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Inspra does cause very bad headaches initially. I got them as well

and quit Inspra.

I went back to Inspra, becuase I cannot take Spironolactone.

I restarted again on Inspra with just 25 mg per day for a few weeks.

I gradually increased slowly to 150 mg per day.

After the body gets use to Inspra, you will no longer have headaches.

It takes about 4 weeks on 25 mg of Inspra for the body to get used

to it, and in sensitive people 8 weeks at this low dose. You may

even have to try 12.5 mg twice a day.

Spironolactone (Aldactone) is a great medication if you can use it

without getting gynocomastia and impotence. Unfortunately, those 2

side effects are very possible - especially for men, among others.

If you were doing well on Spironolactone, why did you try Inspra?

Inspra is a lot more expensive.

>

> >

> > I am sure more then 6 people in this group are

> > taking INSPRA, but only 6

> > have answered the POLL.

> >

> > If you are taking INSPRA, can you please answer the

> > POLL question:

> >

> > How much total INSPRA are you taking per day?

> >

> >

> hyperaldosteronism/surveys?

id=15897\

> > 44

> >

> <hyperaldosteronism/surveys?

id=1589\

> > 744>

> >

> >

> >

> > (Do not reply to this message with your answer,

> > instead enter your

> > answer by clicking on the LINK above to participate

> > in the POLL.

> > Thanks.)

> >

> >

> >

> >

>

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Being female, I've never had a problem with spiro. My

endo wanted me to try Inspra for some reason, he said

it was new and more effective. I tried it for 3

weeks, 50 mg twice per day, the headaches got no

better and my blood pressure was waaay high. Spiro

seems to work well for me so I'll stick with it.

a

--- airlinerg <airlinerg@...> wrote:

> Inspra does cause very bad headaches initially. I

> got them as well

> and quit Inspra.

>

> I went back to Inspra, becuase I cannot take

> Spironolactone.

> I restarted again on Inspra with just 25 mg per day

> for a few weeks.

> I gradually increased slowly to 150 mg per day.

>

> After the body gets use to Inspra, you will no

> longer have headaches.

> It takes about 4 weeks on 25 mg of Inspra for the

> body to get used

> to it, and in sensitive people 8 weeks at this low

> dose. You may

> even have to try 12.5 mg twice a day.

>

> Spironolactone (Aldactone) is a great medication if

> you can use it

> without getting gynocomastia and impotence.

> Unfortunately, those 2

> side effects are very possible - especially for men,

> among others.

>

> If you were doing well on Spironolactone, why did

> you try Inspra?

> Inspra is a lot more expensive.

>

>

>

>

>

> >

> > >

> > > I am sure more then 6 people in this group are

> > > taking INSPRA, but only 6

> > > have answered the POLL.

> > >

> > > If you are taking INSPRA, can you please answer

> the

> > > POLL question:

> > >

> > > How much total INSPRA are you taking per day?

> > >

> > >

> >

>

hyperaldosteronism/surveys?

> id=15897\

> > > 44

> > >

> >

>

<hyperaldosteronism/surveys?

> id=1589\

> > > 744>

> > >

> > >

> > >

> > > (Do not reply to this message with your answer,

> > > instead enter your

> > > answer by clicking on the LINK above to

> participate

> > > in the POLL.

> > > Thanks.)

> > >

> > >

> > >

> > >

> >

>

>

>

>

>

>

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In a message dated 5/27/06 2:11:43 PM, farahbar@... writes:

The only negative

thing is my kidneys are being affected on Spiro so it makes me feel

sick all over and I can't describe what it feels like.

How are your kidneys being affected?

May your pressure be low!

CE Grim, BS(Chem/Math), MS(Biochem), MD.

Board Certified in Internal Medicine, Geriatrics and Hypertension

Former Epidemiologic Intelligence Services Officer (Lt. Comdr.), CDC

Specializing in Difficult to Manage High Blood Pressure

Clinical Professor of Medicine, Medical College of Wisconsin

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In a message dated 5/27/06 9:49:56 AM, shahall@... writes:

Being female, I've never had a problem with spiro.  My

endo wanted me to try Inspra for some reason, he said

it was new and more effective.  I tried it for 3

weeks, 50 mg twice per day, the headaches got no

better and my blood pressure was waaay high.  Spiro

seems to work well for me so I'll stick with it. 

a

Agree if it does the job there is no good reason to choose Inspra. Spiro has been arounnd for at least 40 years.

May your pressure be low!

CE Grim, BS(Chem/Math), MS(Biochem), MD.

Board Certified in Internal Medicine, Geriatrics and Hypertension

Former Epidemiologic Intelligence Services Officer (Lt. Comdr.), CDC

Specializing in Difficult to Manage High Blood Pressure

Clinical Professor of Medicine, Medical College of Wisconsin

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I am with a. My doctor switched me to Inspra because she said

she didn't like the side effects of Spiro. I started with 25 mg of

Inspra and my bp just kept getting higher, headaches, chest pain,

flushing and I was just miserable. Increased it eventually to 100mgs

within a month. After a month on Inspra my bp was as high as 200/100

so I stopped and went back on spiro. 100(50 twice/day) spiro keeps

my bp under 120/80 and I dont have to take anything else. Being

female I even experienced some gynecomastia but it went away after a

month or so. I wonder if this condition is for everyone if they stay

on it long enough. My only problem with spiro now is feeling very

tired in the mornings I can't move a muscle and ocasional dizziness

when I am standing. My K has been in 4.5-4.7 range. My Sodium in

lower normal range. I get tingling in my arms and legs occasionally

and goes away when I increase my intake of Magnesium through foods

only(like I will eat a couple of spoons of peanut butter or eat a

bunch of peanuts and the tingling goes away). The only negative

thing is my kidneys are being affected on Spiro so it makes me feel

sick all over and I can't describe what it feels like.

> > >

> > > >

> > > > I am sure more then 6 people in this group are

> > > > taking INSPRA, but only 6

> > > > have answered the POLL.

> > > >

> > > > If you are taking INSPRA, can you please answer

> > the

> > > > POLL question:

> > > >

> > > > How much total INSPRA are you taking per day?

> > > >

> > > >

> > >

> >

> hyperaldosteronism/surveys?

> > id=15897\

> > > > 44

> > > >

> > >

> >

> <hyperaldosteronism/surveys?

> > id=1589\

> > > > 744>

> > > >

> > > >

> > > >

> > > > (Do not reply to this message with your answer,

> > > > instead enter your

> > > > answer by clicking on the LINK above to

> > participate

> > > > in the POLL.

> > > > Thanks.)

> > > >

> > > >

> > > >

> > > >

> > >

> >

> >

> >

> >

> >

> >

>

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I feel tired pretty much all the time, some days are worse than

others. I wonder if this goes along with PA or we're just weird :)?

It sounds like you might be having some orthostatic hypotension like I

have sometimes. My BP will be fine sitting but drops precipitously

upon standing. It doesn't bother me too much at home but I have to

bend and stoop at work quite a bit some days and I've almost passed

out twice. Very annoying. I've been taking a magnesium supplement

500 mg mg/day for over two weeks now. Maybe it's just coincidence but

the tingling in my feet is about 95% gone. What has the spiro done to

your kidneys? I had one creatinine level come back elevated but my

last one was ok.

a

> on it long enough. My only problem with spiro now is feeling very

> tired in the mornings I can't move a muscle and ocasional dizziness

> when I am standing. My K has been in 4.5-4.7 range. My Sodium in

> lower normal range. I get tingling in my arms and legs occasionally

> and goes away when I increase my intake of Magnesium through foods

> only(like I will eat a couple of spoons of peanut butter or eat a

> bunch of peanuts and the tingling goes away). The only negative

> thing is my kidneys are being affected on Spiro so it makes me feel

> sick all over and I can't describe what it feels like.

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In a message dated 5/27/06 5:39:52 PM, farahbar@... writes:

My creatinine goes up and eGFR comes low.

This is telling you that it is effectively lowering your BP. The hope is that by keeping the BP low the kidneys will heal and the creat go back donw and the GFR go up.

What other meds are or were you on when this happened.

In general small increase in Cr cannot be felt by the pt.

May your pressure be low!

CE Grim, BS(Chem/Math), MS(Biochem), MD.

Board Certified in Internal Medicine, Geriatrics and Hypertension

Former Epidemiologic Intelligence Services Officer (Lt. Comdr.), CDC

Specializing in Difficult to Manage High Blood Pressure

Clinical Professor of Medicine, Medical College of Wisconsin

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In a message dated 5/27/06 5:47:54 PM, shahall@... writes:

My BP will be fine sitting but drops precipitously

upon standing.  It doesn't bother me too much at home but I have to

bend and stoop at work quite a bit some days and I've almost passed

out twice. 

Your BP control systems and perhaps your body may have not yet adjusted to having a lower BP. How long have you been on Spiro and how much did your BP come down and when? What other meds are you on.

The DASH should get you all the Mg you need (and K).

May your pressure be low!

CE Grim, BS(Chem/Math), MS(Biochem), MD.

Board Certified in Internal Medicine, Geriatrics and Hypertension

Former Epidemiologic Intelligence Services Officer (Lt. Comdr.), CDC

Specializing in Difficult to Manage High Blood Pressure

Clinical Professor of Medicine, Medical College of Wisconsin

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That's worse than weird, a. Was it a generalized headache, or

localized to a specific region? Or did it vary? I am interested

because I've had one go--around with it, and am approaching my second,

sans many other useless (for PA) meds. Finally (forgive me if I am

duplicating questions here), how long did the headache(s) last each

time you took your dose, and how long before you quit?

Dave

On May 28, 2006, at 8:43 AM, a Hall wrote:

> It went way up, 190-200 range. Only weird effect I

> noticed was raging headache every day I took it.

>

> a

>

>

> --- Dave <dave@...> wrote:

>

>> Same milligrams, and you simply switched. So what

>> happened to your BP?

>> Any odd effects?

>>

>> dave

>>

>> On May 28, 2006, at 6:34 AM, a Hall wrote:

>>

>>> He told me to stop the spiro & start the inspra,

>> no

>>> taper. I was on the same dose of spiro at the

>> time.

>>>

>>> a

>>>

>>> --- Dave <dave@...> wrote:

>>>

>>>> That's interesting. When you made the switch,

>> did

>>>> you stop all spiro

>>>> and go straight to inspra, or do a taper-switch?

>>>> Was it double the

>>>> spiro milligrams?

>>>>

>>>> Dave

>>

>>

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No other medications. I have only taken 1 month of Inspra about 10 months ago for a month that didn't work. Since then I have been on Spiro and occasionally fish oil. No supplements or any other meds.

Why is the creatine going up if the bp is effectively coming down? Shouldn't it be the other way around?

THX,

Farah

My creatinine goes up and eGFR comes low.

This is telling you that it is effectively lowering your BP. The hope is that by keeping the BP low the kidneys will heal and the creat go back donw and the GFR go up. What other meds are or were you on when this happened. In general small increase in Cr cannot be felt by the pt. May your pressure be low!CE Grim, BS(Chem/Math), MS(Biochem), MD.Board Certified in Internal Medicine, Geriatrics and Hypertension

Former Epidemiologic Intelligence Services Officer (Lt. Comdr.), CDCSpecializing in Difficult to Manage High Blood PressureClinical Professor of Medicine, Medical College of Wisconsin

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I don't know how to describe it, it wasn't like the

dull, aching pain I get from regular headaches. It

was a more sharp, stabbing pain. It wasn't a constant

thing but it was present more than not and tylenol

didn't help. After two weeks on I went back to my

Endo. He was very surprised to see that my BP was so

high and wanted to increase the dose. I told him

about the headaches and said I couldn't believe that

they would get any better on a higher dose. He said

headache was a common side-effect with Inspra and

wanted me to try it for another two weeks to see if it

got any better. I told him I'd give it a try for

another week but the headaches really were

interferring with my life, if it wasn't any better

after three weeks I was going back on the spiro. They

didn't get any better. I hope you have better luck

with it.

a

--- Dave <dave@...> wrote:

> That's worse than weird, a. Was it a

> generalized headache, or

> localized to a specific region? Or did it vary? I

> am interested

> because I've had one go--around with it, and am

> approaching my second,

> sans many other useless (for PA) meds. Finally

> (forgive me if I am

> duplicating questions here), how long did the

> headache(s) last each

> time you took your dose, and how long before you

> quit?

>

> Dave

>

> On May 28, 2006, at 8:43 AM, a Hall wrote:

>

> > It went way up, 190-200 range. Only weird effect

> I

> > noticed was raging headache every day I took it.

> >

> > a

> >

> >

> > --- Dave <dave@...> wrote:

> >

> >> Same milligrams, and you simply switched. So

> what

> >> happened to your BP?

> >> Any odd effects?

> >>

> >> dave

> >>

> >> On May 28, 2006, at 6:34 AM, a Hall wrote:

> >>

> >>> He told me to stop the spiro & start the inspra,

> >> no

> >>> taper. I was on the same dose of spiro at the

> >> time.

> >>>

> >>> a

> >>>

> >>> --- Dave <dave@...> wrote:

> >>>

> >>>> That's interesting. When you made the switch,

> >> did

> >>>> you stop all spiro

> >>>> and go straight to inspra, or do a

> taper-switch?

> >>>> Was it double the

> >>>> spiro milligrams?

> >>>>

> >>>> Dave

> >>

> >>

>

>

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It seems to be a common side effect for folks on this site. But we don't have good numbers of lots of other pts on it.

If you look at the Pfizer site you see that headaches are the most common reason for discontinuing in HTN, but I cant see the %. Maybe others can track this down at this site. Pfizer.com

Maybe Farah could query the Mayo on their experience. It may be more common in PA than in reg HTN.

One mechanism I can think of is in PA their may be higher sodium in the brain cells and when this is corrected by Epl swelling may result in a headache but this may be reaching for straws.

May your pressure be low!

CE Grim, BS(Chem/Math), MS(Biochem), MD.

Board Certified in Internal Medicine, Geriatrics and Hypertension

Former Epidemiologic Intelligence Services Officer (Lt. Comdr.), CDC

Specializing in Difficult to Manage High Blood Pressure

Clinical Professor of Medicine, Medical College of Wisconsin

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In a message dated 5/28/06 6:12:23 PM, farahbar@... writes:

No other medications. I have only taken 1 month of Inspra about 10 months ago for a month that didn't work. Since then I have been on Spiro and occasionally fish oil. No supplements or any other meds.

Why is the creatine going up if the bp is effectively coming down? Shouldn't it be the other way around?

THX,

Farah

If you kidneys have been damaged by HTN then when BP is lowered the blood going to the kidneys decreases. GFR is partly related to BP and is normally regulated so when BP falls GFR does not. It may take some time for the kidneys to heal and the GFR with rise again. But may not. The first consideration is how low is your BP now. Letting it come up to around 135 at home might be better for the GFR and the kidney.

May your pressure be low!

CE Grim, BS(Chem/Math), MS(Biochem), MD.

Board Certified in Internal Medicine, Geriatrics and Hypertension

Former Epidemiologic Intelligence Services Officer (Lt. Comdr.), CDC

Specializing in Difficult to Manage High Blood Pressure

Clinical Professor of Medicine, Medical College of Wisconsin

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In a message dated 5/28/06 6:12:23 PM, farahbar@... writes:

No other medications. I have only taken 1 month of Inspra about 10 months ago for a month that didn't work. Since then I have been on Spiro and occasionally fish oil. No supplements or any other meds.

Why is the creatine going up if the bp is effectively coming down? Shouldn't it be the other way around?

THX,

Farah

PS it is not the creatine that is going up it is the creatinine if you are talking about kidney function. Rarely do we measure creatine.

May your pressure be low!

CE Grim, BS(Chem/Math), MS(Biochem), MD.

Board Certified in Internal Medicine, Geriatrics and Hypertension

Former Epidemiologic Intelligence Services Officer (Lt. Comdr.), CDC

Specializing in Difficult to Manage High Blood Pressure

Clinical Professor of Medicine, Medical College of Wisconsin

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I was looking for region because the lower occipital, or upper back of

the neck is often a sign of toxicity, Pfizer said. Other areas not.

But I don't understand why there is a headache at all. Higher BP can

cause a headache. So can many other things. When you start a new med,

you have to be careful about not doing anything else w/meds, diet etc.

Just to isolate its effect.

My headache was in that toxic region, but I was on a bevy of

ineffective HTN meds. Now that those are tapered, spiro works great to

control BP, but I am getting the male Sfx syndrome. I am hoping the

interactions w/other meds also specified in Pfizer study was the cause

of my headaches.

I'll provide specifics when I start the new experiment. I wish someone

was keeping track of all this clinical case data. The drug companies

are de-regulated and wildly negligent on this.

Dave

On May 28, 2006, at 4:51 PM, a Hall wrote:

> I don't know how to describe it, it wasn't like the

> dull, aching pain I get from regular headaches. It

> was a more sharp, stabbing pain. It wasn't a constant

> thing but it was present more than not and tylenol

> didn't help. After two weeks on I went back to my

> Endo. He was very surprised to see that my BP was so

> high and wanted to increase the dose. I told him

> about the headaches and said I couldn't believe that

> they would get any better on a higher dose. He said

> headache was a common side-effect with Inspra and

> wanted me to try it for another two weeks to see if it

> got any better. I told him I'd give it a try for

> another week but the headaches really were

> interferring with my life, if it wasn't any better

> after three weeks I was going back on the spiro. They

> didn't get any better. I hope you have better luck

> with it.

>

> a

>

> --- Dave <dave@...> wrote:

>

>> That's worse than weird, a. Was it a

>> generalized headache, or

>> localized to a specific region? Or did it vary? I

>> am interested

>> because I've had one go--around with it, and am

>> approaching my second,

>> sans many other useless (for PA) meds. Finally

>> (forgive me if I am

>> duplicating questions here), how long did the

>> headache(s) last each

>> time you took your dose, and how long before you

>> quit?

>>

>> Dave

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So what we need it to collect a series of Inspra Stories in PA.

Here is what is needed.

Age, gender, Age of Dx of HTN, Age of Dx of PA, Dx of PA data to define type of PA.

List of side effects thought to occur on Inspra or Spiro

For each side effect listed give the following information.

When did it start?

When did it stop?

What was it like?

Where was the problem. If headache unilateral or bilateral. Like other HAs you have had?

Describe the nature of the pain if any. Throbbing, Knife like, Dull ache on skin or in muscle or in bone?

How long did it last?

What made it come on?

What made it go away?

If the pain started in one place did it move to another? Describe in detail.

What did you think was causing it?

What did your health care team think was causing it?

What tests were done?

What did they show?

Was any treatment undertaken?

Did it help?

List all meds the month before the problem started-and all OTC things taken.

List any new stresses in your life.

By collecting data in a systematic manner we should be able to establish a syndrome that may be related to Inspra Rx.

As I said headache could be realted to shifts in brain sodium balance with the new aldo blockage. Maybe like what is called dialysis headache where changes in blood and brain sodium balance are thought to be related to headache.

May your pressure be low!

CE Grim, BS(Chem/Math), MS(Biochem), MD.

Board Certified in Internal Medicine, Geriatrics and Hypertension

Former Epidemiologic Intelligence Services Officer (Lt. Comdr.), CDC

Specializing in Difficult to Manage High Blood Pressure

Clinical Professor of Medicine, Medical College of Wisconsin

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In a message dated 5/30/06 9:10:00 AM, shahall@... writes:

At the time of diagnosis of PA, I was on spiro 50 mg

bid, atacand 32 mg, toprol XL 50 mg and BP was running

160-170 range.

AS I have stated before Atacand (ARB) and toprol (BB) dont work well in PA.

After diagnosis the Dr. at U-M

increased spiro to 100 bid and told me to start

weaning off other meds. He added HCT 12.5 and

suggested staying on it if K+ stayed good, which it

has. I have since cut spiro down to 75 bid as 100

brought my BP down too much.  I weaned off the atacand

with no problem but I'm having a heck of a time coming

off the Toprol.  My HR before starting it ran about

90.  It decreased to low 70's when I first began

taking it but was running about 80 when I tried to

wean.  When I cut back to 25 mg my HR goes up to

100-110 and my heart feels like it's going to pound

out of my chest.  It's a very disconcerting feeling

and after 4 days with no change I went back on the

full dose.  I've tried this twice and the same thing

happened both times. 

Are you taking Top 2 x a day. Even though it is allegedly a once a day drug I still give it bid in some. How were you trying to taper it? I would switch to bid then start cutting as I think I outlined before to someone else here.

so would break to in 1/2 and take 1/2 in am and 1/2 in pm. for 2 weeks tnen take 1/4 in am and pm. for 2 weeks. Then 1/4 pm only for 2 weeks then stop. Discuss with your Dr.

If you are feeling tired this is the most likely culprit.

May your pressure be low!

CE Grim, BS(Chem/Math), MS(Biochem), MD.

Board Certified in Internal Medicine, Geriatrics and Hypertension

Former Epidemiologic Intelligence Services Officer (Lt. Comdr.), CDC

Specializing in Difficult to Manage High Blood Pressure

Clinical Professor of Medicine, Medical College of Wisconsin

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In a message dated 5/30/06 8:25:59 AM, shahall@... writes:

My headaches weren't in the back, they were in the

front and temple areas.  I didn't have a headache when

my BP was so high, in fact no symptoms at all and I

always wondered why. 

Some dont have headaches even with very high BP. When one has a HA and HTN the only way to tell if it is due to HTN or something else is to see if it gets better when BP is better.

I could never tell by the way I

felt if my BP was 210/110 or 120/80. 

This is typical and the reason it is called the Silent Killer.

Keep us posted

on how you do when you re-try the Inspra, I think we'd

all be interested.

a

May your pressure be low!

CE Grim, BS(Chem/Math), MS(Biochem), MD.

Board Certified in Internal Medicine, Geriatrics and Hypertension

Former Epidemiologic Intelligence Services Officer (Lt. Comdr.), CDC

Specializing in Difficult to Manage High Blood Pressure

Clinical Professor of Medicine, Medical College of Wisconsin

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My headaches weren't in the back, they were in the

front and temple areas. I didn't have a headache when

my BP was so high, in fact no symptoms at all and I

always wondered why. I could never tell by the way I

felt if my BP was 210/110 or 120/80. Keep us posted

on how you do when you re-try the Inspra, I think we'd

all be interested.

a

--- Dave <dave@...> wrote:

> I was looking for region because the lower

> occipital, or upper back of

> the neck is often a sign of toxicity, Pfizer said.

> Other areas not.

> But I don't understand why there is a headache at

> all. Higher BP can

> cause a headache. So can many other things. When

> you start a new med,

> you have to be careful about not doing anything else

> w/meds, diet etc.

> Just to isolate its effect.

>

> My headache was in that toxic region, but I was on a

> bevy of

> ineffective HTN meds. Now that those are tapered,

> spiro works great to

> control BP, but I am getting the male Sfx syndrome.

> I am hoping the

> interactions w/other meds also specified in Pfizer

> study was the cause

> of my headaches.

>

> I'll provide specifics when I start the new

> experiment. I wish someone

> was keeping track of all this clinical case data.

> The drug companies

> are de-regulated and wildly negligent on this.

>

> Dave

>

>

> On May 28, 2006, at 4:51 PM, a Hall wrote:

>

> > I don't know how to describe it, it wasn't like

> the

> > dull, aching pain I get from regular headaches.

> It

> > was a more sharp, stabbing pain. It wasn't a

> constant

> > thing but it was present more than not and tylenol

> > didn't help. After two weeks on I went back to my

> > Endo. He was very surprised to see that my BP was

> so

> > high and wanted to increase the dose. I told him

> > about the headaches and said I couldn't believe

> that

> > they would get any better on a higher dose. He

> said

> > headache was a common side-effect with Inspra and

> > wanted me to try it for another two weeks to see

> if it

> > got any better. I told him I'd give it a try for

> > another week but the headaches really were

> > interferring with my life, if it wasn't any better

> > after three weeks I was going back on the spiro.

> They

> > didn't get any better. I hope you have better

> luck

> > with it.

> >

> > a

> >

> > --- Dave <dave@...> wrote:

> >

> >> That's worse than weird, a. Was it a

> >> generalized headache, or

> >> localized to a specific region? Or did it vary?

> I

> >> am interested

> >> because I've had one go--around with it, and am

> >> approaching my second,

> >> sans many other useless (for PA) meds. Finally

> >> (forgive me if I am

> >> duplicating questions here), how long did the

> >> headache(s) last each

> >> time you took your dose, and how long before you

> >> quit?

> >>

> >> Dave

>

>

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At the time of diagnosis of PA, I was on spiro 50 mg

bid, atacand 32 mg, toprol XL 50 mg and BP was running

160-170 range. After diagnosis the Dr. at U-M

increased spiro to 100 bid and told me to start

weaning off other meds. He added HCT 12.5 and

suggested staying on it if K+ stayed good, which it

has. I have since cut spiro down to 75 bid as 100

brought my BP down too much. I weaned off the atacand

with no problem but I'm having a heck of a time coming

off the Toprol. My HR before starting it ran about

90. It decreased to low 70's when I first began

taking it but was running about 80 when I tried to

wean. When I cut back to 25 mg my HR goes up to

100-110 and my heart feels like it's going to pound

out of my chest. It's a very disconcerting feeling

and after 4 days with no change I went back on the

full dose. I've tried this twice and the same thing

happened both times.

a

--- lowerbp2@... wrote:

>

> In a message dated 5/27/06 5:47:54 PM,

> shahall@... writes:

>

>

> > My BP will be fine sitting but drops precipitously

> > upon standing.  It doesn't bother me too much at

> home but I have to

> > bend and stoop at work quite a bit some days and

> I've almost passed

> > out twice. 

> >

>

> Your BP control systems and perhaps your body may

> have not yet adjusted to

> having a lower BP. How long have you been on Spiro

> and how much did your BP

> come down and when? What other meds are you on.

>

> The DASH should get you all the Mg you need (and K).

>

>

>

>

>

> May your pressure be low!

>

> CE Grim, BS(Chem/Math), MS(Biochem), MD.

> Board Certified in Internal Medicine, Geriatrics and

> Hypertension

> Former Epidemiologic Intelligence Services Officer

> (Lt. Comdr.), CDC

> Specializing in Difficult to Manage High Blood

> Pressure

> Clinical Professor of Medicine, Medical College of

> Wisconsin

>

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