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Re: Spiro Dosage Question

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In a message dated 11/22/05 7:26:25 PM, suzanne_paolini@... writes:

Seems like most people in this group take their Spiro in smaller doses

multiple time per day. Is there a reason for this?

I notice that I seem to feel better in the am hours after I take my

Spiro than in the evening.

I am only taking 50mg in the am.

Thanks!

Suzanne

I have used it 400 once a day or split it up in my patients. At the higher dose splitting it makes sense. As it has a long 1/2 life once day is plenty but some seem to tolerate it better split. So as all other meds its an individula thing.

May your pressure be low!

Clarence E. Grim, BS (Chem/Math), MS (Biochem), MD, FACP, FACC, FAHS

Clinical Professor of Medicine and Epidemiology

Director, Hypertension Diagnosis and Treatment Center

Board Certified in Internal Medicine, Geriatrics and Hypertension

Published over 220 scientific papers, book chapters and 220 abstracts in the area of high blood pressure epidemiology, physiology, endocrinology measurement, treatment and how to detect curable causes.

Listed in Best Doctors in America

Specializing in Difficult to Control High Blood Pressure and the History and Physiology of High Blood pressure in the African Diaspora

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LVH and subsequent hypotension dizzy spells in my case. I take three

doses morning noon and night, and that never happens.

Dave

On Nov 22, 2005, at 5:13 PM, suzanne_paolini wrote:

> Seems like most people in this group take their Spiro in smaller doses

> multiple time per day. Is there a reason for this?

> I notice that I seem to feel better in the am hours after I take my

> Spiro than in the evening.

> I am only taking 50mg in the am.

> Thanks!

> Suzanne

>

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I've been taking 100 mg spiro every morning + dashing for about 6 months now. my bp has been under 120/80 mainly 115/70 or less. So a couple of weeks ago I cut the dose in half and take 50 in the morning and 50 at night(basically same amount). I notice that my bp is rising. It is now 120/80 with occasional evenings of 130-140/80-90. I am also experiencing chills and sweats more often specially in the mornings and evenings(couple of hrs following taking spiro) + occasional dizziness. Is anyone else experiencing any similar reaction? Also is there a proper way of getting off spiro?I may have to consider getting off spiro to do another AVS for 6 weeks because the first one was not done right. Any suggestions on how to get off spiro and what do I do meanwhile? My md has had no experience with other PA patients and his knowledge of spiro is only general as he says that I sweat because I am taking a diuretic and its suppose to be that way. When I was taking

100 mg I wasn't feeling the chills and the sweats. Not taking any other meds or supplements except for fish oil(1000 mg 2x. I've been taking it since Aug)

Thanks,

Farah

Dave <dave@...> wrote:

LVH and subsequent hypotension dizzy spells in my case. I take three doses morning noon and night, and that never happens.DaveOn Nov 22, 2005, at 5:13 PM, suzanne_paolini wrote:> Seems like most people in this group take their Spiro in smaller doses> multiple time per day. Is there a reason for this?> I notice that I seem to feel better in the am hours after I take my> Spiro than in the evening.> I am only taking 50mg in the am.> Thanks!> Suzanne>

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In a message dated 11/23/05 12:50:25 AM, farahbar@... writes:

I've been taking 100 mg spiro every morning + dashing  for about 6 months now. my bp has been under 120/80 mainly 115/70 or less. So a couple of weeks ago I cut the dose in half and take 50 in the morning and 50 at night(basically same amount). I notice that my bp is rising. It is now 120/80 with occasional evenings of 130-140/80-90. I am also experiencing chills and sweats more often specially in the mornings and evenings(couple of hrs following taking spiro) + occasional dizziness. Is anyone else experiencing any similar reaction? Also is there a proper way of getting off spiro?I may  have to consider getting off spiro to do another AVS for 6 weeks because  the first one was not done right.

If you are doing OK on this dose I would plan on keeping on it rather than doing AVS.

Any suggestions on how to get off spiro and what do I do meanwhile?

I would step it down say 25 mg a week and then stop but from you past Hx your BP will likley go up. I would DASH very strickly during this time.

My md has had no experience with other PA patients and his knowledge of spiro is only general as he says that I sweat because I am taking a diuretic and its suppose to be that way. When I was taking 100 mg I wasn't feeling the chills and the sweats.

I have never heard of this with diuretics.

Not taking any other meds or supplements except for fish oil(1000 mg 2x. I've been taking it since Aug)

Thanks,

Farah

I would also consider stopping the fish oil to see if it might be related to the sweating. Never heard of this either but safer than stopping spiro would be my assessment.

May your pressure be low!

Clarence E. Grim, BS (Chem/Math), MS (Biochem), MD, FACP, FACC, FAHS

Clinical Professor of Medicine and Epidemiology

Director, Hypertension Diagnosis and Treatment Center

Board Certified in Internal Medicine, Geriatrics and Hypertension

Published over 220 scientific papers, book chapters and 220 abstracts in the area of high blood pressure epidemiology, physiology, endocrinology measurement, treatment and how to detect curable causes.

Listed in Best Doctors in America

Specializing in Difficult to Control High Blood Pressure and the History and Physiology of High Blood pressure in the African Diaspora

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Thank you Dr Grim,

Will follow you advise. I notice that when my hands and feet are freezing cold or when I sweat, bp is up. I also googled cold hands and feet and search came up with possibility of mercury poisoning. May be I am showing side effects of some mercury poisoning. I will ask my doctor to see if they could test my mercury level. I have been taking lots of fish oil since August.

Thanks again,

Farahlowerbp2@... wrote:

In a message dated 11/23/05 12:50:25 AM, farahbar@... writes:

I've been taking 100 mg spiro every morning + dashing for about 6 months now. my bp has been under 120/80 mainly 115/70 or less. So a couple of weeks ago I cut the dose in half and take 50 in the morning and 50 at night(basically same amount). I notice that my bp is rising. It is now 120/80 with occasional evenings of 130-140/80-90. I am also experiencing chills and sweats more often specially in the mornings and evenings(couple of hrs following taking spiro) + occasional dizziness. Is anyone else experiencing any similar reaction? Also is there a proper way of getting off spiro?I may have to consider getting off spiro to do another AVS for 6 weeks because the first one was not done right. If you are doing OK on this dose I would plan on keeping on it rather than doing AVS.

Any suggestions on how to get off spiro and what do I do meanwhile? I would step it down say 25 mg a week and then stop but from you past Hx your BP will likley go up. I would DASH very strickly during this time.

My md has had no experience with other PA patients and his knowledge of spiro is only general as he says that I sweat because I am taking a diuretic and its suppose to be that way. When I was taking 100 mg I wasn't feeling the chills and the sweats. I have never heard of this with diuretics.

Not taking any other meds or supplements except for fish oil(1000 mg 2x. I've been taking it since Aug)Thanks,FarahI would also consider stopping the fish oil to see if it might be related to the sweating. Never heard of this either but safer than stopping spiro would be my assessment.

May your pressure be low!Clarence E. Grim, BS (Chem/Math), MS (Biochem), MD, FACP, FACC, FAHSClinical Professor of Medicine and EpidemiologyDirector, Hypertension Diagnosis and Treatment CenterBoard Certified in Internal Medicine, Geriatrics and HypertensionPublished over 220 scientific papers, book chapters and 220 abstracts in the area of high blood pressure epidemiology, physiology, endocrinology measurement, treatment and how to detect curable causes.Listed in Best Doctors in AmericaSpecializing in Difficult to Control High Blood Pressure and the History and Physiology of High Blood

pressure in the African Diaspora

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I am now taking 50mg Spiro in the morning and 50mg Spiro at early

evening. My bp has been in the range from 120-140/72-90s since August

this year.

There are still those times when that weird feeling comes about, hard

even to describe, but I recover and go on normally.

I think due the long years(12 years) being ,misdiagnosed for PA, a

doctor said I have some reduced kidney functions. When I was taking

100mg Spiro twice a day, my potassium went up. So he gave me

Furosemides to help stabilize my potassium levels as well as help my

kidneys.

He said this is my long term therapeutic regimen...shall I understand

as meaning....for life I will be taking Spiro-Furosemides combination?

DAvid

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In a message dated 11/24/05 10:06:35 PM, bayabas76@... writes:

I think due the long years(12 years) being ,misdiagnosed for PA, a

doctor said I have some reduced kidney functions. When I was taking

100mg Spiro twice a day, my potassium went up. So he gave me

Furosemides to help stabilize my potassium levels as well as help my

kidneys.

My approach would have been to reduce the Spiro but ask him why he took this route? He knows you better than we do---I hope!

May your pressure be low!

Clarence E. Grim, BS (Chem/Math), MS (Biochem), MD, FACP, FACC, FAHS

Clinical Professor of Medicine and Epidemiology

Director, Hypertension Diagnosis and Treatment Center

Board Certified in Internal Medicine, Geriatrics and Hypertension

Published over 220 scientific papers, book chapters and 220 abstracts in the area of high blood pressure epidemiology, physiology, endocrinology measurement, treatment and how to detect curable causes.

Listed in Best Doctors in America

Specializing in Difficult to Control High Blood Pressure and the History and Physiology of High Blood pressure in the African Diaspora

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In a message dated 11/23/05 10:01:09 PM, farahbar@... writes:

Thank you Dr Grim,

Will follow you advise. I notice that when my hands and feet are freezing cold or when I  sweat,  bp is up. I also googled cold hands and feet and search came up with possibility of mercury poisoning. May be I am showing side effects of some mercury poisoning. I will ask my doctor to see if they could test my mercury level. I have been taking lots of fish oil since August.  

Thanks again,

 

Farah

and where would you be getting the mercury? Not likely these days unless you harvest gold from fillings or work around mercury. What work have you done in the past?

May your pressure be low!

Clarence E. Grim, BS (Chem/Math), MS (Biochem), MD, FACP, FACC, FAHS

Clinical Professor of Medicine and Epidemiology

Director, Hypertension Diagnosis and Treatment Center

Board Certified in Internal Medicine, Geriatrics and Hypertension

Published over 220 scientific papers, book chapters and 220 abstracts in the area of high blood pressure epidemiology, physiology, endocrinology measurement, treatment and how to detect curable causes.

Listed in Best Doctors in America

Specializing in Difficult to Control High Blood Pressure and the History and Physiology of High Blood pressure in the African Diaspora

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Not from eating too much fish oil?

lowerbp2@... wrote:

In a message dated 11/23/05 10:01:09 PM, farahbar@... writes:

Thank you Dr Grim,Will follow you advise. I notice that when my hands and feet are freezing cold or when I sweat, bp is up. I also googled cold hands and feet and search came up with possibility of mercury poisoning. May be I am showing side effects of some mercury poisoning. I will ask my doctor to see if they could test my mercury level. I have been taking lots of fish oil since August. Thanks again, Farahand where would you be getting the mercury? Not likely these days unless you harvest gold from fillings or work around mercury. What work have you done in the

past?May your pressure be low!Clarence E. Grim, BS (Chem/Math), MS (Biochem), MD, FACP, FACC, FAHSClinical Professor of Medicine and EpidemiologyDirector, Hypertension Diagnosis and Treatment CenterBoard Certified in Internal Medicine, Geriatrics and HypertensionPublished over 220 scientific papers, book chapters and 220 abstracts in the area of high blood pressure epidemiology, physiology, endocrinology measurement, treatment and how to detect curable causes.Listed in Best Doctors in AmericaSpecializing in Difficult to Control High Blood Pressure and the History and Physiology of High Blood pressure in the African Diaspora

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Depends on the mercury content of the fish oil. Ask the manufacturer they should know.

May your pressure be low!

Clarence E. Grim, BS (Chem/Math), MS (Biochem), MD, FACP, FACC, FAHS

Clinical Professor of Medicine and Epidemiology

Director, Hypertension Diagnosis and Treatment Center

Board Certified in Internal Medicine, Geriatrics and Hypertension

Published over 220 scientific papers, book chapters and 220 abstracts in the area of high blood pressure epidemiology, physiology, endocrinology measurement, treatment and how to detect curable causes.

Listed in Best Doctors in America

Specializing in Difficult to Control High Blood Pressure and the History and Physiology of High Blood pressure in the African Diaspora

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