Re: Zinc protects against heart disease

[Guest guest]

Correction to summary:

" . . . .zinc supplementation did not significantly

change total cholesterol, LDL, or triglyceride levels, but a

significant decrease in HDL levels was observed. "

>

> Summary:

>

> Study done at National University of Singapore shows zinc

> supplementation in animals reduces CVD. Zinc does not lower blood

> cholesterol levels, but reduced aortic lesions by 66 per cent in

> rabbits, by possibly influencing iron metabolism.

>

>

> Link and full text:

>

>

http://www.nutraingredients.com/news/ng.asp?n=68177 & m=1NIE605 & c=lqeudkujayvvlpc

>

>

> Zinc supplements could protect against CVD

>

> 05/06/2006- Zinc supplements may decrease the risk of heart disease,

> says an animal study from Singapore, results that appear to support

> previous benefits afforded by the mineral.

>

> Atherosclerosis is the process whereby fatty substances such as

> cholesterol and calcium form plaque on the inner lining of an artery,

> causing them to harden. If enough builds up the plaque can reduce

> blood flow through the artery, and if it ruptures blood clots can

> form, which can block the flow of blood to the heart and cause a heart

> attack.

>

> Atherosclerosis occurs naturally in humans as part of the aging

> process, but certain factors including high blood cholesterol,

> smoking, high blood pressure, obesity and diabetes increase the risk.

>

> A report last year in the Journal of Nutrition (Vol. 135, pp.

> 2114-2118) reported that deficiency in zinc in mice was associated

> with an increase in the risk of cardiovascular disease (CVD) through

> inflammation and a decreased level of compounds that protect against

> atherosclerosis.

>

> The new research, published on-line in the journal Free Radical

> Biology and Medicine (doi: 10.1016/j.freeradbiomed.2006.03.017),

> reports that supplementation of a high cholesterol diet with zinc

> reduced the formation of lesions in the arteries of rabbits, but the

> effects were not linked to changes in cholesterol levels.

>

> Lead researcher Barry Halliwell and colleagues from the National

> University of Singapore divided 18 white rabbits into three groups.

> The first was fed a normal diet (control), the second fed a

> high-cholesterol diet (HCD, one per cent cholesterol), and the third

> was fed the HCD diet but was supplemented with zinc in the carbonate

> form (0.1 per cent).

>

> After eight weeks, the researchers measured blood levels of HDL, LDL,

> and total cholesterol, as well as triglyceride levels. The number of

> white and red blood cells were also measured.

>

> The researchers found that zinc supplementation did not significantly

> change total cholesterol, LDL, or triglyceride levels, but a

> significant decrease in HDL levels was observed – 6.9 millimoles per

> litre in the HCD group and 2.6 millimoles per litre in the HCD plus

> zinc group.

>

> This result appears to agree with last years report that zinc

> deficiency is associated with increased levels of HDL.

>

> " Since HDL is antiatherosclerotic, it seems unlikely that the

> protective effects of zinc are mediated by altering plasma lipid

> levels, " wrote lead author Minquin Ren.

>

> When the scientists investigated the formation of lesions in the

> rabbit aorta. They found that zinc supplementation significantly

> decreased the area of the lesions by 66 per cent, a result linked to a

> decrease in iron concentrations in the tissue, which has previously

> been reported to catalytically promote damaging free-radical reactions

> and the development of atherosclerosis.

>

> " Other evidence that zinc is influencing iron metabolism is that the

> red blood cell dropped in the HCD animals from 5.9 to 3.04bn per

> litre, whereas in the Zn-supplemented HCD animals the drop was

> smaller, from 5.9 to 4.07bn per litre, " said Ren.

>

> " Zinc may thus play a role in inhibiting lesion formation through the

> indirect prevention of iron-mediated free-radical damage, in that it

> decreases the iron content of the lesion, " concluded the researchers.

>

> Research is reported to be on-going to determine the mechanism behind

> the reported benefits.

>

[Guest guest]

Hi folks:

When I did a full one-month analysis of my nutrient intake at the

time I started CRON, zinc was one of the two elements for which I

showed up as deficient. But you don't want too much of it either.

Oregon State seems to be doing a decent job for dietary micronutrient

analysis. Here is what they say about zinc:

http://lpi.oregonstate.edu/infocenter/minerals/zinc/

A 50 mg tablet once a week brings my intake up to the RDA. But it

would be easy to go above the tolerable upper limit if you weren't

paying attention and took one tablet a day instead. Take a look at

the problems that result from too much zinc.

Rodney.

> >

> > Summary:

> >

> > Study done at National University of Singapore shows zinc

> > supplementation in animals reduces CVD. Zinc does not lower blood

> > cholesterol levels, but reduced aortic lesions by 66 per cent in

> > rabbits, by possibly influencing iron metabolism.

> >

> >

> > Link and full text:

> >

> >

> http://www.nutraingredients.com/news/ng.asp?

n=68177 & m=1NIE605 & c=lqeudkujayvvlpc

> >

> >

> > Zinc supplements could protect against CVD

> >

> > 05/06/2006- Zinc supplements may decrease the risk of heart

disease,

> > says an animal study from Singapore, results that appear to

support

> > previous benefits afforded by the mineral.

> >

> > Atherosclerosis is the process whereby fatty substances such as

> > cholesterol and calcium form plaque on the inner lining of an

artery,

> > causing them to harden. If enough builds up the plaque can reduce

> > blood flow through the artery, and if it ruptures blood clots can

> > form, which can block the flow of blood to the heart and cause a

heart

> > attack.

> >

> > Atherosclerosis occurs naturally in humans as part of the aging

> > process, but certain factors including high blood cholesterol,

> > smoking, high blood pressure, obesity and diabetes increase the

risk.

> >

> > A report last year in the Journal of Nutrition (Vol. 135, pp.

> > 2114-2118) reported that deficiency in zinc in mice was associated

> > with an increase in the risk of cardiovascular disease (CVD)

through

> > inflammation and a decreased level of compounds that protect

against

> > atherosclerosis.

> >

> > The new research, published on-line in the journal Free Radical

> > Biology and Medicine (doi: 10.1016/j.freeradbiomed.2006.03.017),

> > reports that supplementation of a high cholesterol diet with zinc

> > reduced the formation of lesions in the arteries of rabbits, but

the

> > effects were not linked to changes in cholesterol levels.

> >

> > Lead researcher Barry Halliwell and colleagues from the National

> > University of Singapore divided 18 white rabbits into three

groups.

> > The first was fed a normal diet (control), the second fed a

> > high-cholesterol diet (HCD, one per cent cholesterol), and the

third

> > was fed the HCD diet but was supplemented with zinc in the

carbonate

> > form (0.1 per cent).

> >

> > After eight weeks, the researchers measured blood levels of HDL,

LDL,

> > and total cholesterol, as well as triglyceride levels. The number

of

> > white and red blood cells were also measured.

> >

> > The researchers found that zinc supplementation did not

significantly

> > change total cholesterol, LDL, or triglyceride levels, but a

> > significant decrease in HDL levels was observed – 6.9 millimoles

per

> > litre in the HCD group and 2.6 millimoles per litre in the HCD

plus

> > zinc group.

> >

> > This result appears to agree with last years report that zinc

> > deficiency is associated with increased levels of HDL.

> >

> > " Since HDL is antiatherosclerotic, it seems unlikely that the

> > protective effects of zinc are mediated by altering plasma lipid

> > levels, " wrote lead author Minquin Ren.

> >

> > When the scientists investigated the formation of lesions in the

> > rabbit aorta. They found that zinc supplementation significantly

> > decreased the area of the lesions by 66 per cent, a result linked

to a

> > decrease in iron concentrations in the tissue, which has

previously

> > been reported to catalytically promote damaging free-radical

reactions

> > and the development of atherosclerosis.

> >

> > " Other evidence that zinc is influencing iron metabolism is that

the

> > red blood cell dropped in the HCD animals from 5.9 to 3.04bn per

> > litre, whereas in the Zn-supplemented HCD animals the drop was

> > smaller, from 5.9 to 4.07bn per litre, " said Ren.

> >

> > " Zinc may thus play a role in inhibiting lesion formation through

the

> > indirect prevention of iron-mediated free-radical damage, in that

it

> > decreases the iron content of the lesion, " concluded the

researchers.

> >

> > Research is reported to be on-going to determine the mechanism

behind

> > the reported benefits.

> >

>

[Guest guest]

Hi Rodney,

Any basic multi-vitamin should have 15 mg, which I believe is the RDA.

Zinc and Folic acid are 2 nutrients that came to my mind as being very

important when an " expert panel " at the National Institute of Health

released a report to the media recently that determined multi-vitamins

were worthless.

I think taking a multi-vit at least a few days per week is good

insurance to make sure you are not completely deficient in any one thing.

Dave

> > >

> > > Summary:

> > >

> > > Study done at National University of Singapore shows zinc

> > > supplementation in animals reduces CVD. Zinc does not lower blood

> > > cholesterol levels, but reduced aortic lesions by 66 per cent in

> > > rabbits, by possibly influencing iron metabolism.

> > >

> > >

> > > Link and full text:

> > >

> > >

> > http://www.nutraingredients.com/news/ng.asp?

> n=68177 & m=1NIE605 & c=lqeudkujayvvlpc

> > >

> > >

> > > Zinc supplements could protect against CVD

> > >

> > > 05/06/2006- Zinc supplements may decrease the risk of heart

> disease,

> > > says an animal study from Singapore, results that appear to

> support

> > > previous benefits afforded by the mineral.

> > >

> > > Atherosclerosis is the process whereby fatty substances such as

> > > cholesterol and calcium form plaque on the inner lining of an

> artery,

> > > causing them to harden. If enough builds up the plaque can reduce

> > > blood flow through the artery, and if it ruptures blood clots can

> > > form, which can block the flow of blood to the heart and cause a

> heart

> > > attack.

> > >

> > > Atherosclerosis occurs naturally in humans as part of the aging

> > > process, but certain factors including high blood cholesterol,

> > > smoking, high blood pressure, obesity and diabetes increase the

> risk.

> > >

> > > A report last year in the Journal of Nutrition (Vol. 135, pp.

> > > 2114-2118) reported that deficiency in zinc in mice was associated

> > > with an increase in the risk of cardiovascular disease (CVD)

> through

> > > inflammation and a decreased level of compounds that protect

> against

> > > atherosclerosis.

> > >

> > > The new research, published on-line in the journal Free Radical

> > > Biology and Medicine (doi: 10.1016/j.freeradbiomed.2006.03.017),

> > > reports that supplementation of a high cholesterol diet with zinc

> > > reduced the formation of lesions in the arteries of rabbits, but

> the

> > > effects were not linked to changes in cholesterol levels.

> > >

> > > Lead researcher Barry Halliwell and colleagues from the National

> > > University of Singapore divided 18 white rabbits into three

> groups.

> > > The first was fed a normal diet (control), the second fed a

> > > high-cholesterol diet (HCD, one per cent cholesterol), and the

> third

> > > was fed the HCD diet but was supplemented with zinc in the

> carbonate

> > > form (0.1 per cent).

> > >

> > > After eight weeks, the researchers measured blood levels of HDL,

> LDL,

> > > and total cholesterol, as well as triglyceride levels. The number

> of

> > > white and red blood cells were also measured.

> > >

> > > The researchers found that zinc supplementation did not

> significantly

> > > change total cholesterol, LDL, or triglyceride levels, but a

> > > significant decrease in HDL levels was observed – 6.9 millimoles

> per

> > > litre in the HCD group and 2.6 millimoles per litre in the HCD

> plus

> > > zinc group.

> > >

> > > This result appears to agree with last years report that zinc

> > > deficiency is associated with increased levels of HDL.

> > >

> > > " Since HDL is antiatherosclerotic, it seems unlikely that the

> > > protective effects of zinc are mediated by altering plasma lipid

> > > levels, " wrote lead author Minquin Ren.

> > >

> > > When the scientists investigated the formation of lesions in the

> > > rabbit aorta. They found that zinc supplementation significantly

> > > decreased the area of the lesions by 66 per cent, a result linked

> to a

> > > decrease in iron concentrations in the tissue, which has

> previously

> > > been reported to catalytically promote damaging free-radical

> reactions

> > > and the development of atherosclerosis.

> > >

> > > " Other evidence that zinc is influencing iron metabolism is that

> the

> > > red blood cell dropped in the HCD animals from 5.9 to 3.04bn per

> > > litre, whereas in the Zn-supplemented HCD animals the drop was

> > > smaller, from 5.9 to 4.07bn per litre, " said Ren.

> > >

> > > " Zinc may thus play a role in inhibiting lesion formation through

> the

> > > indirect prevention of iron-mediated free-radical damage, in that

> it

> > > decreases the iron content of the lesion, " concluded the

> researchers.

> > >

> > > Research is reported to be on-going to determine the mechanism

> behind

> > > the reported benefits.

> > >

> >

>

[Guest guest]

Hi Dave:

The problem I personally found with that approach was that for

calcium I would need to take 2.2 multivitamin pills a day to plug

that deficiency. But if I were to do that it would mean getting more

than anyone would want of other stuff which you cannot remove from

the pill.

In particular, when I first noticed this it was iron that was the

biggest problem. All males, and many females, certainly do not want

to overdo their iron intake. (I have since found a multivitamin that

contains zero iron). But, in addition, from diet I am massively

overdosed in vitamins A and C for example. So it really makes no

sense to take a whole lot more of those in a daily multivitamin.

Perhaps for people who are generally deficient in many nutrients then

a pill that contains some of everything may be perfect.

For me, I take one multivitamin pill a week, along with a few other

things ........ lycopene, aspirin, for example, and take the

specific amount I need for my two overt deficiencies.

fwiw. Whatever it takes in each particular situation.

Rodney.

> > >

> > > Correction to summary:

> > >

> > > " . . . .zinc supplementation did not significantly

> > > change total cholesterol, LDL, or triglyceride levels, but a

> > > significant decrease in HDL levels was observed. "

> > >

> > >

> > > --- In , " Dave " <davemaddux@>

wrote:

> > > >

> > > > Summary:

> > > >

> > > > Study done at National University of Singapore shows zinc

> > > > supplementation in animals reduces CVD. Zinc does not lower

blood

> > > > cholesterol levels, but reduced aortic lesions by 66 per cent

in

> > > > rabbits, by possibly influencing iron metabolism.

> > > >

> > > >

> > > > Link and full text:

> > > >

> > > >

> > > http://www.nutraingredients.com/news/ng.asp?

> > n=68177 & m=1NIE605 & c=lqeudkujayvvlpc

> > > >

> > > >

> > > > Zinc supplements could protect against CVD

> > > >

> > > > 05/06/2006- Zinc supplements may decrease the risk of heart

> > disease,

> > > > says an animal study from Singapore, results that appear to

> > support

> > > > previous benefits afforded by the mineral.

> > > >

> > > > Atherosclerosis is the process whereby fatty substances such

as

> > > > cholesterol and calcium form plaque on the inner lining of an

> > artery,

> > > > causing them to harden. If enough builds up the plaque can

reduce

> > > > blood flow through the artery, and if it ruptures blood clots

can

> > > > form, which can block the flow of blood to the heart and

cause a

> > heart

> > > > attack.

> > > >

> > > > Atherosclerosis occurs naturally in humans as part of the

aging

> > > > process, but certain factors including high blood cholesterol,

> > > > smoking, high blood pressure, obesity and diabetes increase

the

> > risk.

> > > >

> > > > A report last year in the Journal of Nutrition (Vol. 135, pp.

> > > > 2114-2118) reported that deficiency in zinc in mice was

associated

> > > > with an increase in the risk of cardiovascular disease (CVD)

> > through

> > > > inflammation and a decreased level of compounds that protect

> > against

> > > > atherosclerosis.

> > > >

> > > > The new research, published on-line in the journal Free

Radical

> > > > Biology and Medicine (doi:

10.1016/j.freeradbiomed.2006.03.017),

> > > > reports that supplementation of a high cholesterol diet with

zinc

> > > > reduced the formation of lesions in the arteries of rabbits,

but

> > the

> > > > effects were not linked to changes in cholesterol levels.

> > > >

> > > > Lead researcher Barry Halliwell and colleagues from the

National

> > > > University of Singapore divided 18 white rabbits into three

> > groups.

> > > > The first was fed a normal diet (control), the second fed a

> > > > high-cholesterol diet (HCD, one per cent cholesterol), and

the

> > third

> > > > was fed the HCD diet but was supplemented with zinc in the

> > carbonate

> > > > form (0.1 per cent).

> > > >

> > > > After eight weeks, the researchers measured blood levels of

HDL,

> > LDL,

> > > > and total cholesterol, as well as triglyceride levels. The

number

> > of

> > > > white and red blood cells were also measured.

> > > >

> > > > The researchers found that zinc supplementation did not

> > significantly

> > > > change total cholesterol, LDL, or triglyceride levels, but a

> > > > significant decrease in HDL levels was observed – 6.9

millimoles

> > per

> > > > litre in the HCD group and 2.6 millimoles per litre in the

HCD

> > plus

> > > > zinc group.

> > > >

> > > > This result appears to agree with last years report that zinc

> > > > deficiency is associated with increased levels of HDL.

> > > >

> > > > " Since HDL is antiatherosclerotic, it seems unlikely that the

> > > > protective effects of zinc are mediated by altering plasma

lipid

> > > > levels, " wrote lead author Minquin Ren.

> > > >

> > > > When the scientists investigated the formation of lesions in

the

> > > > rabbit aorta. They found that zinc supplementation

significantly

> > > > decreased the area of the lesions by 66 per cent, a result

linked

> > to a

> > > > decrease in iron concentrations in the tissue, which has

> > previously

> > > > been reported to catalytically promote damaging free-radical

> > reactions

> > > > and the development of atherosclerosis.

> > > >

> > > > " Other evidence that zinc is influencing iron metabolism is

that

> > the

> > > > red blood cell dropped in the HCD animals from 5.9 to 3.04bn

per

> > > > litre, whereas in the Zn-supplemented HCD animals the drop was

> > > > smaller, from 5.9 to 4.07bn per litre, " said Ren.

> > > >

> > > > " Zinc may thus play a role in inhibiting lesion formation

through

> > the

> > > > indirect prevention of iron-mediated free-radical damage, in

that

> > it

> > > > decreases the iron content of the lesion, " concluded the

> > researchers.

> > > >

> > > > Research is reported to be on-going to determine the

mechanism

> > behind

> > > > the reported benefits.

> > > >

> > >

> >

>