MCS-immunological abnormalities

[Guest guest]

With the coverups, especially the PHARMA, came across this article.

Was written in 2003, may have been on the net and missed it. With

's wife and the breathing problems, and others like I developing

pneumonia

and respiratory infections from a brief encounter with perfumes, etc.

is no wonder we become ill so fast because our immune systems are

compromised.

Clin Diagn Lab Immunol. 2003; 10(6):1029-36 (ISSN: 1071-412X)

Hoover DR; Donnay A; CS; Ziem G; Rose NR; Sabath DE; Yurkow

EJ; Nakamura R; Vogt RF; Waxdal M; Margolick JB

Department of Statistics and Institute for Health, Health Care Policy

and Aging Research, Rutgers University, Piscataway, New Jersey, USA.

Whether persons with multiple chemical sensitivity syndrome (MCS) have

immunological abnormalities is unknown. To assess the reliability of

selected immunological tests that have been hypothesized to be

associated with MCS, replicate blood samples from 19 healthy

volunteers, 15 persons diagnosed with MCS, and 11 persons diagnosed

with autoimmune disease were analyzed in five laboratories for

expression of four T-cell surface activation markers (CD25, CD26,

CD38, and HLA-DR) and in four laboratories for autoantibodies (to

smooth muscle, thyroid antigens, and myelin). For T-cell activation

markers, the intralaboratory reproducibility was very good, with 90%

of the replicates analyzed in the same laboratory differing by < or =

3%. Interlaboratory differences were statistically significant for all

T-cell subsets except CD4+ cells, ranging from minor to eightfold for

CD25+ subsets. Within laboratories, the date of analysis was

significantly associated with the values for all cellular activation

markers. Although reproducibility of autoantibodies could not be

precisely assessed due to the rarity of abnormal results, there were

inconsistencies across laboratories. The effect of shipping on all

measurements, while sometimes statistically significant, was very

small. These results support the reliability of fresh and shipped

samples for detecting large (but perhaps not small) differences

between groups of donors in the T-cell subsets tested. When comparing

markers that are not well standardized, it may be important to

distribute samples from different study groups evenly over time.

Subject Headings

Major Subject Heading(s) Minor Subject Heading(s) CAS Registry / EC

Numbers

* Antigens, Differentiation, T-Lymphocyte [blood]

* Autoantibodies [blood]

* Autoimmune Diseases [diagnosis]

* Case-Control Studies

* Humans

* Immunologic Tests [methods] [standards]

* Lymphocyte Activation

* Multiple Chemical Sensitivity [diagnosis]

* Observer Variation

* Reproducibility of Results

* Research Support, Non-U.S. Gov't

* Research Support, U.S. Gov't, Non-P.H.S.

* Research Support, U.S. Gov't, P.H.S.

* 0 (Antigens, Differentiation, T-Lymphocyte)

* 0 (Autoantibodies)

* PreMedline Identifier: 14607863