Guest guest Posted March 9, 2006 Report Share Posted March 9, 2006 As a card carrying toxicologist, allow me to add my 2 cents: Paracelsus, the 15th century alchemist often considered the father of toxicology said (in short), " The dose makes the poison. " The long version was: " All things are poison and nothing (is) without poison; only the dose makes that a thing is no poison. " -Will Please provide a ref for that caffeine is toxic? Many things we eat are " toxic " , but to what degree? Forensic Sci Int. 2005 Oct 4;153(1):67-9. Fatal caffeine overdose: two case reports. Kerrigan S, Lindsey T. New Mexico Department of Health, Scientific Laboratory Division, Toxicology Bureau, P.O. Box 4700, Albuquerque, NM 87196-4700, USA. sarah.kerrigan@... Caffeine is a mild central nervous stimulant that occurs naturally in coffee beans, cocoa beans and tea leaves. In large doses, it can be profoundly toxic, resulting in arrhythmia, tachycardia, vomiting, convulsions, coma and death. The average cup of coffee or tea in the United States is reported to contain between 40 and 150 mg caffeine although specialty coffees may contain much higher doses. Over-the-counter supplements that are used to combat fatigue typically contain 100-200 mg caffeine per tablet and doses of 32-200mg are included in a variety of prescription drug mixtures. Fatal caffeine overdoses in adults are relatively rare and require the ingestion of a large quantity of the drug, typically in excess of 5 g. Over a period of approximately 12 months our office reported two cases of fatal caffeine intoxication. In the first case, the femoral blood of a 39-year-old female with a history of intravenous drug use contained 192 mg/L caffeine. In the second case, femoral blood from a 29-year-old male with a history of obesity and diabetes contained 567 mg/L caffeine. In both cases, the cause of death was ruled as caffeine intoxication and the manner of death was accidental. Publication Types: Case Reports PMID: 15935584 [ ] Re: Cocoa Consumption: a sobering study Yes, truly amazing findings. I wonder why they are so few studies directed toward an evaluation of theobromine toxicity (except in dogs). After all it is a stimulant closely related to caffeine. We know caffeine to be toxic. Economic reasons? One such study I found, out of india, ironically concludes that this important compound of cacoa is toxic to the heart muscle. What's the good of lowering blood pressure through consumption of cocoa when there are so many other ways, if it weakens the heart muscle? The ultimate effects of this practice are not likely to show for many years. http://www.ijp-online.com/article.asp?issn=0253-7613;year=1998;volume=30;issue=5;spage=339;epage=342;aulast=Eteng;type=0 > > > > Hi folks: > > > > Just 4.2 g a day of it. And it presumably included all kinds of > fat > > and sugar with it. So imagine how good the de-fatted sugar-free > > cocoa must be! > > > > > http://heart.healthcentersonline.com/newsstories/cocoaconsumershavelow > > erdiseaseriskstudy.cfm?nl=1 > > > > http://snipurl.com/nce3 > > > > Rodney. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 9, 2006 Report Share Posted March 9, 2006 As a card carrying toxicologist, allow me to add my 2 cents: Paracelsus, the 15th century alchemist often considered the father of toxicology said (in short), " The dose makes the poison. " The long version was: " All things are poison and nothing (is) without poison; only the dose makes that a thing is no poison. " -Will Please provide a ref for that caffeine is toxic? Many things we eat are " toxic " , but to what degree? Forensic Sci Int. 2005 Oct 4;153(1):67-9. Fatal caffeine overdose: two case reports. Kerrigan S, Lindsey T. New Mexico Department of Health, Scientific Laboratory Division, Toxicology Bureau, P.O. Box 4700, Albuquerque, NM 87196-4700, USA. sarah.kerrigan@... Caffeine is a mild central nervous stimulant that occurs naturally in coffee beans, cocoa beans and tea leaves. In large doses, it can be profoundly toxic, resulting in arrhythmia, tachycardia, vomiting, convulsions, coma and death. The average cup of coffee or tea in the United States is reported to contain between 40 and 150 mg caffeine although specialty coffees may contain much higher doses. Over-the-counter supplements that are used to combat fatigue typically contain 100-200 mg caffeine per tablet and doses of 32-200mg are included in a variety of prescription drug mixtures. Fatal caffeine overdoses in adults are relatively rare and require the ingestion of a large quantity of the drug, typically in excess of 5 g. Over a period of approximately 12 months our office reported two cases of fatal caffeine intoxication. In the first case, the femoral blood of a 39-year-old female with a history of intravenous drug use contained 192 mg/L caffeine. In the second case, femoral blood from a 29-year-old male with a history of obesity and diabetes contained 567 mg/L caffeine. In both cases, the cause of death was ruled as caffeine intoxication and the manner of death was accidental. Publication Types: Case Reports PMID: 15935584 [ ] Re: Cocoa Consumption: a sobering study Yes, truly amazing findings. I wonder why they are so few studies directed toward an evaluation of theobromine toxicity (except in dogs). After all it is a stimulant closely related to caffeine. We know caffeine to be toxic. Economic reasons? One such study I found, out of india, ironically concludes that this important compound of cacoa is toxic to the heart muscle. What's the good of lowering blood pressure through consumption of cocoa when there are so many other ways, if it weakens the heart muscle? The ultimate effects of this practice are not likely to show for many years. http://www.ijp-online.com/article.asp?issn=0253-7613;year=1998;volume=30;issue=5;spage=339;epage=342;aulast=Eteng;type=0 > > > > Hi folks: > > > > Just 4.2 g a day of it. And it presumably included all kinds of > fat > > and sugar with it. So imagine how good the de-fatted sugar-free > > cocoa must be! > > > > > http://heart.healthcentersonline.com/newsstories/cocoaconsumershavelow > > erdiseaseriskstudy.cfm?nl=1 > > > > http://snipurl.com/nce3 > > > > Rodney. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 9, 2006 Report Share Posted March 9, 2006 >> "The dose makes the poison." True, but Starbucks is sure making it easier to cross the line. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 9, 2006 Report Share Posted March 9, 2006 >> "The dose makes the poison." True, but Starbucks is sure making it easier to cross the line. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 11, 2006 Report Share Posted March 11, 2006 --- In , " Jeff Novick " <jnovick@...> wrote: > >> " The dose makes the poison. " > True, but Starbucks is sure making it easier to cross the line. *****But Starbucks doesn't coerce the consumer into consuming its beverage. It all seems to be a matter of self-control. Why do some people pay close attention to their health (both physical and/or mental), and others, who are aware of at least some of the risks of unwise behavior, treat their health in a cavalier manner? Some people appear to exercise control. Some don't. It seems to me that some of us are so wired as to be able to stop at 1 cup of java (or whatever our health limit is). Others, even when they " know " better, consume far more than is wise. Our ability to control our actions seems to arise out of the brain's programming. Who controls what gets programmed? Quote Link to comment Share on other sites More sharing options...
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