joint pain

February 29, 2008

If you go to pubmed and put in " CVID " the most current article (2008 done at

Walter ) concludes that infection and/or *autoimmune* disease are signs of

CVID. They are looking at CD27. So, it's starting to make sense to me why so

many of our children are vulnerable to joint pain. (There are many other

reasons for joint pain...but, according to the authors, its part of the CVID

package for some patients).

Re: joint pain

Hello Sally,

I have a 3 yr old with a combine immune deficiency that also has what

they are calling JRA (juvenile rheumatological arthritis). He gets IVIG

(gamunex)every 3 weeks. In his case the IVIG helps his arthritis. He

actually complains more prior to his IVIG infusion. Afterwards, no

complains for awhile. Not sure if it is from the IVIG itself or the IV

steroids he gets with it or the combination of the two. But, I remember

his rheumatologist saying that some people with arthritis the IVIG may

make it worse. Not sure if this helps or not. Feel free to email if you

have more questions. Good luck!

Proud Mom of 4:

3yr old : PID~combine immune deficiency and etc.....

8yr old Hannah: asthma, allergies, urinary reflux, T & A

6yr old Noah: asthma, ADD

5yr old : allergies, chronic sinusitis, one enlarge tonsil

www.caringbridge. org/visit/ matthewfranson

>

> Hello, my son who is 10 years old has been on Gammunex for 5 years

now

> and with no side affects. But recently he has complained more that

his

> back, legs and ankles hurt after his treatments. He just got his

> treatment today and about 2 hours after his treatment he started

> yelling at the top of his lungs that his ankles were in extreme pain!

> Do you think that this could be a side affect of the IVIG or that

> something else could be going on? Does anyone else have a child that

> has joint pain?

>

> Any help would be appreciated.

> Thanks

> Sally Mom to Wesley, 10 years old with CVID, Asthma, Allergies, GI

> problems,

>

<!--

#ygrp-mkp{

border:1px solid #d8d8d8;font-family:Arial;margin:14px 0px;padding:0px 14px;}

#ygrp-mkp hr{

border:1px solid #d8d8d8;}

#ygrp-mkp #hd{

color:#628c2a;font-size:85%;font-weight:bold;line-height:122%;margin:10px 0px;}

#ygrp-mkp #ads{

margin-bottom:10px;}

#ygrp-mkp .ad{

padding:0 0;}

#ygrp-mkp .ad a{

color:#0000ff;text-decoration:none;}

-->

<!--

#ygrp-sponsor #ygrp-lc{

font-family:Arial;}

#ygrp-sponsor #ygrp-lc #hd{

margin:10px 0px;font-weight:bold;font-size:78%;line-height:122%;}

#ygrp-sponsor #ygrp-lc .ad{

margin-bottom:10px;padding:0 0;}

-->

<!--

#ygrp-mlmsg {font-size:13px;font-family:arial, helvetica, clean, sans-serif;}

#ygrp-mlmsg table {font-size:inherit;font:100%;}

#ygrp-mlmsg select, input, textarea {font:99% arial, helvetica, clean,

sans-serif;}

#ygrp-mlmsg pre, code {font:115% monospace;}

#ygrp-mlmsg * {line-height:1.22em;}

#ygrp-text{

font-family:Georgia;

}

#ygrp-text p{

margin:0 0 1em 0;}

#ygrp-tpmsgs{

font-family:Arial;

clear:both;}

#ygrp-vitnav{

padding-top:10px;font-family:Verdana;font-size:77%;margin:0;}

#ygrp-vitnav a{

padding:0 1px;}

#ygrp-actbar{

clear:both;margin:25px 0;white-space:nowrap;color:#666;text-align:right;}

#ygrp-actbar .left{

float:left;white-space:nowrap;}

..bld{font-weight:bold;}

#ygrp-grft{

font-family:Verdana;font-size:77%;padding:15px 0;}

#ygrp-ft{

font-family:verdana;font-size:77%;border-top:1px solid #666;

padding:5px 0;

}

#ygrp-mlmsg #logo{

padding-bottom:10px;}

#ygrp-vital{

background-color:#e0ecee;margin-bottom:20px;padding:2px 0 8px 8px;}

#ygrp-vital #vithd{

font-size:77%;font-family:Verdana;font-weight:bold;color:#333;text-transform:upp\

ercase;}

#ygrp-vital ul{

padding:0;margin:2px 0;}

#ygrp-vital ul li{

list-style-type:none;clear:both;border:1px solid #e0ecee;

}

#ygrp-vital ul li .ct{

font-weight:bold;color:#ff7900;float:right;width:2em;text-align:right;padding-ri\

ght:.5em;}

#ygrp-vital ul li .cat{

font-weight:bold;}

#ygrp-vital a{

text-decoration:none;}

#ygrp-vital a:hover{

text-decoration:underline;}

#ygrp-sponsor #hd{

color:#999;font-size:77%;}

#ygrp-sponsor #ov{

padding:6px 13px;background-color:#e0ecee;margin-bottom:20px;}

#ygrp-sponsor #ov ul{

padding:0 0 0 8px;margin:0;}

#ygrp-sponsor #ov li{

list-style-type:square;padding:6px 0;font-size:77%;}

#ygrp-sponsor #ov li a{

text-decoration:none;font-size:130%;}

#ygrp-sponsor #nc{

background-color:#eee;margin-bottom:20px;padding:0 8px;}

#ygrp-sponsor .ad{

padding:8px 0;}

#ygrp-sponsor .ad #hd1{

font-family:Arial;font-weight:bold;color:#628c2a;font-size:100%;line-height:122%\

;}

#ygrp-sponsor .ad a{

text-decoration:none;}

#ygrp-sponsor .ad a:hover{

text-decoration:underline;}

#ygrp-sponsor .ad p{

margin:0;}

o{font-size:0;}

..MsoNormal{

margin:0 0 0 0;}

#ygrp-text tt{

font-size:120%;}

blockquote{margin:0 0 0 4px;}

..replbq{margin:4;}

-->

February 29, 2008

Wow . I have not seen that article. Thank you so much for pasing it along

as you know Charlie suffers from this and just last week Dr M. Said also

has it in his knee and ankle.

Dayna

Sent via BlackBerry from T-Mobile

Re: Re: joint pain

If you go to pubmed and put in " CVID " the most current article (2008 done at

Walter ) concludes that infection and/or *autoimmune* disease are signs of

CVID. They are looking at CD27. So, it's starting to make sense to me why so

many of our children are vulnerable to joint pain. (There are many other reasons

for joint pain...but, according to the authors, its part of the CVID package for

some patients).