Re: Ketones vs Amyotrophic lateral sclerosis

[Guest guest]

Al: Dr W's illness seemed to have started as a result of extreme conditions in the biosphere. There he was subjected to a radical diet change and rapid loss of weight as well as having to work just as hard as the others who were much younger. He was in his 60's at the time. He recounts all this in our file called " Dr Walford's posts " . More reason to be moderate in our CRON, especially those of us in our middle years. Remember the older mice died earlier not later as a result of extreme CRON.

Of course we can't be positive of any reason why Dr W contracted ALS, but he does conjecture on the above, and his exposure to toxic gases in the biosphere. It was after release from the biosphere that he started losing his balance.

on 5/3/2006 11:01 AM, Al Pater at old542000@... wrote:

Hi All,

Click for: ScienceDaily: High Caloric Diet May Prevent Progression Of Amyotrophic

Lateral Sclerosis (ALS)

http://www.sciencedaily.com/releases/2006/04/060417104324.htm

Dr. Walford died of ALS. His calorie restricted, high carbohydrate diet, it seems,

and was rather the opposite diet type found helpful in this study against ALS.

The details are in the below, including the free-to-all available pdf. However, the

diets were either ketogenic or not fed ad libitum. Weight was examined, not the

calories consumed. The sciencedaily report may have compared the ketogenic diet to

other diets that use CR in their description of the ketogenic diet as a high caloric

diet.

Zhao Z, Lange DJ, Voustianiouk A, Macgrogan D, Ho L, Suh J, Humala N, Thiyagarajan

M, Wang J, Pasinetti GM.

A ketogenic diet as a potential novel therapeutic intervention in amyotrophic

lateral sclerosis.

BMC Neurosci. 2006 Apr 3;7(1):29 [Epub ahead of print]

PMID: 16584562 http://tinyurl.com/prsm4 http://tinyurl.com/lw72c

-- Al Pater, alpater@...

__________________________________________________

[Guest guest]

Al: Dr W's illness seemed to have started as a result of extreme conditions in the biosphere. There he was subjected to a radical diet change and rapid loss of weight as well as having to work just as hard as the others who were much younger. He was in his 60's at the time. He recounts all this in our file called " Dr Walford's posts " . More reason to be moderate in our CRON, especially those of us in our middle years. Remember the older mice died earlier not later as a result of extreme CRON.

Of course we can't be positive of any reason why Dr W contracted ALS, but he does conjecture on the above, and his exposure to toxic gases in the biosphere. It was after release from the biosphere that he started losing his balance.

on 5/3/2006 11:01 AM, Al Pater at old542000@... wrote:

Hi All,

Click for: ScienceDaily: High Caloric Diet May Prevent Progression Of Amyotrophic

Lateral Sclerosis (ALS)

http://www.sciencedaily.com/releases/2006/04/060417104324.htm

Dr. Walford died of ALS. His calorie restricted, high carbohydrate diet, it seems,

and was rather the opposite diet type found helpful in this study against ALS.

The details are in the below, including the free-to-all available pdf. However, the

diets were either ketogenic or not fed ad libitum. Weight was examined, not the

calories consumed. The sciencedaily report may have compared the ketogenic diet to

other diets that use CR in their description of the ketogenic diet as a high caloric

diet.

Zhao Z, Lange DJ, Voustianiouk A, Macgrogan D, Ho L, Suh J, Humala N, Thiyagarajan

M, Wang J, Pasinetti GM.

A ketogenic diet as a potential novel therapeutic intervention in amyotrophic

lateral sclerosis.

BMC Neurosci. 2006 Apr 3;7(1):29 [Epub ahead of print]

PMID: 16584562 http://tinyurl.com/prsm4 http://tinyurl.com/lw72c

-- Al Pater, alpater@...

__________________________________________________

[Guest guest]

Hi folks:

Although the full text is supposed to be free, I haven't been able to

locate it.

Does anyone know what the foods are that are ketogenic when eaten in

large quantities?

Lack of oxygen (hypoxia) was a problem in Biosphere. Also about a

year ago I posted a link indicating that very large quantities of

sweet potatoes was in some way related to neurologic problems.

It looks like Dr. Walford may have been the unfortunate victim of the

confluence of a number of different phenomena.

Rodney.

>

> Hi All,

>

> Click for: ScienceDaily: High Caloric Diet May Prevent Progression

Of Amyotrophic

> Lateral Sclerosis (ALS)

>

> http://www.sciencedaily.com/releases/2006/04/060417104324.htm

>

> Dr. Walford died of ALS. His calorie restricted, high carbohydrate

diet, it seems,

> and was rather the opposite diet type found helpful in this study

against ALS.

>

> The details are in the below, including the free-to-all available

pdf. However, the

> diets were either ketogenic or not fed ad libitum. Weight was

examined, not the

> calories consumed. The sciencedaily report may have compared the

ketogenic diet to

> other diets that use CR in their description of the ketogenic diet

as a high caloric

> diet.

>

> Zhao Z, Lange DJ, Voustianiouk A, Macgrogan D, Ho L, Suh J, Humala

N, Thiyagarajan

> M, Wang J, Pasinetti GM.

> A ketogenic diet as a potential novel therapeutic intervention in

amyotrophic

> lateral sclerosis.

> BMC Neurosci. 2006 Apr 3;7(1):29 [Epub ahead of print]

> PMID: 16584562 http://tinyurl.com/prsm4 http://tinyurl.com/lw72c

>

> -- Al Pater, alpater@...

>

> __________________________________________________

>

[Guest guest]

Hi folks:

Although the full text is supposed to be free, I haven't been able to

locate it.

Does anyone know what the foods are that are ketogenic when eaten in

large quantities?

Lack of oxygen (hypoxia) was a problem in Biosphere. Also about a

year ago I posted a link indicating that very large quantities of

sweet potatoes was in some way related to neurologic problems.

It looks like Dr. Walford may have been the unfortunate victim of the

confluence of a number of different phenomena.

Rodney.

>

> Hi All,

>

> Click for: ScienceDaily: High Caloric Diet May Prevent Progression

Of Amyotrophic

> Lateral Sclerosis (ALS)

>

> http://www.sciencedaily.com/releases/2006/04/060417104324.htm

>

> Dr. Walford died of ALS. His calorie restricted, high carbohydrate

diet, it seems,

> and was rather the opposite diet type found helpful in this study

against ALS.

>

> The details are in the below, including the free-to-all available

pdf. However, the

> diets were either ketogenic or not fed ad libitum. Weight was

examined, not the

> calories consumed. The sciencedaily report may have compared the

ketogenic diet to

> other diets that use CR in their description of the ketogenic diet

as a high caloric

> diet.

>

> Zhao Z, Lange DJ, Voustianiouk A, Macgrogan D, Ho L, Suh J, Humala

N, Thiyagarajan

> M, Wang J, Pasinetti GM.

> A ketogenic diet as a potential novel therapeutic intervention in

amyotrophic

> lateral sclerosis.

> BMC Neurosci. 2006 Apr 3;7(1):29 [Epub ahead of print]

> PMID: 16584562 http://tinyurl.com/prsm4 http://tinyurl.com/lw72c

>

> -- Al Pater, alpater@...

>

> __________________________________________________

>

[Guest guest]

Hi Francesca:

It was post # 16412.

Rodney.

>

> Also about a

> year ago I posted a link indicating that very large quantities of

> sweet potatoes was in some way related to neurologic problems.

>

[Guest guest]

Hi Francesca:

It was post # 16412.

Rodney.

>

> Also about a

> year ago I posted a link indicating that very large quantities of

> sweet potatoes was in some way related to neurologic problems.

>

[Guest guest]

This is from the University of Texas:

" Long before chemists developed pesticides in the lab, many plants

evolved their own natural insecticides to protect themselves from

voracious insects. A cyanogenic glycoside is a cyanide-releasing

compound that occurs naturally in more than 3,000 species of plants.

The compounds are found in important food plants such as cassava,

almonds, lima beans, sweet potatoes, yams, white clover and sorghum.

Such plants make good food crops because they are relatively pest

free.

Engler explained that cyanogenic compounds are inactive by

themselves, but generally they are found with an enzyme that triggers

their release. When a feeding caterpillar bites a passion vine leaf,

it's like setting off a tiny chemical bomb. The enzyme breaks down,

joining the compound and releasing the poison, hydrogen cyanide. "

http://www.utexas.edu/opa/news/00newsreleases/nr_200007/nr_butterfly00

0712.html

http://snipurl.com/q01g

Rodney.

> >

> > Also about a

> > year ago I posted a link indicating that very large quantities of

> > sweet potatoes was in some way related to neurologic problems.

> >

>

[Guest guest]

This is from the University of Texas:

" Long before chemists developed pesticides in the lab, many plants

evolved their own natural insecticides to protect themselves from

voracious insects. A cyanogenic glycoside is a cyanide-releasing

compound that occurs naturally in more than 3,000 species of plants.

The compounds are found in important food plants such as cassava,

almonds, lima beans, sweet potatoes, yams, white clover and sorghum.

Such plants make good food crops because they are relatively pest

free.

Engler explained that cyanogenic compounds are inactive by

themselves, but generally they are found with an enzyme that triggers

their release. When a feeding caterpillar bites a passion vine leaf,

it's like setting off a tiny chemical bomb. The enzyme breaks down,

joining the compound and releasing the poison, hydrogen cyanide. "

http://www.utexas.edu/opa/news/00newsreleases/nr_200007/nr_butterfly00

0712.html

http://snipurl.com/q01g

Rodney.

> >

> > Also about a

> > year ago I posted a link indicating that very large quantities of

> > sweet potatoes was in some way related to neurologic problems.

> >

>

[Guest guest]

more info here:

http://www.fao.org/documents/show_cdr.asp?url_file=/docrep/T0207E/T0207E08.htm

> >

> > Also about a

> > year ago I posted a link indicating that very large quantities of

> > sweet potatoes was in some way related to neurologic problems.

> >

>

[Guest guest]

more info here:

http://www.fao.org/documents/show_cdr.asp?url_file=/docrep/T0207E/T0207E08.htm

> >

> > Also about a

> > year ago I posted a link indicating that very large quantities of

> > sweet potatoes was in some way related to neurologic problems.

> >

>

[Guest guest]

Hi All,

Few people develop amyotrophic lateral sclerosis. The risk of diabetes may be

larger. There may be a greater risk that is possibly from the loss of our

insulin-producing http://en.wikipedia.org/wiki/Beta_cells and, therefore,

related to

this discussion may be the pdf-available paper below.

Zhou YP, Grill V.

Long term exposure to fatty acids and ketones inhibits B-cell functions in human

pancreatic islets of Langerhans.

J Clin Endocrinol Metab. 1995 May;80(5):1584-90.

PMID: 7745004 http://tinyurl.com/kubmn

-- Al Pater, PhD; email: old542000@...

__________________________________________________

[Guest guest]

Hi All,

Few people develop amyotrophic lateral sclerosis. The risk of diabetes may be

larger. There may be a greater risk that is possibly from the loss of our

insulin-producing http://en.wikipedia.org/wiki/Beta_cells and, therefore,

related to

this discussion may be the pdf-available paper below.

Zhou YP, Grill V.

Long term exposure to fatty acids and ketones inhibits B-cell functions in human

pancreatic islets of Langerhans.

J Clin Endocrinol Metab. 1995 May;80(5):1584-90.

PMID: 7745004 http://tinyurl.com/kubmn

-- Al Pater, PhD; email: old542000@...

__________________________________________________