L-Deprenyl Increases Maximum Lifespan

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Surprisingly, underappreciated L-Deprenyl is the only

agent succesfully tested to extend maximum lifespan on

par with calorie restriction. The below review

proposes how it may do so.

Logan

Mech Ageing Dev. 2002 Apr 30;123(8):1087-100.

Why (--)deprenyl prolongs survivals of experimental

animals: increase of anti-oxidant enzymes in brain and

other body tissues as well as mobilization of various

humoral factors may lead to systemic anti-aging

effects.

Kitani K, Minami C, Isobe K, Maehara K, Kanai S, Ivy

GO, Carrillo MC.

National Institute for Longevity Sciences, 36-3,

Gengo, Morioka-cho, Obu-shi, Aichi 474-8522, Japan.

kitani@...

(--)Deprenyl, a monoamine oxidase B (MAO inhibitor

is known to upregulate activities of anti-oxidant

enzymes such as superoxide dismutase (SOD) and

catalase (CAT) in brain dopaminergic regions. The drug

is also the sole chemical which has been repeatedly

shown to increase life spans of several animal species

including rats, mice, hamsters and dogs. Further, the

drug was recently found to enhance anti-oxidant enzyme

activities not only in brain dopaminergic regions but

also in extra-brain tissues such as the heart,

kidneys, adrenal glands and the spleen. We and others

have also observed mobilization of many humoral

factors (interferone (INF)-gamma, tumor necrosis

factor (TNF)-alpha, interleukine (IL)-1beta,2,6,

trophic factors, etc.) and enhancement of natural

killer (NK) cell functions by (-)deprenyl

administration. An apparent extension of life spans of

experimental animals reported in the past may be

better explained by these new observations that

(-)deprenyl upregulate SOD and CAT activities not only

in the brain but also in extra-brain vital organs and

involve anti-tumorigenic as well as immunomodulatory

effect as well. These combined drug effects may lead

to the protection of the homeostatic regulations of

the neuro-immuno-endocrine axis of an organism against

aging.

Publication Types:

Review

PMID: 12044958 [PubMed - indexed for MEDLINE]

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