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Re: BP with CRON

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Rodney may have a point. Also it seems contradictory in the general

scientific context established by 50 years of CR data to have work

done where it is shown that one has to spend a lot of extra energy to

produce healthful physiological states. Pro exercise research seems to

behave as though CR does not exist, or that energy depletion leads to

greater vitality and that energy conservation (better dissipation of

energy in CR producing restful energized cellular states) also leads

to greater vitality??? Can both be the case?

>

> Hi folks:

>

> This from Dr. Mirkin:

>

> " Dear Dr. Mirkin: How does exercise lower blood pressure?

>

> If humans are like rats, those with high blood pressure

> will live longer when they exercise, even if their blood pressures

> do not return to normal. Rats can be bred to develop a genetic

> trait in which they develop high blood pressure, but when they

> exercise, they live much longer than the rats that do not exercise

> (Medicine & Science in Sports & Exercise, May 2006).

> Having high blood pressure can kill you. It increases your

> chances of suffering a heart attack, stroke, or kidney disease.

> Exercise usually lowers high blood pressure because high blood

> pressure usually is determined by blood volume. Anything that

> reduces blood volume also reduces high blood pressure. That's

> why diuretics are the most effective drugs to lower high blood

> pressure. Exercising for a few minutes usually does not lower

> high blood pressure, but exercising for several hours dehydrates

> you and usually does lower high blood pressure. This study

> shows that even if exercise does not lower high blood pressure in

> rats, it still helps them to live longer, and the same may apply to

> you. See http://www.drmirkin.com/heart/blood_pressure.html "

>

> If the above is correct, I wonder whether the astonishing decline in

> BP associated with CRON is accounted for simply by a greater

> reduction in blood volume (along with smaller everything else that

> seems to go with CR) than in the circulatory system's capacity to

> carry it?

>

> Rodney.

>

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One thing I believe is that joints wear out. And I don't see a nutrition solution for replacing knee cartilage. It's not just Ca.

If you get to 80 yo and need a knee replacement, well, that's something I don't want to do, so I look to preserve those joints. Surgery complications like blood clots, fibrillation, conflicting medications, not being able to get into an ER (which I used to take for granted).

And then consider that replacement is good for about 12 yrs. What do I/they do at 92 yo?

There is a level of exercise that benefits HTN. It doesn't have to be running 5 miles.

It might be as little as 20 mins walking, maybe just yoga.

Regards.

[ ] Re: BP with CRON

Rodney may have a point. Also it seems contradictory in the generalscientific context established by 50 years of CR data to have workdone where it is shown that one has to spend a lot of extra energy toproduce healthful physiological states. Pro exercise research seems tobehave as though CR does not exist, or that energy depletion leads togreater vitality and that energy conservation (better dissipation ofenergy in CR producing restful energized cellular states) also leadsto greater vitality??? Can both be the case?>> Hi folks:> > This from Dr. Mirkin:> > "Dear Dr. Mirkin: How does exercise lower blood pressure?> > If humans are like rats, those with high blood pressure > will live longer when they exercise, even if their blood pressures > do not return to normal. Rats can be bred to develop a genetic > trait in which they develop high blood pressure, but when they > exercise, they live much longer than the rats that do not exercise > (Medicine & Science in Sports & Exercise, May 2006). > Having high blood pressure can kill you. It increases your > chances of suffering a heart attack, stroke, or kidney disease. > Exercise usually lowers high blood pressure because high blood > pressure usually is determined by blood volume. Anything that > reduces blood volume also reduces high blood pressure. That's > why diuretics are the most effective drugs to lower high blood > pressure. Exercising for a few minutes usually does not lower > high blood pressure, but exercising for several hours dehydrates > you and usually does lower high blood pressure. This study > shows that even if exercise does not lower high blood pressure in > rats, it still helps them to live longer, and the same may apply to > you. See http://www.drmirkin.com/heart/blood_pressure.html"> > If the above is correct, I wonder whether the astonishing decline in > BP associated with CRON is accounted for simply by a greater > reduction in blood volume (along with smaller everything else that > seems to go with CR) than in the circulatory system's capacity to > carry it?> > Rodney.>

..

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Perhaps we are now getting far less exercise than nature intended for

us? What we here may consider " excessive " nature may have built into

us, over millions of years of evolution, the need to " move " , and move

often. Might be time to include the treadmill into a regular schedule.

" Our data support the idea that moderate physical exercise modulates

age-associated decline in the cell-mediated immunity of old

Sprague-Dawley rats significantly more than corresponding dietary

restrictions. "

Aging Clin Exp Res. 2006 Jun;18(3):179-86.

Impact of moderate physical exercise - in comparison with dietary

restrictions - on age-associated decline in cell-mediated immunity of

Sprague-Dawley rats.

Strasser A, Skalicky M, Viidik A.

Institute of Physiology, Department of Natural Sciences,

University of Veterinary Medicine Vienna, 1210 Wien, Austria.

alois.strasser@....

BACKGROUND AND AIMS: Moderate physical exercise and dietary

restriction have both been demonstrated to delay some of the adverse

effects of aging. In order to elucidate similarities or

dissimilarities in their mode of action on the aging immune system in

a comparative setting, we examined significant parameters of

cell-mediated immunity in Sprague- Dawley rats. METHODS: Male

Sprague-Dawley rats, housed individually, were divided into four

groups, living from 5 months (baseline group BL) up to 15, 19 and 23

months of age as follows: voluntary running in wheels (RW), food

restricted by feeding to pair weight with RW animals (PW), forced

running on treadmills , and sedentary controls with ad libitum

access to food (S1). White blood cell counts, capacity for lymphocyte

proliferation in response to Concanavalin A, and interleukin-2 (IL-2)

plasma concentrations were determined. RESULTS: White blood cell

counts and the cell numbers of lymphocytes, neutrophil and eosinophil

granulocytes were significantly lower in the older RW and PW groups.

We observed influences of forced exercise on lymphocyte proliferation:

blastogenic reactivity was higher in TM animals compared with RW and

PW animals at 23 months of age. Exclusively for RW animals, we found

lower plasma concentrations of IL-2 at 23 months. CONCLUSIONS: Our

data support the idea that moderate physical exercise modulates

age-associated decline in the cell-mediated immunity of old

Sprague-Dawley rats significantly more than corresponding dietary

restrictions.

PMID: 16804362

> >

> > Hi folks:

> >

> > This from Dr. Mirkin:

> >

> > " Dear Dr. Mirkin: How does exercise lower blood pressure?

> >

> > If humans are like rats, those with high blood pressure

> > will live longer when they exercise, even if their blood pressures

> > do not return to normal. Rats can be bred to develop a genetic

> > trait in which they develop high blood pressure, but when they

> > exercise, they live much longer than the rats that do not exercise

> > (Medicine & Science in Sports & Exercise, May 2006).

> > Having high blood pressure can kill you. It increases your

> > chances of suffering a heart attack, stroke, or kidney disease.

> > Exercise usually lowers high blood pressure because high blood

> > pressure usually is determined by blood volume. Anything that

> > reduces blood volume also reduces high blood pressure. That's

> > why diuretics are the most effective drugs to lower high blood

> > pressure. Exercising for a few minutes usually does not lower

> > high blood pressure, but exercising for several hours dehydrates

> > you and usually does lower high blood pressure. This study

> > shows that even if exercise does not lower high blood pressure in

> > rats, it still helps them to live longer, and the same may apply to

> > you. See http://www.drmirkin.com/heart/blood_pressure.html "

> >

> > If the above is correct, I wonder whether the astonishing decline in

> > BP associated with CRON is accounted for simply by a greater

> > reduction in blood volume (along with smaller everything else that

> > seems to go with CR) than in the circulatory system's capacity to

> > carry it?

> >

> > Rodney.

> >

>

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