RE: Studies Show Grapefruit Fights Battle of the Bulge and More

[Guest guest]

Thanks Logan,

But I wonder how grapefruit fights obesity when it contains chemicals which promote "bioavailability". It's the chemicals that cause a medication to be absorbed more quickly and dumped, so the medication's effect is altered. Yes it will raise blood pressure, more than if I hadn't taken the mediation.

In conclusion, pretreatment of naringin enhanced the oral bioavailability of verapamil. Based on these results, the verapamil dosage should be adjusted when given with naringin or a naringin-containing dietary supplement. PMID: 16491851

At least 20 other drugs have been assessed for an interaction with grapefruit juice metabolism mediated by CYP3A4 appear affected by grapefruit juice. Subsequent investigations showed that grapefruit juice acted by reducing presystemic felodipine metabolism through selective post-translational down regulation of cytochrome P450 3A4 (CYP3A4) expression in the intestinal wall. Clinically relevant interactions seem likely for most dihydropyridines, terfenadine, saquinavir, cyclosporin, midazolam, triazolam and verapamil and may also occur with lovastatin, cisapride and astemizole. ....Although in vitro findings support the flavonoid, naringin, or the furanocoumarin, 6', 7'-dihydroxybergamottin, as being active ingredients. A recent investigation indicated that neither of these substances made a major contribution to grapefruit juice-drug interactions in humans (Guo et al., 2000). PMID: 16380358

Regards.

[ ] Studies Show Grapefruit Fights Battle of the Bulge and More

Studies Show Grapefruit Fights Battle of the Bulge andMore; Three Published Reports Coincide with NationalNutrition Month® Business Wire 03-03-06 SHERMAN OAKS, Calif., Mar 03, 2006 (BUSINESS WIRE) --From weight loss to heart health to diseaseprotection, three recent studies confirm the multiplehealth benefits of grapefruit. With March designatedas National Nutrition Month®, it's an opportune timeto highlight the benefits of the tangy nutrient-packedfruit, which unlike some citrus fruits is availableyear round. Human Study Confirms Grapefruit Promotes Weight Loss A study published in the March 2006 issue of theJournal of Medicinal Foods supports the long-heldbelief that grapefruit is useful in the battle of thebulge. Dr. Ken Fujioka from Scripps Clinic in SanDiego conducted a 12-week study of 100 obese men andwomen and found that consuming one half grapefruitbefore meals resulted in an average weight loss of 3.6pounds with some participants losing up to 10 pounds.Individuals who ate the grapefruit had significantlylower levels of insulin in their blood, which theresearchers speculate resulted in the weight loss. Thesmaller the amount of insulin in the blood after ameal, the more efficiently the body uses food forenergy rather than storing it as fat. The researchersfurther speculated that a natural plant compound ingrapefruit, not the fiber content, was responsible forthe weight loss since those who consumed grapefruitjuice also lost weight despite the lack of fiber. Grapefruit Lowers Cholesterol Levels Researchers in Israel found that red and whitegrapefruit contain powerful antioxidants that may helpreduce the risk of heart disease. Published in theFebruary 2006 issue of the Journal of Agricultural andFood Chemistry(1) scientists found that serving heartbypass patients the equivalent of one grapefruit a daysignificantly reduced cholesterol levels. The studyincluded 57 patients, both men and women, who recentlyhad coronary bypass surgery and failed to respond tocholesterol-lowering medication. Red grapefruit wasespecially effective, reducing cholesterol by 15percent and triglycerides (a type of fat thatincreases the risk of heart disease) by 17 percent. Compound in Grapefruit May Protect Against ProstateCancer A laboratory study conducted by researchers at UCLAand Zhongshan University in China discovered thatnaringenin -- a beneficial plant compound ingrapefruit and oranges -- helped repair damagedgenetic material (DNA) in human prostate cancer cells.DNA repair is an important factor in cancer preventionsince it stops cancer cells from multiplying. Theresearch was published in the February 2006 issue ofthe Journal of Nutritional Biochemistry(2). Scientistsnoted that DNA repair by naringenin might contributeto the cancer-fighting effects associated with a diethigh in fruits and vegetables. At only 60 calories, one half a grapefruit is anexcellent source of Vitamin C and fiber and alsooffers Vitamin A, potassium and folate. Grapefruit andother citrus fruits are included in the dietaryprograms of some of the world's leading nutritionorganizations including USDA's Dietary Guidelines forAmericans, the Produce for Better Health (PBH)Foundation's 5 A Day Program, American HeartAssociation, American Cancer Society and the NationalCancer Institute. About Sunkist Growers As one of the world's oldest and largest citrusmarketing cooperatives, Sunkist Growers is owned bymore than 6,000 citrus growers in California andArizona, most of whom are small family farmersharvesting oranges, lemons and grapefruit. For morecitrus information, nutrition tips and healthyrecipes, visit www.sunkist.com. (1) Gorinstein S, Caspi A, Libman I, et al. RedGrapefruit Positively Influences Serum TryglycerideLevel in Patients Suffering from Coronary Atherosclerosis: Studies in Vitro and inHumans. J. Agric Food Chem. ASAP Web Article releasedFeb. 3, 2006. (2) Gao K, Henning SM, Niu Y, et al. Thecitrus flavonoid naringenin stimulates DNA repair inprostate cancer cells. J of Nutr Biochem 2006;17(2):89-95. SOURCE: Sunkist Nutrition Bureau CONTACT: Integrated Marketing Works for SunkistNutrition Bureau Randolph or Liz Wilkins,949-833-3822 Srandolph@...Lwilkins@... __________________________________________________

[Guest guest]

Thanks Logan,

But I wonder how grapefruit fights obesity when it contains chemicals which promote "bioavailability". It's the chemicals that cause a medication to be absorbed more quickly and dumped, so the medication's effect is altered. Yes it will raise blood pressure, more than if I hadn't taken the mediation.

In conclusion, pretreatment of naringin enhanced the oral bioavailability of verapamil. Based on these results, the verapamil dosage should be adjusted when given with naringin or a naringin-containing dietary supplement. PMID: 16491851

At least 20 other drugs have been assessed for an interaction with grapefruit juice metabolism mediated by CYP3A4 appear affected by grapefruit juice. Subsequent investigations showed that grapefruit juice acted by reducing presystemic felodipine metabolism through selective post-translational down regulation of cytochrome P450 3A4 (CYP3A4) expression in the intestinal wall. Clinically relevant interactions seem likely for most dihydropyridines, terfenadine, saquinavir, cyclosporin, midazolam, triazolam and verapamil and may also occur with lovastatin, cisapride and astemizole. ....Although in vitro findings support the flavonoid, naringin, or the furanocoumarin, 6', 7'-dihydroxybergamottin, as being active ingredients. A recent investigation indicated that neither of these substances made a major contribution to grapefruit juice-drug interactions in humans (Guo et al., 2000). PMID: 16380358

Regards.

[ ] Studies Show Grapefruit Fights Battle of the Bulge and More

Studies Show Grapefruit Fights Battle of the Bulge andMore; Three Published Reports Coincide with NationalNutrition Month® Business Wire 03-03-06 SHERMAN OAKS, Calif., Mar 03, 2006 (BUSINESS WIRE) --From weight loss to heart health to diseaseprotection, three recent studies confirm the multiplehealth benefits of grapefruit. With March designatedas National Nutrition Month®, it's an opportune timeto highlight the benefits of the tangy nutrient-packedfruit, which unlike some citrus fruits is availableyear round. Human Study Confirms Grapefruit Promotes Weight Loss A study published in the March 2006 issue of theJournal of Medicinal Foods supports the long-heldbelief that grapefruit is useful in the battle of thebulge. Dr. Ken Fujioka from Scripps Clinic in SanDiego conducted a 12-week study of 100 obese men andwomen and found that consuming one half grapefruitbefore meals resulted in an average weight loss of 3.6pounds with some participants losing up to 10 pounds.Individuals who ate the grapefruit had significantlylower levels of insulin in their blood, which theresearchers speculate resulted in the weight loss. Thesmaller the amount of insulin in the blood after ameal, the more efficiently the body uses food forenergy rather than storing it as fat. The researchersfurther speculated that a natural plant compound ingrapefruit, not the fiber content, was responsible forthe weight loss since those who consumed grapefruitjuice also lost weight despite the lack of fiber. Grapefruit Lowers Cholesterol Levels Researchers in Israel found that red and whitegrapefruit contain powerful antioxidants that may helpreduce the risk of heart disease. Published in theFebruary 2006 issue of the Journal of Agricultural andFood Chemistry(1) scientists found that serving heartbypass patients the equivalent of one grapefruit a daysignificantly reduced cholesterol levels. The studyincluded 57 patients, both men and women, who recentlyhad coronary bypass surgery and failed to respond tocholesterol-lowering medication. Red grapefruit wasespecially effective, reducing cholesterol by 15percent and triglycerides (a type of fat thatincreases the risk of heart disease) by 17 percent. Compound in Grapefruit May Protect Against ProstateCancer A laboratory study conducted by researchers at UCLAand Zhongshan University in China discovered thatnaringenin -- a beneficial plant compound ingrapefruit and oranges -- helped repair damagedgenetic material (DNA) in human prostate cancer cells.DNA repair is an important factor in cancer preventionsince it stops cancer cells from multiplying. Theresearch was published in the February 2006 issue ofthe Journal of Nutritional Biochemistry(2). Scientistsnoted that DNA repair by naringenin might contributeto the cancer-fighting effects associated with a diethigh in fruits and vegetables. At only 60 calories, one half a grapefruit is anexcellent source of Vitamin C and fiber and alsooffers Vitamin A, potassium and folate. Grapefruit andother citrus fruits are included in the dietaryprograms of some of the world's leading nutritionorganizations including USDA's Dietary Guidelines forAmericans, the Produce for Better Health (PBH)Foundation's 5 A Day Program, American HeartAssociation, American Cancer Society and the NationalCancer Institute. About Sunkist Growers As one of the world's oldest and largest citrusmarketing cooperatives, Sunkist Growers is owned bymore than 6,000 citrus growers in California andArizona, most of whom are small family farmersharvesting oranges, lemons and grapefruit. For morecitrus information, nutrition tips and healthyrecipes, visit www.sunkist.com. (1) Gorinstein S, Caspi A, Libman I, et al. RedGrapefruit Positively Influences Serum TryglycerideLevel in Patients Suffering from Coronary Atherosclerosis: Studies in Vitro and inHumans. J. Agric Food Chem. ASAP Web Article releasedFeb. 3, 2006. (2) Gao K, Henning SM, Niu Y, et al. Thecitrus flavonoid naringenin stimulates DNA repair inprostate cancer cells. J of Nutr Biochem 2006;17(2):89-95. SOURCE: Sunkist Nutrition Bureau CONTACT: Integrated Marketing Works for SunkistNutrition Bureau Randolph or Liz Wilkins,949-833-3822 Srandolph@...Lwilkins@... __________________________________________________

[Guest guest]

>>>A study published in the March 2006 issue of the

Journal of Medicinal Foods supports the long-held

belief that grapefruit is useful in the battle of the

bulge. Dr. Ken Fujioka from Scripps Clinic in San

Diego conducted a 12-week study of 100 obese men and

women and found that consuming one half grapefruit

before meals resulted in an average weight loss of 3.6

pounds with some participants losing up to 10 pounds.

Maybe due to the satiation/bulk factor. Grapefruit is very low in calorie

density and filling. And B Rolls has shown time and time again, that starting

meals with foods low in calorie density, lower the total caloric intake at the

meal. In her studies, it was 7-12%.

>>Individuals who ate the grapefruit had significantly

lower levels of insulin in their blood, which the

researchers speculate resulted in the weight loss.

The lower insulin would more likely be due to the lower caloric intake and the

higher fiber due to the grapefruit (and maybe lower total sugar intake).

Weight loss is due to reduced caloric intake, not lowered insulin.

Jeff

[Guest guest]

>>>A study published in the March 2006 issue of the

Journal of Medicinal Foods supports the long-held

belief that grapefruit is useful in the battle of the

bulge. Dr. Ken Fujioka from Scripps Clinic in San

Diego conducted a 12-week study of 100 obese men and

women and found that consuming one half grapefruit

before meals resulted in an average weight loss of 3.6

pounds with some participants losing up to 10 pounds.

Maybe due to the satiation/bulk factor. Grapefruit is very low in calorie

density and filling. And B Rolls has shown time and time again, that starting

meals with foods low in calorie density, lower the total caloric intake at the

meal. In her studies, it was 7-12%.

>>Individuals who ate the grapefruit had significantly

lower levels of insulin in their blood, which the

researchers speculate resulted in the weight loss.

The lower insulin would more likely be due to the lower caloric intake and the

higher fiber due to the grapefruit (and maybe lower total sugar intake).

Weight loss is due to reduced caloric intake, not lowered insulin.

Jeff