Guest guest Posted March 26, 2006 Report Share Posted March 26, 2006 citpeks wrote: > Recently, six volunteers in a UK clinical trial became violently ill > following administration of the drug TGN1412 which has been under > development since 2000 for immunological diseases such as multiple > sclerosis, rheumatoid arthritis and certain cancers. > > Animal tests had not shown adverse reactions. > > http://news.bbc.co.uk/1/hi/health/4817178.stm > > We frequently discuss the effects of CR on life extension of > experimental animals. It may be wise to consider that what works for > mice may not work in the same way for humans. While definitely true, calorie restriction has been shown to be repeatable against a broad variety of animals. The drug in the study, so I've been given to understand, was intended to treat rheumatoid arthritis by reducing immune system activity by enhancing the suppressing portions of the immune system (hey, it was already in pretty basic layman's terms when I heard it on the radio). Supposedly it enhanced instead the activity of their entire immune system, sending it amok like super-rheumatoid arthritis or something. Just saying it is worth keeping in mind that there's a bit of a difference between broad studies on a genes that appear to exist in almost every animal tested, and a highly targetted biotech that worked almost the same in humans, just on the entire immune system instead of the part they were trying to target. .... the radio show also had some researchers expressing serious concerns about the technique in that British study - worried that it could have precisely this effect. Don't know if that's a hind-sight 20/20 thing, or if these concerns were expressed beforehand. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 26, 2006 Report Share Posted March 26, 2006 citpeks wrote: > Recently, six volunteers in a UK clinical trial became violently ill > following administration of the drug TGN1412 which has been under > development since 2000 for immunological diseases such as multiple > sclerosis, rheumatoid arthritis and certain cancers. > > Animal tests had not shown adverse reactions. > > http://news.bbc.co.uk/1/hi/health/4817178.stm > > We frequently discuss the effects of CR on life extension of > experimental animals. It may be wise to consider that what works for > mice may not work in the same way for humans. While definitely true, calorie restriction has been shown to be repeatable against a broad variety of animals. The drug in the study, so I've been given to understand, was intended to treat rheumatoid arthritis by reducing immune system activity by enhancing the suppressing portions of the immune system (hey, it was already in pretty basic layman's terms when I heard it on the radio). Supposedly it enhanced instead the activity of their entire immune system, sending it amok like super-rheumatoid arthritis or something. Just saying it is worth keeping in mind that there's a bit of a difference between broad studies on a genes that appear to exist in almost every animal tested, and a highly targetted biotech that worked almost the same in humans, just on the entire immune system instead of the part they were trying to target. .... the radio show also had some researchers expressing serious concerns about the technique in that British study - worried that it could have precisely this effect. Don't know if that's a hind-sight 20/20 thing, or if these concerns were expressed beforehand. Quote Link to comment Share on other sites More sharing options...
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