Re: Starch, Monounsaturated Fats and Prostate Cancer - prevention

[Guest guest]

The Coming Cancer Boom http://www.msnbc.msn.com/id/7325063/site/newsweek/page/2/

Lean body mass may lower prostate cancer riskA high lean body mass — calculated using an equation to determine body mass minus the fat — may lower the risk of prostate cancer, a new study indicates.

Prostate cancer is a hormone-related disease affected by a variety of other factors including genetics, age, ethnicity and family history.

The researchers found that the higher the lean body mass, the lower the risk of prostate cancer, especially in men with more aggressive disease or who were older when their cancer was diagnosed.

The investigators suspect that the inverse associations between higher lean body mass and prostate cancer risk may reflect the potentially protective effect of high levels of the male hormone androgen in patients with high lean body mass on the development and progression of prostate cancer.

http://www.msnbc.msn.com/id/10467131/from/RL.1/

In 2003, the National Cancer Institute (NCI) ended its Prostate Cancer Prevention Trial, a long-term study involving nearly 19,000 men to see if the Merck drug finasteride (marketed as Proscar) could reduce the risk of developing prostate cancer. Finasteride, which is already used to treat enlargement of the prostate gland, works by blocking the conversion of testosterone into a more potent hormone called dihydrotestosterone (or DHT) that's known to promote the growth of both normal and cancerous prostate cells. The researchers found that men who took finasteride cut their chances of getting prostate cancer by nearly 25 percent compared to men who took a placebo—a significant reduction. But they also noted one negative outcome in the trial. Those men who did develop prostate cancer while taking finasteride were more likely to have high-grade cancers, which are tougher to treat. “There was a clear decrease in the number of cases diagnosed [among those on finasteride] but with a small, but real, increase in the diagnoses of high-grade cancer,” says Ford, acting deputy director of NCI’s division of cancer prevention. Finasteride has not yet received FDA approval for use in preventing prostate cancer.

http://www.msnbc.msn.com/id/7325063/site/newsweek/

Not likely you'll get a biopsy unless PSA is high, and not likely you'll get Proscar without BPH.

Larsen: Textbook of Endocrinology, 10th ed.,

Genetic factors play an important role as well.[330] [331] [332] Twin studies suggest a genetic component in 44% of patients with prostate cancer.[42] [333] Men with prostate cancer report a family history of this tumor 3.1 to 4.3 times more commonly than healthy men.

Prostate Cancer Prevention

http://www.nci.nih.gov/cancertopics/pdq/prevention/prostate/Patient/page2

"Chemoprevention: Chemoprevention is the use of specific natural or man-made drugs, vitamins, or other agents to reverse, suppress, or prevent cancer growth. Several agents, including difluoromethylornithine (DFMO), isoflavonoids, selenium, vitamins D and E, and lycopene have shown potential benefit in studies. Further studies are needed to confirm this.

Diet and Lifestyle: The effect of diet on prostate cancer risk is under study. A diet high in fat, especially animal fat, may be associated with an increased risk of prostate cancer. More studies are needed to determine if a low-fat diet with more fruits and vegetables helps prevent prostate cancer.

Hormonal Prevention: Studies are underway to discover the role of certain drugs, such as finasteride, that reduce the amount of male hormone as preventive agents for prostate cancer.

Regards [ ] Starch, Monounsaturated Fats and Prostate CancerHi folks:Males should find this of interest:"CONCLUSIONS: Starch and monounsaturated fatty acids were directly associated with prostate cancer risk and polyunsaturated fatty acids were inversely associated."PMID: 15598953Free full text is available.Rodney.

[Guest guest]

The Coming Cancer Boom http://www.msnbc.msn.com/id/7325063/site/newsweek/page/2/

Lean body mass may lower prostate cancer riskA high lean body mass — calculated using an equation to determine body mass minus the fat — may lower the risk of prostate cancer, a new study indicates.

Prostate cancer is a hormone-related disease affected by a variety of other factors including genetics, age, ethnicity and family history.

The researchers found that the higher the lean body mass, the lower the risk of prostate cancer, especially in men with more aggressive disease or who were older when their cancer was diagnosed.

The investigators suspect that the inverse associations between higher lean body mass and prostate cancer risk may reflect the potentially protective effect of high levels of the male hormone androgen in patients with high lean body mass on the development and progression of prostate cancer.

http://www.msnbc.msn.com/id/10467131/from/RL.1/

In 2003, the National Cancer Institute (NCI) ended its Prostate Cancer Prevention Trial, a long-term study involving nearly 19,000 men to see if the Merck drug finasteride (marketed as Proscar) could reduce the risk of developing prostate cancer. Finasteride, which is already used to treat enlargement of the prostate gland, works by blocking the conversion of testosterone into a more potent hormone called dihydrotestosterone (or DHT) that's known to promote the growth of both normal and cancerous prostate cells. The researchers found that men who took finasteride cut their chances of getting prostate cancer by nearly 25 percent compared to men who took a placebo—a significant reduction. But they also noted one negative outcome in the trial. Those men who did develop prostate cancer while taking finasteride were more likely to have high-grade cancers, which are tougher to treat. “There was a clear decrease in the number of cases diagnosed [among those on finasteride] but with a small, but real, increase in the diagnoses of high-grade cancer,” says Ford, acting deputy director of NCI’s division of cancer prevention. Finasteride has not yet received FDA approval for use in preventing prostate cancer.

http://www.msnbc.msn.com/id/7325063/site/newsweek/

Not likely you'll get a biopsy unless PSA is high, and not likely you'll get Proscar without BPH.

Larsen: Textbook of Endocrinology, 10th ed.,

Genetic factors play an important role as well.[330] [331] [332] Twin studies suggest a genetic component in 44% of patients with prostate cancer.[42] [333] Men with prostate cancer report a family history of this tumor 3.1 to 4.3 times more commonly than healthy men.

Prostate Cancer Prevention

http://www.nci.nih.gov/cancertopics/pdq/prevention/prostate/Patient/page2

"Chemoprevention: Chemoprevention is the use of specific natural or man-made drugs, vitamins, or other agents to reverse, suppress, or prevent cancer growth. Several agents, including difluoromethylornithine (DFMO), isoflavonoids, selenium, vitamins D and E, and lycopene have shown potential benefit in studies. Further studies are needed to confirm this.

Diet and Lifestyle: The effect of diet on prostate cancer risk is under study. A diet high in fat, especially animal fat, may be associated with an increased risk of prostate cancer. More studies are needed to determine if a low-fat diet with more fruits and vegetables helps prevent prostate cancer.

Hormonal Prevention: Studies are underway to discover the role of certain drugs, such as finasteride, that reduce the amount of male hormone as preventive agents for prostate cancer.

Regards [ ] Starch, Monounsaturated Fats and Prostate CancerHi folks:Males should find this of interest:"CONCLUSIONS: Starch and monounsaturated fatty acids were directly associated with prostate cancer risk and polyunsaturated fatty acids were inversely associated."PMID: 15598953Free full text is available.Rodney.