Guest guest Posted February 10, 2006 Report Share Posted February 10, 2006 >>So, obviously, milk is a food I take some trouble to de-emphasize. Based on this and other evidence, our recent and current studies on prostate and breast cancer are " dairyless " also. Jeff Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 10, 2006 Report Share Posted February 10, 2006 >>So, obviously, milk is a food I take some trouble to de-emphasize. Based on this and other evidence, our recent and current studies on prostate and breast cancer are " dairyless " also. Jeff Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 11, 2006 Report Share Posted February 11, 2006 Just to clarify, you say studies. Is that a change in your treatment protocol or are you just studying whether you will change it? Apparently you have been using say an Ornish type diet in the past? Are you treating PCa patients, or analyzing data from say the a program over the last 20 yrs to see if it avoids PCa? Regards. RE: [ ] Milk >>> Prostate Cancer >>So, obviously, milk is a food I take some trouble to de-emphasize.Based on this and other evidence, our recent and current studies on prostate and breast cancer are "dairyless" also.Jeff Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 11, 2006 Report Share Posted February 11, 2006 Just to clarify, you say studies. Is that a change in your treatment protocol or are you just studying whether you will change it? Apparently you have been using say an Ornish type diet in the past? Are you treating PCa patients, or analyzing data from say the a program over the last 20 yrs to see if it avoids PCa? Regards. RE: [ ] Milk >>> Prostate Cancer >>So, obviously, milk is a food I take some trouble to de-emphasize.Based on this and other evidence, our recent and current studies on prostate and breast cancer are "dairyless" also.Jeff Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 11, 2006 Report Share Posted February 11, 2006 We are doing studies in conjunction with Ornish on Breast and Prostate cancer. One was published rectently that was in the news. We are " modifying " the traditional approach as Ornish and Pritikin both allow 2 servings of non fat dairy a day. However, in these studies, the dairy is left out of the " treatment " group. We are also analyzing the blood fo people who have been on the program for 10 years or more to see how they compare Jeff ________________________________ From: on behalf of jwwright Sent: Sat 02/11/06 11:13 AM Subject: Re: [ ] Milk >>> Prostate Cancer Just to clarify, you say studies. Is that a change in your treatment protocol or are you just studying whether you will change it? Apparently you have been using say an Ornish type diet in the past? Are you treating PCa patients, or analyzing data from say the a program over the last 20 yrs to see if it avoids PCa? Regards. RE: [ ] Milk >>> Prostate Cancer >>So, obviously, milk is a food I take some trouble to de-emphasize. Based on this and other evidence, our recent and current studies on prostate and breast cancer are " dairyless " also. Jeff Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 11, 2006 Report Share Posted February 11, 2006 We are doing studies in conjunction with Ornish on Breast and Prostate cancer. One was published rectently that was in the news. We are " modifying " the traditional approach as Ornish and Pritikin both allow 2 servings of non fat dairy a day. However, in these studies, the dairy is left out of the " treatment " group. We are also analyzing the blood fo people who have been on the program for 10 years or more to see how they compare Jeff ________________________________ From: on behalf of jwwright Sent: Sat 02/11/06 11:13 AM Subject: Re: [ ] Milk >>> Prostate Cancer Just to clarify, you say studies. Is that a change in your treatment protocol or are you just studying whether you will change it? Apparently you have been using say an Ornish type diet in the past? Are you treating PCa patients, or analyzing data from say the a program over the last 20 yrs to see if it avoids PCa? Regards. RE: [ ] Milk >>> Prostate Cancer >>So, obviously, milk is a food I take some trouble to de-emphasize. Based on this and other evidence, our recent and current studies on prostate and breast cancer are " dairyless " also. Jeff Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 11, 2006 Report Share Posted February 11, 2006 Hi JW: LOL. I think it might be a tad more accurate to say that Ornish is using a Pritikin type diet! : ^ ))) Rodney. --- In , " jwwright " <jwwright@...> wrote: > > Just to clarify, you say studies. Is that a change in your treatment protocol or are you just studying whether you will change it? > Apparently you have been using say an Ornish type diet in the past? > Are you treating PCa patients, or analyzing data from say the a program over the last 20 yrs to see if it avoids PCa? > > Regards. > > RE: [ ] Milk >>> Prostate Cancer > > > >>So, obviously, milk is a food I take some trouble to de- emphasize. > > Based on this and other evidence, our recent and current studies on prostate and breast cancer are " dairyless " also. > > Jeff > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 11, 2006 Report Share Posted February 11, 2006 Hi JW: LOL. I think it might be a tad more accurate to say that Ornish is using a Pritikin type diet! : ^ ))) Rodney. --- In , " jwwright " <jwwright@...> wrote: > > Just to clarify, you say studies. Is that a change in your treatment protocol or are you just studying whether you will change it? > Apparently you have been using say an Ornish type diet in the past? > Are you treating PCa patients, or analyzing data from say the a program over the last 20 yrs to see if it avoids PCa? > > Regards. > > RE: [ ] Milk >>> Prostate Cancer > > > >>So, obviously, milk is a food I take some trouble to de- emphasize. > > Based on this and other evidence, our recent and current studies on prostate and breast cancer are " dairyless " also. > > Jeff > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 12, 2006 Report Share Posted February 12, 2006 Very cool study. Look forward to results. Do you supplement for calcium from other foods & /or supplements? Jeff Novick wrote: >We are doing studies in conjunction with Ornish on Breast and Prostate cancer. One was published rectently that was in the news. We are " modifying " the traditional approach as Ornish and Pritikin both allow 2 servings of non fat dairy a day. However, in these studies, the dairy is left out of the " treatment " group. We are also analyzing the blood fo people who have been on the program for 10 years or more to see how they compare > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 12, 2006 Report Share Posted February 12, 2006 Very cool study. Look forward to results. Do you supplement for calcium from other foods & /or supplements? Jeff Novick wrote: >We are doing studies in conjunction with Ornish on Breast and Prostate cancer. One was published rectently that was in the news. We are " modifying " the traditional approach as Ornish and Pritikin both allow 2 servings of non fat dairy a day. However, in these studies, the dairy is left out of the " treatment " group. We are also analyzing the blood fo people who have been on the program for 10 years or more to see how they compare > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 13, 2006 Report Share Posted February 13, 2006 >>Very cool study. Look forward to results. Do you supplement for calcium from other foods & /or supplements? There has been some results already published I have listed the abstracts below. At the center, we recommend 2 servings of non fat dairy or low fat soy dairy products a day or the inclusion of foods rich in calcium/calorie.. In the studies below, the dairy is eliminated but they are still taught how to consume a nutrient dense diet and as you can see below, a publihsed recent study alnalyzed the recommend " vegan " diet and found it to be adequate in all nutrients except Vit D, which was no suprise. Also, remember, while dairy may be a good source of calcium for some people, a very large percent of the human population on this planet can not digest dairy products, many of whom, have better bone health than we do (see stats below). So, for those who may choose to eliminate dairy, or do so due to allergies, ensuring adequate calcium is an important, but not difficult issue. Regards Jeff Lifestyle and health-related quality of life of men with prostate cancer managed with active surveillance. Urology. <javascript:AL_get(this, 'jour', 'Urology.');> 2006 Jan;67(1):125-30. Daubenmier JJ <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Daubenmier+JJ%22%5BAuthor%5D> , Weidner G <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Weidner+G%22%5BAuthor%5D> , Marlin R <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Marlin+R%22%5BAuthor%5D> , Crutchfield L <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Crutchfield+L%22%5BAuthor%5D> , Dunn-Emke S <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Dunn%2DEmke+S%22%5BAuthor%5D> , Chi C <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Chi+C%22%5BAuthor%5D> , Gao B <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Gao+B%22%5BAuthor%5D> , Carroll P <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Carroll+P%22%5BAuthor%5D> , Ornish D <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Ornish+D%22%5BAuthor%5D> . Preventive Medicine Research Institute, Sausalito, California 94965, USA. jennifer.daubenmier@... OBJECTIVES: To assess the impact of lifestyle on health-related quality of life (HR-QOL), perceived stress, and self-reported sexual function in men with early-stage prostate cancer electing active surveillance. METHODS: A total of 44 intervention and 49 usual-care control participants were enrolled in a randomized clinical trial examining the effects of lifestyle changes on prostate cancer progression. The intervention consisted of a low-fat, vegan diet, exercise, and stress management. Participants completed the Medical Outcomes Study Short Form-36 Health Status Survey (a measure of mental and physical HR-QOL), the Perceived Stress Scale, the Sexual Function subscale of the University of California, Los Angeles, Prostate Cancer Index, and measures of lifestyle behaviors (to yield an overall lifestyle index) at baseline and 12 months. The data were analyzed using analysis of variance for repeated measures. The relationship between lifestyle and QOL was also analyzed using multiple linear regression analyses. RESULTS: Intervention participants had significantly improved their lifestyle compared with controls at 12 months. The quality-of-life scores were high across groups and time points. However, a healthier lifestyle was related to better QOL at baseline. Participants in both groups who reported a healthier lifestyle also reported better mental and physical HR-QOL and sexual function. Furthermore, participants whose lifestyle improved over time showed enhanced physical HR-QOL and decreased perceived stress. CONCLUSIONS: Men who choose active surveillance for early-stage prostate cancer are able to make comprehensive lifestyle changes. Although the average QOL was already high in this sample, individuals who improved their lifestyle enhanced their QOL further. Intensive lifestyle changes may affect the progression of prostate cancer. J Urol. <javascript:AL_get(this, 'jour', 'J Urol.');> 2005 Sep;174(3):1065-9; discussion 1069-70 Ornish D <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Ornish+D%22%5BAuthor%5D> , Weidner G <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Weidner+G%22%5BAuthor%5D> , Fair WR <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Fair+WR%22%5BAuthor%5D> , Marlin R <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Marlin+R%22%5BAuthor%5D> , Pettengill EB <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Pettengill+EB%22%5BAuthor%5D> , Raisin CJ <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Raisin+CJ%22%5BAuthor%5D> , Dunn-Emke S <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Dunn%2DEmke+S%22%5BAuthor%5D> , Crutchfield L <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Crutchfield+L%22%5BAuthor%5D> , s FN <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22s+FN%22%5BAuthor%5D> , Barnard RJ <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Barnard+RJ%22%5BAuthor%5D> , Aronson WJ <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Aronson+WJ%22%5BAuthor%5D> , McCormac P <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22McCormac+P%22%5BAuthor%5D> , McKnight DJ <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22McKnight+DJ%22%5BAuthor%5D> , Fein JD <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Fein+JD%22%5BAuthor%5D> , Dnistrian AM <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Dnistrian+AM%22%5BAuthor%5D> , Weinstein J <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Weinstein+J%22%5BAuthor%5D> , Ngo TH <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Ngo+TH%22%5BAuthor%5D> , Mendell NR <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Mendell+NR%22%5BAuthor%5D> , Carroll PR <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Carroll+PR%22%5BAuthor%5D> . Department of Medicine, Preventive Medicine Research Institute, University of California-San Francisco, 94965, USA. d.ornish@... PURPOSE: Men with prostate cancer are often advised to make changes in diet and lifestyle, although the impact of these changes has not been well documented. Therefore, we evaluated the effects of comprehensive lifestyle changes on prostate specific antigen (PSA), treatment trends and serum stimulated LNCaP cell growth in men with early, biopsy proven prostate cancer after 1 year. MATERIALS AND METHODS: Patient recruitment was limited to men who had chosen not to undergo any conventional treatment, which provided an unusual opportunity to have a nonintervention randomized control group to avoid the confounding effects of interventions such as radiation, surgery or androgen deprivation therapy. A total of 93 volunteers with serum PSA 4 to 10 ng/ml and cancer Gleason scores less than 7 were randomly assigned to an experimental group that was asked to make comprehensive lifestyle changes or to a usual care control group. RESULTS: None of the experimental group patients but 6 control patients underwent conventional treatment due to an increase in PSA and/or progression of disease on magnetic resonance imaging. PSA decreased 4% in the experimental group but increased 6% in the control group (p = 0.016). The growth of LNCaP prostate cancer cells (American Type Culture Collection, Manassas, Virginia) was inhibited almost 8 times more by serum from the experimental than from the control group (70% vs 9%, p <0.001). Changes in serum PSA and also in LNCaP cell growth were significantly associated with the degree of change in diet and lifestyle. CONCLUSIONS: Intensive lifestyle changes may affect the progression of early, low grade prostate cancer in men. Further studies and longer term followup are warranted. A qualitative analysis of interviews of men with early stage prostate cancer: the Prostate Cancer Lifestyle Trial. Cancer Nurs. <javascript:AL_get(this, 'jour', 'Cancer Nurs.');> 2005 Mar-Apr;28(2):99-107. Kronenwetter C <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Kronenwetter+C%22%5BAuthor%5D> , Weidner G <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Weidner+G%22%5BAuthor%5D> , Pettengill E <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Pettengill+E%22%5BAuthor%5D> , Marlin R <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Marlin+R%22%5BAuthor%5D> , Crutchfield L <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Crutchfield+L%22%5BAuthor%5D> , McCormac P <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22McCormac+P%22%5BAuthor%5D> , Raisin CJ <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Raisin+CJ%22%5BAuthor%5D> , Ornish D <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Ornish+D%22%5BAuthor%5D> . Preventive Medicine Research Institute, Sausalito, CA 94965, USA. We conducted interviews with a subsample of men (n = 26) participating in the Prostate Cancer Lifestyle Trial (PCLT), who had biopsy-proven prostate cancer (Gleason grade <7; prostate-specific antigen 4-10 ng/mL) and chose " watchful waiting " after diagnosis. The PCLT aimed at improving diet, exercise, stress management practices, and group support within a peer community setting. The aims of this study were to examine psychological, emotional, spiritual, and social reactions to (a) a diagnosis of early stage prostate cancer and ( participation in the PCLT. Qualitative analyses were completed using MAXqda. Results indicated that the cancer diagnosis was met with anxiety, distress, and denial, or a " bump in the road " attitude. There was some indication that conflict with partners was exacerbated by the diagnosis. A significant component of the lifestyle intervention was involvement in the peer community. This community provided opportunities to experience connections with others facing similar health difficulties. Men generally expressed positive attitudes (emotionally, physically, and spiritually) about the lifestyle change, and felt that their participation in the program contributed to feelings of hope, optimism, and fighting spirit. Additionally, participants frequently mentioned increased comfort with emotional expression. Nutrient adequacy of a very low-fat vegan diet. J Am Diet Assoc. <javascript:AL_get(this, 'jour', 'J Am Diet Assoc.');> 2005 Sep;105(9):1442-6 Dunn-Emke SR <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Dunn%2DEmke+SR%22%5BAuthor%5D> , Weidner G <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Weidner+G%22%5BAuthor%5D> , Pettengill EB <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Pettengill+EB%22%5BAuthor%5D> , Marlin RO <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Marlin+RO%22%5BAuthor%5D> , Chi C <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Chi+C%22%5BAuthor%5D> , Ornish DM <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Ornish+DM%22%5BAuthor%5D> . Preventive Medicine Research Institute, Sausalito, CA, USA. This study assessed the nutrient adequacy of a very low-fat vegan diet. Thirty-nine men (mean age=65 years) with early stage prostate cancer who chose the " watchful waiting " approach to disease management, were instructed by a registered dietitian and a chef on following a very low-fat (10%) vegan diet with the addition of a fortified soy protein powdered beverage. Three-day food diaries, excluding vitamin and mineral supplements, were analyzed and nutrient values were compared against Dietary Reference Intakes (DRI). Mean dietary intake met the recommended DRIs. On the basis of the Adequate Intake standard, a less than adequate intake was observed for vitamin D. This demonstrates that a very low-fat vegan diet with comprehensive nutrition education emphasizing nutrient-fortified plant foods is nutritionally adequate, with the exception of vitamin D. Vitamin D supplementation, especially for those with limited sun exposure, can help assure nutritional adequacy. American Family Physician® > Vol. 65/No. 9 (May 1, 2002) TABLE 2 Prevalence of Primary Lactase Deficiency in Various Ethnic Groups ________________________________ Group Prevalence (%) Northern Europeans 2 to 15 American whites 6 to 22 Central Europeans 9 to 23 Indians (Indian subcontinent) Northern 20 to 30 Southern 60 to 70 Hispanics 50 to 80 Ashkenazi Jews 60 to 80 Blacks 60 to 80 American Indians 80 to 100 Asians 95 to 100 ________________________________ .. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 13, 2006 Report Share Posted February 13, 2006 >>Very cool study. Look forward to results. Do you supplement for calcium from other foods & /or supplements? There has been some results already published I have listed the abstracts below. At the center, we recommend 2 servings of non fat dairy or low fat soy dairy products a day or the inclusion of foods rich in calcium/calorie.. In the studies below, the dairy is eliminated but they are still taught how to consume a nutrient dense diet and as you can see below, a publihsed recent study alnalyzed the recommend " vegan " diet and found it to be adequate in all nutrients except Vit D, which was no suprise. Also, remember, while dairy may be a good source of calcium for some people, a very large percent of the human population on this planet can not digest dairy products, many of whom, have better bone health than we do (see stats below). So, for those who may choose to eliminate dairy, or do so due to allergies, ensuring adequate calcium is an important, but not difficult issue. Regards Jeff Lifestyle and health-related quality of life of men with prostate cancer managed with active surveillance. Urology. <javascript:AL_get(this, 'jour', 'Urology.');> 2006 Jan;67(1):125-30. Daubenmier JJ <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Daubenmier+JJ%22%5BAuthor%5D> , Weidner G <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Weidner+G%22%5BAuthor%5D> , Marlin R <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Marlin+R%22%5BAuthor%5D> , Crutchfield L <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Crutchfield+L%22%5BAuthor%5D> , Dunn-Emke S <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Dunn%2DEmke+S%22%5BAuthor%5D> , Chi C <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Chi+C%22%5BAuthor%5D> , Gao B <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Gao+B%22%5BAuthor%5D> , Carroll P <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Carroll+P%22%5BAuthor%5D> , Ornish D <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Ornish+D%22%5BAuthor%5D> . Preventive Medicine Research Institute, Sausalito, California 94965, USA. jennifer.daubenmier@... OBJECTIVES: To assess the impact of lifestyle on health-related quality of life (HR-QOL), perceived stress, and self-reported sexual function in men with early-stage prostate cancer electing active surveillance. METHODS: A total of 44 intervention and 49 usual-care control participants were enrolled in a randomized clinical trial examining the effects of lifestyle changes on prostate cancer progression. The intervention consisted of a low-fat, vegan diet, exercise, and stress management. Participants completed the Medical Outcomes Study Short Form-36 Health Status Survey (a measure of mental and physical HR-QOL), the Perceived Stress Scale, the Sexual Function subscale of the University of California, Los Angeles, Prostate Cancer Index, and measures of lifestyle behaviors (to yield an overall lifestyle index) at baseline and 12 months. The data were analyzed using analysis of variance for repeated measures. The relationship between lifestyle and QOL was also analyzed using multiple linear regression analyses. RESULTS: Intervention participants had significantly improved their lifestyle compared with controls at 12 months. The quality-of-life scores were high across groups and time points. However, a healthier lifestyle was related to better QOL at baseline. Participants in both groups who reported a healthier lifestyle also reported better mental and physical HR-QOL and sexual function. Furthermore, participants whose lifestyle improved over time showed enhanced physical HR-QOL and decreased perceived stress. CONCLUSIONS: Men who choose active surveillance for early-stage prostate cancer are able to make comprehensive lifestyle changes. Although the average QOL was already high in this sample, individuals who improved their lifestyle enhanced their QOL further. Intensive lifestyle changes may affect the progression of prostate cancer. J Urol. <javascript:AL_get(this, 'jour', 'J Urol.');> 2005 Sep;174(3):1065-9; discussion 1069-70 Ornish D <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Ornish+D%22%5BAuthor%5D> , Weidner G <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Weidner+G%22%5BAuthor%5D> , Fair WR <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Fair+WR%22%5BAuthor%5D> , Marlin R <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Marlin+R%22%5BAuthor%5D> , Pettengill EB <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Pettengill+EB%22%5BAuthor%5D> , Raisin CJ <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Raisin+CJ%22%5BAuthor%5D> , Dunn-Emke S <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Dunn%2DEmke+S%22%5BAuthor%5D> , Crutchfield L <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Crutchfield+L%22%5BAuthor%5D> , s FN <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22s+FN%22%5BAuthor%5D> , Barnard RJ <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Barnard+RJ%22%5BAuthor%5D> , Aronson WJ <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Aronson+WJ%22%5BAuthor%5D> , McCormac P <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22McCormac+P%22%5BAuthor%5D> , McKnight DJ <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22McKnight+DJ%22%5BAuthor%5D> , Fein JD <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Fein+JD%22%5BAuthor%5D> , Dnistrian AM <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Dnistrian+AM%22%5BAuthor%5D> , Weinstein J <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Weinstein+J%22%5BAuthor%5D> , Ngo TH <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Ngo+TH%22%5BAuthor%5D> , Mendell NR <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Mendell+NR%22%5BAuthor%5D> , Carroll PR <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Carroll+PR%22%5BAuthor%5D> . Department of Medicine, Preventive Medicine Research Institute, University of California-San Francisco, 94965, USA. d.ornish@... PURPOSE: Men with prostate cancer are often advised to make changes in diet and lifestyle, although the impact of these changes has not been well documented. Therefore, we evaluated the effects of comprehensive lifestyle changes on prostate specific antigen (PSA), treatment trends and serum stimulated LNCaP cell growth in men with early, biopsy proven prostate cancer after 1 year. MATERIALS AND METHODS: Patient recruitment was limited to men who had chosen not to undergo any conventional treatment, which provided an unusual opportunity to have a nonintervention randomized control group to avoid the confounding effects of interventions such as radiation, surgery or androgen deprivation therapy. A total of 93 volunteers with serum PSA 4 to 10 ng/ml and cancer Gleason scores less than 7 were randomly assigned to an experimental group that was asked to make comprehensive lifestyle changes or to a usual care control group. RESULTS: None of the experimental group patients but 6 control patients underwent conventional treatment due to an increase in PSA and/or progression of disease on magnetic resonance imaging. PSA decreased 4% in the experimental group but increased 6% in the control group (p = 0.016). The growth of LNCaP prostate cancer cells (American Type Culture Collection, Manassas, Virginia) was inhibited almost 8 times more by serum from the experimental than from the control group (70% vs 9%, p <0.001). Changes in serum PSA and also in LNCaP cell growth were significantly associated with the degree of change in diet and lifestyle. CONCLUSIONS: Intensive lifestyle changes may affect the progression of early, low grade prostate cancer in men. Further studies and longer term followup are warranted. A qualitative analysis of interviews of men with early stage prostate cancer: the Prostate Cancer Lifestyle Trial. Cancer Nurs. <javascript:AL_get(this, 'jour', 'Cancer Nurs.');> 2005 Mar-Apr;28(2):99-107. Kronenwetter C <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Kronenwetter+C%22%5BAuthor%5D> , Weidner G <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Weidner+G%22%5BAuthor%5D> , Pettengill E <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Pettengill+E%22%5BAuthor%5D> , Marlin R <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Marlin+R%22%5BAuthor%5D> , Crutchfield L <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Crutchfield+L%22%5BAuthor%5D> , McCormac P <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22McCormac+P%22%5BAuthor%5D> , Raisin CJ <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Raisin+CJ%22%5BAuthor%5D> , Ornish D <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Ornish+D%22%5BAuthor%5D> . Preventive Medicine Research Institute, Sausalito, CA 94965, USA. We conducted interviews with a subsample of men (n = 26) participating in the Prostate Cancer Lifestyle Trial (PCLT), who had biopsy-proven prostate cancer (Gleason grade <7; prostate-specific antigen 4-10 ng/mL) and chose " watchful waiting " after diagnosis. The PCLT aimed at improving diet, exercise, stress management practices, and group support within a peer community setting. The aims of this study were to examine psychological, emotional, spiritual, and social reactions to (a) a diagnosis of early stage prostate cancer and ( participation in the PCLT. Qualitative analyses were completed using MAXqda. Results indicated that the cancer diagnosis was met with anxiety, distress, and denial, or a " bump in the road " attitude. There was some indication that conflict with partners was exacerbated by the diagnosis. A significant component of the lifestyle intervention was involvement in the peer community. This community provided opportunities to experience connections with others facing similar health difficulties. Men generally expressed positive attitudes (emotionally, physically, and spiritually) about the lifestyle change, and felt that their participation in the program contributed to feelings of hope, optimism, and fighting spirit. Additionally, participants frequently mentioned increased comfort with emotional expression. Nutrient adequacy of a very low-fat vegan diet. J Am Diet Assoc. <javascript:AL_get(this, 'jour', 'J Am Diet Assoc.');> 2005 Sep;105(9):1442-6 Dunn-Emke SR <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Dunn%2DEmke+SR%22%5BAuthor%5D> , Weidner G <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Weidner+G%22%5BAuthor%5D> , Pettengill EB <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Pettengill+EB%22%5BAuthor%5D> , Marlin RO <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Marlin+RO%22%5BAuthor%5D> , Chi C <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Chi+C%22%5BAuthor%5D> , Ornish DM <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\ _Abstract & term=%22Ornish+DM%22%5BAuthor%5D> . Preventive Medicine Research Institute, Sausalito, CA, USA. This study assessed the nutrient adequacy of a very low-fat vegan diet. Thirty-nine men (mean age=65 years) with early stage prostate cancer who chose the " watchful waiting " approach to disease management, were instructed by a registered dietitian and a chef on following a very low-fat (10%) vegan diet with the addition of a fortified soy protein powdered beverage. Three-day food diaries, excluding vitamin and mineral supplements, were analyzed and nutrient values were compared against Dietary Reference Intakes (DRI). Mean dietary intake met the recommended DRIs. On the basis of the Adequate Intake standard, a less than adequate intake was observed for vitamin D. This demonstrates that a very low-fat vegan diet with comprehensive nutrition education emphasizing nutrient-fortified plant foods is nutritionally adequate, with the exception of vitamin D. Vitamin D supplementation, especially for those with limited sun exposure, can help assure nutritional adequacy. American Family Physician® > Vol. 65/No. 9 (May 1, 2002) TABLE 2 Prevalence of Primary Lactase Deficiency in Various Ethnic Groups ________________________________ Group Prevalence (%) Northern Europeans 2 to 15 American whites 6 to 22 Central Europeans 9 to 23 Indians (Indian subcontinent) Northern 20 to 30 Southern 60 to 70 Hispanics 50 to 80 Ashkenazi Jews 60 to 80 Blacks 60 to 80 American Indians 80 to 100 Asians 95 to 100 ________________________________ .. Quote Link to comment Share on other sites More sharing options...
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