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Here I go trying to answer my own questions.

I've been reading about Inspra and spiro. I guess neither reduces the

absolute amount of aldo. How could aldo be suppressed (as opposed to the

reception of aldo)?

Val

From: hyperaldosteronism

[mailto:hyperaldosteronism ] On Behalf Of Valarie

Dr. Grim, Farah mentioned that she still has the sweats, even with spiro.

What causes the sweats in people with PA?

Could it be that actually lowering aldo (Inspra) would work better than

blocking the reception of aldo (spiro)?

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Hi :

The meds that we take dont reduce the amount of aldosterone. They just work

as a mineral corticoid blocker to block the effects of Aldosterone. In fact,

if you do a blood test following serveral months of taking Spironolactone,

you will realize that your serum Aldosterone is actually higher than it was

before taking the meds. (at least this is in my case). What makes a

difference, is the ratio of Aldosterone to Renin. Once on medications, the

Renin goes up making the ratio less.

By the way I dont have any flushing experience when I am totally off the

spiro or aldactone. I have tried this several times when I had to prepare

for an AVS and went off spiro for 8 weeks twice. It is however reduced by

Aldactone and at least tolerable for now.

Farah

On Dec 31, 2007 12:02 PM, Valarie <val@...> wrote:

> Here I go trying to answer my own questions.

>

> I've been reading about Inspra and spiro. I guess neither reduces the

> absolute amount of aldo. How could aldo be suppressed (as opposed to the

> reception of aldo)?

>

> Val

>

> From: hyperaldosteronism <hyperaldosteronism%40>

>

[mailto:hyperaldosteronism <hyperaldosteronism%40>\

]

> On Behalf Of Valarie

>

>

> Dr. Grim, Farah mentioned that she still has the sweats, even with spiro.

>

> What causes the sweats in people with PA?

>

> Could it be that actually lowering aldo (Inspra) would work better than

> blocking the reception of aldo (spiro)?

>

>

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Hi Val,

I take Inspra (200 mg per day) and I only sweat when I exercise

walking uphill but my friend does not take Inspra and he sweats

plenty too. I have never noticed any sweating on Inspra when I am

not exercising, but I do usually feel warm. I just use the air

conditioner alot while I am at home.

Airlinerg

>

> Dr. Grim, Farah mentioned that she still has the sweats, even with

spiro.

>

> What causes the sweats in people with PA?

>

> Could it be that actually lowering aldo (Inspra) would work better

than

> blocking the reception of aldo (spiro)?

>

> Val

>

>

>

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Hi Farah,

I have been on Inspra for several years (ever since it was first FDA

approved,) and my Renin has not increased. It is still below normal

(less than 0.2 ngmLhr.) But on 200 mg of Inspra, my blood pressure

is now 120/80 and my potassium is 4.5. When I was on 150 mg of

Inspra, my blood pressure was 130/90 and my potassium was 3.7.

Airlinerg

>

> > Here I go trying to answer my own questions.

> >

> > I've been reading about Inspra and spiro. I guess neither

reduces the

> > absolute amount of aldo. How could aldo be suppressed (as

opposed to the

> > reception of aldo)?

> >

> > Val

> >

> > From: hyperaldosteronism <hyperaldosteronism%

40>

> > [mailto:hyperaldosteronism <hyperaldosteronism%

40>]

> > On Behalf Of Valarie

> >

> >

> > Dr. Grim, Farah mentioned that she still has the sweats, even

with spiro.

> >

> > What causes the sweats in people with PA?

> >

> > Could it be that actually lowering aldo (Inspra) would work

better than

> > blocking the reception of aldo (spiro)?

> >

> >

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Oh thats interesting. I only took Inspra for over a month and could not

tolerate it. But with Spiro, my doctor(my hmo doctor) goes on panic mode

every time he sees my blood work and insists I should increase the Spiro

because Aldosterone is on the rise. I have to remind him of the ratio that

stays on the low side. He thinks I most likely have a tumor that is causing

the aldosterone to constantly rise. Though he does admit he is learning a

lot too as I am his only patient. I also see an endo who is more

knowledgeable and has other patients like me and keeps wanting to reduce the

med. My K has been around 4.5 too since I started Spiro. But my salt level

has been on the border low side and sometimes lower than normal,

occasionally I have to take extra salt in my food. Thankfully I have not

experienced it on Aldactone recently.

Farah

On Dec 31, 2007 12:57 PM, airlinerg <airlinerg@...> wrote:

>

> Hi Farah,

>

> I have been on Inspra for several years (ever since it was first FDA

> approved,) and my Renin has not increased. It is still below normal

> (less than 0.2 ngmLhr.) But on 200 mg of Inspra, my blood pressure

> is now 120/80 and my potassium is 4.5. When I was on 150 mg of

> Inspra, my blood pressure was 130/90 and my potassium was 3.7.

>

> Airlinerg

>

>

> >

> > > Here I go trying to answer my own questions.

> > >

> > > I've been reading about Inspra and spiro. I guess neither

> reduces the

> > > absolute amount of aldo. How could aldo be suppressed (as

> opposed to the

> > > reception of aldo)?

> > >

> > > Val

> > >

> > > From:

hyperaldosteronism <hyperaldosteronism%40>

> <hyperaldosteronism%

> 40>

> > >

[mailto:hyperaldosteronism <hyperaldosteronism%40>

> <hyperaldosteronism%

> 40>]

> > > On Behalf Of Valarie

> > >

> > >

> > > Dr. Grim, Farah mentioned that she still has the sweats, even

> with spiro.

> > >

> > > What causes the sweats in people with PA?

> > >

> > > Could it be that actually lowering aldo (Inspra) would work

> better than

> > > blocking the reception of aldo (spiro)?

> > >

> > >

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Hmm, and Farah only has sweats when on spiro. I'm being awakened at any

time between 2 and 6 a.m. with terrible sweats. I get so anxious I have to

get up. That continues. A week ago, I was in the ER with 210/114 BP.

Today, it is 129/77. Wish I could figure this out. My last ARR was 32.5

but that was 2.5 years ago.

Val

From: hyperaldosteronism

[mailto:hyperaldosteronism ] On Behalf Of airlinerg

I take Inspra (200 mg per day) and I only sweat when I exercise

walking uphill but my friend does not take Inspra and he sweats

plenty too. I have never noticed any sweating on Inspra when I am

not exercising, but I do usually feel warm. I just use the air

conditioner alot while I am at home.

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Hi Farah,

My doctor (a nephrologist) has had me do yearly MRIs and CT scans to

see if I have a tumor that is causing hyperaldosteronism (Conn's

Syndrome) but the MRIs and CT scans always just show hyperplasia and

no tumor.

How do you determine if your salt level is on the border low side

and sometimes lower than normal? How do you know when you need

extra salt in your food?

Airlinerg

> > >

> > > > Here I go trying to answer my own questions.

> > > >

> > > > I've been reading about Inspra and spiro. I guess neither

> > reduces the

> > > > absolute amount of aldo. How could aldo be suppressed (as

> > opposed to the

> > > > reception of aldo)?

> > > >

> > > > Val

> > > >

> > > > From: hyperaldosteronism <hyperaldosteronism%

40>

> > <hyperaldosteronism%

> > 40>

> > > >

[mailto:hyperaldosteronism <hyperaldosteronism%

40>

> > <hyperaldosteronism%

> > 40>]

> > > > On Behalf Of Valarie

> > > >

> > > >

> > > > Dr. Grim, Farah mentioned that she still has the sweats, even

> > with spiro.

> > > >

> > > > What causes the sweats in people with PA?

> > > >

> > > > Could it be that actually lowering aldo (Inspra) would work

> > better than

> > > > blocking the reception of aldo (spiro)?

> > > >

> > > >

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Several of my blood tests have shown being low in sodium and when normal, it

is border line. This was following an episode of feeling so out of energy

that I felt I had no muscles. I was so tired and exhausted. Couldn't think

right and couldn't move. The endo that saw me in this condition recognized

it right away and sent me to the lab for a blood test first then said to

take salt crackers which helped within the hour. So now, when I feel this

way, I just have to remember to take some saltine crackers. Or better yet, a

cup of orange juice sprinkled with a 1/2 tsp kosher salt will do the trick

faster. I normally dont add salt to the foods I cook and only take sodium

when I feel totally drained like I am going to die any moment.

Farah

On Dec 31, 2007 5:23 PM, airlinerg <airlinerg@...> wrote:

> Hi Farah,

>

> My doctor (a nephrologist) has had me do yearly MRIs and CT scans to

> see if I have a tumor that is causing hyperaldosteronism (Conn's

> Syndrome) but the MRIs and CT scans always just show hyperplasia and

> no tumor.

>

> How do you determine if your salt level is on the border low side

> and sometimes lower than normal? How do you know when you need

> extra salt in your food?

>

>

> Airlinerg

>

>

> > > >

> > > > > Here I go trying to answer my own questions.

> > > > >

> > > > > I've been reading about Inspra and spiro. I guess neither

> > > reduces the

> > > > > absolute amount of aldo. How could aldo be suppressed (as

> > > opposed to the

> > > > > reception of aldo)?

> > > > >

> > > > > Val

> > > > >

> > > > > From:

hyperaldosteronism <hyperaldosteronism%40>

> <hyperaldosteronism%

> 40>

> > > <hyperaldosteronism%

> > > 40>

> > > > >

>

[mailto:hyperaldosteronism <hyperaldosteronism%40>

> <hyperaldosteronism%

> 40>

> > > <hyperaldosteronism%

> > > 40>]

> > > > > On Behalf Of Valarie

> > > > >

> > > > >

> > > > > Dr. Grim, Farah mentioned that she still has the sweats, even

> > > with spiro.

> > > > >

> > > > > What causes the sweats in people with PA?

> > > > >

> > > > > Could it be that actually lowering aldo (Inspra) would work

> > > better than

> > > > > blocking the reception of aldo (spiro)?

> > > > >

> > > > >

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It is hard to convince the doctors who think of their patients as

illiterates and dont listen to what they say. My first endo and now my

general practitioner keep on insisting that when the ARR is very high, it is

due to an adenoma and most likely not hyperplasia. Even when I was seen by

Dr. Quan Duh in UCSF, he insisted that I must have an adenoma causing me to

have a very high ARR even though it was not detected by any scan.- and

these are the supposedly experts in the field.

The doctors at Mayo clinic suggested that I be tested by them in three years

again.

Cheers!

Farah

On Jan 1, 2008 7:39 AM, <lowerbp2@...> wrote:

>

> In a message dated 12/31/07 7:23:33 PM,

airlinerg@...<airlinerg%40grad.com>writes:

>

> >

> > Hi Farah,

> >

> > My doctor (a nephrologist) has had me do yearly MRIs and CT scans to

> > see if I have a tumor that is causing hyperaldosteronism (Conn's

> > Syndrome) but the MRIs and CT scans always just show hyperplasia and

> > no tumor.

> >

> As long as you dont have to pay for them but the rest of us are. The scan

> costs about $1500 is my guess and not worth it. We know you have PA and as

>

> long as BP and K are controlled that is all you need to know. Take him my

> article.

> >

> > How do you determine if your salt level is on the border low side

> > and sometimes lower than normal? How do you know when you need

> > extra salt in your food?

> >

> > Airlinerg

> >

> >

> >

>

> May your pressure be low!

>

> Clarence E. Grim, BS, MS, MD

> Senior Consultant to Shared Care Research and Consulting, Inc.

> (sharedcareinc.com)

> Clinical Professor of Internal Medicine and Epidemiology Med. Col. WI

> Clinical Professor of Nursing, Univ. of WI, Milwaukee

>

> Specializing in Difficult to Control High Blood Pressure

> and the Physiology and History of Survival During

> Hard Times and Heart Disease today.

>

> **************************************

> See AOL's top rated recipes

> (http://food.aol.com/top-rated-recipes?NCID=aoltop00030000000004)

>

>

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In a message dated 1/2/08 3:40:55 AM, riothamus2@... writes:

>

> I know Quan Duh - saw him for an evaluation. He is a surgeon and

> surgeons like to do surgery.

>

> Dave

>

> Farah Rahbar wrote:

> >

> > It is hard to convince the doctors who think of their patients as

> > illiterates and dont listen to what they say. My first endo and now my

> > general practitioner keep on insisting that when the ARR is very high,

> > it is

> > due to an adenoma and most likely not hyperplasia. Even when I was seen by

> > Dr. Quan Duh in UCSF, he insisted that I must have an adenoma causing

> > me to

> > have a very high ARR even though it was not detected by any scan.- and

> > these are the supposedly experts in the field.

> >

> > The doctors at Mayo clinic suggested that I be tested by them in three

> > years

> > again.

> >

> > Cheers!

> > Farah

> >

> > On Jan 1, 2008 7:39 AM, <lowerbp2@... <mailto:lowerbp2%mailto:lo>>

> > wrote:

> >

> > >

> > > In a message dated 12/31/07 7:23:33 PM, airlinerg@...

> > <mailto:airlinerg%mailto:air><airlinerg%airlinerg%><wbr>wr

> > >

> > > >

> > > > Hi Farah,

> > > >

> > > > My doctor (a nephrologist) has had me do yearly MRIs and CT scans to

> > > > see if I have a tumor that is causing hyperaldosteronism (Conn's

> > > > Syndrome) but the MRIs and CT scans always just show hyperplasia and

> > > > no tumor.

> > > >

> > > As long as you dont have to pay for them but the rest of us are. The

> > scan

> > > costs about $1500 is my guess and not worth it. We know you have PA

> > and as

> > >

> > > long as BP and K are controlled that is all you need to know. Take

> > him my

> > > article.

> > > >

> > > > How do you determine if your salt level is on the border low side

> > > > and sometimes lower than normal? How do you know when you need

> > > > extra salt in your food?

> > > >

> > > > Airlinerg

> > > >

> > > >

> > > >

> > >

> > > May your pressure be low!

> > >

> > > Clarence E. Grim, BS, MS, MD

> > > Senior Consultant to Shared Care Research and Consulting, Inc.

> > > (sharedcareinc. (sh

> > > Clinical Professor of Internal Medicine and Epidemiology Med. Col. WI

> > > Clinical Professor of Nursing, Univ. of WI, Milwaukee

> > >

> > > Specializing in Difficult to Control High Blood Pressure

> > > and the Physiology and History of Survival During

> > > Hard Times and Heart Disease today.

> >

>

>

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