vitamin C

[Guest guest]

Gretchen,

Have you heard anything recently about the publication status of the Italian

ascorbic acid trial? Thanks for any information,

Matt

[Guest guest]

Matt,

All I know is it is in process.

Gretchen

[Guest guest]

Another study from 2008 (although in french) can be found here:

http://cmt-france.org/index.php?option=com_content & view=article & id=93:essai-news\

& catid=71:actualite & Itemid=67

CMT1A: First results of l' test Vitamin C L' Public assistance - Hospital of

Marseilles announced, this day, the first results of l' test carried out by l'

equip with clinical pharmacology of Dr. le Micallef-Roll on l' action of l'

ascorbic acid (vitamin C) in the disease of Charcot-Marie-Tooth of the 1A type.

This randomized test, as a double blind man against placebo, allowed l'

inclusion, of 2005 to 2008,

180 patients from 18 to 70 years out of 3 sites in France (Marseilles, Lyon and

Paris). The patients were divided, in a random way, in 3 groups: placebo/amount

of 1g /dose of 3g, each one taking 3 gélules per day the morning during one

year. A good tolerance was observed, whatever the amount, during this period. No

significant difference between the 3 n' groups; was observed on the principal

criterion of l' test (scale CMTNS which measures the symptoms driving, sensitive

and the speed of nervous conduction), nor on the secondary criteria like the

muscular testing, the up time or the scales of quality of life.

However, in 12 months, an effectiveness of the strongest amount d' ascorbic acid

(3g) appears on the driving and sensitive symptoms patients (through score

CMT-ES). These results are a first stage: they show the need for setting up,

subject to l' opinion of the authorities of health, a new longer-term test (over

2 years) to confirm these new data which must now be validated by a publication

in an scientific magazine. L' AFM and CMT-France, which gave their support for

this study, make a point of recalling that l' ascorbic acid (Vitamin C) should

not be taken without medical monitoring.

Recent work, indeed, showed that this molecule, could, with very strong amount,

to have toxic effects, particularly in the children and the expectant mothers.

Recall: This test was set up following the publication into 2004 of experimental

work in the mouse showing l' improvement of the driving functions and the

lifespan of the mice following l' absorption d' a strong amount d' ascorbic

acid. This molecule would allow, indeed, l' inhibition of gene PMP22 and thus a

repair of the sheath of myéline which surrounds the nerve. In the CMT1A, the

sheath of myéline is, indeed, affected causing a deceleration of nervous

conduction.

[Guest guest]

I'd ask my naturopath, but right now he's taking a trip up or is it down the Amazon !

Shari

[Guest guest]

I was on the Vitamin C regime from my neurologist at the

Universty of Chicago. I am diagnosed with CMT 1A. He told me to

stop the Vitamin C. He stated that the study he was following, there

was no help. He said he was afraid of the kidney stone implications. I hope this

helps.