Re: Re: INSPRA side effects, angiotensin system illustration, new walking shoes

[Guest guest]

In a message dated 6/2/06 8:42:22 AM, dave@... writes:

http://www.cvphysiology.com/Blood%20Pressure/BP015.htm

I like mine better but have never put it on the site. I have an animated series of slides in ppt that do a better job I think. Would they be able to be seen if we put them in the files on our site. It is good size-about 5 mb.

May your pressure be low!

CE Grim, BS(Chem/Math), MS(Biochem), MD.

Board Certified in Internal Medicine, Geriatrics and Hypertension

Former Epidemiologic Intelligence Services Officer (Lt. Comdr.), CDC

Specializing in Difficult to Manage High Blood Pressure

Clinical Professor of Medicine, Medical College of Wisconsin

[Guest guest]

Should I send it to you Dave for a preview?

May your pressure be low!

CE Grim, BS(Chem/Math), MS(Biochem), MD.

Board Certified in Internal Medicine, Geriatrics and Hypertension

Former Epidemiologic Intelligence Services Officer (Lt. Comdr.), CDC

Specializing in Difficult to Manage High Blood Pressure

Clinical Professor of Medicine, Medical College of Wisconsin

[Guest guest]

Drug interactions are poorly understood, if known at all in pharmo (my

grad field for awhile). Vitamin routines, including C and some of the

electrolytes can mess with hyperaldosteronism. C (especially the

ascorbate forms so popular now) and calcium can be interpreted as

sodium by the body. Centrum is particularly odious, with its synthetic

formulation and lopsided proportions. As Dr Grim ceaselessly points

out, the DASH diet (with its best-supported-by-scientific-evidence

general eating plan) and in the low sodium version, can be used to give

you all the nutrients you need, and lowers BP and medication dosage in

many cases. Any metabolic condition, IMO, says " no synthetic

vitamins. " The angiotenisn system is having enough troubles and

strains.

The fact that Spiro worked so well for your BP is what inspires my

comments. I recommend strongly for all in the group to LOOK AT THIS

DRAWING OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM :

http://www.cvphysiology.com/Blood%20Pressure/BP015.htm

It shows how the kidneys, endocrine, cardio and vascular systems

interact. Or, why docs seem to shy away from PA (in addition to no

economic incentives).

On rehab-walking, I just discovered the hard way how damaging most

footwear can be for middle agers starting rehab-walk, so researched

these :

http://www.mbt-uk.com/

which actually help your posturals, and exercize the body correctly all

the time you wear them, even while just standing. University

biomechanics depts are abuzz with MBT's. Also :

http://www.spirafootwear.com/

are similar, with similar medical and athletic-world excitement, but

are more for injury-therapy, and less for workout regimens. Both

require orthotic inserts.

Thanks for your enlightening and helpful Inspra tapering-in story. I

am facing exactly the same switch from Spiro now, and will forward to

my doctor. It sounds perfect for my drug response style, and maybe for

others as well who suffer from gynecomastia. Or, who just need to use

Eplerenone for any reason.

Thanks again - what is your first name, by the way?

Dave

On Jun 2, 2006, at 12:30 AM, airlinerg wrote:

>

> I am a 49 year old male. Originally, 75 mg of Spironolactone worked

> great and brought my blood pressure down to 120/80. I developed painful

> breasts with apricot sized nodules in them and had to discontinue it.

>

> I then switched to Midamor with Norvasc. I hated the swelling from

> Norvasc.

>

> I started Inspra, 25 mg a day and got BAD headaches and felt very

> dehydrated, so I went back to Midamor and Norvasc.

>

> Upon the advise of a new doctor, I tried Inspra alone again at 12.5 mg

> a

> day. The headaches and hypertension were less severe, and diminished

> after 2 weeks.

>

> I increased to 12.5 mg of Inspra (half a tablet twice a day) and

> tolerated that. Because my blood pressure was still not in control, I

> increased the Inspra after 2 weeks to 25 mg in the morning and 12.5 mg

> in the evening.

>

> I then increased the Inspra to 25 mg in the morning and 25 mg at

> bedtime

> after 2 more weeks.

>

> I slowly increased the Inspra to 75 mg in the morning and 75 mg at

> bedtime. My blood pressure is now about 130/85 average.

>

> This is twice the does I was taking of Spironolactone which was 75 mg

> per day.

>

>

>

> So my suggestion to avoid headaches and other side effects from Inspra

> is to start at 12.5 mg per day and increase slowly and drink 4 glasses

> of water between meals (12 glasses a day) to prevent the dehydration

> effect. Of course you will urinate more.

>

> _______________________________________________________________________

> _\

> ________________________

>

> Besides Inspra 75 mg in the morning and 75 mg at bedtime I take these

> medications:

>

> Cymbalta 30 mg (for fibromyalgia)

>

> Omacor 1 gram (for high triglycerides)

>

> Cardura 1 mg (for prostatodynia)

>

> Lipitor 10 mg (for high cholesterol)

>

> Tricor 145 mg (for high cholesterol and high triglycerides)

>

> Metformin 1000 mg (for metabolic syndrome)

>

> Aciphex 20 mg (for reflux)

>

> Vitamin C (500 mg twice a day)

>

> Coenzyme Q10 (50 mg per day)

>

> Multivitamin (Centrum)

>

> Vitamin E (400 IU)

>

> GTF Chromium (2oo mcg)

>

> L-Carnitine (250 mg)

>

> _______________________________________________________________________

> _\

> _________________________

>

> My main problem is daytime fatigue and non-restorative sleep. Also

> loosing 40 pounds. I am 5'6 " and 186 pounds (down from 196 pounds.) I

> need to loose 40 more pounds.

>

> I also have sleep apnea, daytime hypersonmolence, and I take 100 mg

> Provigil as needed. This does not increase my blood pressure. I am

> considering taking Tenuate (diethylpropion) 25 mg twice a day as an

> appetitie supressant for a carbohydrate restricted diet to loose more

> weight, but it could increase my blood pressure.

>

> I will also try to start walking again 45 minutes to 1 hour per day and

> doing 15 minutes of weight resistance training per day.

>

> If you have any feedback for me, please reply.

>

>

>

>

>

>>>

>>>> That's worse than weird, a. Was it a

>>>> generalized headache, or

>>>> localized to a specific region? Or did it vary? I

>>>> am interested

>>>> because I've had one go--around with it, and am

>>>> approaching my second,

>>>> sans many other useless (for PA) meds. Finally

>>>> (forgive me if I am

>>>> duplicating questions here), how long did the

>>>> headache(s) last each

>>>> time you took your dose, and how long before you

>>>> quit?

>>>>

>>>> Dave

>>

>

>

[Guest guest]

I am going to send a sample to see how it works. The ppt slides are animated on my Mac and sometimes it does not go thu well when going to PC.

I am attaching a talk I just gave to the National Medical Assoc Regional meeting here as a trial.

whoops it says it is greater that 16 MB. Will try to pare it down.

May your pressure be low!

CE Grim, BS(Chem/Math), MS(Biochem), MD.

Board Certified in Internal Medicine, Geriatrics and Hypertension

Former Epidemiologic Intelligence Services Officer (Lt. Comdr.), CDC

Specializing in Difficult to Manage High Blood Pressure

Clinical Professor of Medicine, Medical College of Wisconsin

[Guest guest]

That sounds great. I'm sure there are many who could understand the

general overview better. Lots of FAQ's are answered by this. Maybe

it can be broken into 1MB pieces? Some browsers won't download larger

files.

Dave

On Jun 2, 2006, at 8:48 AM, lowerbp2@... wrote:

>

> In a message dated 6/2/06 8:42:22 AM, dave@... writes:

>

>

>> http://www.cvphysiology.com/Blood%20Pressure/BP015.htm

>

>

> I like mine better but have never put it on the site.  I have an

> animated series of slides in ppt that do a better job I think. Would

> they be able to be seen if we put them in the files on our site. It is

> good size-about 5 mb.

>

>

>

> May your pressure be low!

>

> CE Grim, BS(Chem/Math), MS(Biochem), MD.

> Board Certified in Internal Medicine, Geriatrics and Hypertension

> Former Epidemiologic Intelligence Services Officer (Lt. Comdr.), CDC

> Specializing in Difficult to Manage High Blood Pressure

> Clinical Professor of Medicine, Medical College of Wisconsin

>

[Guest guest]

Yes sir, I can make it into 1MB pieces and post in FILES. Our

publishing house has all the tools for computer graphics. I can

receive big e-mail attachments.

Dave

On Jun 2, 2006, at 10:12 AM, lowerbp2@... wrote:

> Should I send it to you Dave for a preview?

>

>

>

> May your pressure be low!

>

> CE Grim, BS(Chem/Math), MS(Biochem), MD.

> Board Certified in Internal Medicine, Geriatrics and Hypertension

> Former Epidemiologic Intelligence Services Officer (Lt. Comdr.), CDC

> Specializing in Difficult to Manage High Blood Pressure

> Clinical Professor of Medicine, Medical College of Wisconsin

>

[Guest guest]

I am a MAC user too. What software is it in?

Dave

On Jun 2, 2006, at 11:30 AM, lowerbp2@... wrote:

> I am going to send a sample to see how it works.  The ppt slides are

> animated on my Mac and sometimes it does not go thu well when going to

> PC. 

>

> I am attaching a talk I just gave to the National Medical Assoc

> Regional meeting here as a trial.

>

> whoops it says it is greater that 16 MB.  Will try to pare it down.

>

>

>

> May your pressure be low!

>

> CE Grim, BS(Chem/Math), MS(Biochem), MD.

> Board Certified in Internal Medicine, Geriatrics and Hypertension

> Former Epidemiologic Intelligence Services Officer (Lt. Comdr.), CDC

> Specializing in Difficult to Manage High Blood Pressure

> Clinical Professor of Medicine, Medical College of Wisconsin

>

>

[Guest guest]

MS Powerpoint.

May your pressure be low!

CE Grim, BS(Chem/Math), MS(Biochem), MD.

Board Certified in Internal Medicine, Geriatrics and Hypertension

Former Epidemiologic Intelligence Services Officer (Lt. Comdr.), CDC

Specializing in Difficult to Manage High Blood Pressure

Clinical Professor of Medicine, Medical College of Wisconsin

[Guest guest]

I also do Filemaker Pro. Do you know how to publish a FM database on the web? It is the best database I have found.

May your pressure be low!

CE Grim, BS(Chem/Math), MS(Biochem), MD.

Board Certified in Internal Medicine, Geriatrics and Hypertension

Former Epidemiologic Intelligence Services Officer (Lt. Comdr.), CDC

Specializing in Difficult to Manage High Blood Pressure

Clinical Professor of Medicine, Medical College of Wisconsin

[Guest guest]

Yes, I am mid-conversion for all browser types, and all server

governor times of day.

Dave

On Jun 3, 2006, at 7:58 AM, lowerbp2@... wrote:

> MS Powerpoint.

>

>

>

> May your pressure be low!

>

> CE Grim, BS(Chem/Math), MS(Biochem), MD.

> Board Certified in Internal Medicine, Geriatrics and Hypertension

> Former Epidemiologic Intelligence Services Officer (Lt. Comdr.), CDC

> Specializing in Difficult to Manage High Blood Pressure

> Clinical Professor of Medicine, Medical College of Wisconsin

>