Re: Bradycardia with CR - another study in humans.

[Guest guest]

Here's another study:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=8589784 & query_hl=1 & itool=pubmed_docsum

Int J Obes Relat Metab Disord. 1995 Nov;19(11):817-9.

Electrocardiographic findings associated with very low calorie dieting.

Seim HC, JE, Pomeroy C, de Zwaan M.

Department of Family Practice and Community Health, University of

Minnesota, Minneapolis 55414, USA.

OBJECTIVE: To determine the safety of very low calorie diets (VLCD) in

regard to their effects on cardiac function. DESIGN: EKG changes were

analyzed for 126 women on a VLCD of 3349 kJ/d (800 kcal/d). EKGs were

done when the diet was begun, after 3 months of dieting, and at a 6

month follow up after being off the diet for 3 months. SETTING:

Subjects were solicited through advertisements and charged $1,000 for

participating after being screened for age, weight, and health status.

MAIN OUTCOME MEASURES: EKG QTc intervals, PR interval, QRS interval,

ST-T wave changes, and heart rate. RESULTS: Over one-fourth (27.0%) of

subjects had normal EKGs at all three time points studied. Sinus

bradycardia was the most common abnormality, observed in 60 subjects

(47.6%) on at least one of the three EKGs. Fifty-eight (46%) patients

had EKGs with ST-T wave abnormalities observed on at least one of the

EKGs. Eight subjects (6.4%) had prolonged QTc (more than one standard

deviation beyond the average for women) intervals on at least one EKG.

None of these eight persons had significant untoward medical

consequences. CONCLUSION: A VLCD diet of 3349 kJ/d (800 kcal/d) for up

to 3 months is not associated with significant electrocardiographic

abnormalities or clinical cardiac complications, provided the patients

have low cardiovascular risk at baseline.

[Guest guest]

Here's another study:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=8589784 & query_hl=1 & itool=pubmed_docsum

Int J Obes Relat Metab Disord. 1995 Nov;19(11):817-9.

Electrocardiographic findings associated with very low calorie dieting.

Seim HC, JE, Pomeroy C, de Zwaan M.

Department of Family Practice and Community Health, University of

Minnesota, Minneapolis 55414, USA.

OBJECTIVE: To determine the safety of very low calorie diets (VLCD) in

regard to their effects on cardiac function. DESIGN: EKG changes were

analyzed for 126 women on a VLCD of 3349 kJ/d (800 kcal/d). EKGs were

done when the diet was begun, after 3 months of dieting, and at a 6

month follow up after being off the diet for 3 months. SETTING:

Subjects were solicited through advertisements and charged $1,000 for

participating after being screened for age, weight, and health status.

MAIN OUTCOME MEASURES: EKG QTc intervals, PR interval, QRS interval,

ST-T wave changes, and heart rate. RESULTS: Over one-fourth (27.0%) of

subjects had normal EKGs at all three time points studied. Sinus

bradycardia was the most common abnormality, observed in 60 subjects

(47.6%) on at least one of the three EKGs. Fifty-eight (46%) patients

had EKGs with ST-T wave abnormalities observed on at least one of the

EKGs. Eight subjects (6.4%) had prolonged QTc (more than one standard

deviation beyond the average for women) intervals on at least one EKG.

None of these eight persons had significant untoward medical

consequences. CONCLUSION: A VLCD diet of 3349 kJ/d (800 kcal/d) for up

to 3 months is not associated with significant electrocardiographic

abnormalities or clinical cardiac complications, provided the patients

have low cardiovascular risk at baseline.

[Guest guest]

What is the real fear with Bradyc, like it gets so slow it doesn't pump?

A number like 45 is common in CR, as I recall.

Several years ago there was quite a discussion, CRONies saying it was common in exercise folks.

Best to heed medical advice, but people doing CR don't have a lot of medical science for humans backing them up. A different set of parameters, perhaps?

And I don't think anyone here is rec'ing 800 kcal diets.

Regards.

[ ] Re: Bradycardia with CR - another study in humans.

Here's another study:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstract & list_uids=8589784 & query_hl=1 & itool=pubmed_docsumInt J Obes Relat Metab Disord. 1995 Nov;19(11):817-9. Electrocardiographic findings associated with very low calorie dieting.Seim HC, JE, Pomeroy C, de Zwaan M.Department of Family Practice and Community Health, University ofMinnesota, Minneapolis 55414, USA.OBJECTIVE: To determine the safety of very low calorie diets (VLCD) inregard to their effects on cardiac function. DESIGN: EKG changes wereanalyzed for 126 women on a VLCD of 3349 kJ/d (800 kcal/d). EKGs weredone when the diet was begun, after 3 months of dieting, and at a 6month follow up after being off the diet for 3 months. SETTING:Subjects were solicited through advertisements and charged $1,000 forparticipating after being screened for age, weight, and health status.MAIN OUTCOME MEASURES: EKG QTc intervals, PR interval, QRS interval,ST-T wave changes, and heart rate. RESULTS: Over one-fourth (27.0%) ofsubjects had normal EKGs at all three time points studied. Sinusbradycardia was the most common abnormality, observed in 60 subjects(47.6%) on at least one of the three EKGs. Fifty-eight (46%) patientshad EKGs with ST-T wave abnormalities observed on at least one of theEKGs. Eight subjects (6.4%) had prolonged QTc (more than one standarddeviation beyond the average for women) intervals on at least one EKG.None of these eight persons had significant untoward medicalconsequences. CONCLUSION: A VLCD diet of 3349 kJ/d (800 kcal/d) for upto 3 months is not associated with significant electrocardiographicabnormalities or clinical cardiac complications, provided the patientshave low cardiovascular risk at baseline.

[Guest guest]

What is the real fear with Bradyc, like it gets so slow it doesn't pump?

A number like 45 is common in CR, as I recall.

Several years ago there was quite a discussion, CRONies saying it was common in exercise folks.

Best to heed medical advice, but people doing CR don't have a lot of medical science for humans backing them up. A different set of parameters, perhaps?

And I don't think anyone here is rec'ing 800 kcal diets.

Regards.

[ ] Re: Bradycardia with CR - another study in humans.

Here's another study:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstract & list_uids=8589784 & query_hl=1 & itool=pubmed_docsumInt J Obes Relat Metab Disord. 1995 Nov;19(11):817-9. Electrocardiographic findings associated with very low calorie dieting.Seim HC, JE, Pomeroy C, de Zwaan M.Department of Family Practice and Community Health, University ofMinnesota, Minneapolis 55414, USA.OBJECTIVE: To determine the safety of very low calorie diets (VLCD) inregard to their effects on cardiac function. DESIGN: EKG changes wereanalyzed for 126 women on a VLCD of 3349 kJ/d (800 kcal/d). EKGs weredone when the diet was begun, after 3 months of dieting, and at a 6month follow up after being off the diet for 3 months. SETTING:Subjects were solicited through advertisements and charged $1,000 forparticipating after being screened for age, weight, and health status.MAIN OUTCOME MEASURES: EKG QTc intervals, PR interval, QRS interval,ST-T wave changes, and heart rate. RESULTS: Over one-fourth (27.0%) ofsubjects had normal EKGs at all three time points studied. Sinusbradycardia was the most common abnormality, observed in 60 subjects(47.6%) on at least one of the three EKGs. Fifty-eight (46%) patientshad EKGs with ST-T wave abnormalities observed on at least one of theEKGs. Eight subjects (6.4%) had prolonged QTc (more than one standarddeviation beyond the average for women) intervals on at least one EKG.None of these eight persons had significant untoward medicalconsequences. CONCLUSION: A VLCD diet of 3349 kJ/d (800 kcal/d) for upto 3 months is not associated with significant electrocardiographicabnormalities or clinical cardiac complications, provided the patientshave low cardiovascular risk at baseline.