Guest guest Posted October 27, 2002 Report Share Posted October 27, 2002 well i have seen severely mercury toxic asd adults with amalgam in improve very conmsiderably taking 100 mcg of selenomethionine. in fact the inprovement is so pronounced i wonder if the more toxic effects of mercury from amaglam compoared to a generation ago in the general population is due to lower food selenium content. there is quite a discrete upper limit for selenenium like 200 mcg is too much... also amino acid chelate forms and not the elemental form should be taken and capsules should be swallowed so that the selenium doesn't run over the amalgams and have some chelating effect from tha amalgam... also i am still of the opinion that boron may have some amplifying effect on mercury removal with selenium... dentists are mechnaical people and should not be trusted too much with thinking. it may be that mercury attaches to selenium preferentially to sulphur. > > I started taking selenium, as according to recent posts it seemed a > > good idea to reduce mercury absoption from my fillings until I am > > able to do something about them. > > I then heard from a mercury free dentist, that they have stopped > > recomending selenium. They believe, that the selenium will attach to > > the mercury and stop it from being excreted, because the selenium > > itself doesn't get excreted easily. > > Is this all aload of rubbish or worth thinking about? > > It can be argued either way. I honestly don't know what the answer > is. It does make you feel better right now. Whether it makes it > harder to clear the stuff later is something I don't know. You have > to decide what your own personal needs are. .. . . . . . . > > > > Thank you for any advice. > > > > Dagm Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 27, 2002 Report Share Posted October 27, 2002 Thank you! [ ] Re: Selenium > I started taking selenium, as according to recent posts it seemed a > good idea to reduce mercury absoption from my fillings until I am > able to do something about them. > I then heard from a mercury free dentist, that they have stopped > recomending selenium. They believe, that the selenium will attach to > the mercury and stop it from being excreted, because the selenium > itself doesn't get excreted easily. > Is this all aload of rubbish or worth thinking about? It can be argued either way. I honestly don't know what the answer is. It does make you feel better right now. Whether it makes it harder to clear the stuff later is something I don't know. You have to decide what your own personal needs are. .. . . . . . . > > Thank you for any advice. > > Dagm Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 27, 2002 Report Share Posted October 27, 2002 Thank you, I have been taking it for a bit over a week and not noticed much improvement, so I think I will stop. Dagmar. [ ] Re: Selenium well i have seen severely mercury toxic asd adults with amalgam in improve very conmsiderably taking 100 mcg of selenomethionine. in fact the inprovement is so pronounced i wonder if the more toxic effects of mercury from amaglam compoared to a generation ago in the general population is due to lower food selenium content. there is quite a discrete upper limit for selenenium like 200 mcg is too much... also amino acid chelate forms and not the elemental form should be taken and capsules should be swallowed so that the selenium doesn't run over the amalgams and have some chelating effect from tha amalgam... also i am still of the opinion that boron may have some amplifying effect on mercury removal with selenium... dentists are mechnaical people and should not be trusted too much with thinking. it may be that mercury attaches to selenium preferentially to sulphur. > > I started taking selenium, as according to recent posts it seemed a > > good idea to reduce mercury absoption from my fillings until I am > > able to do something about them. > > I then heard from a mercury free dentist, that they have stopped > > recomending selenium. They believe, that the selenium will attach to > > the mercury and stop it from being excreted, because the selenium > > itself doesn't get excreted easily. > > Is this all aload of rubbish or worth thinking about? > > It can be argued either way. I honestly don't know what the answer > is. It does make you feel better right now. Whether it makes it > harder to clear the stuff later is something I don't know. You have > to decide what your own personal needs are. .. . . . . . . > > > > Thank you for any advice. > > > > Dagm Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 28, 2002 Report Share Posted October 28, 2002 not noticing an improvement is not the same as there being none. selenium is unusal in that it doesn't give an improvement in the general sense of some thing which might be better, what it does do is make for more robustness like i tolerate migraine better and the duration is shorter and there seems to be more stamina. if some-one can post without saying what type and how much then i am suspicous of a lack of attention to fine detail. > > --- In @y..., " dagmarjahr " <dagmarjahr@e...> wrote: > > > I started taking selenium, as according to recent posts it seemed > a > > > good idea to reduce mercury absoption from my fillings until I am > > > able to do something about them. > > > I then heard from a mercury free dentist, that they have stopped > > > recomending selenium. They believe, that the selenium will attach > to > > > the mercury and stop it from being excreted, because the selenium > > > itself doesn't get excreted easily. > > > Is this all aload of rubbish or worth thinking about? > > > > It can be argued either way. I honestly don't know what the answer > > is. It does make you feel better right now. Whether it makes it > > harder to clear the stuff later is something I don't know. You > have > > to decide what your own personal needs are. .. . . . . . . > > > > > > Thank you for any advice. > > > > > > Dagm > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 28, 2002 Report Share Posted October 28, 2002 Anyone living in the UK or industrialised Europe should take selenium supps anyway as the incumbant agricultural methods ensure selenium poor soils. [ ] Re: Selenium not noticing an improvement is not the same as there being none. selenium is unusal in that it doesn't give an improvement in the general sense of some thing which might be better, what it does do is make for more robustness like i tolerate migraine better and the duration is shorter and there seems to be more stamina. if some-one can post without saying what type and how much then i am suspicous of a lack of attention to fine detail. > > > I started taking selenium, as according to recent posts it seemed > a > > > good idea to reduce mercury absoption from my fillings until I am > > > able to do something about them. > > > I then heard from a mercury free dentist, that they have stopped > > > recomending selenium. They believe, that the selenium will attach > to > > > the mercury and stop it from being excreted, because the selenium > > > itself doesn't get excreted easily. > > > Is this all aload of rubbish or worth thinking about? > > > > It can be argued either way. I honestly don't know what the answer > > is. It does make you feel better right now. Whether it makes it > > harder to clear the stuff later is something I don't know. You > have > > to decide what your own personal needs are. .. . . . . . . > > > > > > Thank you for any advice. > > > > > > Dagm > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 26, 2002 Report Share Posted November 26, 2002 Andy, what would be a good weight-based formula for supplementing selenomethionine? Is it okay to give to mercury-poisoned kids? --- In @y..., " andrewhallcutler " <AndyCutler@a...> wrote: > You probably need pschiatric care given how much your attitude appears > to be interfering with your life. > > However, it is absolutely true that selenium is more selective than > sulfur for mercury. > > Unfortunately the available selenium compounds don't cause it to be > excreted, they just tie it down in place for a while. If you want to > actually remove it from the body you need to use certain specific > sulfur containing compounds which are the most useful things availble. > Neither I nor anyone else ever claimed they were the theoretically > best possible choice, they simply happen to be the best available at > present. > > You may note that I typically suggest people take selenomethionine. > This is to passivate some of the mercury they aren't going to be > chelating out in the near future anyway so as to reduce symptoms. > > Besides, heresy is a term properly reserved for religious debates, > such as the " medical science " garbage about vaccines being safe, > dental amalgam being safe, MD medicine being the only reasonable > choice, MD's having a clue about what is medically necessary, etc. Or > questions about transubstantiation, who was God's last true prophet, > etc. It isn't the right concept for debates on this list. > > Andy . . . . . . . . . . . . . . . . . . . . . . . . > > > i never said it noooo! > > not me > > some-0one else > > > > but if it is > > > > might be > > > > he Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 26, 2002 Report Share Posted November 26, 2002 > > You probably need pschiatric care given how much your attitude > appears > > to be interfering with your life. > > > > However, it is absolutely true that selenium is more selective than > > sulfur for mercury. > > > > Unfortunately the available selenium compounds don't cause it to be > > excreted, they just tie it down in place for a while. If you want > to > > actually remove it from the body you need to use certain specific > > sulfur containing compounds which are the most useful things > availble. > > Neither I nor anyone else ever claimed they were the theoretically > > best possible choice, they simply happen to be the best available > at > > present. > > > > You may note that I typically suggest people take > selenomethionine. > > This is to passivate some of the mercury they aren't going to be > > chelating out in the near future anyway so as to reduce symptoms. > > > > Besides, heresy is a term properly reserved for religious debates, > > such as the " medical science " garbage about vaccines being safe, > > dental amalgam being safe, MD medicine being the only reasonable > > choice, MD's having a clue about what is medically necessary, etc. > Or > > questions about transubstantiation, who was God's last true > prophet, > > etc. It isn't the right concept for debates on this list. > > > > Andy . . . . . . . . . . . . . . . . . . . . . . . . > > > > > i never said it noooo! > > > not me > > > some-0one else > > > > > > but if it is > > > > > > might be > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 27, 2002 Report Share Posted November 27, 2002 thats mcg microgram and not mg milligram? just a btw i am not that fond of being referred to psychiatric institutions seen too many people i know irreparably damaged............................................................... ....................................................................... ....................................................................... ........... toxicity takes different forms ......................................... selenium seems to have quite discrete upper limits. lef have an interesting form Se-methylselenocysteine " Unlike selenomethionine, which is incorporated into proteins in place of methionine, SeSMC is not incorporated into any proteins thereby being fully available for chemoprevention of cancer and the synthesis of selenium-containing enzymes such as glutathione peroxidase. Animal studies also indicate that this form of selenium is as much as 10 times less toxic, than any other known form of selenium. " steve_rotherham " <srotherham@h...> wrote: > > Andy, what would be a good weight-based formula for supplementing > > selenomethionine? Is it okay to give to mercury-poisoned kids? > > It is OK to give mercury poisoned kids 1-2 mg of selenomethionine per > pound of kid per day. For convenience you can give it some days and > not others if you can't find reasonable size doses in commercially > available material for it to be OK to do every day. > > Andy . . .. . . . . . . . . . .. . . . . > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 13, 2003 Report Share Posted April 13, 2003 In a message dated 13/4/03 12:26:02 pm, rcmlam@... writes: > more reliable tests > will directly contradict the mineral reports generated from hair > tests on a regular basis. > Lorna, what did your immunolgist recommend as more reliable? thanks, marti Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 13, 2003 Report Share Posted April 13, 2003 > get a ddi elements hair test which gives a mineral profile. > > http://www.doctorsdata.com > > $75 i think. > FYI, our immunologist (NYCity) told me that I should absolutely not rely on the mineral reports produced by Doctor's Data. She said that she had spoken with Amy Holmes about this several times and Dr. Holmes said the mineral reports were not a reliable marker of actual mineral intake whatsoever. She added that other, more reliable tests will directly contradict the mineral reports generated from hair tests on a regular basis. Hope that helps someone~ Lorna Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 13, 2003 Report Share Posted April 13, 2003 > FYI, our immunologist (NYCity) told me that I should absolutely not > rely on the mineral reports produced by Doctor's Data. She said that > she had spoken with Amy Holmes about this several times and Dr. > Holmes said the mineral reports were not a reliable marker of actual > mineral intake whatsoever. So far as I understand it, this is corrent. The mineral test will not tell you anything about mineral INTAKE. And in fact sometimes you can supplement with a mineral forever, and the person's body still is not absorbing it. The mineral test, for the most part, CAN tell you if there is a problem with mineral transport, meaning mercury or other issues are present. I don't really know more than that tho. Is the original person wanting the mineral test to check for absorption of minerals, or for mercury? Dana Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 13, 2003 Report Share Posted April 13, 2003 far from helping its misinformation. amy holmes unfortunatele has had problems with signs of early dementia for several years, perhaps related to the condition that forced her to retire and her last couple of years in practice have not done justice to her earlier work. hair tests are a particualrely good reflection of the mineral transport system....... its sulphur oriented and refelcts what is attaching to sulphur as it passes through the system. why doctors have issues with it is that it is very inferential, like low mercury levels and out of range high and low minerals are indicative of mercury toxcity rather than just showing plain high mercury. but it can also reflect direct mineral levels quite well if there is a reasonable level of minerlas transport order amy holmes must have been the sole intelligence behind dan because when she started to have her difficulties the 'concensus group' blindly followed. incidently doctors have quite a high rate of this sort of problem. > > get a ddi elements hair test which gives a mineral profile. > > > > http://www.doctorsdata.com > > > > $75 i think. > > > > > FYI, our immunologist (NYCity) told me that I should absolutely not > rely on the mineral reports produced by Doctor's Data. She said that > she had spoken with Amy Holmes about this several times and Dr. > Holmes said the mineral reports were not a reliable marker of actual > mineral intake whatsoever. She added that other, more reliable tests > will directly contradict the mineral reports generated from hair > tests on a regular basis. > > Hope that helps someone~ > > Lorna Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 7, 2003 Report Share Posted May 7, 2003 I have been taking for the last 4 days and it has no yeast. It is too soon to see any changes. Selenium is good to convert T4 to T3 and rT3.Nur slcamp <slcamp@...> wrote:Anyone here take selenium or know anything about it? I have been taking it for a few days and I realized a couple days ago that it is Selenium 200 mcg With yeast. Can this cause any kind of yeast problems? Thanks :-) ~Leah Love Chinchillas?? Check out Chinchilla Fluff & Stuff for GREAT chinchilla collectibles!!! http://www.cafeshops.com/chinchillastuff Also check out my other online store " Animal Art " http://www.cafeshops.com/petsandwildlife Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 7, 2003 Report Share Posted May 7, 2003 So, Armour has Selenium in it? If someones taking aromour then they don't need to take selenium? ~Leah Love Chinchillas?? Check out Chinchilla Fluff & Stuff for GREAT chinchilla collectibles!!! http://www.cafeshops.com/chinchillastuff Also check out my other online store " Animal Art " http://www.cafeshops.com/petsandwildlife Selenium I am also concerned that most selenium you find has yeast in it. I have found a place at 1-800-338-7979 that has yeast free selenium and they have good prices. I plan to order this eventually. I am trying armour which has selenium but if that does not work and I go back to the levoxyl I plan to get this. Anita Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 22, 2003 Report Share Posted June 22, 2003 >>> (though I favour higher doses of selenium to start out with than > does). What rate of selenium and forms to you like? I forgot what andrew suggested. I did some some number recommendations at some doctors site for selenium but will have to go back and look them up. After andrew brought it up, I spent a couple days looking at selenium and metals and other things on pubmed and there was quite a bit of research on it. . Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 22, 2003 Report Share Posted June 22, 2003 recommends methylselenocysteine, selenomethionine and sodium selenite. I've tried the latter two and found them to be useful. I haven't yet tried methylselenocysteine, but I'm sure it's good; intend to order some soon. recommends 0.87mcg per pound, a dose derived from dividing a 100mcg cap by his weight (115lb). Since this is a rather idiosyncratic way of deriving the optimum dose (what if the capsules were 90mcg or 110mcg or weighed a little more?) I guess we could read it as between 0.80mcg and 1mcg per pound. I really value input from adults with ASD. has experimented a lot on himself and we can accept that this is the best dose for him (give or take a few micrograms). But I'm not sure it is the best dose for everyone. Andy Cutler recommends between 1 and 2mcg per pound, but he sees selenium as an adjunct to detox, not a primary means of detox. 's ideas on minerals transport have a lot of merit, and I tried out his recommendations, but they made no difference to our son. It was only when we raised the dose of selenium to 2mcg per pound (1 Kirkman cap for our 50lb boy) that things started happening. Since then we have also added sodium selenite and had further improvements. Now the dose is more like 4mcg per pound. I don't believe this dose is sustainable in the long term, but hair tests have shown no problems so far. We plan to taper off soon when we begin DMSA chelation next month (we will give selenium only on chelating days). I think heavily metals toxic people need a large amount of selenium initially to sequester mercury and lead. Once a certain amount has been sequestered, the body's minerals transport system can start repairing itself. This process is aided by adding liver and bile support and a diet rich in good fats (and free of trans-fatty acids). I think Ojibwa tea also helps. 's ideas are based on empiricism; so are mine. His recommended dose works for him; mine works for my son. Perhaps people thinking of using selenium should try his suggestions first, then slowly and cautiously build up if they aren't getting results. Steve > >>> (though I favour higher doses of selenium to start out with than > > does). > > What rate of selenium and forms to you like? I forgot what andrew > suggested. I did some some number recommendations at some doctors > site for selenium but will have to go back and look them up. After > andrew brought it up, I spent a couple days looking at selenium and > metals and other things on pubmed and there was quite a bit of > research on it. > > . Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 4, 2003 Report Share Posted August 4, 2003 you have to swallow it in the capsule so that the selenium doesn't drag mercury out of the amalgams. also you need both seleniums for effect............ and molybdenum too if you get migraine. > Is it safe to take Se when you have amalgam fillings? > TIA > Prue > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 5, 2003 Report Share Posted August 5, 2003 adequate selenium is the base on which any supplement program has to be built. if its not there then the card houses fall. you just supplement it if you think that the diet is unlikely to be providing it............by and large it won't, unless you are eating say south dekota beef which is selenium rich. aprox .85 mcg/lb of selenomethionine one day(i use kal/solaray) and methyselenocysteine(lef.org) the next. both types are needed as the methyselenocsyteine appears to do something extra. > Hi would you explain about the seleniums that you are talking > about..I havent really heard much about it. Do we need to test for it > or is it something I could just start to supplement? Thanks Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 10, 2003 Report Share Posted August 10, 2003 Sure sounds like it's safe for rats. Any data re. human safety? -- -- Neil Jensen: neil@... The WWW VL: Sumeria http://www.sumeria.net/ It has recently been discovered that research causes cancer in rats. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 12, 2003 Report Share Posted August 12, 2003 My wife and I have been taking SEMC For about 19 months now, I think it's very good stuff in my opinion. We use two different brands. http://nutri.com/selenium/ http://www.lef.org/newshop/items/item00567.html > > Below is a description (kinda lengthy!) of the status of selenium these days in fighting cancer. Of course it was prepared by a company who manufactures selenium compounds for that purpose, but there is some good info here nonetheless. > > I've read elsewhere that many studies indicate selenium is useful in prevention. Here they talk about its therapeutic applications. > > Not sure whether links below will still work after the copy and pasting routine done here. If anyone is interested, contact me and I will forward the original email as an attachment. It will probably work that way. > > - Art > > -------------------------------------- > > > > Welcome To PharmaSe, Inc. and Eburon Organics, USA, Inc. We bring innovation to Selenium Nutritional Supplements and to 35 Years of Nutrition Research involving Selenium. Read on and then contact us! > > > > New Product Evaluation Checklist for SeMC > > Se-Methylselenocysteine > > > > 1. Description of product or technology (including novel features): > > Se-Methylselenocysteine (SeMCTM) is a potent carcinostatic non- protein amino acid naturally made by garlic, onions, leeks, ramps, broccoli, Astragalus and likely other plants. > > > > 2. Safety Data: > > The toxicity of SeMCTM as tested in rats is similar to or less than the toxicity of L-selenomethionine the most widely marketed selenium supplement as Se-yeast or L-selenomethionine. The National Cancer Institute has approved a $5 million dollar toxicity trial of SeMCTM in animals. (Results in abstract form reports that the NOAEL for male rats is 1.0 mg/kg/day, 28-Day Oral Toxicity Study of Se- Methylselenocysteine in Rats, W.D et al, Society of Toxicology, Nashville, TN March, 2002.) Our understanding is that all animal toxicology has now been completed and an IND, Investigation New Drug, application is to be filed by the NCI to the FDA in early 2003. PharmaSe, Inc supplied all the SeMCTM to the NCI sponsored research. > > > > 3. Potential Claims and Substantiation: > > The literature and recent human research has established selenium as a potent anticarcinogen. The evidence for this effect in humans on human lung, prostate and colorectal cancer was published in JAMA. A recent article on prostate cancer in The Journal of the National Cancer Institute reports consumption of Allium plants, those plants that make SeMCTM , significantly reduced this cancer in Chinese men. See the following link. (http://www.newsday.com/news/health/nyhspros06q2994037nov06.emailstor y) > > > > Animal data on cancer protection is extensive and an understanding of the underlying chemistry is emerging. SeMCTM is the most effective anticarcinogen of all the natural selenium supplements tested in animals. See the references below, especially the one by Whanger. Abstracts can be viewed at pubmed. New! The FDA has approved a labeling claim for selenium and its anti-cancer effects. Go to www.fda.gov. > > > > 4: Regulatory Status in US, Major European Markets > > SeMCTM has received food supplement approval (DESHEA regulations) from the US Food and Drug (FDA) Administration in February 2002 for adult supplementation at 200 ug Se/day. PharmaSe, Inc originally submitted the FDA application in October 1999 and SeMC was approved for 100 ug Se/day supplementation in 2000. Selenium supplements in Europe usually contain 100 ug Se. > > > > 5. Patents/Patent Fillings: > > European Patents and US Patents are pending for both the synthesis and use of SeMCTM as a food supplement for humans and pets. > > > > 6. Physical Properties of Material: > > Two forms of the supplement are available, one in the free L-amino acid form and one in the HCL form. The free amino acid has the higher percentage of selenium by weight (43.4%). SeMCTM is produced as the L-amino acid. It is stable, off white to yellowish in color depending on form with a characteristic " selenium " odor much like L- selenomethionine. Its melting point as the free amino acid is 171 degrees Celsius. It is homogeneous (100% pure) by chiral HPLC analysis. > > > > Approximate Cost of the Ingredient/Product. > > NEW! PharmaSe, Inc is pleased to now offer an SeMC trit, 0.5% Se (5000 ppm Se) in anhydrous dicalcium phosphate. We will ship the trit to your facility by FedEx Ground FOB. The price for 1-15 kgs is $237.50/kg, 16- 25 kgs is $224.50/kg and over 25 kgs $209.50/kg FOB by FedEx Ground. Additional discount for larger purchases (need not be purchased now). > > > > The present cost is $10,000.00 for one kilogram Pure SeMC (discounts for more than a single kg order) for the free amino acid, 43.4% selenium by weight. SeMC selenium cost for 100; 200 ug Se dosages is approximately US $0.20. > > > > The effective protective cost for similar selenium cancer protection from selenomethionine would between $15.00-24.00. PharmaSe, Inc can supply custom, packaged formulations, trit or bulk material in commercial quantities. Always compare costs by calculating your final cost per ug of Se. One kg of SeMC contains 434,000,000 ug Se. Please supply your interests and formulation in confidence for a quotation. > > NEW TOO! We will formulate tablets or capsules with L- selenomethionine, SeMC and other nutrients on a custom basis and deliver to you. Call with your request for a quote. 2000 to 2 million capsules! > > > > Timing of Commercial Availability: > > > > Commercial amounts of the SeMCTM free L-amino acid are available right now for your own product formulation or formulation by PharmaSe, Inc for you own label. Shipment for the concentrate is made to your facility at no additional cost by FedEx air within 24- 48 hrs of your order. SeMC trit is shipped FOB by FedEx ground. Allow 5-7 days delivery depending on day of shipment and distance. > > Additional descriptive information on our selenium products and SeMCTM is attached along with references to the " Selenium Supplements backed by Science " TM. PharmaSe, Inc will be pleased to send you copies of any of the references. > > > > Links to Selenium Products > > Links to Selenium Products > > Selenium SeMC TM Products Online > > www.nutri.com/selenium > > www.lef.org/newshop/items/item00567.html > > www.lowen.co.nz/ > > orders@a...__________________________________________ > > > > > > Links to Selenium Information > > USDA Announces SeMC TM Reduces Colon Cancer http://www.ars.usda.gov/is/AR/archive/jun00/colon0600.htm > > Search for More Information on SeMC > > www.google.com enter methylselenocysteine, or selenium and cancer or Select Trial, or selenomethionine > > Questions about Selenium or SeMC specifically or to Contact us: > > pharmase@a... > > Ph 806-786-8349 > > L- Se-METHYLSELENOCYSTEINE: The Story behind The Science > > L-Se-methylselenocysteine, SeMCTM, a naturally occurring selenoamino acid which is synthesized by Allium plants including garlic, onions, broccoli and species of the genus Astragalus is now available on a commercial basis from PharmaSe, Inc. Extracts of selenium-enriched garlic have shown that SeMCTM is the active ingredient in the chemoprevention of mammary cancer and may be the active ingredient in the protection of men from prostate cancer as reported in the Journal of the National Cancer Institute. SeMCTM metabolism has been studied in animals and the chemoprevention effect of SeMCTM is presently believed to occur due to the generation of monomethylated selenium species by endogenous enzymes (see Nutrition and Cancer Volume 40, 2001). Monomethylated selenium species have been shown to generate superoxide and induce apoptosis to cancer cells in culture. Unlike L-selenomethionine, which is incorporated into proteins in place of methionine, SeMCTM is not incorporated into any > proteins thereby being fully bioavailable for chemoprevention and the synthesis of selenium containing enzymes such as glutathione peroxidase. Preliminary animal data indicates that SeMCTM is less toxic than L-selenomethionine when included in diets which may be related to the accumulation of L-selenomethionine in tissues. PharmaSe, Inc has a European Patent and U.S. Patents pending for a novel synthesis of L-SeMCTM and its exclusive use as a dietary supplement for humans and domestic animals. > > > > Research Quantities of Unit Price/Unit > > L-Se-methylselenocysteine* 10 mg $30.00 > > SeMCTM 50 mg $65.00 > > L-Selenomethionine 100 mg $100.00 > > Selenodiglutathione 1000mg $500.00 > > Methylseleninic acid (up to 20 gms) > > > > *Analysis by HPLC Chromatography, Chiral GC-MS, Titration, and Melting Point > > > > Carboxypolyselenocyanate (for attachment to antibodies and other molecules, generates superoxide in the presence of thiols like GSH, Now Available Fall 2002) CALL! 806-786-8349 > > > > Seleno-dihydrotestosterone ( a drug for experimental prostate cancer research ) NOW Available CALL! 806-786-8349 > > Gamma-glutamyl-Se-methylselenocysteine (NOW Available ) Call for information (~75% of selenium in garlic is this dipeptide) > > > > Reference: Dong, Y., Lisk, D., Block E. and Ip, C., Characterization of the Biological Activity of Gamma-Glutamyl-Se- methylselenocysteine: A Novel, Naturally Occurring Anticancer Agent from Garlic. Cancer Res: 61,2923-2928, 2001. > > Special Selenium Compounds Synthesized by Request, Please Call! 806-786-8349 > > PharmaSe, Inc. > > 3416 Knoxville Ave. > > Lubbock, TX 79413 > > PH: 806-786-8349 E-mail: pharmase@a... > > > > Terms: Net 30 days in US funds. Shipping costs and taxes (where applicable) are not included.. 50% deposit required on orders of 25 or more grams for research. > > For Research and Human Supplementation as a Selenium Food Supplement as per the Nutritional Supplement Regulations of the FDA. > > > > References Publications > > For the most up to date references go to www.ncbi.nlm.nih.gov and check PubMed then search keyword: methylselenocysteine or methylseleninic acid for references to SeMCTM > > > > For Reviews with references on Selenium and Cancer go to email pharmase@a... May (Part1) and October (Part 2) Bulletins of the STDA by Spallholz, 2001 and request copies by email. > > > > Delineation of the Molecular Basis for Selenium-Induced Growth Arrest in Human Prostate Cancer Cells by (Methylselenol) Oligonucleotide Array. Y. Dong, H. Zhang, L.Hawthorn, H.E Ganther and C. Ip. Cancer Research, 63, 52-59, 2003. > > Se-Methylselenocysteine (SeMC). M. Rae. Advances in Orthomolecular Research, 2, 5-13, 2003. (Review with 65 references) > > > > Selenocompounds in Plants and Animals and Their Biological Significance. P. D. Whanger. Journal of The American College of Nutrition, 21,223-232, 2002. > > Selenium-enriched Broccoli Decreases Intestinal Tumorigenesis in Multiple Intestinal Neoplasia in Mice. C.D. ,H. Zeng and J.W. Finley. Journal of Nutrition 132,307-309, 2002. > > Allium Vegetables and the Risk of Prostate Cancer. A.D. Hsing, A.P. Chokkalingam et al. J. National Cancer Institute. 94, 1648- 1651, 2002. > > Se-methylselenocysteine Induces Apoptosis through Capase Activation and Bax Cleavage Mediated by Calpin in SKOV-3 Ovarian Cancer Cells. J.K. Yeo, et al. Cancer Letters, 182, 83-92, 2002. > > Intracellular Glutathione is a Cofactor in Methylseleninic Acid- Induced Apoptotic Cell Death of Human Hepatoma HEPG2 Cells. H.M. Shen and C.O. Ong. Free Radical Biology and Medicine, 33, 552-561, 2002. > > New Concepts in Selenium Chemoprevention. C. Ip, Y. Dong and H.E. Ganther. Cancer Metastasis Reviews. 21, 281-289, 2002. > > Dimethyldiselenide and Methylseleninic Acid Generate Superoxide in an In Vitro Chemiluminescence Assay: Implications for the Anticarcinogenic Activity of L-Selenomethionine and L-Se- methlyselenocysteine. J.E. Spallholz, B.J. Shriver and T.W. Reid. Nutrition and Cancer 40, 31-34, 2001. > > Bioactivation of Chemopreventive Selenocysteine Se-conjugates and related Amino Acids by Amino Acid Oxidases Novel Route of Metabolism of Selenoamino Acids. M. Rooseboom et al. Chemical Research and Toxicology, 14, 995-1005, 2001. > > Se-Methylselenocysteine; A New Compound for the Treatment of Breast Cancer. D. Medina, H. . H. Ganther and C. Ip. Nutrition and Cancer, 40,34-41, 2001. > > Se-methylselenocysteine Induces Apoptosis Mediated by Reactive Oxygen Species in HL-60 Cells. U. Jung et al. Free Radical Biology and Medicine, 31,479-489, 2001. > > Selenium(Se) From High-Selenium Broccoli is Utilized Differently Than selenite, Selenate and Selenomethionine, but is More Effective in Inhibiting Colon Carcinogenesis. J.W. Finley and C.D. . Biofactors. 14, 191-196, 2001. > > Preventing and Treating Cancer with Selenium in the New Millenium. J.E. Spallholz, B. Shriver, L.M. Boylan and T.R. Reid Proceedings of the Seventh Internation Symposium on Selenium in Biology and Medicine. Venice, Italy, 2000. > > Selenium From High-Selenium Broccoli Protects Rats from Colon Cancer. J.W. Findley, C.D. and Y. Feng. Journal of Nutrition 103, 2384-2389, 2000. > > In Vitro and In Vivo Studies of Methylseleninic Acid: Evidence That a Monomethylated Selenium Metabolite is Critical for Cancer Prevention. > > C. Ip, H.J. Thompon, Z. Zhu, and H.E. Ganther. Cancer Research, 60, 2882-2886, 2000. > > Chemical Speciation Influences Comparative Activity of Selenium- Enriched Garlic and Yeast in Mammary Cancer Prevention. C. Ip, M. Birringer, E. Block, M. Kotrebai, J.F. Tyson, P.C. Uden and D.J. Lisk. Journal of Agriculture and Food Chemistry, 5. 2000. > > Selenium Metabolism, Selenoproteins and Mechanisms of Cancer Prevention: Compexities with Thioredoxin Reductase. H.E.Ganther. Cancinogenesis 20. 1657-1666, 1999 > > Selenium-induced Inhibitionof Angiogenesis in Mammary Cancer at Chemopreventive Levels of (Dietary) Intake. C. Jiang,W.Jiang, Ip,C., Ganther, H. and Lu,I. Molecular Carcinogenesis. 26,213-225, 1999. > > The Retention and Distribution by Healthy Young men of Stable Isotopes of Selenium Consumed as Selenite, Selenate or Hydroponically Grown Broccoli are Dependent on the Chemical Form. J. FINDLEY Journal of Nutrition 129,865-871,1999. > > Growing Alliums And Brassicas In Selenium- Enriched Soils Increases Their Anticarcinogenic Potential. Medical Hypothesis. 53, 232-235, 1999. > > Selenium from Broccoli is Metabolized Differently Than Se From Selenite, Selenate or Selenomethionine. J. Findley. Journal of Agricultural and Food Chemistry. 46,3702-3707, 1998. > > Chemopreventive Agents: Selenium. G.F. Combes and W.P. Grey. Pharmacological Therapy 79, 179-192, 1998 > > Lessons from Basic Research in Selenium and Cancer Prevention. C. Ip. Journal of Nutrition 128, 1845-1854, 1998. > > Should Selenium Enriched Vegetables be Consumed For the Prevention of Cancer? P.D. Whanger, J.L. Green and J.A. . Proceedings of the Sixth International Symposium on the Uses of Selenium and Tellurium. 57-61, 1998. sdale, AZ > > Novel strategies in Selenium Cancer Chemoprevention Research. C. Ip and H.E. Ganther. In, Selenium in Biology and Human Health, R.F. Burk, Ed. Chapter 9, pp170-180. Springer-Verlag, Publisher New York. 1998, > > Study of Prediagnostic Selenium Level in Toenails and the Risk of Advanced Prostate Cancer. K. Yoshizawa, W.C. Willet, S.L. , S.J. Stampfer, D. Spiegelman, E.B. Rimm and E. Giovannucci. Journal of the National Cancer Institute 90, 1219-1224, 1998. > > Chemical Transformations of Selenium in Living Organisms. Improved Forms of Selenium for Cancer Prevention. H.E. Ganther and J.R. Lawrence. Tetrahedron 53, 12299-12310,1997. > > DIETARY SELENIUM: TIME TO ACT-LOW BIOAVALIBILITY IN BRITIAN AND EUROPE COULD BE CONTRIBUTING TO CANCERS, CARDIOVASCULAR DISEASE AND SUBFERTILITY. M.P. RAYMAN BRITISH MEDICAL JOURNAL 314,387-388,1997. > > Speciation of Selenoamino acids and Organoselenium compounds in Selenium-enriched Yeast using High-performance Liquid Chromatography- inductively Coupled Plasma Mass Spectrometry./ S.M. Bird, P.C. Uden, J.F. Tyson, E. Block and E. Denoyer. J. Analytical Atomic Spectrophotometry. 12, 785-788, 1997. > > Effects of Selenium Supplementation for Cancer Prevention in Patients with Carcinoma of the Skin. L.C. et al. Journal of the American Medical Association. 276, 1957-1963, 1996. > > Effect of an Aqueous Extract of Selenium-Enriched Garlic on in vitro and in vivo efficacy in Cancer Prevention. J. Lu, H. Pei, C. Ip, D.J. Lisk, H. Ganther and H. J. . Carcinogenesis 17, 1903-1907, 1995. > > Efficacy of Cancer Prevention by High-Selenium Garlic is Primarily Dependent on the Action of Selenium. Carcinogenesis 16,2649- 2652,1995 > > Allium Chemistry: Identification of Selenoaminoacids in Ordinary and Selenium-enriched garlis, onion, and broccoli using Gas Chromatography with Atomic Emission Detection. X.J. Cai, E. Block, P.C. Uden, Z. Zhang, B. D. Quimbly, and J.J. Sullivan. Journal of Agricultural Chemistry. 43, 1754-1757, 1995. > > Characterization of Tissue Profiles and Anicarcinogenic Responses in Rats Fed Natural Sources of Selenium-Enriched Products. C. Ip and J. Lisk. Carcinogenesis. 15, 573. 1994. > > Enrichment of Selenium in Allium Vegetables for Cancer Prevention. C.P. Ip and D.J. Lisk. Carcinogenesis 15, 1881-1885, 1994. > > Enrichment of Selenium in Allium Vegetables for Cancer Prevention. Ibid. Carcinogenesis 9,1881-1885,1994a. > > Novel Strategies in Selenium Cancer Chemoprevention Research. Ip,C. and Ganther, H.E. in Selenium in Biology and Human Health R.F. Burk, Ed. Chapter 9. Springer-Verlag, New York 171-180. 1994. > > Effect of Methylated Forms of Selenium on Cell Viability and the Induction of DNA Strand Breaks.A.C. , H.J. , P.J. Schedin, N.W. Gibson, and H.E. Ganther. Biochemical Pharamacology 43, 1137-1141, 1992. > > Comparison of Selenium ans Sulfur Analogs in Cancer Prevention. C. Ip and H.E. Ganther. Carcinogenesis 13, 1167-1170, 1992. > > Mammary Cancer Prevention by Regular Garlic and Selenium-Enriched Garlic. C.Ip, D.J. Lisk and G.S. Stoewsand. Nutrition and Cancer 17, 279-286, 1992. > > Chemical Form of Selenium, Critical Metabolites, and Cancer Prevention > > C. Ip, C. . R.M. Budnick and H. Ganther. Cancer Research 51,595-600,1991. > > Activity of Methylated Forms of Selenium in Cancer Prevention. C. Ip and H.E. Ganther Cancer Research, 50, 1206-1211,1990. > > The Metabolism of Selenomethionine, Se-methylselenocysteine. their Selenonium Derivatives, and Trimethylselenonium in the Rat. S. J. , R.J. Kraus and H.E. Ganther. Archives of Biochemistry and Biophysics 251, 77-86, 1986b. > > Interaction of Vitamin C and Selenium Supplementation in the Modification of Mammary Carcinogenesis in the Rat. C. Ip Journal National Cancer Institute 77, 299-303, 1986. > > Oxidation-Reduction Reactions of Organoselenium Compounds. I. Mechanism of Reaction between Seleninic Acids and Thiols. Journal of the American Chemical Society. 100,5094-5102,1978. > > Biosynthesis of Se-methylselenocysteine and S-methylcysteine in Astragalus bisulcatus. D.M. Chen, S.N. Nigam and W.B. McConnell. Canadian J. of Biochemistry 48,1278-1283, 1970. > > > > _____________________________________________________________ > > Other Products Available From PharmaSe, Inc > > Methylseleninic Acid, CH3SeOOH, (The likely active metabolite from SeMC, Selenomethionine and Se-garlic) > > L-Selenomethionine USP > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 18, 2003 Report Share Posted August 18, 2003 what of time of day r u giving it, what type and brand of selenium, is that .85mcg per lb? In , " zoelle1995 " <rashikino@n...> wrote: > Hi would giving selenium effect sleep..I started giving Machaela > selenium .85mcg once a day and the last 3 nights she had problems > falling asleep..We give her klonidine at night and that will put her > to sleep after 45 min..now I ended up giving her melatonin 2hrs after > the klonidine as she couldnt fall asleep..We were away for 2 night > and this change of routine may be the reason, but I was just > wondering if it may be due to the selenium.. > Thanks in advance. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 18, 2003 Report Share Posted August 18, 2003 Hi , I am giving it around 1200 it is the vitamin shoppe selenium and the Se-methyl-selenocysteine from Life extensions...and yes it is .85mcg per lb..of both..one every day..and I alternate the form of selenium..each day.she weighs 60 pds so Im giving her appox 51mcg..What do you think? to late in the day..I could only give it in the morning If I give with her other supplements... Let me know. Thanks alot -- In , " andrew " <alevin@i...> wrote: > > > what of time of day r u giving it, what type and brand of selenium, > is that .85mcg per lb? > > > > > > In , " zoelle1995 " <rashikino@n...> > wrote: > > Hi would giving selenium effect sleep..I started giving Machaela > > selenium .85mcg once a day and the last 3 nights she had problems > > falling asleep..We give her klonidine at night and that will put > her > > to sleep after 45 min..now I ended up giving her melatonin 2hrs > after > > the klonidine as she couldnt fall asleep..We were away for 2 night > > and this change of routine may be the reason, but I was just > > wondering if it may be due to the selenium.. > > Thanks in advance. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 18, 2003 Report Share Posted August 18, 2003 what is the type of selenium you are getting from vitamin shoppe? i'm not happy with selenium selenite. is it the vitamin shope brand or another? this level of detail is important. 1200 is too late i think, selenomethionine is stimulatory. i know someone who takes the methyselenocysiene before bed so i assume that this form is different, but bascially i take mine an hour or to after breakfast, but if theres school or something then the longer you can delay it after breakfast the better, like even 1/4 of an hour is an improvement over taking straight after the meal. is she reacting to the rice filler. you are really advised to take it yourself for a while to provide a reference point. if she has severe metals problems then selenium does move metals a bit, even though the overall effect is benefical, in that case i would cut right back. where there is metals diffculty then it may pay to say take more methlyselenocysteine compared to selenomethionine. valerian can help with getting to sleep, but basically sleep is serotoninic and tyrptophan is needed in addition to melatonin. also zinc could be low and histamine high. she may respond to an occasional low dose of ala. > > > Hi would giving selenium effect sleep..I started giving Machaela > > > selenium .85mcg once a day and the last 3 nights she had problems > > > falling asleep..We give her klonidine at night and that will put > > her > > > to sleep after 45 min..now I ended up giving her melatonin 2hrs > > after > > > the klonidine as she couldnt fall asleep..We were away for 2 > night > > > and this change of routine may be the reason, but I was just > > > wondering if it may be due to the selenium.. > > > Thanks in advance. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 18, 2003 Report Share Posted August 18, 2003 Hi we have the vitamin shoppe brand (Selenomethionine) 100 Mcg 143% ... I either have to give it with all her other supplements or at lunch 30 minutes before eating with her enzymes..I know you said to give it away from the other supplements..We are also chelating (andys protocol) We shall just hang in there..The melatonin seems to help also so If I notice her not getting tired after 0900 I will give her the melatonin...I shall start talking the selenium also and see how it effects me...She is very hyper will the selenium make her more hyper?? Im hoping for a calming effect after an adjustment period.. What do you think... Thanks for your help > > > > Hi would giving selenium effect sleep..I started giving > Machaela > > > > selenium .85mcg once a day and the last 3 nights she had > problems > > > > falling asleep..We give her klonidine at night and that will > put > > > her > > > > to sleep after 45 min..now I ended up giving her melatonin 2hrs > > > after > > > > the klonidine as she couldnt fall asleep..We were away for 2 > > night > > > > and this change of routine may be the reason, but I was just > > > > wondering if it may be due to the selenium.. > > > > Thanks in advance. > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 18, 2003 Report Share Posted August 18, 2003 well brands vary in quality so theres no garantee that the vitamin shoppe brand doesn't have problems. its probably ok but you never know. i really stick to brands i have experience of are ok. supplements are very dicey in terms of potential problems like heavy metals contamination. if you take the selenium yourself you will find out. as far as i can see the vitamin shoppe selenmethionines are all in tablet form with dicalcuim phospate in, i don;t really like it but can't say for sure its a problem. i use the 200mcg solaray yeast free(selenomethionine) as the frice filler i can cope with and it subdivides easily. you didn't say you were chelating!!!!!!!!!!!!!!!!!!!!!!!!! thats like a huge thing. HYPER CAN MEAN MOBILISED MERCURY. bascially i don;t know enough about the effects of chelating but if she is not chelating the selenium at .85mcg/lb given in the morning should not make her more hyper. i don't really agree with chelation but even if you are going to chelate i would supplement selenium minerals for a while first and then try an occasional single low ala dose, once a week or something and then i would look at chelation if it seemed warranted. > Hi we have the vitamin shoppe brand (Selenomethionine) 100 Mcg 143% > .. I either have to give it with all her other supplements or at > lunch 30 minutes before eating with her enzymes..I know you said to > give it away from the other supplements..We are also chelating (andys > protocol) We shall just hang in there..The melatonin seems to help > also so If I notice her not getting tired after 0900 I will give her > the melatonin...I shall start talking the selenium also and see how > it effects me...She is very hyper will the selenium make her more > hyper?? Im hoping for a calming effect after an adjustment period.. > What do you think... > Thanks for your help > > Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.