Re: Calorie controlled diet and ageing

[Guest guest]

Hi, this looks like the same " Comprehensive Assessment of the Long

Term Effects of Reducing Intake of Energy " (CALERIE) study posted

earlier from Louisiana State that was just published in JAMA. (Diane

Walter's post #22883). Funny how each write-up portrays it a little

differently.

The original JAMA abstract is here:

http://jama.ama-assn.org/cgi/content/abstract/295/13/1539?maxtoshow= & HITS=10 & hit\

\

s=10 & RESULTFORMAT= & fulltext=calerie & searchid=1 & FIRSTINDEX=0 & resourcetype=HWCIT

Regards,

Dave

++++++++++++++++++++++++++++++

>

>

> Another study, another positive indication:

>

>

> Eating a little less could mean living a lot longer

> by JENNY HOPE, Daily Mail

>

> Eating less really can lead to a longer life, scientists claimed

> yesterday.

>

> The first human study on a calorie-controlled diet resulted in

> reduced signs of ageing.

>

> It found that just six months on the regime cut volunteers' chances

> of developing diseases associated with old age such as cancer.

>

> The US study supported previous research on monkeys which established

> a link between diet and longevity.

>

> A team from Louisiana State University monitored a group of 48

> overweight men and women aged between 25 and 50 over six months.

>

> A quarter of them were put on a diet of 25 per cent fewer calories

> than they would be expected to eat for their age and weight.

>

> Another quarter had their calorie intake reduced by 12.5 per cent and

> were also put on a strict exercise regime.

>

> A third group stuck to a very strict diet of 890 calories a day -

> which compares with UK guidelines for people with low activity levels

> of 1,640 calories for women and 2,550 for men.

>

> The remainder were placed on a regime designed to maintain their

> weight. The volunteers on the fewest calories lost 14 per cent of

> their body weight on average over the six months, while the other

> calorie-restricted dieters both lost 10 per cent.

>

> All of those who cut down on their calories showed a fall in average

> core body temperature and reduced fasting insulin levels, both linked

> to living longer.

>

> The rate at which their DNA decayed - a natural process - also

> slowed, reducing their chances of developing mutations and

> degenerative diseases related to ageing such as cancer.

>

> The study, reported in the Journal of the American Medical

> Association today, follows research earlier this year which found

> that the hearts of people on calorie-controlled diets appeared more

> elastic than others of the same age and gender.

>

> After an average of six years on the regime, the Washington

> University experiment established that their hearts were able to

> relax between beats in a manner associated with much younger people.

>

> Dr Luigi Fontana, who led the Washington study, said the latest

> research was the first to show a significant decline in DNA damage

> from calorie restriction.

>

> He said: " The value of these studies is that they suggest possible

> mechanisms of ageing in humans and points of intervention to modify

> the effects of ageing. "

>

> Dr Fontana's colleague, Holloszy, who originally found caloric

> restriction increased lifespan in mice and rats by 30 per cent, said

> the research was a turning point.

>

> He said: " It's becoming clear from studies that calorie restriction

> does change some of the markers we associate with ageing. "

>

> Doctors Fontana and Holloszy will soon begin a study into the effects

> of a calorie-restricted diet over two years.

>

> " We know people on calorie restriction will lose weight, " Dr Fontana

> said. " But this study isn't a weight-loss study. We're hoping to

> learn more about whether calorie restriction can alter the ageing

> process. "

>

> In long-term studies on monkeys carried out by the US National

> Institutes of Health, those on calorie-controlled diets suffered

> fewer ailments such as cancer, cardiovascular disease and diabetes.

>

> One of the underfed monkeys reached 38 years, the human equivalent of

> 114 years.

>

> Experts believe cutting calories works by causing biochemical changes

> in the body, reducing free radicals, the toxic particles created by

> the breakdown of food which are more difficult to eradicate in an

> ageing body.

>

[Guest guest]

Hi, this looks like the same " Comprehensive Assessment of the Long

Term Effects of Reducing Intake of Energy " (CALERIE) study posted

earlier from Louisiana State that was just published in JAMA. (Diane

Walter's post #22883). Funny how each write-up portrays it a little

differently.

The original JAMA abstract is here:

http://jama.ama-assn.org/cgi/content/abstract/295/13/1539?maxtoshow= & HITS=10 & hit\

\

s=10 & RESULTFORMAT= & fulltext=calerie & searchid=1 & FIRSTINDEX=0 & resourcetype=HWCIT

Regards,

Dave

++++++++++++++++++++++++++++++

>

>

> Another study, another positive indication:

>

>

> Eating a little less could mean living a lot longer

> by JENNY HOPE, Daily Mail

>

> Eating less really can lead to a longer life, scientists claimed

> yesterday.

>

> The first human study on a calorie-controlled diet resulted in

> reduced signs of ageing.

>

> It found that just six months on the regime cut volunteers' chances

> of developing diseases associated with old age such as cancer.

>

> The US study supported previous research on monkeys which established

> a link between diet and longevity.

>

> A team from Louisiana State University monitored a group of 48

> overweight men and women aged between 25 and 50 over six months.

>

> A quarter of them were put on a diet of 25 per cent fewer calories

> than they would be expected to eat for their age and weight.

>

> Another quarter had their calorie intake reduced by 12.5 per cent and

> were also put on a strict exercise regime.

>

> A third group stuck to a very strict diet of 890 calories a day -

> which compares with UK guidelines for people with low activity levels

> of 1,640 calories for women and 2,550 for men.

>

> The remainder were placed on a regime designed to maintain their

> weight. The volunteers on the fewest calories lost 14 per cent of

> their body weight on average over the six months, while the other

> calorie-restricted dieters both lost 10 per cent.

>

> All of those who cut down on their calories showed a fall in average

> core body temperature and reduced fasting insulin levels, both linked

> to living longer.

>

> The rate at which their DNA decayed - a natural process - also

> slowed, reducing their chances of developing mutations and

> degenerative diseases related to ageing such as cancer.

>

> The study, reported in the Journal of the American Medical

> Association today, follows research earlier this year which found

> that the hearts of people on calorie-controlled diets appeared more

> elastic than others of the same age and gender.

>

> After an average of six years on the regime, the Washington

> University experiment established that their hearts were able to

> relax between beats in a manner associated with much younger people.

>

> Dr Luigi Fontana, who led the Washington study, said the latest

> research was the first to show a significant decline in DNA damage

> from calorie restriction.

>

> He said: " The value of these studies is that they suggest possible

> mechanisms of ageing in humans and points of intervention to modify

> the effects of ageing. "

>

> Dr Fontana's colleague, Holloszy, who originally found caloric

> restriction increased lifespan in mice and rats by 30 per cent, said

> the research was a turning point.

>

> He said: " It's becoming clear from studies that calorie restriction

> does change some of the markers we associate with ageing. "

>

> Doctors Fontana and Holloszy will soon begin a study into the effects

> of a calorie-restricted diet over two years.

>

> " We know people on calorie restriction will lose weight, " Dr Fontana

> said. " But this study isn't a weight-loss study. We're hoping to

> learn more about whether calorie restriction can alter the ageing

> process. "

>

> In long-term studies on monkeys carried out by the US National

> Institutes of Health, those on calorie-controlled diets suffered

> fewer ailments such as cancer, cardiovascular disease and diabetes.

>

> One of the underfed monkeys reached 38 years, the human equivalent of

> 114 years.

>

> Experts believe cutting calories works by causing biochemical changes

> in the body, reducing free radicals, the toxic particles created by

> the breakdown of food which are more difficult to eradicate in an

> ageing body.

>