a dietary

supplement, however, manufacturers were free to sell it in much higher

dosages, " even though we knew they wouldn't work, " Wurtman said.

As a result, until recently the hormone was commercially unavailable

to the public in small doses. " People who knew that small doses were

best often bought the high-dose pills, then divided them with a

knife, " Wurtman said. " But that's not very accurate. "

The company Nature's Bounty has since licensed the work, and now the

hormone is easily available in the effective dosages.

Wurtman's colleagues in the meta-analysis work are Amnon Brzezinski of

Hadassah-Hebrew University Medical Center in Israel; Mark G. Vangel, a

visiting scientist at the Clinical Research Center; Gillian Norrie and

Ian Ford of the University of Glasgow in Scotland; and Irina Zhdanova

of the Boston University School of Medicine.

###

The work was supported by the National Institutes of Health, the

Center for Brain Sciences and Metabolism Charitable Trust, and the

Womens' Health Center of Hadassah-Hebrew University Medical Center.

http://www.sciencedaily.com/releases/2005/03/050308134331.htm

On Wed, 23 Mar 2005 20:50:27 -0700, steve <dudescholar@...> wrote:

> I take 9 mg each night and it's not that effective. An additional sleep aid

> like Ambien helps but doesn't have much of an effect without the Melatonin.

>

> As to blood pressure, it never had an effect one way or the other. I take

> medication for that and typically about 2 hours after taking the melatonin

> my

> BP runs about between 115/70 and 107/65.

>

> --

>

> Steve - dudescholar@...

>

> On Thursday 17 March 2005 12:04 pm, best bad example wrote:

> > I take a very low dose, like half a 1 MG tablet.

> > More seems to bring on a sluggish morning

> > headache.

> > BuddyRay

> >

> > --- Sharon <sharon-anderson@...>

> >

> > wrote:

> > > Melatonin may raise high blood pressure.

> > > You may want to monitor your blood pressure at

> > > various times of the day.

> > > A blood pressure of 120/80 seems to be the

> > > consensus for BP. ALLHAT found

> > > that 77% of people being treated for HBP did

> > > not have their blood pressure

> > > adequately under control.

> > >

> > > Re: Rest Easy: MIT Study

> > > Confirms Melatonin's Value As

> > > Sleep Aid

> > >

> > > On reading the label on a bottle of 3 mg

> > > Melatonin I noticed a warning about

> > >

> > > taking it if on HBP medication or if you have

> > > HBP. Anyone know why that

> > > might be?? I take 80 mg a day of Diovan. I

> > > find the Melatonin helpful with

> > >

> > > my sleep and have noticed no particular problem

> > > with regard to the HBP.

> > >

> > > Bill

> > > Rest Easy: MIT Study

> > > Confirms Melatonin's Value As

> > > Sleep Aid

> > >

> > > > Rest Easy: MIT Study Confirms Melatonin's

> > >

> > > Value As Sleep Aid

> > >

> > > > A new study by MIT scientists and

> > >

> > > colleagues confirms that melatonin

> > >

> > > > is an

> > > > effective sleep aid for older insomniacs and

> > >

> > > others. Misuse of the hormone

> > >

> > > > had

> > > > led some to question its efficacy, but the

> > >

> > > latest work (published in the

> > >

> > > > February issue of Sleep Medicine Reviews)

> > >

> > > could jump-start interest in the

> > >

> > > > dietary supplement and help more people get a

> > >

> > > good night's sleep.

> > >

> > > > [Non-text portions of this message have been

> > >

> > > removed]

> > >

> > > > Note: This forum is for discussion of health

> > >

> > > related subjects but under no

> > >

> > > > circumstances should any information

> > >

> > > published here be considered a

> > >

> > > > substitute for personal medical advice from a

> > >

> > > qualified physician. -the

> > >

> > > > owner

> > > >

March 24, 2005

Exactly...because you are taking 30 times their recommended dose,

thus inhibiting its effect by excess.

More is not always better, as you may understand.

Ignacio

Ignacio Fojgel, M.D.

Maimónides University,

Buenos Aires, Argentina.

Dave Narby wrote:

>>I take 9 mg each night and it's not that effective.

>>

>

>Sounds like you're taking way too much...

>

>Rest Easy: MIT Study Confirms Melatonin's Value As Sleep Aid

>CAMBRIDGE, Mass. -- A new study by MIT scientists and colleagues

>confirms that melatonin is an effective sleep aid for older insomniacs

>and others. Misuse of the hormone had led some to question its

>efficacy, but the latest work (published in the February issue of

>Sleep Medicine Reviews) could jump-start interest in the dietary

>supplement and help more people get a good night's sleep.

>

>In earlier research, scientists led by Professor Wurtman,

>principal investigator for the current study, showed that only a small

>dose of melatonin (about 0.3 milligrams) is necessary for a restful

>effect. Taken in that quantity, it not only helps people fall asleep,

>but also makes it easier for them to return to sleep after waking up

>during the night--a problem for many older adults.

>

>The researchers also found, however, that commercially available

>melatonin pills contain 10 times the effective amount. And at that

>dose, " after a few days it stops working, " said Wurtman, director of

>MIT's Clinical Research Center and the Cecil H. Green Distinguished

>Professor. When the melatonin receptors in the brain are exposed to

>too much of the hormone, they become unresponsive.

>

>As a result of these inadvertent overdoses, " many people don't think

>melatonin works at all, " said Wurtman, who is also affiliated with the

>Department of Brain and Cognitive Sciences. This belief, coupled with

>potentially serious side effects related to high doses such as

>hypothermia, has earned the hormone a bad reputation in some

>quarters-- " and something that could be very useful to a lot of people

>isn't, " said Wurtman, who said that he and his wife have been taking

>melatonin every night for about a year now.

>

>To determine conclusively whether melatonin works or not, the

>scientists in the current study analyzed 17 peer-reviewed scientific

>papers about the hormone. To be included in this study, or

>meta-analysis, the experiments reported in each paper had to satisfy

>specific criteria. For example, each had to be placebo-controlled and

>include objective measurements on at least six adult subjects.

>

> " A meta-analysis essentially tells 'yes' or 'no'--that a treatment

>does or does not have a significant effect, " Wurtman said. " When a

>meta-analysis says 'yes,' there should no longer be any controversy

>about whether the treatment works. "

>

>The melatonin meta-analysis delivered a definitive " yes. "

>

>Wurtman notes that some of the 17 studies included in the analysis

>involved very high doses of the hormone over long periods, a

> " situation where we know it's not going to work. " Yet the

>meta-analysis still showed that the hormone's positive effects on

>sleep " are statistically significant. "

>

>When Wurtman first discovered the efficacy of small doses of

>melatonin, he and MIT patented its use for dosages up to one

>milligram. Because the FDA defined the hormone as a dietary

>supplement, however, manufacturers were free to sell it in much higher

>dosages, " even though we knew they wouldn't work, " Wurtman said.

>

>As a result, until recently the hormone was commercially unavailable

>to the public in small doses. " People who knew that small doses were

>best often bought the high-dose pills, then divided them with a

>knife, " Wurtman said. " But that's not very accurate. "

>

>The company Nature's Bounty has since licensed the work, and now the

>hormone is easily available in the effective dosages.

>

>Wurtman's colleagues in the meta-analysis work are Amnon Brzezinski of

>Hadassah-Hebrew University Medical Center in Israel; Mark G. Vangel, a

>visiting scientist at the Clinical Research Center; Gillian Norrie and

>Ian Ford of the University of Glasgow in Scotland; and Irina Zhdanova

>of the Boston University School of Medicine.

>

>###

>

>The work was supported by the National Institutes of Health, the

>Center for Brain Sciences and Metabolism Charitable Trust, and the

>Womens' Health Center of Hadassah-Hebrew University Medical Center.

>

>http://www.sciencedaily.com/releases/2005/03/050308134331.htm

>

>On Wed, 23 Mar 2005 20:50:27 -0700, steve <dudescholar@...> wrote:

>

>>I take 9 mg each night and it's not that effective. An additional sleep aid

>>like Ambien helps but doesn't have much of an effect without the Melatonin.

>>

>>As to blood pressure, it never had an effect one way or the other. I take

>>medication for that and typically about 2 hours after taking the melatonin

>>my

>>BP runs about between 115/70 and 107/65.

>>

>>--

>>

>>Steve - dudescholar@...

>>

>>On Thursday 17 March 2005 12:04 pm, best bad example wrote:

>>

>>>I take a very low dose, like half a 1 MG tablet.

>>>More seems to bring on a sluggish morning

>>>headache.

>>>BuddyRay

>>>

>>>--- Sharon <sharon-anderson@...>

>>>

>>>wrote:

>>>

>>>>Melatonin may raise high blood pressure.

>>>> You may want to monitor your blood pressure at

>>>>various times of the day.

>>>>A blood pressure of 120/80 seems to be the

>>>>consensus for BP. ALLHAT found

>>>>that 77% of people being treated for HBP did

>>>>not have their blood pressure

>>>>adequately under control.

>>>>

>>>> Re: Rest Easy: MIT Study

>>>>Confirms Melatonin's Value As

>>>>Sleep Aid

>>>>

>>>>On reading the label on a bottle of 3 mg

>>>>Melatonin I noticed a warning about

>>>>

>>>>taking it if on HBP medication or if you have

>>>>HBP. Anyone know why that

>>>>might be?? I take 80 mg a day of Diovan. I

>>>>find the Melatonin helpful with

>>>>

>>>>my sleep and have noticed no particular problem

>>>>with regard to the HBP.

>>>>

>>>>Bill

>>>> Rest Easy: MIT Study

>>>>Confirms Melatonin's Value As

>>>>Sleep Aid

>>>>

>>>>>Rest Easy: MIT Study Confirms Melatonin's

>>>>>

>>>>Value As Sleep Aid

>>>>

>>>>> A new study by MIT scientists and

>>>>>

>>>>colleagues confirms that melatonin

>>>>

>>>>>is an

>>>>>effective sleep aid for older insomniacs and

>>>>>

>>>>others. Misuse of the hormone

>>>>

>>>>>had

>>>>>led some to question its efficacy, but the

>>>>>

>>>>latest work (published in the

>>>>

>>>>>February issue of Sleep Medicine Reviews)

>>>>>

>>>>could jump-start interest in the

>>>>

>>>>>dietary supplement and help more people get a

>>>>>

>>>>good night's sleep.

>>>>

>>>>>[Non-text portions of this message have been

>>>>>

>>>>removed]

>>>>

>>>>>Note: This forum is for discussion of health

>>>>>

>>>>related subjects but under no

>>>>

>>>>>circumstances should any information

>>>>>

>>>>published here be considered a

>>>>

>>>>>substitute for personal medical advice from a

>>>>>

>>>>qualified physician. -the

>>>>

>>>>>owner

>>>>>

March 25, 2005

I tried to get a low dose of Melatonin at CVS and Walgreen in my area. They

are retailers for Nature's Bounty. I looked for .3 mg but they had never

heard of it. I called Nature's Bounty 800 # and the low dose they produce

is 200 mcg (Microgram) which is .2 mg.

I suppose this is the dose MIT finally settled on as optimum. I will get

the druggist to order it for me when I run out. In the meantime I will cut

my 1 mg into four pieces for 250 mcg.

Rest Easy: MIT Study

>>>>Confirms Melatonin's Value As

>>>>Sleep Aid

>>>>

>>>>>Rest Easy: MIT Study Confirms Melatonin's

>>>>>

>>>>Value As Sleep Aid

>>>>

>>>>> A new study by MIT scientists and

>>>>>

>>>>colleagues confirms that melatonin

>>>>

>>>>>is an

>>>>>effective sleep aid for older insomniacs and

>>>>>

>>>>others. Misuse of the hormone

>>>>

>>>>>had

>>>>>led some to question its efficacy, but the

>>>>>

>>>>latest work (published in the

>>>>

>>>>>February issue of Sleep Medicine Reviews)

>>>>>

>>>>could jump-start interest in the

>>>>

>>>>>dietary supplement and help more people get a

>>>>>

>>>>good night's sleep.

>>>>

>>>>>[Non-text portions of this message have been

>>>>>

>>>>removed]

>>>>

>>>>>Note: This forum is for discussion of health

>>>>>

>>>>related subjects but under no

>>>>

>>>>>circumstances should any information

>>>>>

>>>>published here be considered a

>>>>

>>>>>substitute for personal medical advice from a

>>>>>

>>>>qualified physician. -the

>>>>

>>>>>owner

>>>>>

March 30, 2005

Actually, 9 mg works better than 6 mg which works better than 3 mg which works

better than none - my personal experience that is. I could be that somewhere

between 0 and 3 mg there is a spike in effectiveness, but when I started with

Melatonin 5 years ago, I was at less than 500 mcg and I quickly moved up to 3

mg to get some effect which at the time I was quite happy with.

How much is " best " depends on the individual. The MIT 'study' is trying to

say that if I only took 300 mcg, I would get a " restful effect " , whatever

that is. Personally, I'm interested in sleeping through the night or being

able to go right back to sleep after a trip to the bathroom. I'm always

surprised how an " M.D " of any kind can be so certain of something when no two

doctors I've ever seen in the same specialty has had the same opinion about

anything.

P.S. There is no " recommend " dose of Melatonin. And, while a good night's

sleep is delightful, the potential longevity effect of Melatonin is it's own

reward.

--

Steve - dudescholar@...

" Convictions are more dangerous enemies of truth than lies. "

--Friedrich Nietzsche

On Thursday 24 March 2005 8:18 am, IgnacioFojgel, M.D. wrote:

> Exactly...because you are taking 30 times their recommended dose,

> thus inhibiting its effect by excess.

> More is not always better, as you may understand.

> Ignacio

> Ignacio Fojgel, M.D.

> Maimónides University,

> Buenos Aires, Argentina.

>

> Dave Narby wrote:

> >>I take 9 mg each night and it's not that effective.

> >

> >Sounds like you're taking way too much...

> >

> >Rest Easy: MIT Study Confirms Melatonin's Value As Sleep Aid

> >CAMBRIDGE, Mass. -- A new study by MIT scientists and colleagues

> >confirms that melatonin is an effective sleep aid for older insomniacs

> >and others. Misuse of the hormone had led some to question its

> >efficacy, but the latest work (published in the February issue of

> >Sleep Medicine Reviews) could jump-start interest in the dietary

> >supplement and help more people get a good night's sleep.

> >

> >In earlier research, scientists led by Professor Wurtman,

> >principal investigator for the current study, showed that only a small

> >dose of melatonin (about 0.3 milligrams) is necessary for a restful

> >effect. Taken in that quantity, it not only helps people fall asleep,

> >but also makes it easier for them to return to sleep after waking up

> >during the night--a problem for many older adults.

> >

> >The researchers also found, however, that commercially available

> >melatonin pills contain 10 times the effective amount. And at that

> >dose, " after a few days it stops working, " said Wurtman, director of

> >MIT's Clinical Research Center and the Cecil H. Green Distinguished

> >Professor. When the melatonin receptors in the brain are exposed to

> >too much of the hormone, they become unresponsive.

> >

> >As a result of these inadvertent overdoses, " many people don't think

> >melatonin works at all, " said Wurtman, who is also affiliated with the

> >Department of Brain and Cognitive Sciences. This belief, coupled with

> >potentially serious side effects related to high doses such as

> >hypothermia, has earned the hormone a bad reputation in some

> >quarters-- " and something that could be very useful to a lot of people

> >isn't, " said Wurtman, who said that he and his wife have been taking

> >melatonin every night for about a year now.

> >

> >To determine conclusively whether melatonin works or not, the

> >scientists in the current study analyzed 17 peer-reviewed scientific

> >papers about the hormone. To be included in this study, or

> >meta-analysis, the experiments reported in each paper had to satisfy

> >specific criteria. For example, each had to be placebo-controlled and

> >include objective measurements on at least six adult subjects.

> >

> > " A meta-analysis essentially tells 'yes' or 'no'--that a treatment

> >does or does not have a significant effect, " Wurtman said. " When a

> >meta-analysis says 'yes,' there should no longer be any controversy

> >about whether the treatment works. "

> >

> >The melatonin meta-analysis delivered a definitive " yes. "

> >

> >Wurtman notes that some of the 17 studies included in the analysis

> >involved very high doses of the hormone over long periods, a

> > " situation where we know it's not going to work. " Yet the

> >meta-analysis still showed that the hormone's positive effects on

> >sleep " are statistically significant. "

> >

> >When Wurtman first discovered the efficacy of small doses of

> >melatonin, he and MIT patented its use for dosages up to one

> >milligram. Because the FDA defined the hormone as a dietary

> >supplement, however, manufacturers were free to sell it in much higher

> >dosages, " even though we knew they wouldn't work, " Wurtman said.

> >

> >As a result, until recently the hormone was commercially unavailable

> >to the public in small doses. " People who knew that small doses were

> >best often bought the high-dose pills, then divided them with a

> >knife, " Wurtman said. " But that's not very accurate. "

> >

> >The company Nature's Bounty has since licensed the work, and now the

> >hormone is easily available in the effective dosages.

> >

> >Wurtman's colleagues in the meta-analysis work are Amnon Brzezinski of

> >Hadassah-Hebrew University Medical Center in Israel; Mark G. Vangel, a

> >visiting scientist at the Clinical Research Center; Gillian Norrie and

> >Ian Ford of the University of Glasgow in Scotland; and Irina Zhdanova

> >of the Boston University School of Medicine.

> >

> >###

> >

> >The work was supported by the National Institutes of Health, the

> >Center for Brain Sciences and Metabolism Charitable Trust, and the

> >Womens' Health Center of Hadassah-Hebrew University Medical Center.

> >

> >http://www.sciencedaily.com/releases/2005/03/050308134331.htm

> >

> >On Wed, 23 Mar 2005 20:50:27 -0700, steve <dudescholar@...>

wrote:

> >>I take 9 mg each night and it's not that effective. An additional sleep

> >> aid like Ambien helps but doesn't have much of an effect without the

> >> Melatonin.

> >>

> >>As to blood pressure, it never had an effect one way or the other. I

> >> take medication for that and typically about 2 hours after taking the

> >> melatonin my

> >>BP runs about between 115/70 and 107/65.

> >>

> >>--

> >>

> >>Steve - dudescholar@...

> >>

> >>On Thursday 17 March 2005 12:04 pm, best bad example wrote:

> >>>I take a very low dose, like half a 1 MG tablet.

> >>>More seems to bring on a sluggish morning

> >>>headache.

> >>>BuddyRay

> >>>

> >>>--- Sharon <sharon-anderson@...>

> >>>

> >>>wrote:

> >>>>Melatonin may raise high blood pressure.

> >>>> You may want to monitor your blood pressure at

> >>>>various times of the day.

> >>>>A blood pressure of 120/80 seems to be the

> >>>>consensus for BP. ALLHAT found

> >>>>that 77% of people being treated for HBP did

> >>>>not have their blood pressure

> >>>>adequately under control.

> >>>>

> >>>> Re: Rest Easy: MIT Study

> >>>>Confirms Melatonin's Value As

> >>>>Sleep Aid

> >>>>

> >>>>On reading the label on a bottle of 3 mg

> >>>>Melatonin I noticed a warning about

> >>>>

> >>>>taking it if on HBP medication or if you have

> >>>>HBP. Anyone know why that

> >>>>might be?? I take 80 mg a day of Diovan. I

> >>>>find the Melatonin helpful with

> >>>>

> >>>>my sleep and have noticed no particular problem

> >>>>with regard to the HBP.

> >>>>

> >>>>Bill

> >>>> Rest Easy: MIT Study

> >>>>Confirms Melatonin's Value As

> >>>>Sleep Aid

> >>>>

> >>>>>Rest Easy: MIT Study Confirms Melatonin's

> >>>>

> >>>>Value As Sleep Aid

> >>>>

> >>>>> A new study by MIT scientists and

> >>>>

> >>>>colleagues confirms that melatonin

> >>>>

> >>>>>is an

> >>>>>effective sleep aid for older insomniacs and

> >>>>

> >>>>others. Misuse of the hormone

> >>>>

> >>>>>had

> >>>>>led some to question its efficacy, but the

> >>>>

> >>>>latest work (published in the

> >>>>

> >>>>>February issue of Sleep Medicine Reviews)

> >>>>

> >>>>could jump-start interest in the

> >>>>

> >>>>>dietary supplement and help more people get a

> >>>>

> >>>>good night's sleep.

> >>>>

> >>>>>[Non-text portions of this message have been

> >>>>

> >>>>removed]

> >>>>

> >>>>>Note: This forum is for discussion of health

> >>>>

> >>>>related subjects but under no

> >>>>

> >>>>>circumstances should any information

> >>>>

> >>>>published here be considered a

> >>>>

> >>>>>substitute for personal medical advice from a

> >>>>

> >>>>qualified physician. -the

> >>>>

> >>>>>owner

> >>>>>

March 30, 2005