It gets worse (it seems) for diets higher in MUFAs and PUFAs high in LA

[Guest guest]

consider the following abstract

Dietary fat and risk for advanced age-related macular degeneration.

Seddon JM, Rosner B, Sperduto RD, Yannuzzi L, Haller JA, Blair NP,

Willett W.

Epidemiology Unit, Department of Ophthalmology, Massachusetts Eye

and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA.

Johanna_Seddon@...

OBJECTIVE: To evaluate the relationship between intake of total

and specific types of fat and risk for advanced age-related macular

degeneration (AMD), the leading cause of irreversible blindness in

adults. DESIGN: A multicenter eye disease case-control study. SETTING:

Five US clinical ophthalmology centers. PATIENTS: Case subjects

included 349 individuals (age range, 55-80 years) with the advanced,

neovascular stage of AMD diagnosed within 1 year of their enrollment

into the study who resided near a participating clinical center.

Control subjects included 504 individuals without AMD but with other

ocular diseases. Controls were from the same geographic areas as cases

and were frequency-matched to cases by age and sex. MAIN OUTCOME

MEASURES: Relative risk for AMD according to level of fat intake,

controlling for cigarette smoking and other risk factors. RESULTS:

Higher vegetable fat consumption was associated with an elevated risk

for AMD. After adjusting for age, sex, education, cigarette smoking,

and other risk factors, the odds ratio (OR) was 2.22 (95% confidence

interval [CI], 1.32-3.74) for persons in the highest vs those in the

lowest quintiles of intake (P for trend,.007). The risk for AMD was

also significantly elevated for the highest vs lowest quintiles of

intake of monounsaturated (OR, 1.71) and polyunsaturated (OR, 1.86)

fats (Ps for trend,.03 and.03, respectively). Higher consumption of

linoleic acid was also associated with a higher risk for AMD (P for

trend,.02). Higher intake of omega-3 fatty acids was associated with a

lower risk for AMD among individuals consuming diets low in linoleic

acid, an omega-6 fatty acid (P for trend,.05; P for continuous

variable,.03). Similarly, higher frequency of fish intake tended to

reduce risk for AMD when the diet was low in linoleic acid (P for

trend,.05). Conversely, neither omega-3 fatty acids nor fish intake

were related to risk for AMD among people with high levels of linoleic

acid intake. CONCLUSION: Higher intake of specific types of

fat--including vegetable, monounsaturated, and polyunsaturated fats

and linoleic acid--rather than total fat intake may be associated with

a greater risk for advanced AMD. Diets high in omega-3 fatty acids and

fish were inversely associated with risk for AMD when intake of

linoleic acid was low.

Publication Types:

* Multicenter Study

PMID: 11483088 [PubMed - indexed for MEDLINE]

Display Show

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=11483088 & query_hl=11