Guest guest Posted May 13, 2006 Report Share Posted May 13, 2006 Hi folks: Here is one study on WBC that suggests numbers above 4.69 may be warning signs of inflammation: " WBC count, atherosclerosis and coronary risk factors. Hasegawa T, Negishi T, Deguchi M. Public Health Division, Takenozuka Public Health Center, Nishi Takenozuka, Adachi-ku, Tokyo, Japan. takahasegawa-circ@... An association between total white blood cell (WBC) count and the risk of coronary heart disease (CHD) is well known.In the present study, we investigated the relationship between WBC counts and other clinical factors including coronary risk factors, and periodontal disease in 1,620 adults. Factors found to have a significant association with the WBC count by multivariate regression analysis were age (negative association), body mass index (negative association), serum triglycerides, high-density lipoprotein cholesterol (negative association), and periodontal levels in the smoking group.Whereas, in the non-smoking group, systolic blood pressure and diastolic blood pressure (negative association) were included and serum triglycerides were excluded.Non-smoking subjects who were free of periodontal disease had a mean WBC count of 4.69 +/- 1.0 x 109 cells/l.This value can be used as a reference for WBC counts in healthy subjects.Our data suggest that values significantly higher than this could be an important indicator of inflammation derived from cigarette smoking or periodontal disease.Further study is necessary to determine whether an improvement in the WBC count could prevent the occurrence of CHD. PMID: 12409631 " --- In , " jwwright " <jwwright@...> wrote: > > > Clin Nephrol. 2005 Jan;63(1):22-34. > > > A low lymphocyte percentage is a predictor of mortality and hospitalization in hemodialysis patients. > > Kuwae N, Kopple JD, Kalantar-Zadeh K. > > Division of Nephrology and Hypertension, Research and Education Institute, Harbor-UCLA Medical Center, Torrance, CA 90509-2910, USA. > > OBJECTIVES: Lymphocyte percentage (LYM%), an independently measured value to reflect peripheral lymphocyte count and a possible nutritional marker, may be related to clinical outcome in maintenance dialysis (MHD) patients. STUDY DESIGN AND SETTING: We examined the associations of the baseline white blood cell count (WBC) and LYM% with 12-month mortality and three measures of hospitalization in a cohort of 1,283 MHD patients from 10 outpatient DaVita dialysis clinics in Los Angeles County, as well as in a subcohort of 372 MHD patients with additional measures of inflammation, nutrition and comorbidity. Multi-variate and Poisson models that included 13 co- variates including case-mix features, dialysis dose, blood hemoglobin and serum albumin were explored. RESULTS: Patients, aged 57.8 +/- 15.2 years, included 49% men and 49% diabetics. Baseline WBC was 7,353 +/- 2.427 per microl, and LYM% was 21.2 +/- 7.3%. LYM% had significant correlations with " malnutrition-inflammation score " and inverse correlations with serum interleukin-6. The WBC and LYM% had significant but opposite predicting values for mortality and hospitalization, indicating that a high WBC and a low LYM% were each independently associated with increased mortality. After dividing each variable into four quartiles, only the highest WBC quartile (> or = 8,500) but not the other middle two quartiles, predicted increased mortality. However, all three lower quartiles of LYM% vs. the highest quartile (based on quartile cutoffs of 16%, 20.3% and 25.5%) were significantly and progressively associated with greater risks of mortality and hospitalizations. The absolute lymphocyte count (LYM% times WBC/100) exhibited somewhat similar trends but its outcome predictability was not as strong as LYM%. CONCLUSIONS: A high WBC and a low LYM% are associated with significant increase in mortality and hospitalization in MHD patients. Lymphocyte percentage, compared to absolute lymphocyte count, appears to be a better nutritional and anti-inflammatory marker and a more sensitive predictor of mortality and hospitalization in MHD patients. > > PMID: 15678693 > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 13, 2006 Report Share Posted May 13, 2006 > [Original Message] > From: Rodney <perspect1111@...> > < > > Date: 5/12/2006 9:05:51 PM > Subject: [ ] Re: WBC and mortality > > Hi folks: > > Here is one study on WBC that suggests numbers above 4.69 may be > warning signs of inflammation: > > " WBC count, atherosclerosis and coronary risk factors. > > Hasegawa T, Negishi T, Deguchi M. > > Public Health Division, Takenozuka Public Health Center, Nishi > Takenozuka, Adachi-ku, Tokyo, Japan. takahasegawa-circ@... > > An association between total white blood cell (WBC) count and the > risk of coronary heart disease (CHD) is well known.In the present > study, we investigated the relationship between WBC counts and other > clinical factors including coronary risk factors, and periodontal > disease in 1,620 adults. Factors found to have a significant > association with the WBC count by multivariate regression analysis > were age (negative association), body mass index (negative > association), serum triglycerides, high-density lipoprotein > cholesterol (negative association), and periodontal levels in the > smoking group.Whereas, in the non-smoking group, systolic blood > pressure and diastolic blood pressure (negative association) were > included and serum triglycerides were excluded.Non-smoking subjects > who were free of periodontal disease had a mean WBC count of 4.69 +/- > 1.0 x 109 cells/l.This value can be used as a reference for WBC > counts in healthy subjects.Our data suggest that values significantly > higher than this could be an important indicator of inflammation > derived from cigarette smoking or periodontal disease.Further study > is necessary to determine whether an improvement in the WBC count > could prevent the occurrence of CHD. Isn't this saying that higher BMIs and higher BPs are associated with a lower WBC? Maco Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 13, 2006 Report Share Posted May 13, 2006 Hi Maco: Hmmmmm. (!) Thank you for pointing that out. Perhaps this is more complicated than I had figured? I wonder if the explanation MIGHT be that the variations found in that study of 1600 regular (non-CRON) people were comparatively small, but nevertheless statistically significant. While the changes in WBC in CRON are dramatic (they certainly seem to be), and in the other direction, in some cases. [A sort of analogy with Jeff's notes about some supposed 'low fat' diet studies, where 30% of calories from fat is supposed to represent a low fat diet?] But I certainly cannot provide an explanation as to why the apparent difference in the direction of the effect between the CRON experience and the data in this study. Rodney. --- In , " Maco " <mstewart@...> wrote: > > > > > > [Original Message] > > From: Rodney <perspect1111@...> > > < > > > Date: 5/12/2006 9:05:51 PM > > Subject: [ ] Re: WBC and mortality > > > > Hi folks: > > > > Here is one study on WBC that suggests numbers above 4.69 may be > > warning signs of inflammation: > > > > " WBC count, atherosclerosis and coronary risk factors. > > > > Hasegawa T, Negishi T, Deguchi M. > > > > Public Health Division, Takenozuka Public Health Center, Nishi > > Takenozuka, Adachi-ku, Tokyo, Japan. takahasegawa-circ@... > > > > An association between total white blood cell (WBC) count and the > > risk of coronary heart disease (CHD) is well known.In the present > > study, we investigated the relationship between WBC counts and other > > clinical factors including coronary risk factors, and periodontal > > disease in 1,620 adults. Factors found to have a significant > > association with the WBC count by multivariate regression analysis > > were age (negative association), body mass index (negative > > association), serum triglycerides, high-density lipoprotein > > cholesterol (negative association), and periodontal levels in the > > smoking group.Whereas, in the non-smoking group, systolic blood > > pressure and diastolic blood pressure (negative association) were > > included and serum triglycerides were excluded.Non-smoking subjects > > who were free of periodontal disease had a mean WBC count of 4.69 +/- > > 1.0 x 109 cells/l.This value can be used as a reference for WBC > > counts in healthy subjects.Our data suggest that values significantly > > higher than this could be an important indicator of inflammation > > derived from cigarette smoking or periodontal disease.Further study > > is necessary to determine whether an improvement in the WBC count > > could prevent the occurrence of CHD. > > Isn't this saying that higher BMIs and higher BPs are associated with > a lower WBC? > > Maco > Quote Link to comment Share on other sites More sharing options...
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