Re: Thyroid and 's Syndrome

[Guest guest]

Dear oxyplusers,

Has anyone on the list had experience with the 's Syndrome treatment?

I've heard good and bad info.

Though I guess with my high TSH readings, I'm not the classic 's

Syndrome

patient.

Thanks,

[Guest guest]

wrote:

> Dear oxyplusers,

> Has anyone on the list had experience with the 's

> Syndrome treatment? I've heard good and bad info.

> Though I guess with my high TSH readings, I'm not the

> classic 's Syndrome patient. Thanks,

Any hypothyroidism " should " be treatable with the

protocol. However, it's more costly, so it's usually only

used by those who don't respond to the commercial thyroid

replacement hormones, due to elevated " reverse T3, " or

decreased peripheral conversion of T4 to T3, etc.

See: http://www.wilsonssyndrome.com

http://www.wilsonssyndrome.com/FAQ.htm

The following article contains some related information which

should be ruled-out, before banking on the protocol.

(Euthyroid means " normal thyroid. " )

from:

The Merck Manual

http://www.merck.com/pubs/mmanual/section2/chapter8/8c.htm

Euthyroid Sick Syndrome

A syndrome characterized by abnormal thyroid function

tests in clinically euthyroid patients suffering from

severe nonthyroidal systemic illness.

Patients with a variety of acute or chronic nonthyroidal

illnesses may have abnormal thyroid function tests, usually

secondary to decreased peripheral conversion of T4 to T3,

decreased clearance of reverse T3 generated from T4, and

decreased binding of thyroid hormones to TBG. Conditions

commonly associated with this syndrome include acute and

chronic illness, fasting, starvation, protein-calorie

malnutrition, general surgical trauma, myocardial infarction,

chronic renal failure, diabetic ketoacidosis, anorexia nervosa,

cirrhosis, thermal injury, and sepsis. The interpretation of

abnormal thyroid function test results observed in euthyroid

sick syndrome is further complicated by (1) the effects of a

variety of drugs, including the iodine-rich contrast agents and

amiodarone, which further impair the peripheral conversion of

T4 to T3, and (2) drugs such as dopamine and corticosteroids,

which decrease pituitary secretion of TSH, resulting in low

serum TSH levels and subsequent decreased thyroidal secretion

of T4.

The patients are euthyroid, and the clinical and laboratory

features have been termed the euthyroid sick syndrome. The

characteristic thyroid function abnormalities found in the

euthyroid sick syndrome include a decreased total serum T3,

increased serum reverse T3, normal or increased T3 resin

uptake, normal or decreased total serum T4, and variable serum

TSH levels.

Diagnosis and Treatment

The diagnostic dilemma is whether the patient has

hypothyroidism or the euthyroid sick syndrome. The most

sensitive indication of hypothyroidism due to primary thyroid

gland failure is a marked elevation of serum TSH. In contrast,

patients with the euthyroid sick syndrome have suppressed,

normal, or slightly elevated levels of serum TSH depending on

the course of the illness. Coexistent hypothyroidism in the

patient with an acute or chronic systemic illness is also

suggested by a low or low-normal serum reverse T3 level. A more

difficult differential diagnosis is central hypothyroidism.

Serum cortisol levels may aid diagnosis because they will be

elevated in patients with euthyroid sick syndrome and low or

low-normal in patients with pituitary-hypothalamic disease.

Alteration of T4 metabolism in acute illness may also obscure

the laboratory diagnosis of hyperthyroidism by lowering the

total serum T3 level. Thus, the physician must frequently rely

on clinical judgment based on a meticulous history and physical

examination when attempting to interpret abnormal thyroid

function test results in the acutely or chronically ill

patient. Unless thyroid dysfunction is highly suspected,

thyroid function tests should not be ordered for ICU patients.

The treatment is that of the underlying disorder.

Copyright © 1995-2000 Merck & Co., Inc.,

Whitehouse Station, NJ, USA. All rights reserved.

Also see:

Hypothyroidism

http://www.merck.com/pubs/mmanual/section2/chapter8/8e.htm

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