Guest guest Posted January 30, 2008 Report Share Posted January 30, 2008 *****NEW ENGLAND JOURNAL OF MEDICINE***** Siegal FP C Hammer GS Brown AE Kornfeld SJ Gold J Hassett J Hirschman SZ Cunningham-Rundles C Adelsberg BR et al Severe acquired immunodeficiency in male homosexuals, manifested by chronic perianal ulcerative herpes simplex lesions. In: N Engl J Med (1981 Dec 10) 305(24):1439-44 ISSN: 0028-4793 Four homosexual men presented with gradually enlarging perianal ulcers, from which herpes simplex virus was cultured. Each patient had a prolonged course characterized by eight loss, fever, and evidence of infection by other opportunistic microorganisms including cytomegalovirus, Pneumocystis carinii, and Candida albicans. Three patients died; Kaposi's sarcoma developed in the fourth. All were found to have depressed cell-mediated immunity, as evidenced by skin anergy, lymphopenia, and poor or absent responses to plant lectins and antigens in vitro. Natural-killer-cell activity directed against target cells infected with herpes simplex virus was depressed in all patients. The absence of a history of recurrent infections or of histologic evidence of lymphoproliferative or other neoplastic diseases suggests that the immune defects were acquired. s. fuchs dc Quote Link to comment Share on other sites More sharing options...
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