Another reason to shoot your mother-in-law?

[Guest guest]

LOLOL Bob... some people will look for any loophole... LOL

Connie

In a message dated 1/31/2006 5:07:23 P.M. Eastern Standard Time,

wrblack@... writes:

DS baby increases by 30%, " out of context, you could extend the logic to its

illogical conclusion. Shooting your MIL at, say, age 60, would reduce by

150% the chance of Down syndrome in one of her grandchildren to be born when

she would be 65.

Any takers out there? -- Bob

[Guest guest]

The syntax of this abstract seems a bit contorted. I think what they've

found is that maternal grandmother's age at time of mother's birth may be a

risk indicator, independent of mother's age or father's age. I.e., a 25

yearold mother who was born to a 35 yearold woman is at greater risk than a

25 yearold mother born to a 25 yearold mother. Mmmm, little contortion of my

own there.

But the abstract almost makes it sound like birth of a child with Down

syndrome, at least in India, is more likely if maternal grandmother is

really old. If you took that one statement, " Therefore, for every year of

advancement of age of the maternal grandmother, the risk (odds) of birth of

DS baby increases by 30%, " out of context, you could extend the logic to its

illogical conclusion. Shooting your MIL at, say, age 60, would reduce by

150% the chance of Down syndrome in one of her grandchildren to be born when

she would be 65.

Any takers out there? -- Bob

<< 1: BMC Med Genet. 2006 Jan 14;7(1):4 [Epub ahead of print] Related

Articles, Links

Influence of advanced age of maternal grandmothers on Down syndrome.

Malini SS, Ramachandra NB.

ABSTRACT: BACKGROUND: Down syndrome (DS) is the most common chromosomal

anomaly associated with mental retardation. This is due to the occurrence of

free trisomy 21 (92-95%), mosaic trisomy 21 (2-4%) and translocation (3-4%).

Advanced maternal age is a well documented risk factor for maternal meiotic

nondisjunction. In India three children with DS are born every hour and more

DS children are given birth to by young age mothers than by advanced age

mothers. Therefore, detailed analysis of the families with DS is needed to

find out other possible causative factors for nondisjunction. METHODS: We

investigated 69 families of cytogenetically confirmed DS children and

constructed pedigrees of these families. We also studied 200 randomly

selected families belonging to different religions as controls. Statistical

analysis was carried out using logistic regression. RESULTS: Out of the 69

DS cases studied, 67 were free trisomy 21, two cases were mosaic trisomy 21

and there were none with translocation. The number of DS births was greater

for the young age mothers compared with the advanced age mothers. It has

also been recorded that young age mothers ( 18 to 29 years) born to their

mothers at the age 30 years and above produced as high as 91.3% of children

with DS. The logistic regression of case- control study of DS children

revealed that the odds ratio of age of grandmother was significant when all

the four variables were used once at a time. However, the effect of age of

mother and father was smaller than the effect of age of maternal

grandmother. Therefore, for every year of advancement of age of the maternal

grandmother, the risk (odds) of birth of DS baby increases by 30%.

CONCLUSIONS: Besides the known risk factors, mother's age, father's age, the

age of the maternal grandmother at the time of birth of the mother is a risk

factor for the occurrence of Down syndrome.

PMID: 16412239 [PubMed - as supplied by publisher] >>

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_ui

ds=16412239 & dopt=Citation

[Guest guest]

My great-grandmother was 14 when she had her first child, my grandmother was

15, my mother was 16 with her first (24 with me). I had my first child at 35

(nda) and my child with ds at 42.

Sue mom to Kate 16 and Karrie 9 w/ds and other issues

-- Re: Another reason to shoot your mother-in-law?

My mom was 23 when she had me. I was 34 when I had (ooops- you will

all figure out my age now....) And I had my son when I was older than who

has no genetic disabilities.

I'm not buying....

[Guest guest]

I swear this has to be a joke! Lol

My grandmother had her first at 18, although she did have my mother at

42...oops

My mother had me at 25

I had Myah at 22.

Must be great grandma's fault...lol

Another reason to shoot your mother-in-law?

The syntax of this abstract seems a bit contorted. I think what they've

found is that maternal grandmother's age at time of mother's birth may be a

risk indicator, independent of mother's age or father's age. I.e., a 25

yearold mother who was born to a 35 yearold woman is at greater risk than a

25 yearold mother born to a 25 yearold mother. Mmmm, little contortion of my

own there.

But the abstract almost makes it sound like birth of a child with Down

syndrome, at least in India, is more likely if maternal grandmother is

really old. If you took that one statement, " Therefore, for every year of

advancement of age of the maternal grandmother, the risk (odds) of birth of

DS baby increases by 30%, " out of context, you could extend the logic to its

illogical conclusion. Shooting your MIL at, say, age 60, would reduce by

150% the chance of Down syndrome in one of her grandchildren to be born when

she would be 65.

Any takers out there? -- Bob

<< 1: BMC Med Genet. 2006 Jan 14;7(1):4 [Epub ahead of print] Related

Articles, Links

Influence of advanced age of maternal grandmothers on Down syndrome.

Malini SS, Ramachandra NB.

ABSTRACT: BACKGROUND: Down syndrome (DS) is the most common chromosomal

anomaly associated with mental retardation. This is due to the occurrence of

free trisomy 21 (92-95%), mosaic trisomy 21 (2-4%) and translocation (3-4%).

Advanced maternal age is a well documented risk factor for maternal meiotic

nondisjunction. In India three children with DS are born every hour and more

DS children are given birth to by young age mothers than by advanced age

mothers. Therefore, detailed analysis of the families with DS is needed to

find out other possible causative factors for nondisjunction. METHODS: We

investigated 69 families of cytogenetically confirmed DS children and

constructed pedigrees of these families. We also studied 200 randomly

selected families belonging to different religions as controls. Statistical

analysis was carried out using logistic regression. RESULTS: Out of the 69

DS cases studied, 67 were free trisomy 21, two cases were mosaic trisomy 21

and there were none with translocation. The number of DS births was greater

for the young age mothers compared with the advanced age mothers. It has

also been recorded that young age mothers ( 18 to 29 years) born to their

mothers at the age 30 years and above produced as high as 91.3% of children

with DS. The logistic regression of case- control study of DS children

revealed that the odds ratio of age of grandmother was significant when all

the four variables were used once at a time. However, the effect of age of

mother and father was smaller than the effect of age of maternal

grandmother. Therefore, for every year of advancement of age of the maternal

grandmother, the risk (odds) of birth of DS baby increases by 30%.

CONCLUSIONS: Besides the known risk factors, mother's age, father's age, the

age of the maternal grandmother at the time of birth of the mother is a risk

factor for the occurrence of Down syndrome.

PMID: 16412239 [PubMed - as supplied by publisher] >>

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_ui

ds=16412239 & dopt=Citation

Click reply to all for messages to go to the list. Just hit reply for

messages to go to the sender of the message.

[Guest guest]

In a message dated 2/1/2006 8:46:28 A.M. Eastern Standard Time,

RSYOSH@... writes:

On the other hand, I was 33 when my daughter (who has Down syndrome) was

born. I know of a mom who was 17 and gave birth to a child with DS>

I also know of a mother who at 17 gave birth to a child with DS. Micah's

birth mother was only 23 at the time of his birth!

Loree

[Guest guest]

My mother was 42 when I was born. One of my sisters had her last two kids at 36

and 38. Both of my Grandmothers had babies at age 42 and one of my great

grandmothers had a baby at age 47. None of us have Down syndrome, but I have

been told that all " Change of life " babies have sort of problems--be them

physical, emotional, or other. I don't necessarily buy this. Famous change of

life babies include Senator Ted Kennedy, actress Kathy Bates, movie star Shirley

Temple, singer Celine Dion, former First Daughters Amy and Ford,

and a bunch of ther people who have made their mark on the world.

Dad to , Kristi, and (all three Down syndrome) and (Cri du

chat syndrome)

Husband to C. in Mo.

" Daddy " to and in Califonria (both Down syndrome)

Sue Brown <karriemom@...> wrote:

My great-grandmother was 14 when she had her first child, my grandmother was

15, my mother was 16 with her first (24 with me). I had my first child at 35

(nda) and my child with ds at 42.

Sue mom to Kate 16 and Karrie 9 w/ds and other issues

-- Re: Another reason to shoot your mother-in-law?

My mom was 23 when she had me. I was 34 when I had (ooops- you will

all figure out my age now....) And I had my son when I was older than who

has no genetic disabilities.

I'm not buying....

[Guest guest]

I might have to argue that Ted Kennedy does have some problems!! lol

Re: Another reason to shoot your mother-in-law?

My mom was 23 when she had me. I was 34 when I had (ooops- you will

all figure out my age now....) And I had my son when I was older than who

has no genetic disabilities.

I'm not buying....

[Guest guest]

Re: Another reason to shoot your mother-in-law?

My mom was 23 when she had me. I was 34 when I had (ooops- you will

all figure out my age now....) And I had my son when I was older than who

has no genetic disabilities.

I'm not buying....

[Guest guest]

I had just turned 30 when was born. I know 2 women, both were 21 when

they had their children with DS. Where I used to live, we did an informal

survey, and the majority of moms had their children with DS before the age of

35.

Sharon H.

Mom to , (14, DS) and , (10)

South Carolina

Re: Another reason to shoot your mother-in-law?

In a message dated 2/1/2006 8:46:28 A.M. Eastern Standard Time,

RSYOSH@... writes:

On the other hand, I was 33 when my daughter (who has Down syndrome) was

born. I know of a mom who was 17 and gave birth to a child with DS>

I also know of a mother who at 17 gave birth to a child with DS. Micah's

birth mother was only 23 at the time of his birth!

Loree

[Guest guest]

Let see, I was 30, 33, and 34 when my girls were born..... my middle one

has DS.

My mom was 25 when she had me

My maternal grandmother was ~25 when she had my mom.

Interestingly my maternal grandmother was hit and killed by a car when

my mom was 11, yet her inability to advance in age still didn't prevent

the birth of my daughter with DS. Perhaps I should write to the

scientists in the article and ask them, since my maternal grandmother

only lived to age 35 :-)

, mom to (10), (8 DS), and (6)

>

>

[Guest guest]

Interesting. Didn't know that about the water. Is that any water or just

water in India? Good story about watercarrier in India at

http://www.dangibson.net/thecrackedpot.html

Good story to tell our kids.

Did you mean to send this to me or to ? I've received several

emails giving maternal age data in the last couple of days. So, don't feel

alone.

Regards,

Bob

Re: Another reason to shoot your mother-in-law?

---while i sometimes know that my husband would like to shoot my

mother i can assure you it wouldnt be for this reason lol and since

everyone else shared i will also say that i just cant believe there is truth

to this i was born when my mom was 22 and my son was born when i was 22 so

guess i dont fit indias mold either maybe they should test the water it

could be in the water you know they say thats how you get twins?? lol

[Guest guest]

" Where I used to live, we did an informal survey, and the majority of moms

had their children with DS before the age of 35. "

I think you'll find that these statistics are " skewed " by other factors.

Particularly since the majority of mother's giving birth over the age of

35yrs have genetic testing done in the early stages of pregnancy, so many of

the babies that " should " be born with DS aren't. I know that when

was really small a medical expert did tell me that. (I had when I

was 28yrs. My mother had me at 36yrs, and her mother had her at 18yrs...

Regards in Sydney, Australia (over 40degrees expected today, which

in " our speak " is a HOT HOT day - there'll probably be bushfires by the end

of the day...)

wife of Tony, mother of (14) (12 with DS) and Greg (10)

_____

From: [mailto: ] On Behalf

Of Sharon

Sent: Thursday, 2 February 2006 4:10 AM

Loree5@...; RSYOSH@...;

Subject: Re: Another reason to shoot your mother-in-law?

Where I used to live, we did an informal survey, and the majority of moms

had their children with DS before the age of 35.

Sharon H.

Mom to , (14, DS) and , (10)

South Carolina

[Guest guest]

Actually, my paternal Grandmother had my Dad and uncle at ages 36 and 38. I

know there was another baby who died when she as about a year old...and I'm

pretty sure she was the youngest so she must have had her around age 40.

I had 2 in my 20's, 2 in my 30's and 2 in my 40's

Sue

My mother was 42 when I was born. One of my sisters had her last two kids at

36 and 38. Both of my Grandmothers had babies at age 42 and one of my great

grandmothers had a baby at age 47.

[Guest guest]

I was 30 when I had Trent, at 32 had Shannen, 26 and 28 for and

. My mother was in her early 30's when she had me, her mother would

have been around 40 when she had her (guessing but as my mother was the last

of 12 she certainly wasn't in her 20's).

Personally I think scientists are grasping at straws, in view of the fact

that many of us where not 'older' mothers when we had our children with DS,

and the many first time 'older' mothers of today are not giving birth to

children with DS. They are looking for another common reason. In my

little group of friends,(3 with children with DS) the common factor is we

all worked in the medical profession and around x-ray machines - 2 nurses,

1 radiological administrator. Then we have a mother (whose child has spina

bifida) who worked in a veterinary practice and also around x-ray machines.

Along with working around x-ray machines, over the years I have had loads of

x-rays taken of my lower spine - is radiation a contributing factor.

Another work place environment thought my husband and I have is chemicals.

He is a spray painter and some of the paint he uses contain some very nasty

chemicals that can be absorbed by the body - one of Trent's program friends

with Autism father was also a spray painter. Is our environment which is

full of chemicals and radiation causing more problems than scientists are

aware.

, enjoy the hot - we here in are now enjoying the cooler

days and over the past 48 hours lots of good soaking rain, which have helped

the fire-fighters to blackout the devasting fires of the past week. Oh

well, summer is nearly over and in reality we haven't had that many hot hot

days.

Keep smiling

Jan, mother of Trent 21yo w/DS from the LandDownUnder

Re: Another reason to shoot your mother-in-law?

Where I used to live, we did an informal survey, and the majority of moms

had their children with DS before the age of 35.

Sharon H.

Mom to , (14, DS) and , (10)

South Carolina

[Guest guest]

I had one at 23, one at 28, and one at 30 and the son I had

at 28 is the one with DS oh one came to me when I was 26

- Mom to 4- Robbie (8), Zoe (7), (3) DS,

(1) Massachusetts

Re: Another reason to shoot your

mother-in-law?

I had just turned 30 when was born. I know 2

women, both were 21 when they had their children with DS.

Where I used to live, we did an informal survey, and the

majority of moms had their children with DS before the age

of 35.

Sharon H.

Mom to , (14, DS) and , (10)

South Carolina

Re: Another reason to shoot your

mother-in-law?

In a message dated 2/1/2006 8:46:28 A.M. Eastern

Standard Time,

RSYOSH@... writes:

On the other hand, I was 33 when my daughter (who has

Down syndrome) was

born. I know of a mom who was 17 and gave birth to a

child with DS>

I also know of a mother who at 17 gave birth to a child

with DS. Micah's

birth mother was only 23 at the time of his birth!

Loree

[Guest guest]

Well, my mom was 27 when she had me, and I had Nic at 21 - I'm not buying it

either...

Sandy Love

Monona, WI

[Guest guest]

I was 30 when I had and my mom was 25 when she had me. Her

mom was 25 when she had my mom (kid #7 with 6 more to go!).