Re: Calorie Restriction and Hormonal Replacement

December 30, 2006

Injecting older americans with certain hormones like HGH and testesterone has

show some short term improvements in certain areas like body fat, body comp,

increased HDL, and energy levels, etc... But I know of no evidence it has made

the healthier in the long run. Just the opposite including increased rates of

certain homrone related cancers like prostate.

Regards

jeff

[ ] Calorie Restriction and Hormonal Replacement

Here's something I've been pondering of late:

Calorie restriction extends lifespan. Calorie restriction is

associated with reduced hormonal levels (obviously, insulin would be

decreased, but testosterone, estrogen, will all go down).

On the other hand: optimal (usually high) levels of hormones are

strongly associated with health and well being.

So this makes me think that calorie restriction increases lifespan in

SPITE of hormonal drops. If this is the case, calorie restriction and

hormonal replacement would be an extremely potent combination, not

only in terms of lifespan, but in terms of quality of life (muscle

mass, libido, bone mass, mood).

December 30, 2006

Injecting older americans with certain hormones like HGH and testesterone has

show some short term improvements in certain areas like body fat, body comp,

increased HDL, and energy levels, etc... But I know of no evidence it has made

the healthier in the long run. Just the opposite including increased rates of

certain homrone related cancers like prostate.

Regards

jeff

[ ] Calorie Restriction and Hormonal Replacement

Here's something I've been pondering of late:

Calorie restriction extends lifespan. Calorie restriction is

associated with reduced hormonal levels (obviously, insulin would be

decreased, but testosterone, estrogen, will all go down).

On the other hand: optimal (usually high) levels of hormones are

strongly associated with health and well being.

So this makes me think that calorie restriction increases lifespan in

SPITE of hormonal drops. If this is the case, calorie restriction and

hormonal replacement would be an extremely potent combination, not

only in terms of lifespan, but in terms of quality of life (muscle

mass, libido, bone mass, mood).

December 31, 2006

Hey Jeff,

Certainly increased muscle mass, decreased fat, increased libido,

improved mood are signs of QUALITY of life, no? And to my knowledge,

this gains are certainly maintained if hormone levels are

maintained.

There is no evidence to suggest exogeneous hormones increase cancer

rates. The alledged danger is that they would increase the RATE of

already present hormono-dependent cancers. This is a strongly

contentious issue given that testosterone does NOT increase the risk

of prostate cancer (prostate cancer is RARE in the young). It is

also being used in palliative treatment. There is a relation between

dihydrotestosterone and increasing estradiol levels, however.

There is a great deal of information on these topics stemming from

research in the anti-aging field.

I'm not saying testosterone/growth hormone/thyroid will make you

live longer. They will certainly prevent disease if you were

deficient. The point is that, in a calorie restriction context, they

may be essential for improving quality of life. Low testosterone is

correlated with sarcopenia, osteopenia, weak libido, poor mood,

anxiety, poor cardiac function, etc.

Cheers,

>

> Injecting older americans with certain hormones like HGH and

testesterone has show some short term improvements in certain areas

like body fat, body comp, increased HDL, and energy levels, etc...

But I know of no evidence it has made the healthier in the long

run. Just the opposite including increased rates of certain

homrone related cancers like prostate.

>

> Regards

> jeff

>

> [ ] Calorie Restriction and Hormonal

Replacement

>

> Here's something I've been pondering of late:

>

> Calorie restriction extends lifespan. Calorie restriction is

> associated with reduced hormonal levels (obviously, insulin would

be

> decreased, but testosterone, estrogen, will all go down).

>

> On the other hand: optimal (usually high) levels of hormones are

> strongly associated with health and well being.

>

> So this makes me think that calorie restriction increases lifespan

in

> SPITE of hormonal drops. If this is the case, calorie restriction

and

> hormonal replacement would be an extremely potent combination, not

> only in terms of lifespan, but in terms of quality of life (muscle

> mass, libido, bone mass, mood).

>

December 31, 2006

If you look at the evidence you will find that animals that are put on

this restrictive diet do have their hormone levels supressed to a

lower level... but what is most important finding is that the CR'd

animals maintain their level of hormones for longer (slower

age-related decline). In fact, you can clearly see this in Okinawans,

they initially start of (age 20) at their highest level of DHEA and

have a really slow decline throughout life. Whereas the average

American will have much higher DHEA at 20, but have a faster decline.

This is found in the okinawa centenarian study. The same holds true

for testosterone and other hormones also.

In calorically restricted animals the same as the above is evident...

yes they start off at a lower muscle mass, lower bone mass, but the

control group eventually declines further at around middle age and the

CR'd mice maintain their bone and muscle mass, and function.

If one is starting off from a frail state, then maybe hormones might

be a consideration, but I absolutely do NOT believe it is advisable to

suggest that we all use hormones to somehow increase our well-being...

I'm not aware that CRers are suffering from poor cardiac function.

> >

> > Injecting older americans with certain hormones like HGH and

> testesterone has show some short term improvements in certain areas

> like body fat, body comp, increased HDL, and energy levels, etc...

> But I know of no evidence it has made the healthier in the long

> run. Just the opposite including increased rates of certain

> homrone related cancers like prostate.

> >

> > Regards

> > jeff

> >

> > [ ] Calorie Restriction and Hormonal

> Replacement

> >

> > Here's something I've been pondering of late:

> >

> > Calorie restriction extends lifespan. Calorie restriction is

> > associated with reduced hormonal levels (obviously, insulin would

> be

> > decreased, but testosterone, estrogen, will all go down).

> >

> > On the other hand: optimal (usually high) levels of hormones are

> > strongly associated with health and well being.

> >

> > So this makes me think that calorie restriction increases lifespan

> in

> > SPITE of hormonal drops. If this is the case, calorie restriction

> and

> > hormonal replacement would be an extremely potent combination, not

> > only in terms of lifespan, but in terms of quality of life (muscle

> > mass, libido, bone mass, mood).

> >

>

December 31, 2006

»Certainly increased muscle mass, decreased fat, increased libido,

improved mood are signs of QUALITY of life, no?

Can you show/cite evidence from peer-reviewed mainstream scientific journals for

these being markers for decreased rates of CVD or DB or HTN or for increased

longevity??

Or the relationship between higher hormone levels and the above also??

Even the author of the studies of HGH in the NEJM printed an follow up article

expressing his concerns that his data was being misused and misrepresented to

promote the use of these hormrones in the anti-aging field without any evidence

for it. And his concern for the l/t side effects.

Considering the incidence of cancers in the US population and the fact that by

the time most have been diagnosed they have been growing for years if not 10 or

more... I would be hesitant to take or recommend anything that may promote

cancer growth.

Again the archives are full of the studies supporting this.

Thanks

jeff

And to my knowledge,