FWD: Dr. Derrick Lonsdale Biochat Notes

[Guest guest]

Feel free to forwardDr. Derrick Lonsdale He is a board certified pediatrician, Fellow of the American College of Nutrition and Certified Nutrition Specialist. I was an invited member of the first DAN initiation but could not make it because of a date clash. I was head of the Section of Biochemical Genetics at Cleveland Clinic until 1982 and helped to bring in the newborn screening tests into Ohio. I was conultant for inborn errors of metabolism in North East Ohio. I have published over 100 papers in the medical literature. My interest in TTFD dates back to 1973 when I was granted an Independent Investigator Licence (IND)for clinical studies of thiamine tetrahydrofurfuryl disulfide (TTFD). This IND is still active. I published an open study of the results of a single injection of Secretin in 68 ASD kids and I also published a pilot study of the effects of TTFD in 10 ASD kids, given by rectal suppository. Since that time I have been studying the benefits of TTFD given transdermally and have initiated the development of a commercially available transdermal preparation known as Authia. The use of transdermal TTFD is patented. Derrick Lonsdale M.B. B.S.(London). F.A.A.P. C.N.S.Notes below are paraphrased; the actual recording is on www.drneubrander.comQ: My son is 9 speech & attention deficit, would TTFD be of help to himA: Definitely. I did a study years ago with 10 children, 8 of them approved with TTFD. I saw arsenic, mercury, lead, cadmium in their urine in nearly all the children. The TTFD helped, and I still use it as part of my treatments. TTFD as a transdermal is very beneficial. I normally use it with transdermal DMSA. Animal studies show mercury is removed using thiamine (which is found in TTFD) and DMSA. The outcome using them together is better then either one alone.Q: TD (transdermal)? How often should I dose him?A: Daily. The cream is available by phone. The cream is given by 1/4 teaspoonful, massaged into the skin, on a nightly basis.Q: Do you believe that all of our kids have high levels of toxic metals? What kind of challenge do you do to determine this? How does TTFD differ from TD DMPS?A: No, I don't think all kids, but I think it's very common. I've seen SH-reactive metals (arsenic, mercury, lead, cadmium) commonly. They react with sulfur and hydrogen atoms. I do a TD-DMSA challenge, and the parents collect urine after the first cycle. DMSA is given for 3 days on, 11 days off. This is a good protocol.TTFD is essentially a vitamin. DMPS is a drug. That is a basic difference. I've used TTFD since 1973, and have never seen any toxicity. I've treated Down's, mental retardation, and ASD disorders. I've usually found TTFD to be very helpful. The best part is it's non-toxic.It's not just for heavy metals, although the removal of heavy metals is an important reaction. You might use it the same as vitamin B1, as a therapeutic tool. Vitamin B1 treats over 230 different conditions. TTFD is simply a method of delivering vitamin B1 into the system.Q: Are there any other supplements to give along with TTFD to help support detoxification or supplements that should be avoided while using it?A: One of the things that happens with the use of TTFD given transdermally is that the child develops a body odor like a skunk. 10 mg of biotin makes the odor disappear within 24 hours. Since then, I have treated a lot of children with TTFD, and in many cases the biotin hides the odor. The odor produced is undoubtedly related to the metabolic changes that are happening in the child, and as the child improves, the odor goes away.There is no toxicity from TTFD – that's simply not true.There are no supplements to avoid while using this vitamin TTFD. All vitamins you would normally use can be used in conjunction with TTFD.Q: Lemon juice takes the odor away as well (wash feet in the am)A: Thank you, that's a very helpful hint.Q: Is it for long term use? Can it be dangerous to give too much vitamin B1?A: Yes, it's for long term use. You can use it indefinitely; I've treated people for months, years, and have given very high doses. It can be dangerous to give too much, but it has to be literally thousands of times the RDA. If you take it that high, it will produce a paralytic effect in the nervous system.Much of the time I've given TTFD by mouth, but kids on the spectrum don't always take supplements orally. On a suggestion by a DAN! colleague, I contacted a compounding pharmacy to make a transdermal cream.TTFD is a disulfide derivative of vitamin B1. When it comes up against a cell membrane, the B1 enters the cell, and it leaves the self-containing molecule outside the cell. This is a very efficient way of delivering vitamin B1 into the cell.Q: How long before seeing results?A: In the pilot study, the children saw results in 4-6 weeks.Q: I have noticed that my son's "TTFD odor" will come and go. It leaves for a few weeks and then will come back. If this is indicative of metabolic changes, why does the odor return? Is the odor a sign of him detoxing more at that time?A: I'm afraid that I don't know the exact answer to that. Skunks produce mercaptans (the stinky sulfur-containing substance). I think some of the action of TTFD is to produce a mercaptan. Studies have been done, and it's shown that the mercaptans are excreted in the urine, with no toxic effect. Bottom line, I think the metabolism in your case might be waxing and waning.Q: My son is constantly hungry. He wants to eat all day long. After he finishes eating, he wants to eat more. He eats more than most adults. His weight is average. We give him only very healthy GFCF food. He only cares about food. He does not seem to have gut pain. He has no inborn errors of metabolism/genetic problems. All this started at 23 months at the same time as his regression with his DPT and has not been helped with dietary intervention. His fasting blood glucose level has gradually gone from normal to slightly low over the past 2 years. I don't know what to do. I am worried he will develop diabetes and it is so hard to deal with his eating all the time. He is not low in chromium and I always give him meat carbs and vegetables together. What can I do? Thanks! A: I have developed a conclusion about ASD. The metabolic lesion is related to the limbic system of the brain. The human brain is made up of cognitive and the primitive element (limbic). The limbic is a computer, it contains all the reflexes for which a human is able to survive in a toxic and hostile world. Appetite is controlled by the computer, not the stomach. When you put food in the stomach, it notifies the brain that food is coming. As you continue to put food in the stomach, the signals crescendo to the brain. Finally, the brain says I've had enough. That's what controls appetite. If that center is damaged in some way, the child goes on feeding and feeding and feeding. Most of the children I see have the opposite, a complete loss of appetite. So I think there is damage here (the satiety center). Many cells and many parts of the brain are affected by ASD. Every child is different. If you're not using TTFD, you definitely should. You can get that from your physician. Vitamin B1 is beneficial to the limbic system. You have to supply plenty of vitamins and oxygen to this system. Q: Do you feel the po (oral) is as effective as the TD? (TTFD) do you combine it with other chelators?A: Yes I combine. I use DMSA cycles along with daily TTFD. I do not feel that the oral is as effective as the transdermal. A lot of the things we use now are given by transdermal, and are efficient. The skin is a marvelous way to get these things in. But you have to be aware that the skin takes in the bad too, such as arsenic from play areas, and such. I think TD DMSA is wonderful, so good that I have not used DMPS.Q: 1. For those who have allergies to sulpha/sulphur, is ttfd safe as you said there was a sulphur molecule used for transport. 2. What are your top treatments for ASD? And can you rate their effectiveness?A: This is important. Sulpha medication is short for sulphonimide. It's an anti-microbial. Sulphur is the kind of sulphur produced from volcanos. TTFD is safe. The sulphur molecule in it may have an important bearing in it's effectiveness.Top treatments for ASD: I always use Nu-thera as a multi-vitamin. Nu-thera was a result of the research carried out by Bernie Rimland years ago. This mixture is beneficial in autism. These children are vitamin deficient. I use TTFD transdermally in the form of Authia cream, which contains a small amount of methyl cobalamin. I use that with TD-DMSA. I use folinic acid. Most of these kids can't use folic acid – folinic is the one you want. I look for yeast by sending urine to Great Plains, then I will add Nystatin. In some cases, I use Diflucan if the yeast is systemic. And I'm just beginning to use the low dose Naltrexone. The order I spoke of them in is the order I would rate them in.Q: We are using TD-DMSA on a 3/11 cycle. Is there a better time to give TTFD? Does it need to be applied away from the chelator?A: It does need to be applied away – use a different site for each of the TD creams you use. I usually advise for parents to give TTFD in the evening, so you can wash the child in the morning to try to get rid of the odor. Most of the children I see begin to get better within a day or so of completing the 3 day cycle of DMSA.