Re: Re: Systolic BP and Vitamin D - Episode 5

January 28, 2006

>> Almost no study of diet, including giving high sodium diet to raise blood

pressure, high potassium to

lower bp, or high calcium diet to lower bp, finds a change of more than 4-6 mm

Hg in systolic blood pressure.

Actually we have published it on several occasions as have others.. (absracts

below)

McDougall reported average BP reductions of 17/13 mm Hg for hypertensive

patients in a 12-day inpatient program with a vegan-vegetarian diet and

MacGregor found an average BP reductions of 16/9 mm Hg for hypertensive

patients on a very low-sodium diet

The Pritikin Center showed average reductions in systolic (19 mm Hg) and

diastolic (8 mm Hg) BP in 3 weeks.

Goldhammer showed an overall mean drop of 37.1/13.3 mm Hg during a water only

fasting program followed by a low fat, low sodium vegan diet.

The rice diet at duke has shown reductions on average of 17/8 and more

J Am Coll Nutr. <javascript:AL_get(this, 'jour', 'J Am Coll Nutr.');> 1995

Oct;14(5):491-6. Related Articles,

<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Display & dopt=pubmed\

_pubmed & from_uid=8522729> Links <javascript:PopUpMenu2_Set(Menu8522729);>

Rapid reduction of serum cholesterol and blood pressure by a twelve-day, very

low fat, strictly vegetarian diet.

McDougall J

<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\

_Abstract & term=%22McDougall+J%22%5BAuthor%5D> , Litzau K

<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\

_Abstract & term=%22Litzau+K%22%5BAuthor%5D> , Haver E

<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\

_Abstract & term=%22Haver+E%22%5BAuthor%5D> , Saunders V

<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\

_Abstract & term=%22Saunders+V%22%5BAuthor%5D> , Spiller GA

<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\

_Abstract & term=%22Spiller+GA%22%5BAuthor%5D> .

St. Helena Hospital, Deer Park, California 94576, USA.

OBJECTIVE: This study was conducted to demonstrate the effectiveness of a

strictly vegetarian, very low-fat diet on cardiac risk factor modification.

METHODS: Five hundred men and women, participants in an intensive 12-day live-in

program, were studied. The program focused on dietary modification, moderate

exercise, and stress management at a hospital-based health-center. RESULTS:

During this short time period, cardiac risk factors improved: there was an

average reduction of total serum cholesterol of 11% (p < 0.001), of blood

pressure of 6% (p < 0.001) and a weight loss of 2.5 kg for men and 1 kg for

women. Serum triglycerides did not increase except for two subgroups: females

age > or = 65 years with serum cholesterol < 6.5 mmol/L and for females 50 to 64

years with baseline serum cholesterol between 5.2-6.5 mmol/L. High-density

lipoprotein cholesterol measured on 66 subjects decreased by 19%. CONCLUSION: A

strict, very low-fat vegetarian diet free from all animal products combined with

lifestyle changes that include exercise and weight loss is an effective way to

lower serum cholesterol and blood pressure.

Lancet. <javascript:AL_get(this, 'jour', 'Lancet.');> 1989 Nov

25;2(8674):1244-7. Related Articles,

<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Display & dopt=pubmed\

_pubmed & from_uid=2573761> Links <javascript:PopUpMenu2_Set(Menu2573761);>

Double-blind study of three sodium intakes and long-term effects of sodium

restriction in essential hypertension.

MacGregor GA

<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\

_Abstract & term=%22MacGregor+GA%22%5BAuthor%5D> , Markandu ND

<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\

_Abstract & term=%22Markandu+ND%22%5BAuthor%5D> , Sagnella GA

<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\

_Abstract & term=%22Sagnella+GA%22%5BAuthor%5D> , Singer DR

<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\

_Abstract & term=%22Singer+DR%22%5BAuthor%5D> , Cappuccio FP

<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\

_Abstract & term=%22Cappuccio+FP%22%5BAuthor%5D> .

Department of Medicine, St 's Hospital Medical School, London.

20 patients with mild hypertension (average supine blood pressure without

treatment, 164/101 mm Hg) reduced their salt intake to 50 mmol (3 g) per day for

a month. They then entered a 3 month double-blind randomised crossover study of

three levels of sodium intake: 200, 100, and 50 mmol per day. Blood pressure was

significantly reduced on the middle and lowest sodium intakes. The average fall

in blood pressure from the highest to the lowest sodium intake was 16/9 mm Hg.

Patients continued to restrict their sodium intake for a further year. In 16 of

the 20 patients blood pressure remained well controlled with salt restriction

alone. Supine blood pressure at 1 year was 142/87 (SE 3/2) mm Hg with a 24 h

urinary sodium excretion of 54 (7) mmol. These results show a progressive blood

pressure fall as salt intake is reduced and that, in many patients with mild

essential hypertension, blood pressure can be controlled without the need for

drug therapy.

Effect of Diet and Exercise Intervention on Blood Pressure, Insulin, Oxidative

Stress, and Nitric Oxide Availability

Christian K. , PhD; Nosratola D. Vaziri, MD; R. Barnard, PhD

From the Department of Physiological Science, University of California, Los

Angeles (C.K.R., R.J.B.), and the Division of Nephrology and Hypertension,

Department of Medicine, University of California, Irvine (C.K.R., N.D.V.).

Correspondence to R. Barnard, Department of Physiological Science, UCLA,

P.O. 951527, Los Angeles, CA 90095-1527. E-mail jbarnard@...

Background- Diet and exercise can affect blood pressure and atherosclerotic

risk.

Methods and Results- The present study was designed to examine the effects of a

short-term, rigorous diet and exercise intervention on blood pressure,

hyperinsulinemia, and nitric oxide (NO) availability. Men (n=11) were placed on

a low-fat, high-fiber diet combined with daily exercise for 45 to 60 minutes for

3 weeks. Pre- and post fasting blood was drawn for serum lipid, insulin,

8-isoprostaglandin F2 (8-iso-PGF2), and glucose measurements. Anthropometric

parameters, blood pressure (BP), and 24-hour urinary NO metabolite excretion

(NOX), a marker of NO bioavailability, were measured. Systolic (P<0.01) and

diastolic BP (P<0.01) and 8-iso-PGF2 decreased (P<0.05), whereas urinary NOX

increased (P<0.05). There was a significant reduction in fasting insulin

(P<0.01) and a significant correlation between the decrease in serum insulin and

the increase in urinary NOX (r2=0.68, P<0.05). All fasting lipids decreased

significantly, and the total cholesterol to high-density lipoprotein cholesterol

ratio improved. Although body weight and body mass index (P<0.01) decreased,

obesity was still present and there were no correlations between the change in

body mass index and the change in insulin, BP, or urinary NOX.

Conclusions- This intervention resulted in dramatic improvements in BP,

oxidative stress, NO availability, and the metabolic profile within 3 weeks,

mitigating the risk for atherosclerosis progression and its clinical sequelae.

Medically Supervised Water-only Fasting in the Treatment of Hypertension

Alan Goldhamer, DC,a Lisle, PhD,b Banoo Parpia, PhD,c V. ,

MD,dand T. Colin , PhDe

ABSTRACT

Background: Hypertension-related diseases are the leading cause of morbidity and

mortality in industrially developed societies. Although antihypertensive drugs

are extensively used, dietary and lifestyle modifications also are effective in

the treatment of patients with hypertension. One such lifestyle intervention is

the use of medically supervised, water-only fasting as a safe and effective

means of normalizing blood pressure and initiating health-promoting behavioral

changes. Methods: One hundred seventy-four consecutive hypertensive patients

with blood pressure in excess of 140 mm Hg systolic, 90 mm Hg diastolic (140/90

mm Hg), or both were treated in an inpatient setting under medical supervision.

The treatment program consisted of a short prefasting period (approximately 2 to

3 days on average) during which food consumption was limited to fruits and

vegetables, followed by medically supervised water-only fasting (approximately

10 to 11 days on average) and a refeeding period (approximately 6 to 7 days on

average) introducing a low-fat, low-sodium, vegan diet. Results: Almost 90% of

the subjects achieved blood pressure less than 140/90 mm Hg by the end of the

treatment program. The average reduction in blood pressure was 37/13 mm Hg, with

the greatest decrease being observed for subjects with the most severe

hypertension. Patients with stage 3 hypertension (those with systolic blood

pressure greater than 180 mg Hg, diastolic blood pressure greater than 110 mg

Hg, or both) had an average reduction of 60/17 mm Hg at the conclusion of

treatment. All of the subjects who were taking antihypertensive medication at

entry (6.3% of the total sample) successfully discontinued the use of

medication. Conclusion: Medically supervised water-only fasting appears to be a

safe and effective means of normalizing blood pressure and may assist in

motivating health-promoting diet and lifestyle changes. (J Manipulative Physiol

Ther 2001;24:335-9)

Arch Intern Med. <javascript:AL_get(this, 'jour', 'Arch Intern Med.');> 1974

May;133(5):758-90. Related Articles,

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_pubmed & from_uid=4595399> Links <javascript:PopUpMenu2_Set(Menu4595399);>

Treatment of hypertensive vascular disease with rice diet.

Kempner W

<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\

_Abstract & term=%22Kempner+W%22%5BAuthor%5D> .

January 28, 2006