Yeast long-life affecting gene

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Hi All,

The not pdf-available below paper indicates that another means of increasing

lifespan, as does CR, may be effective and also works via effects on oxidation

status. The study used yeast, a gene affecting longevity was identified and the

paper below is not available.

Kharade SV, Mittal N, Das SP, Sinha P, Roy N.

Mrg19 depletion increases S. cerevisiae lifespan by augmenting ROS defence.

FEBS Lett. 2005 Dec 19;579(30):6809-6813. Epub 2005 Nov 28.

PMID: 16336970

Caloric restriction (CR) is the most compelling example of lifespan extension by

external manipulation. Although the molecular mechanisms remain unknown, the

theory

of hormesis has been invoked to explain the life promoting effects of CR.

Hormesis

is defined as the beneficial effects of low intensity stressor on a cell or

organism. Mrg19 is a putative transcription factor that regulates carbon and

nitrogen metabolism in yeast. In this study, we have found that deletion of

MRG19

gene causes metabolic shift in yeast cells, leading to higher intracellular

reactive

oxygen species, augmentation of scavenging enzymes and longer lifespan compared

to

wild-type cells. All these results together suggest that similar to CR,

depletion of

Mrg19 leads to a condition of mild stress which in turn enhances vitality.

Al Pater, PhD; email: old542000@...

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