Guest guest Posted August 8, 2006 Report Share Posted August 8, 2006 Hi folks: Occasionally we have people here advocate taking this substance as a supplement. Here are what looks like a few reasons not to: " Conjugated linoleic acid impairs endothelial function. " PMID: 16339498 ----------------------- " Conjugated linoleic acid supplementation for 1 y does not prevent weight or body fat regain. " PMID: 16522907 ----------------------- " Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. " " ..... A CLA preparation containing the purified c9,t11 CLA isomer increased insulin resistance and lipid peroxidation compared with placebo... " PMID: 15277146 ------------------------ " Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. " PMID 12196420 ------------------------ Rodney. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 30, 2008 Report Share Posted June 30, 2008 I am taking it for about 2 months- but I haven't seen any results- yet. I am going to stay with it. it can't hurt you so, I am willing to try it longer. nancie From: Bev Sent: Sunday, June 29, 2008 2:53 PM hypothyroidism Subject: Conjugated Linoleic Acid Hi, Has anybody here tried Conjugated Linoleic Acid for weight loss? It was on About.com saying it does. What's your results? thanks Bev Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 30, 2008 Report Share Posted June 30, 2008 Here's a study with rats and mice. It's from this site: http://www.google.com/search?hl=en & q=Conjugated+Linoleic+Acid+for+weight+loss & bt\ nG=Google+Search Quote: A supplement some people turn to in hopes of losing a few pounds may have some previously unknown, unsavory side effects, suggest two new studies. Researchers studied how mice and rats responded to the supplement conjugated linoleic acid (CLA), an essential amino acid found in trace amounts primarily in beef, lamb and milk. Synthetic forms of CLA are marketed as supplements that help reduce body fat, and some manufacturers also tout CLA for reducing the risk of diabetes and certain types of cancer. The mice and rats responded in very different ways to CLA, said Martha Belury, the lead author of both studies and an associate professor of human nutrition at Ohio State University. Mice fed a CLA-supplemented diet lost weight very fast, but also accumulated excessive amounts of fat in their livers - a common side effect of rapid weight loss. Excessive fat accumulation in the liver is linked to insulin resistance, a hallmark of Type 2 diabetes. Yet CLA didn't help rats lose weight they had gained prior to taking the supplement. But it effectively decreased the amount of fat that had accumulated in the animals' livers due to the weight gain. In turn, the rats were less resistant to insulin. " Many people take CLA as a supplement in hopes of trimming body fat, and it seems to work, " Belury said. " But we're not sure what else it does to the body. Studying CLA's effects in two different animal models may help us to better understand any additional effects in humans. " It seems that these mice and rats represent a continuum of possible side effects induced by CLA, " she continued. " The question is, are humans more like mice or rats? We're probably somewhere in between. " The current mouse study appears in a recent issue of the Journal of Lipid Research, while the rat study will appear in an upcoming issue of the Journal of Nutritional Biochemistry. In a study from 2003, Belury found that CLA supplements lowered body mass and blood sugar levels of diabetics. The study participants took CLA supplements for two months. Researchers fed two groups of mice different diets. The first group ate a diet containing CLA for four weeks, followed by four weeks of a diet without CLA. The second group of animals ate a CLA-free diet for two weeks followed by two weeks of a diet that included CLA. During the latter two weeks, some of the mice received daily injections of the anti-diabetes drug rosiglitazone. Rosiglitazone makes the body more sensitive to insulin. Mice serving as controls for both groups did not consume CLA. The researchers monitored insulin sensitivity in all mice throughout the study. They also monitored levels of adiponectin, a hormone secreted by fat tissue and thought to play a role in insulin resistance. " Adiponectin helps regulate insulin levels, " Belury said. " Lowered levels are associated with obesity and type 2 diabetes. " The researchers found that CLA supplementation significantly decreased body fat in the first group of mice, but at the same time excessive amounts of fat accumulated in the animals' livers. Belury and her colleagues linked this accumulation of fat in the liver to increased insulin resistance. When CLA was removed from the diet, the animals gained weight but lost fat in the liver. The mice also became less resistant to insulin. " When we took CLA away, we lost that suppressive effect on body fat, but we were actually able to restore insulin sensitivity, " Belury said. But the group of mice given rosiglitazone injections while on a CLA-rich diet neither lost weight nor became insulin resistant. " The drug kept adiponectin levels steady during the weeks the mice consumed CLA, " Belury said. " We think that's what kept the animals from becoming resistant to insulin. " While this is an interesting finding, it doesn't mean that someone taking CLA should also take an anti-diabetic drug, " she continued. " It's too soon to tell if that would be the case in humans. " In the rat study, Belury and her colleagues studied a special kind of rat model bred to gain weight quickly. These rats were also less susceptible to CLA-induced weight loss. All rats ate a high-fat diet for four weeks. For the remaining four weeks of the study, half of the rats ate a low-fat diet supplemented with CLA, while the rest of the animals ate a low-fat diet without CLA. The supplement didn't help the rats lose weight. But it seemed to keep fat from accumulating in the animals' livers, compared to the rats eating the diet without CLA. Belury pointed out that up to 75 percent of people with obesity and diabetes develop an illness called non-alcoholic fatty liver disease in which fat accumulates in the liver and can ultimately make a person insulin resistant. CLA may or may not have a similar effect on humans, and it will take time to determine how the human body responds to the supplement. But clinical trials are underway - Belury is currently working with researchers from Ohio State's medical center who are conducting a clinical trial of the effects of CLA on women with diabetes. Belury conducted the studies with Aparna Purushotham and Wendel, both graduate fellows in human nutrition; and Li-Fen Liu and Gayle Shrode, both graduate research associates in human nutrition. Support for the work was provided by Cognis North America, a manufacturer of synthetic CLA headquartered in Cincinnati. Support also came from the Carol S. Kennedy research award and the Anita R. McCormick fellowship. http://www.osu.edu End of quote. Luck, > > > > > .. .. > > > Conjugated Linoleic Acid > <hypothyroidism/message/39781;_ylc=X3oDMTJxcjJjdDl\ tBF9TAzk3MzU5NzE1BGdycElkAzE0NTY2NARncnBzcElkAzE3MDkyNTEwODIEbXNnSWQDMzk3ODEEc2V\ jA2Rtc2cEc2xrA3Ztc2cEc3RpbWUDMTIxNDc3NjQyMg--> > > > > Posted by: " Bev " bdowns45681@... > <mailto:bdowns45681@...?Subject=%20Re%3AConjugated%20Linoleic%20Acid> > bdowns45681 <bdowns45681> > > > Sun Jun 29, 2008 2:53 pm (PDT) > > Hi, > Has anybody here tried Conjugated Linoleic Acid for weight loss? It > was on About.com saying it does. What's your results? > thanks > Bev Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 30, 2008 Report Share Posted June 30, 2008 Thanks for responding Nancie. Have you noticed the fat turning to muscle? The artical said that might & could happen. If you do notice anything would you post the results? Thanks Bev > I am taking it for about 2 months- but I haven't seen any results- yet. I am going to stay with it. it can't hurt you so, I am willing to try it longer. > nancie Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 30, 2008 Report Share Posted June 30, 2008 It's impossible for fat to turn to muscle. So anything saying it can do that must be a scam Crystal -- Re: Conjugated Linoleic Acid Thanks for responding Nancie. Have you noticed the fat turning to muscle? The artical said that might & could happen. If you do notice anything would you post the results? Thanks Bev > I am taking it for about 2 months- but I haven't seen any results- yet. I am going to stay with it. it can't hurt you so, I am willing to try it longer. > nancie Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 30, 2008 Report Share Posted June 30, 2008 CLA has never been touted as turning fat into muscle. all it does is to help rev up the metabolism. From: Crystal Sent: Monday, June 30, 2008 9:28 PM hypothyroidism Subject: Re: Re: Conjugated Linoleic Acid It's impossible for fat to turn to muscle. So anything saying it can do that must be a scam Crystal -- Re: Conjugated Linoleic Acid Thanks for responding Nancie. Have you noticed the fat turning to muscle? The artical said that might & could happen. If you do notice anything would you post the results? Thanks Bev > I am taking it for about 2 months- but I haven't seen any results- yet. I am going to stay with it. it can't hurt you so, I am willing to try it longer. > nancie Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 1, 2008 Report Share Posted July 1, 2008 Hi, Nance. Did you see the report I posted? I'm well aware that mice and rats aren't the same as humans; but they're used in a vast number of studies because of some similarities in responses. Note the excerpt below: > The mice and rats responded in very different ways to CLA, said Martha > Belury, the lead author of both studies and an associate professor of > human nutrition at Ohio State University. > > Mice fed a CLA-supplemented diet lost weight very fast, but also > accumulated excessive amounts of fat in their livers - a common side > effect of rapid weight loss. Excessive fat accumulation in the liver is > linked to insulin resistance, a hallmark of Type 2 diabetes. > > Yet CLA didn't help rats lose weight they had gained prior to taking the > supplement. But it effectively decreased the amount of fat that had > accumulated in the animals' livers due to the weight gain. In turn, the > rats were less resistant to insulin. > > " Many people take CLA as a supplement in hopes of trimming body fat, and > it seems to work, " Belury said. " But we're not sure what else it does to > the body. I would also point out that AFAIK a producer of CLA partially funded the study so if there's any bias I would not be surprised if it's in favor of CLA. In any event unless there's other literature that casts doubt upon the validity or credibility of this study I would hesitate to make a blanket statement as to what exactly CLA does and whether it might have some ill effects. Excessive fat in the liver is not desirable IMHO. Other than that I know absolutely nothing about it. But as I see it one of the things we can do to help each other is to point out any possible negatives that have been missed concerning a treatment method or are not widely known. So I present this only as a caution. > Re: Conjugated Linoleic Acid > <hypothyroidism/message/39804;_ylc=X3oDMTJxbm84azZ\ 1BF9TAzk3MzU5NzE1BGdycElkAzE0NTY2NARncnBzcElkAzE3MDkyNTEwODIEbXNnSWQDMzk4MDQEc2V\ jA2Rtc2cEc2xrA3Ztc2cEc3RpbWUDMTIxNDkwOTMzOQ--> > > > > Posted by: " nancie barnett " deifspirit@... > <mailto:deifspirit@...?Subject=%20Re%3A%20Conjugated%20Linoleic%20Acid> > aspenfairy1 <aspenfairy1> > > > Mon Jun 30, 2008 10:26 pm (PDT) > > CLA has never been touted as turning fat into muscle. all it does is > to help rev up the metabolism. > > From: Crystal > Sent: Monday, June 30, 2008 9:28 PM > hypothyroidism > <mailto:hypothyroidism%40> > Subject: Re: Re: Conjugated Linoleic Acid > > It's impossible for fat to turn to muscle. So anything saying it can do > that must be a scam > Crystal > > -- Re: Conjugated Linoleic Acid > > Thanks for responding Nancie. > Have you noticed the fat turning to muscle? The artical said that > might & could happen. If you do notice anything would you post the > results? > Thanks > Bev > > > I am taking it for about 2 months- but I haven't seen any results- > yet. I am going to stay with it. it can't hurt you so, I am willing to > try it longer. > > nancie Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 1, 2008 Report Share Posted July 1, 2008 testing > > Hi, Nance. Did you see the report I posted? I'm well aware that mice > and rats aren't the same as humans; but they're used in a vast number of > studies because of some similarities in responses. Note the excerpt below: > > > The mice and rats responded in very different ways to CLA, said Martha > > Belury, the lead author of both studies and an associate professor of > > human nutrition at Ohio State University. > > > > Mice fed a CLA-supplemented diet lost weight very fast, but also > > accumulated excessive amounts of fat in their livers - a common side > > effect of rapid weight loss. Excessive fat accumulation in the liver is > > linked to insulin resistance, a hallmark of Type 2 diabetes. > > > > Yet CLA didn't help rats lose weight they had gained prior to taking the > > supplement. But it effectively decreased the amount of fat that had > > accumulated in the animals' livers due to the weight gain. In turn, the > > rats were less resistant to insulin. > > > > " Many people take CLA as a supplement in hopes of trimming body fat, and > > it seems to work, " Belury said. " But we're not sure what else it does to > > the body. > > I would also point out that AFAIK a producer of CLA partially funded the > study so if there's any bias I would not be surprised if it's in favor > of CLA. In any event unless there's other literature that casts doubt > upon the validity or credibility of this study I would hesitate to make > a blanket statement as to what exactly CLA does and whether it might > have some ill effects. Excessive fat in the liver is not desirable IMHO. > > Other than that I know absolutely nothing about it. But as I see it one > of the things we can do to help each other is to point out any possible > negatives that have been missed concerning a treatment method or are not > widely known. So I present this only as a caution. > > > > > > > > Re: Conjugated Linoleic Acid > > <hypothyroidism/message/39804;_ylc=X3oDM TJxbm84azZ1BF9TAzk3MzU5NzE1BGdycElkAzE0NTY2NARncnBzcElkAzE3MDkyNTEwODI EbXNnSWQDMzk4MDQEc2VjA2Rtc2cEc2xrA3Ztc2cEc3RpbWUDMTIxNDkwOTMzOQ--> > > > > > > > > Posted by: " nancie barnett " deifspirit@... > > <mailto:deifspirit@...?Subject=%20Re%3A%20Conjugated% 20Linoleic%20Acid> > > aspenfairy1 <aspenfairy1> > > > > > > Mon Jun 30, 2008 10:26 pm (PDT) > > > > CLA has never been touted as turning fat into muscle. all it does is > > to help rev up the metabolism. > > > > From: Crystal > > Sent: Monday, June 30, 2008 9:28 PM > > hypothyroidism > > <mailto:hypothyroidism%40> > > Subject: Re: Re: Conjugated Linoleic Acid > > > > It's impossible for fat to turn to muscle. So anything saying it can do > > that must be a scam > > Crystal > > > > -- Re: Conjugated Linoleic Acid > > > > Thanks for responding Nancie. > > Have you noticed the fat turning to muscle? The artical said that > > might & could happen. If you do notice anything would you post the > > results? > > Thanks > > Bev > > > > > I am taking it for about 2 months- but I haven't seen any results- > > yet. I am going to stay with it. it can't hurt you so, I am willing to > > try it longer. > > > nancie > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 1, 2008 Report Share Posted July 1, 2008 yes, I saw it but I get my info from a PhD in biochemistry and nutrition. who says otherwise.... From: Sent: Tuesday, July 01, 2008 8:36 AM hypothyroidism Subject: Re: Conjugated Linoleic Acid Hi, Nance. Did you see the report I posted? I'm well aware that mice and rats aren't the same as humans; but they're used in a vast number of studies because of some similarities in responses. Note the excerpt below: > The mice and rats responded in very different ways to CLA, said Martha > Belury, the lead author of both studies and an associate professor of > human nutrition at Ohio State University. > > Mice fed a CLA-supplemented diet lost weight very fast, but also > accumulated excessive amounts of fat in their livers - a common side > effect of rapid weight loss. Excessive fat accumulation in the liver is > linked to insulin resistance, a hallmark of Type 2 diabetes. > > Yet CLA didn't help rats lose weight they had gained prior to taking the > supplement. But it effectively decreased the amount of fat that had > accumulated in the animals' livers due to the weight gain. In turn, the > rats were less resistant to insulin. > > " Many people take CLA as a supplement in hopes of trimming body fat, and > it seems to work, " Belury said. " But we're not sure what else it does to > the body. I would also point out that AFAIK a producer of CLA partially funded the study so if there's any bias I would not be surprised if it's in favor of CLA. In any event unless there's other literature that casts doubt upon the validity or credibility of this study I would hesitate to make a blanket statement as to what exactly CLA does and whether it might have some ill effects. Excessive fat in the liver is not desirable IMHO. Other than that I know absolutely nothing about it. But as I see it one of the things we can do to help each other is to point out any possible negatives that have been missed concerning a treatment method or are not widely known. So I present this only as a caution. > Re: Conjugated Linoleic Acid > <hypothyroidism/message/39804;_ylc=X3oDMTJxbm84azZ\ 1BF9TAzk3MzU5NzE1BGdycElkAzE0NTY2NARncnBzcElkAzE3MDkyNTEwODIEbXNnSWQDMzk4MDQEc2V\ jA2Rtc2cEc2xrA3Ztc2cEc3RpbWUDMTIxNDkwOTMzOQ--> > > > > Posted by: " nancie barnett " deifspirit@... > <mailto:deifspirit@...?Subject=%20Re%3A%20Conjugated%20Linoleic%20Acid> > aspenfairy1 <aspenfairy1> > > > Mon Jun 30, 2008 10:26 pm (PDT) > > CLA has never been touted as turning fat into muscle. all it does is > to help rev up the metabolism. > > From: Crystal > Sent: Monday, June 30, 2008 9:28 PM > hypothyroidism > <mailto:hypothyroidism%40> > Subject: Re: Re: Conjugated Linoleic Acid > > It's impossible for fat to turn to muscle. So anything saying it can do > that must be a scam > Crystal > > -- Re: Conjugated Linoleic Acid > > Thanks for responding Nancie. > Have you noticed the fat turning to muscle? The artical said that > might & could happen. If you do notice anything would you post the > results? > Thanks > Bev > > > I am taking it for about 2 months- but I haven't seen any results- > yet. I am going to stay with it. it can't hurt you so, I am willing to > try it longer. > > nancie Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 1, 2008 Report Share Posted July 1, 2008 Thanks for this artical . It sounds like it may or may not work or it may or may not be good for a person. Bev > > Here's a study with rats and mice. It's from this site: > > http://www.google.com/search? hl=en & q=Conjugated+Linoleic+Acid+for+weight+loss & btnG=Google+Search > > Quote: > > A supplement some people turn to in hopes of losing a few pounds may > have some previously unknown, unsavory side effects, suggest two new > studies. > > Researchers studied how mice and rats responded to the supplement > conjugated linoleic acid (CLA), an essential amino acid found in trace > amounts primarily in beef, lamb and milk. Synthetic forms of CLA are > marketed as supplements that help reduce body fat, and some > manufacturers also tout CLA for reducing the risk of diabetes and > certain types of cancer. > > The mice and rats responded in very different ways to CLA, said Martha > Belury, the lead author of both studies and an associate professor of > human nutrition at Ohio State University. > > Mice fed a CLA-supplemented diet lost weight very fast, but also > accumulated excessive amounts of fat in their livers - a common side > effect of rapid weight loss. Excessive fat accumulation in the liver is > linked to insulin resistance, a hallmark of Type 2 diabetes. > > Yet CLA didn't help rats lose weight they had gained prior to taking the > supplement. But it effectively decreased the amount of fat that had > accumulated in the animals' livers due to the weight gain. In turn, the > rats were less resistant to insulin. > > " Many people take CLA as a supplement in hopes of trimming body fat, and > it seems to work, " Belury said. " But we're not sure what else it does to > the body. Studying CLA's effects in two different animal models may help > us to better understand any additional effects in humans. > > " It seems that these mice and rats represent a continuum of possible > side effects induced by CLA, " she continued. " The question is, are > humans more like mice or rats? We're probably somewhere in between. " > > The current mouse study appears in a recent issue of the Journal of > Lipid Research, while the rat study will appear in an upcoming issue of > the Journal of Nutritional Biochemistry. > > In a study from 2003, Belury found that CLA supplements lowered body > mass and blood sugar levels of diabetics. The study participants took > CLA supplements for two months. > > Researchers fed two groups of mice different diets. The first group ate > a diet containing CLA for four weeks, followed by four weeks of a diet > without CLA. > > The second group of animals ate a CLA-free diet for two weeks followed > by two weeks of a diet that included CLA. During the latter two weeks, > some of the mice received daily injections of the anti-diabetes drug > rosiglitazone. Rosiglitazone makes the body more sensitive to insulin. > Mice serving as controls for both groups did not consume CLA. > > The researchers monitored insulin sensitivity in all mice throughout the > study. They also monitored levels of adiponectin, a hormone secreted by > fat tissue and thought to play a role in insulin resistance. > > " Adiponectin helps regulate insulin levels, " Belury said. " Lowered > levels are associated with obesity and type 2 diabetes. " > > The researchers found that CLA supplementation significantly decreased > body fat in the first group of mice, but at the same time excessive > amounts of fat accumulated in the animals' livers. Belury and her > colleagues linked this accumulation of fat in the liver to increased > insulin resistance. > > When CLA was removed from the diet, the animals gained weight but lost > fat in the liver. The mice also became less resistant to insulin. > > " When we took CLA away, we lost that suppressive effect on body fat, but > we were actually able to restore insulin sensitivity, " Belury said. > > But the group of mice given rosiglitazone injections while on a CLA-rich > diet neither lost weight nor became insulin resistant. > > " The drug kept adiponectin levels steady during the weeks the mice > consumed CLA, " Belury said. " We think that's what kept the animals from > becoming resistant to insulin. > > " While this is an interesting finding, it doesn't mean that someone > taking CLA should also take an anti-diabetic drug, " she continued. " It's > too soon to tell if that would be the case in humans. " > > In the rat study, Belury and her colleagues studied a special kind of > rat model bred to gain weight quickly. These rats were also less > susceptible to CLA-induced weight loss. All rats ate a high-fat diet for > four weeks. For the remaining four weeks of the study, half of the rats > ate a low-fat diet supplemented with CLA, while the rest of the animals > ate a low-fat diet without CLA. > > The supplement didn't help the rats lose weight. But it seemed to keep > fat from accumulating in the animals' livers, compared to the rats > eating the diet without CLA. > > Belury pointed out that up to 75 percent of people with obesity and > diabetes develop an illness called non-alcoholic fatty liver disease in > which fat accumulates in the liver and can ultimately make a person > insulin resistant. > > CLA may or may not have a similar effect on humans, and it will take > time to determine how the human body responds to the supplement. But > clinical trials are underway - Belury is currently working with > researchers from Ohio State's medical center who are conducting a > clinical trial of the effects of CLA on women with diabetes. > > Belury conducted the studies with Aparna Purushotham and Wendel, > both graduate fellows in human nutrition; and Li-Fen Liu and Gayle > Shrode, both graduate research associates in human nutrition. > > Support for the work was provided by Cognis North America, a > manufacturer of synthetic CLA headquartered in Cincinnati. Support also > came from the Carol S. Kennedy research award and the Anita R. McCormick > fellowship. > > http://www.osu.edu > > End of quote. > > Luck, > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 1, 2008 Report Share Posted July 1, 2008 It might have not been worded that way , but I think you know what I mean dont' you? Your fat decreases & your muscle increases. Bev > > It's impossible for fat to turn to muscle. So anything saying it can do > that must be a scam > Crystal > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 1, 2008 Report Share Posted July 1, 2008 Sorry for my wording. Bev > > CLA has never been touted as turning fat into muscle. all it does is to help rev up the metabolism. > > > From: Crystal > Sent: Monday, June 30, 2008 9:28 PM > hypothyroidism > Subject: Re: Re: Conjugated Linoleic Acid > > > It's impossible for fat to turn to muscle. So anything saying it can do > that must be a scam > Crystal > > -- Re: Conjugated Linoleic Acid > > Thanks for responding Nancie. > Have you noticed the fat turning to muscle? The artical said that > might & could happen. If you do notice anything would you post the > results? > Thanks > Bev > > > I am taking it for about 2 months- but I haven't seen any results- > yet. I am going to stay with it. it can't hurt you so, I am willing to > try it longer. > > nancie > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 1, 2008 Report Share Posted July 1, 2008 bev- CLA will not harm you. that study was done on rodents. which are not good crossovers to the human body majority of the time. personally, I don't believe in using any animals for medical research because I don't really think you can equate a human physiology to that of a mouse or rabbit, etc. My natural medicine physician uses it in her practice and I don't think she would endorse a supplement if he was harmful to humans. nancie From: Bev Sent: Tuesday, July 01, 2008 6:28 PM hypothyroidism Subject: Re:Conjugated Linoleic Acid Thanks for this artical . It sounds like it may or may not work or it may or may not be good for a person. Bev > > Here's a study with rats and mice. It's from this site: > > http://www.google.com/search? hl=en & q=Conjugated+Linoleic+Acid+for+weight+loss & btnG=Google+Search > > Quote: > > A supplement some people turn to in hopes of losing a few pounds may > have some previously unknown, unsavory side effects, suggest two new > studies. > > Researchers studied how mice and rats responded to the supplement > conjugated linoleic acid (CLA), an essential amino acid found in trace > amounts primarily in beef, lamb and milk. Synthetic forms of CLA are > marketed as supplements that help reduce body fat, and some > manufacturers also tout CLA for reducing the risk of diabetes and > certain types of cancer. > > The mice and rats responded in very different ways to CLA, said Martha > Belury, the lead author of both studies and an associate professor of > human nutrition at Ohio State University. > > Mice fed a CLA-supplemented diet lost weight very fast, but also > accumulated excessive amounts of fat in their livers - a common side > effect of rapid weight loss. Excessive fat accumulation in the liver is > linked to insulin resistance, a hallmark of Type 2 diabetes. > > Yet CLA didn't help rats lose weight they had gained prior to taking the > supplement. But it effectively decreased the amount of fat that had > accumulated in the animals' livers due to the weight gain. In turn, the > rats were less resistant to insulin. > > " Many people take CLA as a supplement in hopes of trimming body fat, and > it seems to work, " Belury said. " But we're not sure what else it does to > the body. Studying CLA's effects in two different animal models may help > us to better understand any additional effects in humans. > > " It seems that these mice and rats represent a continuum of possible > side effects induced by CLA, " she continued. " The question is, are > humans more like mice or rats? We're probably somewhere in between. " > > The current mouse study appears in a recent issue of the Journal of > Lipid Research, while the rat study will appear in an upcoming issue of > the Journal of Nutritional Biochemistry. > > In a study from 2003, Belury found that CLA supplements lowered body > mass and blood sugar levels of diabetics. The study participants took > CLA supplements for two months. > > Researchers fed two groups of mice different diets. The first group ate > a diet containing CLA for four weeks, followed by four weeks of a diet > without CLA. > > The second group of animals ate a CLA-free diet for two weeks followed > by two weeks of a diet that included CLA. During the latter two weeks, > some of the mice received daily injections of the anti-diabetes drug > rosiglitazone. Rosiglitazone makes the body more sensitive to insulin. > Mice serving as controls for both groups did not consume CLA. > > The researchers monitored insulin sensitivity in all mice throughout the > study. They also monitored levels of adiponectin, a hormone secreted by > fat tissue and thought to play a role in insulin resistance. > > " Adiponectin helps regulate insulin levels, " Belury said. " Lowered > levels are associated with obesity and type 2 diabetes. " > > The researchers found that CLA supplementation significantly decreased > body fat in the first group of mice, but at the same time excessive > amounts of fat accumulated in the animals' livers. Belury and her > colleagues linked this accumulation of fat in the liver to increased > insulin resistance. > > When CLA was removed from the diet, the animals gained weight but lost > fat in the liver. The mice also became less resistant to insulin. > > " When we took CLA away, we lost that suppressive effect on body fat, but > we were actually able to restore insulin sensitivity, " Belury said. > > But the group of mice given rosiglitazone injections while on a CLA-rich > diet neither lost weight nor became insulin resistant. > > " The drug kept adiponectin levels steady during the weeks the mice > consumed CLA, " Belury said. " We think that's what kept the animals from > becoming resistant to insulin. > > " While this is an interesting finding, it doesn't mean that someone > taking CLA should also take an anti-diabetic drug, " she continued. " It's > too soon to tell if that would be the case in humans. " > > In the rat study, Belury and her colleagues studied a special kind of > rat model bred to gain weight quickly. These rats were also less > susceptible to CLA-induced weight loss. All rats ate a high-fat diet for > four weeks. For the remaining four weeks of the study, half of the rats > ate a low-fat diet supplemented with CLA, while the rest of the animals > ate a low-fat diet without CLA. > > The supplement didn't help the rats lose weight. But it seemed to keep > fat from accumulating in the animals' livers, compared to the rats > eating the diet without CLA. > > Belury pointed out that up to 75 percent of people with obesity and > diabetes develop an illness called non-alcoholic fatty liver disease in > which fat accumulates in the liver and can ultimately make a person > insulin resistant. > > CLA may or may not have a similar effect on humans, and it will take > time to determine how the human body responds to the supplement. But > clinical trials are underway - Belury is currently working with > researchers from Ohio State's medical center who are conducting a > clinical trial of the effects of CLA on women with diabetes. > > Belury conducted the studies with Aparna Purushotham and Wendel, > both graduate fellows in human nutrition; and Li-Fen Liu and Gayle > Shrode, both graduate research associates in human nutrition. > > Support for the work was provided by Cognis North America, a > manufacturer of synthetic CLA headquartered in Cincinnati. Support also > came from the Carol S. Kennedy research award and the Anita R. McCormick > fellowship. > > http://www.osu.edu > > End of quote. > > Luck, > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 1, 2008 Report Share Posted July 1, 2008 I didn't know that's why I said what I did. Some people do believe fat turns to muscle. Just making sure you weren't falling for some kind of scam. cw -- Re: Conjugated Linoleic Acid It might have not been worded that way , but I think you know what I mean dont' you? Your fat decreases & your muscle increases. Bev > > It's impossible for fat to turn to muscle. So anything saying it can do > that must be a scam > Crystal > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 4, 2008 Report Share Posted July 4, 2008 thanks for responding Nancie. Bev Quote Link to comment Share on other sites More sharing options...
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