Guest guest Posted April 26, 2006 Report Share Posted April 26, 2006 --- In , Al Pater <old542000@...> wrote: > > Hi All, > > It seems that sea-foods have considerable levels of arsenic. > > ``Foods of marine origin are very rich in arsenic. Many species of bony fish contain > 2 to 8 ppm, oysters 3 to 10 ppm and mussels as high as 120 ppm of arsenic. Chemical These levels of arsenic may not be a bad thing, and could suppress cancer, arguing once again for moderation in all things: http://tinyurl.com/jtogq Arsenic inhibition of telomerase transcription leads to genetic instability Wen-Chien Chou1, Anita L. Hawkins2, F. Barrett3, Constance A. 2,4 and Chi V. Dang1,3,4 Arsenic is effective in the treatment of acute promyelocytic leukemia. Paradoxically, it is also carcinogenic. In the process of elucidating a mechanism of arsenic resistance in a leukemia cell line, NB4, we discovered that arsenic exposure causes chromosomal abnormalities, with a preponderance of end-to-end fusions. These chromosomal end fusions suggested that telomerase activity may be inhibited by arsenic. We found that arsenic inhibits transcription of the hTERT gene, which encodes the reverse transcriptase subunit of human telomerase. This effect may in part be explained by decreased c-Myc and Sp1 transcription factor activities. Decreased telomerase activity leads to chromosomal end lesions, which promote either genomic instability and carcinogenesis or cancer cell death. These phenomena may explain the seemingly paradoxical carcinogenic and antitumor effects of arsenic. Mike Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 26, 2006 Report Share Posted April 26, 2006 --- In , Al Pater <old542000@...> wrote: > > Hi All, > > It seems that sea-foods have considerable levels of arsenic. > > ``Foods of marine origin are very rich in arsenic. Many species of bony fish contain > 2 to 8 ppm, oysters 3 to 10 ppm and mussels as high as 120 ppm of arsenic. Chemical These levels of arsenic may not be a bad thing, and could suppress cancer, arguing once again for moderation in all things: http://tinyurl.com/jtogq Arsenic inhibition of telomerase transcription leads to genetic instability Wen-Chien Chou1, Anita L. Hawkins2, F. Barrett3, Constance A. 2,4 and Chi V. Dang1,3,4 Arsenic is effective in the treatment of acute promyelocytic leukemia. Paradoxically, it is also carcinogenic. In the process of elucidating a mechanism of arsenic resistance in a leukemia cell line, NB4, we discovered that arsenic exposure causes chromosomal abnormalities, with a preponderance of end-to-end fusions. These chromosomal end fusions suggested that telomerase activity may be inhibited by arsenic. We found that arsenic inhibits transcription of the hTERT gene, which encodes the reverse transcriptase subunit of human telomerase. This effect may in part be explained by decreased c-Myc and Sp1 transcription factor activities. Decreased telomerase activity leads to chromosomal end lesions, which promote either genomic instability and carcinogenesis or cancer cell death. These phenomena may explain the seemingly paradoxical carcinogenic and antitumor effects of arsenic. Mike Quote Link to comment Share on other sites More sharing options...
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