Question on thiazide diuretics

[Guest guest]

In a message dated 11/19/04 19:50:39, dp@... writes:

> "Mineralocorticoid antagonists, such as spironolactone, achieve

> remarkable blood pressure control and normalization of the above-

> mentioned parameters, particularly in patients with aldosteronomas.

> The salutary effects of spironolactone appear to be mainly due to

> the effects on salt and water balance rather than to its antagonism

> of aldosterone in the kidney. The combination of spironolactone and

> ***thiazides*** often provides even better blood pressure control

> than spironolactone alone"

>

> Are small doses of thiazide diuretics safe for us to boost the BP

> effect of Inspra?  My potassium levels have always been in the

> normal range, even before treatment (although usually at the bottom

> of normal at the time--hovering around 3.5-3.7)

>

> Thoughts... opinions?

There is a combo on the market called Aldactazide that does this with spiro

Maybe one in the works with Inspra but dont know.

Yes I use both HCTZ and spiron in some flks but HCTZ alone can lead to severe low K in PA and its variants. The DASH should help this a lot.

Clarence E. Grim, BS (Chem/Math), MS (Biochem), MD, FACP, FACC, FAHS

Clinical Professor of Medicine and Epidemiology

Director, Hypertension Diagnosis and Treatment Center

Board Certified in Internal Medicine, Geriatrics and Hypertension

Published over 220 scientific papers, book chapters and 220 abstracts in the area of high blood pressure epidemiology, physiology, endocrinology measurement, treatment and how to detect curable causes.

Listed in Best Doctors in America

Specializing in Difficult to Control High Blood Pressure and the History and Physiology of High Blood pressure in the African Diaspora

[Guest guest]

From: http://www.emedicine.com/med/topic3193.htm

.....which has several EXCELLENT peer reviewed articles on our

condition:

" Mineralocorticoid antagonists, such as spironolactone, achieve

remarkable blood pressure control and normalization of the above-

mentioned parameters, particularly in patients with aldosteronomas.

The salutary effects of spironolactone appear to be mainly due to

the effects on salt and water balance rather than to its antagonism

of aldosterone in the kidney. The combination of spironolactone and

***thiazides*** often provides even better blood pressure control

than spironolactone alone "

Are small doses of thiazide diuretics safe for us to boost the BP

effect of Inspra? My potassium levels have always been in the

normal range, even before treatment (although usually at the bottom

of normal at the time--hovering around 3.5-3.7)

Thoughts... opinions?

Thanks,

Mike

[Guest guest]

thiazides made my K plummet. I too hover around there (with drops

accompanied by BP spikes during " episodes " ), and have also learned to

stay away from tannin, albuterol and some other K-affectors.

When I tried Inspra the first time (ameloride 10mg), K went to the 5's,

and I had to stop because of headaches so bad indescribable. Now,

ameloride to 20mg, BP OK.

I don't yet know if these K affects are just me, but should know more

soon.

Dave

On Nov 19, 2004, at 5:32 PM, lord_mike_the_great wrote:

>

>

> From: http://www.emedicine.com/med/topic3193.htm

>

> ....which has several EXCELLENT peer reviewed articles on our

> condition:

>

> " Mineralocorticoid antagonists, such as spironolactone, achieve

> remarkable blood pressure control and normalization of the above-

> mentioned parameters, particularly in patients with aldosteronomas.

> The salutary effects of spironolactone appear to be mainly due to

> the effects on salt and water balance rather than to its antagonism

> of aldosterone in the kidney. The combination of spironolactone and

> ***thiazides*** often provides even better blood pressure control

> than spironolactone alone "

>

> Are small doses of thiazide diuretics safe for us to boost the BP

> effect of Inspra? My potassium levels have always been in the

> normal range, even before treatment (although usually at the bottom

> of normal at the time--hovering around 3.5-3.7)

>

> Thoughts... opinions?

>

> Thanks,

>

> Mike

>

>

>

>

>

>

>

>

>

>

>

[Guest guest]

I am so grateful to Mike and Dr Grim, and all of you.

Thanks for helping me learn easier,

Dave

On Nov 19, 2004, at 5:32 PM, lord_mike_the_great wrote:

>

>

> From: http://www.emedicine.com/med/topic3193.htm

>

> ....which has several EXCELLENT peer reviewed articles on our

> condition:

>

> " Mineralocorticoid antagonists, such as spironolactone, achieve

> remarkable blood pressure control and normalization of the above-

> mentioned parameters, particularly in patients with aldosteronomas.

> The salutary effects of spironolactone appear to be mainly due to

> the effects on salt and water balance rather than to its antagonism

> of aldosterone in the kidney. The combination of spironolactone and

> ***thiazides*** often provides even better blood pressure control

> than spironolactone alone "

>

> Are small doses of thiazide diuretics safe for us to boost the BP

> effect of Inspra? My potassium levels have always been in the

> normal range, even before treatment (although usually at the bottom

> of normal at the time--hovering around 3.5-3.7)

>

> Thoughts... opinions?

>

> Thanks,

>

> Mike

>

>

>

>

>

>

>

>

>

>

>

[Guest guest]

What exactly is DASH? and what does CHF stand for?

Re: Question on thiazide diuretics

In a message dated 11/19/04 19:50:39, dp@... writes:

> "Mineralocorticoid antagonists, such as spironolactone, achieve> remarkable blood pressure control and normalization of the above-> mentioned parameters, particularly in patients with aldosteronomas.> The salutary effects of spironolactone appear to be mainly due to> the effects on salt and water balance rather than to its antagonism> of aldosterone in the kidney. The combination of spironolactone and> ***thiazides*** often provides even better blood pressure control> than spironolactone alone">> Are small doses of thiazide diuretics safe for us to boost the BP> effect of Inspra? My potassium levels have always been in the> normal range, even before treatment (although usually at the bottom> of normal at the time--hovering around 3.5-3.7)>> Thoughts... opinions?There is a combo on the market called Aldactazide that does this with spiroMaybe one in the works with Inspra but dont know.Yes I use both HCTZ and spiron in some flks but HCTZ alone can lead to severe low K in PA and its variants. The DASH should help this a lot. Clarence E. Grim, BS (Chem/Math), MS (Biochem), MD, FACP, FACC, FAHSClinical Professor of Medicine and EpidemiologyDirector, Hypertension Diagnosis and Treatment CenterBoard Certified in Internal Medicine, Geriatrics and HypertensionPublished over 220 scientific papers, book chapters and 220 abstracts in the area of high blood pressure epidemiology, physiology, endocrinology measurement, treatment and how to detect curable causes.Listed in Best Doctors in AmericaSpecializing in Difficult to Control High Blood Pressure and the History and Physiology of High Blood pressure in the African Diaspora

[Guest guest]

DASH = Dietary Approach to Stopping Hypertension (I just got the book last week after several suggestions from Dr. Grim)

I thought CHF was Congestive Heart Failure, but could be wrong.

Take care,

Re: Question on thiazide diuretics

In a message dated 11/19/04 19:50:39, dp@... writes:

> "Mineralocorticoid antagonists, such as spironolactone, achieve> remarkable blood pressure control and normalization of the above-> mentioned parameters, particularly in patients with aldosteronomas.> The salutary effects of spironolactone appear to be mainly due to> the effects on salt and water balance rather than to its antagonism> of aldosterone in the kidney. The combination of spironolactone and> ***thiazides*** often provides even better blood pressure control> than spironolactone alone">> Are small doses of thiazide diuretics safe for us to boost the BP> effect of Inspra? My potassium levels have always been in the> normal range, even before treatment (although usually at the bottom> of normal at the time--hovering around 3.5-3.7)>> Thoughts... opinions?There is a combo on the market called Aldactazide that does this with spiroMaybe one in the works with Inspra but dont know.Yes I use both HCTZ and spiron in some flks but HCTZ alone can lead to severe low K in PA and its variants. The DASH should help this a lot. Clarence E. Grim, BS (Chem/Math), MS (Biochem), MD, FACP, FACC, FAHSClinical Professor of Medicine and EpidemiologyDirector, Hypertension Diagnosis and Treatment CenterBoard Certified in Internal Medicine, Geriatrics and HypertensionPublished over 220 scientific papers, book chapters and 220 abstracts in the area of high blood pressure epidemiology, physiology, endocrinology measurement, treatment and how to detect curable causes.Listed in Best Doctors in AmericaSpecializing in Difficult to Control High Blood Pressure and the History and Physiology of High Blood pressure in the African Diaspora

[Guest guest]

Hi,

Heart failure is a state in which the heart is not

able to pump a normal percentage of blood out of the

heart with each beat.

CHF is called both congestive heart failure and

chronic heart failure. Technically, being in a state

of congestive heart failure goes with specific changes

in the body's chemistry, electrical response, and

hormones.

An increase in aldosterone is one of those changes,

which is why spironolactone (and now Inspra) is

prescribed for CHF.

A person can be said to " have " chronic heart failure,

and not be " in " a critical state of congestive heart

failure with all of its symptoms, biochemical changes,

and potential complications. This happens if their

heart is beating at a less than normal efficiency

while their chemistry remains stable.

Hope this helps!

Please correct me if anyone knows more than I do.

Warmly,

Pam

--- Malotky <leslie@...> wrote:

> DASH = Dietary Approach to Stopping Hypertension (I

> just got the book last week after several

> suggestions from Dr. Grim)

>

> I thought CHF was Congestive Heart Failure, but

> could be wrong.

>

> Take care,

>

> Re: Question on

> thiazide diuretics

>

>

>

> In a message dated 11/19/04 19:50:39,

> dp@... writes:

>

>

>

>

> > " Mineralocorticoid antagonists, such as

> spironolactone, achieve

> > remarkable blood pressure control and

> normalization of the above-

> > mentioned parameters, particularly in

> patients with aldosteronomas.

> > The salutary effects of spironolactone

> appear to be mainly due to

> > the effects on salt and water balance rather

> than to its antagonism

> > of aldosterone in the kidney. The

> combination of spironolactone and

> > ***thiazides*** often provides even better

> blood pressure control

> > than spironolactone alone "

> >

> > Are small doses of thiazide diuretics safe

> for us to boost the BP

> > effect of Inspra? My potassium levels have

> always been in the

> > normal range, even before treatment

> (although usually at the bottom

> > of normal at the time--hovering around

> 3.5-3.7)

> >

> > Thoughts... opinions?

>

>

>

> There is a combo on the market called

> Aldactazide that does this with spiro

>

> Maybe one in the works with Inspra but dont

> know.

>

> Yes I use both HCTZ and spiron in some flks but

> HCTZ alone can lead to severe low K in PA and its

> variants. The DASH should help this a lot.

>

>

>

> Clarence E. Grim, BS (Chem/Math), MS (Biochem),

> MD, FACP, FACC, FAHS

> Clinical Professor of Medicine and Epidemiology

> Director, Hypertension Diagnosis and Treatment

> Center

> Board Certified in Internal Medicine, Geriatrics

> and Hypertension

>

> Published over 220 scientific papers, book

> chapters and 220 abstracts in the area of high blood

> pressure epidemiology, physiology, endocrinology

> measurement, treatment and how to detect curable

> causes.

> Listed in Best Doctors in America

> Specializing in Difficult to Control High Blood

> Pressure and the History and Physiology of High

> Blood pressure in the African Diaspora

>

>

>

[Guest guest]

OK, that makes sense. Thanks!

Re: Question on> thiazide diuretics> > > > In a message dated 11/19/04 19:50:39,> dp@... writes:> > > > > > "Mineralocorticoid antagonists, such as> spironolactone, achieve> > remarkable blood pressure control and> normalization of the above-> > mentioned parameters, particularly in> patients with aldosteronomas.> > The salutary effects of spironolactone> appear to be mainly due to> > the effects on salt and water balance rather> than to its antagonism> > of aldosterone in the kidney. The> combination of spironolactone and> > ***thiazides*** often provides even better> blood pressure control> > than spironolactone alone"> >> > Are small doses of thiazide diuretics safe> for us to boost the BP> > effect of Inspra? My potassium levels have> always been in the> > normal range, even before treatment> (although usually at the bottom> > of normal at the time--hovering around> 3.5-3.7)> >> > Thoughts... opinions?> > > > There is a combo on the market called> Aldactazide that does this with spiro> > Maybe one in the works with Inspra but dont> know.> > Yes I use both HCTZ and spiron in some flks but> HCTZ alone can lead to severe low K in PA and its> variants. The DASH should help this a lot. > > > > Clarence E. Grim, BS (Chem/Math), MS (Biochem),> MD, FACP, FACC, FAHS> Clinical Professor of Medicine and Epidemiology> Director, Hypertension Diagnosis and Treatment> Center> Board Certified in Internal Medicine, Geriatrics> and Hypertension> > Published over 220 scientific papers, book> chapters and 220 abstracts in the area of high blood> pressure epidemiology, physiology, endocrinology> measurement, treatment and how to detect curable> causes.> Listed in Best Doctors in America> Specializing in Difficult to Control High Blood> Pressure and the History and Physiology of High> Blood pressure in the African Diaspora> > >