Monolaurin-PUB MED

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I was fascinated to see 81 articles on Monolaurin on PubMed. Some quite

curious. Free price. I have no vested interest, but seems curious. In my rushed

email I mistakenly gave it the wrong label chemically. Since in clinical

medicine we are dying for new things to kill infections or promote the

effectiveness of current ones, any ideas worth some look. I have no

opinion...... Just curiosity

FEMS Immunol Med Microbiol. 2003 May 15;36(1-2):9-17.

Antibacterial actions of fatty acids and monoglycerides against Helicobacter

pylori.

The bactericidal potencies of saturated and unsaturated fatty acids (FAs) and

monoglycerides (MGs) against Helicobacter pylori were determined following short

incubations with freshly harvested cells over a range of pHs. FAs and their

derivatives with an equivalent-carbon number of 12 were the most potent: lauric

acid had a minimum bactericidal concentration (MBC) at pH 7.4 of 1 mM,

myristoleic and linolenic acid were the most potent unsaturated FAs (MBCs of 0.5

mM, pH 7.4), and monolaurin was the most potent MG (MBC 0.5 mM). Potencies of

saturated FAs were increased sharply by lowering pH, and a decrease of only 0.5

pH units can cause a change from non-lethal to lethal conditions. Conversely,

the bactericidal action of monolaurin was not pH-dependent. The bactericidal

potencies of unsaturated FAs increased with degree of unsaturation. When more

than one FA or FA plus MGs were present, their combined action was additive.

Urea and endogenous urease did not protect H. pylori from the bactericidal

action of FAs. These results suggest that H. pylori present in the stomach

contents (but not necessarily within the mucus barrier) should be rapidly killed

by the millimolar concentrations of FAs and MGs that are produced by

pre-intestinal lipase(s) acting on suitable triglycerides such as milk fat.