CR decreases risk of death, but ...

[Guest guest]

I chuckled when I finished reading the abstract below. It turns out

that an ad libitum diabetic monkey outlived the CR monkeys, although

the median age of survival was higher for the CR monkeys.

Tony

Bodkin NL, TM, Ortmeyer HK, E, Hansen BC. Mortality

and morbidity in laboratory-maintained Rhesus monkeys and effects of

long-term dietary restriction. J Gerontol A Biol Sci Med Sci. 2003

Mar;58(3):212-9. PMID: 12634286

Mortality and morbidity were examined in 117 laboratory-maintained

rhesus monkeys studied over approximately 25 years (8

dietary-restricted [DR] and 109 ad libitum-fed [AL] monkeys). During

the study, 49 AL monkeys and 3 DR monkeys died. Compared with the DR

monkeys, the AL monkeys had a 2.6-fold increased risk of death.

Hyperinsulinemia led to a 3.7-fold increased risk of death (p <.05);

concordantly, the risk of death decreased by 7%, per unit increase in

insulin sensitivity (M). There was significant organ pathology in the

AL at death. The age at median survival in the AL was approximately 25

years compared with 32 years in the DR. The oldest monkey was a

diabetic female (AL) that lived to be 40 years of age. These results

suggest that dietary restriction leads to an increased average age of

death in primates, associated with the prevention of hyperinsulinemia

and the mitigation of age-related disease.

PMID: 12634286