Re: Combining Inspra (aldo blocker) with Midamor (potassium sparing diuretic)

[Guest guest]

On Nov 1, 2005, at 9:15 AM, airlinerg wrote:

>

> Combining Inspra (aldo blocker) with Midamor (potassium sparing

> diuretic) or hydrocholorthiazide (a non-potassium sparing diuretic)

>

> 1. Has anyone combined Inspra (epelerenone) which is an aldosterone

> blocker with Midamor (amiloride) a potassium sparing diuretic?

Yes, but the inspra gave me spectacular headaches, and I was also on

other meds at the time, so a bad test.

>

> 2. Would this be safe since they both raise potassium?

Depening on your degree of hypokalemia it might be balncing out. I had

to check blood K each day.

>

> 3. Has anyone combined Inspra (epelerenone) with hydrocholorthiazide

> (a non-potassium sparing diuretic) ?

This would be putting one foot on the brakes and one on the gas, if you

have PA or one of its variants, I believe. Replacing K and then

leeching it away. I don't see the need for diuretics in PA at all. My

BP was completely controlled by spironolactone (and probably inspra

once I get off the other incoorect-for-PA antuihypertensives which I'm

tapering), as they block the aldosterone receptors at the root of the

pPA/Conn's etc. patient. The other stuff just causes problems for me.

Dave

[Guest guest]

To be honest I've often wondered the same thing. Since Hctz is the

most common and cheapest diuretic, it would seem to be an adjunct to

Inspra. If Inspra is blocking the potassium wasting of too much

aldosterone, you would be just like any other hypertensive patient and

a diuretic would be the first drug of choise.

My secondary drugs are norvasc, a cc blocker; and quinapril, an ace

inhibitor. They do work in concert with a usual bp of 120/80 or

slightly better.

Maybe the prefered choice is to reduce your salt intake, so that a

diuretic has no effect on eliminating sodium (hence maybe it starts

eliminating potassium). The problem I face is I can't quit salt

entirely, so the bp shoots up every once an awhile-especially after

eating out at a Chinese or Italian place. I end up urinating as if on

a diuretic until the bp comes back to the above. I guess it is a

matter of finding the right drug combination for you and you're

lifestyle.

[Guest guest]

I've never combined Inspra with a diuretic, but I do have to take

supplementary potassium with Inspra or Spiro. I would venture a guess

that the effects of combining Inspra with a K or non-K sparing diuretic

would be dependentant on your degree of hypokalemia on just Inspra alone.

airlinerg wrote:

>

> Combining Inspra (aldo blocker) with Midamor (potassium sparing

> diuretic) or hydrocholorthiazide (a non-potassium sparing diuretic)

>

> 1. Has anyone combined Inspra (epelerenone) which is an aldosterone

> blocker with Midamor (amiloride) a potassium sparing diuretic?

>

> 2. Would this be safe since they both raise potassium?

>

> 3. Has anyone combined Inspra (epelerenone) with hydrocholorthiazide

> (a non-potassium sparing diuretic) ?

>

>

>

>

>

>

>

>

>

[Guest guest]

In a message dated 11/1/05 11:33:35 AM, airlinerg@... writes:

Combining Inspra (aldo blocker) with Midamor (potassium sparing diuretic) or hydrocholorthiazide (a non-potassium sparing diuretic)

1. Has anyone combined Inspra (epelerenone) which is an aldosterone blocker with Midamor (amiloride) a potassium sparing diuretic?

2. Would this be safe since they both raise potassium?

3. Has anyone combined Inspra (epelerenone) with  hydrocholorthiazide (a non-potassium sparing diuretic) ?

[Guest guest]

In a message dated 11/1/05 11:36:47 AM, dave@... writes:

This would be putting one foot on the brakes and one on the gas, if you

have PA or one of its variants, I believe.  Replacing K and then

leeching it away.  I don't see the need for diuretics in PA at all.  My

BP was completely controlled by spironolactone (and probably inspra

once I get off the other incoorect-for-PA antuihypertensives which I'm

tapering), as they block the aldosterone receptors at the root of the

pPA/Conn's etc. patient.  The other stuff just causes problems for me.

DASHING will minimze the need for meds.

Always list that as part of the treatment.

May your pressure be low!

Clarence E. Grim, BS (Chem/Math), MS (Biochem), MD, FACP, FACC, FAHS

Clinical Professor of Medicine and Epidemiology

Director, Hypertension Diagnosis and Treatment Center

Board Certified in Internal Medicine, Geriatrics and Hypertension

Published over 220 scientific papers, book chapters and 220 abstracts in the area of high blood pressure epidemiology, physiology, endocrinology measurement, treatment and how to detect curable causes.

Listed in Best Doctors in America

Specializing in Difficult to Control High Blood Pressure and the History and Physiology of High Blood pressure in the African Diaspora

[Guest guest]

In a message dated 11/1/05 12:15:55 PM, wbongianni@... writes:

Maybe the prefered choice is to reduce your salt intake, so that a

diuretic has no effect on eliminating sodium (hence maybe it starts

eliminating potassium).  The problem I face is I can't quit salt

entirely, so the bp shoots up every once an awhile-especially after

eating out at a Chinese or Italian place.  I end up urinating as if on

a diuretic until the bp comes back to the above.  I guess it is a

matter of finding the right drug combination for you and you're

lifestyle.

I would rephrase this: DASH is a key to the management of PA and most all other forms of HTN>

May your pressure be low!

Clarence E. Grim, BS (Chem/Math), MS (Biochem), MD, FACP, FACC, FAHS

Clinical Professor of Medicine and Epidemiology

Director, Hypertension Diagnosis and Treatment Center

Board Certified in Internal Medicine, Geriatrics and Hypertension

Published over 220 scientific papers, book chapters and 220 abstracts in the area of high blood pressure epidemiology, physiology, endocrinology measurement, treatment and how to detect curable causes.

Listed in Best Doctors in America

Specializing in Difficult to Control High Blood Pressure and the History and Physiology of High Blood pressure in the African Diaspora

[Guest guest]

Yes, that made my need 25MG per day, and without the DASH low Na diet,

I needed 100MG per day, to keep my BP down

That was a dramatic result, and surprised my endo at UCSF. I left him

a copy of 's book.

Dave

On Nov 2, 2005, at 4:12 AM, lowerbp2@... wrote:

>

> In a message dated 11/1/05 11:36:47 AM, dave@... writes:

>

>

>> This would be putting one foot on the brakes and one on the gas, if

>> you

>> have PA or one of its variants, I believe.  Replacing K and then

>> leeching it away.  I don't see the need for diuretics in PA at all. 

>> My

>> BP was completely controlled by spironolactone (and probably inspra

>> once I get off the other incoorect-for-PA antuihypertensives which

>> I'm

>> tapering), as they block the aldosterone receptors at the root of the

>> pPA/Conn's etc. patient.  The other stuff just causes problems for

>> me.

>>

>

>

> DASHING will minimze the need for meds.

> Always list that as part of the treatment.

>

>

>

> May your pressure be low!

>

> Clarence E. Grim, BS (Chem/Math), MS (Biochem), MD, FACP, FACC, FAHS

> Clinical Professor of Medicine and Epidemiology

> Director, Hypertension Diagnosis and Treatment Center

> Board Certified in Internal Medicine, Geriatrics and Hypertension

>

> Published over 220 scientific papers, book chapters and 220 abstracts

> in the area of high blood pressure epidemiology, physiology,

> endocrinology measurement, treatment and how to detect curable causes.

> Listed in Best Doctors in America

> Specializing in Difficult to Control High Blood Pressure and the

> History and Physiology of High Blood pressure in the African Diaspora

>

>

[Guest guest]

How did you test your blood potassium each day when you were on

Inspra with Midamor?

>

> >

> > Combining Inspra (aldo blocker) with Midamor (potassium sparing

> > diuretic) or hydrocholorthiazide (a non-potassium sparing

diuretic)

> >

> > 1. Has anyone combined Inspra (epelerenone) which is an

aldosterone

> > blocker with Midamor (amiloride) a potassium sparing diuretic?

>

> Yes, but the inspra gave me spectacular headaches, and I was also

on

> other meds at the time, so a bad test.

> >

> > 2. Would this be safe since they both raise potassium?

>

> Depening on your degree of hypokalemia it might be balncing out.

I had

> to check blood K each day.

> >

> > 3. Has anyone combined Inspra (epelerenone) with

hydrocholorthiazide

> > (a non-potassium sparing diuretic) ?

>

> This would be putting one foot on the brakes and one on the gas,

if you

> have PA or one of its variants, I believe. Replacing K and then

> leeching it away. I don't see the need for diuretics in PA at

all. My

> BP was completely controlled by spironolactone (and probably

inspra

> once I get off the other incoorect-for-PA antuihypertensives which

I'm

> tapering), as they block the aldosterone receptors at the root of

the

> pPA/Conn's etc. patient. The other stuff just causes problems for

me.

>

> Dave

>

[Guest guest]

In a message dated 11/2/05 11:09:11 AM, dave@... writes:

Yes, that made my need 25MG per day, and without the DASH low Na diet,

I needed 100MG per day, to keep my BP down

That was a dramatic result, and surprised my endo at UCSF.  I left him

a copy of 's book.

In general endos know a lot about diabetes, nothing about salt or DASH. The DASH is really the diet that should be used by all diabetics as well. Will lower BP, improve glucose, lower cholesterol and likely minimize the need for DM meds if BMI is moved down to 25.

May your pressure be low!

Clarence E. Grim, BS (Chem/Math), MS (Biochem), MD, FACP, FACC, FAHS

Clinical Professor of Medicine and Epidemiology

Director, Hypertension Diagnosis and Treatment Center

Board Certified in Internal Medicine, Geriatrics and Hypertension

Published over 220 scientific papers, book chapters and 220 abstracts in the area of high blood pressure epidemiology, physiology, endocrinology measurement, treatment and how to detect curable causes.

Listed in Best Doctors in America

Specializing in Difficult to Control High Blood Pressure and the History and Physiology of High Blood pressure in the African Diaspora