Re: news: Metformin mimics CR gene expression

[Guest guest]

btw, i just bought five hundred capsules of generic glucophage aka

metformin, five hundred milligrams each, for ninety bucks. anybody found a

better price? also, a kilo of carnosine for five hundred bucks.

best to all

robert

[sounds like a good price on the metformin. Where did you buy the carnosine?

-gts]

[Guest guest]

carnosine order follows

[Great, thanks for the source. -gts]

VOIGT GLOBAL DISTRIBUTION LLC

Biologicals, Chemicals, Ingredients, Instruments

WWW Form Submission

Below is the result of your feedback form. It was submitted by

() on Sunday, May 11, 2003 at 01:39:38

---------------------------------------------------------------------------

Quantity of Item #1: 1

Description of Item #1: c 1980 carnosine, 1 kilogram

Price Each of Item #1: 500.00

Total Price of Item #1: 500.00

Order Subtotal : 500.00

Shipping Method: 9.00

Order Total: 509.00

Ship-To Information: same as billiing information

Submit1: Submit Form

[Guest guest]

How do I find the site for these products?

[Metformin is a prescription drug but it can be purchased without a

prescription from overseas pharmacies like IAS at www.antiaging-systems.com.

Carnosine is a supplement and can be purchased from www.lef.org. -gts]

Re: news: Metformin mimics CR gene expression

btw, i just bought five hundred capsules of generic glucophage aka

metformin, five hundred milligrams each, for ninety bucks. anybody found a

better price? also, a kilo of carnosine for five hundred bucks.

best to all

robert

[sounds like a good price on the metformin. Where did you buy the carnosine?

-gts]

[Guest guest]

I have been paying $14.95 US/ 50/ 500mg Metformin, may I enquire as to where

you got 500/50mg/$90.00?

mikeg

R. Gow, CPS

The S2A Group, Michigan Div.

(810) 599-9625

[Guest guest]

dear mike

i have long appreciated your meaningful contributions to this chatboard and

would be more than happy to supply this information....offline. my son is a

dea agent. ironic, huh?

listed below you will at least find a confirmation of the order, in which i

might note the quantity significantly varies from that presecribed in your

question...i purchased five hundred capsules....five hundred milligrams

each...not fifty milligrams, as your inquiryt stated.

see below

best to you

robert

Dear Customer,

Your card has been processed successfully for the following order:

Order Number hcp817

Glucophage ( Generic ) 500 Tablets 500mg x1

Total $95.00

We are a Merchant company that provides billing services for several

online vendors. The charge for the above order will appear as World

Express Processing.

If you have any inquires regarding the above order please contact the

online vendor with whom you placed the order.

Service Manager

[Guest guest]

dear mikeg

addendas

fyi

two new items follow

Dear Customer,

We have been notified by the vendor that the following order has been

shipped on 5/14/2003.

Order Number hcp817

Glucophage ( Generic ) 500 Tablets 500mg x1

Total $95.00

Usually orders take between 10 and 28 days to arrive with an average

delivery time of 14 days.

If you have any inquires regarding the above order please contact the

online vendor with whom you placed the order.

Service Manager

Hello CR ALL:

The following information on Metformin may be of interest.

-- Warren

======================== ================== ===================

> -----Original Message-----

> From: Kitty Antonik Wakfer [mailto:kitty@...]

> Sent: Tuesday, May 13, 2003 6:47 PM

Metformin has been discussed many times on the sci.life-extension

newsgroup.

See http://groups.google.com/groups?hl=en & lr=lang_en & ie=ISO-8859-

1 & newwindow=1 & safe=off & q=metformin & btnG=Google+Search & meta=group%

3Dsci.life-extension

In particular, Wakfer made a report on sci.life-extension

about a poster presentation at the Seventh International Symposium

on Neurobiology and Neuroendocrinology of Aging which we attended

in Bregenz Austria in July 2002. That study (which has never been

published) clearly showed that metformin at a human equivalent

dosage of about 1 gram per day extended the maximum lifespan of

mice almost as much as did calorie restriction. Many of the

physiological parameters were also similar. That poster and his

conversation with Roth (a senior author of the study) about

it were what decided him to restart metformin at 1 gram per day (for

both of us). Roth is no longer at NIA and is with his own company

which also is developing calorie restriction mimetics in competition

with Biomarker Research.

Those who decide to take metformin should, as usual, build up slowly

to their target dose by starting with a maximum of 1/4 of that

target dose and doubling every 2-3 weeks. Even after reaching target

with no untoward effects they should watch for symptoms of

hypoglycemia which is generally rare with this drug and for signs of

liver toxicity (by getting liver enzyme tests at least semi-

annually).

**Kitty Antonik Wakfer

***

MoreLife for the rational - http://morelife.org

Reality based tools for more life in quantity and quality

------

Your " Good Point! " response will go to 800+ people. Reply to the author

instead.

[Guest guest]

, I may have mistyped, I got 50, 500mg caps for $14.95, my

understanding was that you got 500, 500mg caps for $95.00. that would be a

saving of $55.00- shipping, so well worthwhile if I order more than one

product.

Thank you

mikeg

R. Gow, CPS

The S2A Group, Michigan Div.

(810) 599-9625

[Guest guest]

dear mike, you are correct, quite a savings, let me know off line if i can

be of help

best to you

robert

[Guest guest]

If I remember correctly there were studies showing positive correlation

between metformin intake and reduced testosterone levels in men. Any

new info on that subject? Right now I only take metformin as 'damage

control', a few minutes before I begin to eat a high carbohydrate

meal.

[i think so, yes. However I think caloric restriction also reduces levels of

testosterone. Metformin also increases homocysteine levels. Metformin is

hardly the holy grail for anti-aging, but I think it should be considered by

everyone over about age 40. It increases life-expentency in mice, as would be

expected given that it causes changes in gene expression that at least

partially mimic those from caloric restriction. Unfortunately no one seems to

have the data to show exactly how much metformin mimics the gene expression

from caloric restriction. The lastest issue of Life Extension Mag has a bar-

chart which on the surface appears to show that meformin mimics gene

expression 100%, but a closer look shows that the chart is visually

misleading: metformin was simply the most effective drug studied for mimicing

CR gene expression, so they set the bar for metformin at 100%. -gts]

[Guest guest]

I believe that TMG is supposed to hold down homocystien levels. Would one

of our more learned listees comment?

mikeg

R. Gow, CPS

The S2A Group, Michigan Div.

(810) 599-9625

[Yes, also folate, B-12 and B-6 help to control homocysteine. The same study

that showed an increase in homocysteine from metformin also showed reduced

levels of folate and B-12 (or B-6) from metformin so there is hope that

supplementing folate and B-12 and B-6 with metformin will keep metformin from

causing a rise in homocysteine. In any case it's probably a good idea for

metformin users to get their homocysteine checked periodically. -gts]

[Guest guest]

This article is sent courtesy of Bullis, who is having trouble with his

email program.

The link between the insulin receptor and longevity could help explain how

metformin extends life-expectency in lab animals and possibly also in

humans. Among other things, metformin appears to enhance sensitivity of

insulin receptors.

BOSTON -- August 15, 1997 -- Researchers at the Massachusetts General

Hospital (MGH) have discovered that a gene used by the tiny worm C. elegans

to regulate how much it eats, how fat it becomes and how long it lives is

strikingly similar to the gene for the human insulin receptor.

In today's issue of Science, the team led by Ruvkun, PhD, announced

their surprising discovery, implying that insulin-like control of metabolism

is very ancient. The finding also suggests that human counterparts of other

worm genes that interact with this insulin-like signal may be defective in

diabetes, an insight that could lead to new therapies for the disease. In

addition, the discovery that the worm's form of insulin regulates its

lifespan suggests that human aging may be intimately connected to how food

is metabolized.

Ruvkun and his colleagues-postdoctoral fellow Koutarou Kimura, PhD, graduate

student Heidi Tissenbaum, and technician Yanxia Liu-identified and cloned

the gene daf-2, which regulates whether C. elegans lives a short, lean life

focused on reproduction or a long, fat life focused on energy storage and

survival. They discovered that daf-2 has important structural similarities

to genes coding for insulin receptor proteins in humans and other mammals.

[Guest guest]

Can anyone help, what is " homocysteine levels "

[homocysteine is a substance found in the blood which at high levels is

thought to promote heart disease. Here is a web page that explains it well:

http://familydoctor.org/handouts/249.html -gts]

[Guest guest]

Hello all,

I just found a pharmacy in Europe that has Metformin 850mg for 32 euros or

ca $35. One needs a membership (15e) and shipping which for me was 5e.

Sounds like a good price to me.

www.getpharma.com

best to all

MM

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