Re: Aspartame (and sucralose/splenda)

[Guest guest]

Diane,

Have you seen any indication that sucralose or Splenda are unsafe?

I've turned up a lot of anecdotes with web searches, but I have no

idea whether there's any scientific support for claims that these

sweeteners are harmful. I was very reliant on sucralose (and

sometimes Splenda) to get my fix for something sweet-tasting without

the calories until I read all the scary anecdotes about Splenda. And

I'd been wondering about occasional brief dizzy spells with no

apparent cause. I'd really like to know the truth. I miss using

sucralose and Splenda.

>

> Folks,

>

> Strictly speaking, this post isn't about CR, but given that I've

> recently been researching links to sources of artificial sweeteners

> for our files, I thought it might be relevant to the diets of many

of us.

>

> Tony forwarded me the information below that was posted today by

> CRSociety's Dean Pomerleau. It's about a study that apparently

> contradicts previous studies on the safety of aspartame.

>

> - Diane

>

> First Experimental Demonstration of the Multipotential

> Carcinogenic Effects of Aspartame Administered in the

> Feed to Sprague-Dawley Rats

>

> Morando Soffritti, Fiorella Belpoggi, e Degli

> Esposti, Luca Lambertini, Eva Tibaldi, and Rigano

>

> Free full text:

> http://ehp.niehs.nih.gov/members/2005/8711/8711.pdf

>

> The Cesare Maltoni Cancer Research Center of the

> European Ramazzini Foundation has conducted a

> long-term bioassay on aspartame (APM), a widely used

> artificial sweetener. APM was administered with feed

> to 8 week-old Sprague-Dawley rats (100-150/sex/group),

> at concentrations of 100,000; 50,000; 10,000; 2,000;

> 400; 80 or 0 ppm. The treatment lasted until natural

> death, at which time all deceased animals underwent

> complete necropsy. Histopathological evaluation of all

> pathological lesions and of all organs and tissues

> collected was routinely performed on each animal of

> all experimental groups. The results of the study show

> for the first time that APM, in our experimental

> conditions, causes: 1) an increased incidence of

> malignant tumor-bearing animals with a positive

> significant trend in males (p0.05) and in females

> (p0.01), in particular those females treated at

> 50,000 ppm (p0.01); 2) an increase in lymphomas and

> leukemias with a positive significant trend in both

> males (p0.05) and females (p0.01), in particular in

> females treated at doses of 100,000 (p0.01), 50,000

> (p0.01), 10,000 (p0.05), 2,000 (p0.05), 400

> (p0.01) ppm; 3) a statistically significant increased

> incidence, with a positive significant trend (p0.01)

> of transitional cell carcinomas of the renal pelvis

> and ureter and their precursors (dysplasias) in

> females treated at 100,000 (p0.01), 50,000 (p0.01),

> 10,000 (p0.01), 2,000 (p0.05) and 400 ppm (p0.05);

> and 4) an increased incidence of malignant schwannomas

> of peripheral nerves with a positive trend (p 0.05)

> in males. The results of this mega-experiment indicate

> that APM is a multipotential carcinogenic agent, even

> at a daily dose of 20 mg/kg b.w., much less than the

> current acceptable daily intake (ADI). On the basis of

> these results, a re-evaluation of the present

> guidelines on the use and consumption of APM is urgent

> and cannot be delayed.

>

[Guest guest]

Diane,

Have you seen any indication that sucralose or Splenda are unsafe?

I've turned up a lot of anecdotes with web searches, but I have no

idea whether there's any scientific support for claims that these

sweeteners are harmful. I was very reliant on sucralose (and

sometimes Splenda) to get my fix for something sweet-tasting without

the calories until I read all the scary anecdotes about Splenda. And

I'd been wondering about occasional brief dizzy spells with no

apparent cause. I'd really like to know the truth. I miss using

sucralose and Splenda.

>

> Folks,

>

> Strictly speaking, this post isn't about CR, but given that I've

> recently been researching links to sources of artificial sweeteners

> for our files, I thought it might be relevant to the diets of many

of us.

>

> Tony forwarded me the information below that was posted today by

> CRSociety's Dean Pomerleau. It's about a study that apparently

> contradicts previous studies on the safety of aspartame.

>

> - Diane

>

> First Experimental Demonstration of the Multipotential

> Carcinogenic Effects of Aspartame Administered in the

> Feed to Sprague-Dawley Rats

>

> Morando Soffritti, Fiorella Belpoggi, e Degli

> Esposti, Luca Lambertini, Eva Tibaldi, and Rigano

>

> Free full text:

> http://ehp.niehs.nih.gov/members/2005/8711/8711.pdf

>

> The Cesare Maltoni Cancer Research Center of the

> European Ramazzini Foundation has conducted a

> long-term bioassay on aspartame (APM), a widely used

> artificial sweetener. APM was administered with feed

> to 8 week-old Sprague-Dawley rats (100-150/sex/group),

> at concentrations of 100,000; 50,000; 10,000; 2,000;

> 400; 80 or 0 ppm. The treatment lasted until natural

> death, at which time all deceased animals underwent

> complete necropsy. Histopathological evaluation of all

> pathological lesions and of all organs and tissues

> collected was routinely performed on each animal of

> all experimental groups. The results of the study show

> for the first time that APM, in our experimental

> conditions, causes: 1) an increased incidence of

> malignant tumor-bearing animals with a positive

> significant trend in males (p0.05) and in females

> (p0.01), in particular those females treated at

> 50,000 ppm (p0.01); 2) an increase in lymphomas and

> leukemias with a positive significant trend in both

> males (p0.05) and females (p0.01), in particular in

> females treated at doses of 100,000 (p0.01), 50,000

> (p0.01), 10,000 (p0.05), 2,000 (p0.05), 400

> (p0.01) ppm; 3) a statistically significant increased

> incidence, with a positive significant trend (p0.01)

> of transitional cell carcinomas of the renal pelvis

> and ureter and their precursors (dysplasias) in

> females treated at 100,000 (p0.01), 50,000 (p0.01),

> 10,000 (p0.01), 2,000 (p0.05) and 400 ppm (p0.05);

> and 4) an increased incidence of malignant schwannomas

> of peripheral nerves with a positive trend (p 0.05)

> in males. The results of this mega-experiment indicate

> that APM is a multipotential carcinogenic agent, even

> at a daily dose of 20 mg/kg b.w., much less than the

> current acceptable daily intake (ADI). On the basis of

> these results, a re-evaluation of the present

> guidelines on the use and consumption of APM is urgent

> and cannot be delayed.

>

[Guest guest]

Hi :

The problem with sucralose is finding an unbiased source of

information. Here is one:

http://europa.eu.int/comm/food/fs/sc/scf/out68_en.pdf

The conclusions start on page 8, I think.

Rodney.

> >

> > Folks,

> >

> > Strictly speaking, this post isn't about CR, but given that I've

> > recently been researching links to sources of artificial

sweeteners

> > for our files, I thought it might be relevant to the diets of

many

> of us.

> >

> > Tony forwarded me the information below that was posted today by

> > CRSociety's Dean Pomerleau. It's about a study that apparently

> > contradicts previous studies on the safety of aspartame.

> >

> > - Diane

> >

> > First Experimental Demonstration of the Multipotential

> > Carcinogenic Effects of Aspartame Administered in the

> > Feed to Sprague-Dawley Rats

> >

> > Morando Soffritti, Fiorella Belpoggi, e Degli

> > Esposti, Luca Lambertini, Eva Tibaldi, and Rigano

> >

> > Free full text:

> > http://ehp.niehs.nih.gov/members/2005/8711/8711.pdf

> >

> > The Cesare Maltoni Cancer Research Center of the

> > European Ramazzini Foundation has conducted a

> > long-term bioassay on aspartame (APM), a widely used

> > artificial sweetener. APM was administered with feed

> > to 8 week-old Sprague-Dawley rats (100-150/sex/group),

> > at concentrations of 100,000; 50,000; 10,000; 2,000;

> > 400; 80 or 0 ppm. The treatment lasted until natural

> > death, at which time all deceased animals underwent

> > complete necropsy. Histopathological evaluation of all

> > pathological lesions and of all organs and tissues

> > collected was routinely performed on each animal of

> > all experimental groups. The results of the study show

> > for the first time that APM, in our experimental

> > conditions, causes: 1) an increased incidence of

> > malignant tumor-bearing animals with a positive

> > significant trend in males (p0.05) and in females

> > (p0.01), in particular those females treated at

> > 50,000 ppm (p0.01); 2) an increase in lymphomas and

> > leukemias with a positive significant trend in both

> > males (p0.05) and females (p0.01), in particular in

> > females treated at doses of 100,000 (p0.01), 50,000

> > (p0.01), 10,000 (p0.05), 2,000 (p0.05), 400

> > (p0.01) ppm; 3) a statistically significant increased

> > incidence, with a positive significant trend (p0.01)

> > of transitional cell carcinomas of the renal pelvis

> > and ureter and their precursors (dysplasias) in

> > females treated at 100,000 (p0.01), 50,000 (p0.01),

> > 10,000 (p0.01), 2,000 (p0.05) and 400 ppm (p0.05);

> > and 4) an increased incidence of malignant schwannomas

> > of peripheral nerves with a positive trend (p 0.05)

> > in males. The results of this mega-experiment indicate

> > that APM is a multipotential carcinogenic agent, even

> > at a daily dose of 20 mg/kg b.w., much less than the

> > current acceptable daily intake (ADI). On the basis of

> > these results, a re-evaluation of the present

> > guidelines on the use and consumption of APM is urgent

> > and cannot be delayed.

> >

>

[Guest guest]

Hi :

The problem with sucralose is finding an unbiased source of

information. Here is one:

http://europa.eu.int/comm/food/fs/sc/scf/out68_en.pdf

The conclusions start on page 8, I think.

Rodney.

> >

> > Folks,

> >

> > Strictly speaking, this post isn't about CR, but given that I've

> > recently been researching links to sources of artificial

sweeteners

> > for our files, I thought it might be relevant to the diets of

many

> of us.

> >

> > Tony forwarded me the information below that was posted today by

> > CRSociety's Dean Pomerleau. It's about a study that apparently

> > contradicts previous studies on the safety of aspartame.

> >

> > - Diane

> >

> > First Experimental Demonstration of the Multipotential

> > Carcinogenic Effects of Aspartame Administered in the

> > Feed to Sprague-Dawley Rats

> >

> > Morando Soffritti, Fiorella Belpoggi, e Degli

> > Esposti, Luca Lambertini, Eva Tibaldi, and Rigano

> >

> > Free full text:

> > http://ehp.niehs.nih.gov/members/2005/8711/8711.pdf

> >

> > The Cesare Maltoni Cancer Research Center of the

> > European Ramazzini Foundation has conducted a

> > long-term bioassay on aspartame (APM), a widely used

> > artificial sweetener. APM was administered with feed

> > to 8 week-old Sprague-Dawley rats (100-150/sex/group),

> > at concentrations of 100,000; 50,000; 10,000; 2,000;

> > 400; 80 or 0 ppm. The treatment lasted until natural

> > death, at which time all deceased animals underwent

> > complete necropsy. Histopathological evaluation of all

> > pathological lesions and of all organs and tissues

> > collected was routinely performed on each animal of

> > all experimental groups. The results of the study show

> > for the first time that APM, in our experimental

> > conditions, causes: 1) an increased incidence of

> > malignant tumor-bearing animals with a positive

> > significant trend in males (p0.05) and in females

> > (p0.01), in particular those females treated at

> > 50,000 ppm (p0.01); 2) an increase in lymphomas and

> > leukemias with a positive significant trend in both

> > males (p0.05) and females (p0.01), in particular in

> > females treated at doses of 100,000 (p0.01), 50,000

> > (p0.01), 10,000 (p0.05), 2,000 (p0.05), 400

> > (p0.01) ppm; 3) a statistically significant increased

> > incidence, with a positive significant trend (p0.01)

> > of transitional cell carcinomas of the renal pelvis

> > and ureter and their precursors (dysplasias) in

> > females treated at 100,000 (p0.01), 50,000 (p0.01),

> > 10,000 (p0.01), 2,000 (p0.05) and 400 ppm (p0.05);

> > and 4) an increased incidence of malignant schwannomas

> > of peripheral nerves with a positive trend (p 0.05)

> > in males. The results of this mega-experiment indicate

> > that APM is a multipotential carcinogenic agent, even

> > at a daily dose of 20 mg/kg b.w., much less than the

> > current acceptable daily intake (ADI). On the basis of

> > these results, a re-evaluation of the present

> > guidelines on the use and consumption of APM is urgent

> > and cannot be delayed.

> >

>

[Guest guest]

Now that, Rodney, is a good example of a report that needs a summary

abstract at the front!

Rodney summarized what I found very succinctly, . There are

quite a few alarmist web pages out there decrying the use of

sucralose, but they seem to have a paucity of references to research-

just unsubstantiated claims. I plan on continuing to use it in small

amounts.

Diane

> > >

> > > Folks,

> > >

> > > Strictly speaking, this post isn't about CR, but given that I've

> > > recently been researching links to sources of artificial

> sweeteners

> > > for our files, I thought it might be relevant to the diets of

> many

> > of us.

> > >

> > > Tony forwarded me the information below that was posted today by

> > > CRSociety's Dean Pomerleau. It's about a study that apparently

> > > contradicts previous studies on the safety of aspartame.

> > >

> > > - Diane

> > >

> > > First Experimental Demonstration of the Multipotential

> > > Carcinogenic Effects of Aspartame Administered in the

> > > Feed to Sprague-Dawley Rats

> > >

> > > Morando Soffritti, Fiorella Belpoggi, e Degli

> > > Esposti, Luca Lambertini, Eva Tibaldi, and Rigano

> > >

> > > Free full text:

> > > http://ehp.niehs.nih.gov/members/2005/8711/8711.pdf

> > >

> > > The Cesare Maltoni Cancer Research Center of the

> > > European Ramazzini Foundation has conducted a

> > > long-term bioassay on aspartame (APM), a widely used

> > > artificial sweetener. APM was administered with feed

> > > to 8 week-old Sprague-Dawley rats (100-150/sex/group),

> > > at concentrations of 100,000; 50,000; 10,000; 2,000;

> > > 400; 80 or 0 ppm. The treatment lasted until natural

> > > death, at which time all deceased animals underwent

> > > complete necropsy. Histopathological evaluation of all

> > > pathological lesions and of all organs and tissues

> > > collected was routinely performed on each animal of

> > > all experimental groups. The results of the study show

> > > for the first time that APM, in our experimental

> > > conditions, causes: 1) an increased incidence of

> > > malignant tumor-bearing animals with a positive

> > > significant trend in males (p0.05) and in females

> > > (p0.01), in particular those females treated at

> > > 50,000 ppm (p0.01); 2) an increase in lymphomas and

> > > leukemias with a positive significant trend in both

> > > males (p0.05) and females (p0.01), in particular in

> > > females treated at doses of 100,000 (p0.01), 50,000

> > > (p0.01), 10,000 (p0.05), 2,000 (p0.05), 400

> > > (p0.01) ppm; 3) a statistically significant increased

> > > incidence, with a positive significant trend (p0.01)

> > > of transitional cell carcinomas of the renal pelvis

> > > and ureter and their precursors (dysplasias) in

> > > females treated at 100,000 (p0.01), 50,000 (p0.01),

> > > 10,000 (p0.01), 2,000 (p0.05) and 400 ppm (p0.05);

> > > and 4) an increased incidence of malignant schwannomas

> > > of peripheral nerves with a positive trend (p 0.05)

> > > in males. The results of this mega-experiment indicate

> > > that APM is a multipotential carcinogenic agent, even

> > > at a daily dose of 20 mg/kg b.w., much less than the

> > > current acceptable daily intake (ADI). On the basis of

> > > these results, a re-evaluation of the present

> > > guidelines on the use and consumption of APM is urgent

> > > and cannot be delayed.

> > >

> >

>

[Guest guest]

Now that, Rodney, is a good example of a report that needs a summary

abstract at the front!

Rodney summarized what I found very succinctly, . There are

quite a few alarmist web pages out there decrying the use of

sucralose, but they seem to have a paucity of references to research-

just unsubstantiated claims. I plan on continuing to use it in small

amounts.

Diane

> > >

> > > Folks,

> > >

> > > Strictly speaking, this post isn't about CR, but given that I've

> > > recently been researching links to sources of artificial

> sweeteners

> > > for our files, I thought it might be relevant to the diets of

> many

> > of us.

> > >

> > > Tony forwarded me the information below that was posted today by

> > > CRSociety's Dean Pomerleau. It's about a study that apparently

> > > contradicts previous studies on the safety of aspartame.

> > >

> > > - Diane

> > >

> > > First Experimental Demonstration of the Multipotential

> > > Carcinogenic Effects of Aspartame Administered in the

> > > Feed to Sprague-Dawley Rats

> > >

> > > Morando Soffritti, Fiorella Belpoggi, e Degli

> > > Esposti, Luca Lambertini, Eva Tibaldi, and Rigano

> > >

> > > Free full text:

> > > http://ehp.niehs.nih.gov/members/2005/8711/8711.pdf

> > >

> > > The Cesare Maltoni Cancer Research Center of the

> > > European Ramazzini Foundation has conducted a

> > > long-term bioassay on aspartame (APM), a widely used

> > > artificial sweetener. APM was administered with feed

> > > to 8 week-old Sprague-Dawley rats (100-150/sex/group),

> > > at concentrations of 100,000; 50,000; 10,000; 2,000;

> > > 400; 80 or 0 ppm. The treatment lasted until natural

> > > death, at which time all deceased animals underwent

> > > complete necropsy. Histopathological evaluation of all

> > > pathological lesions and of all organs and tissues

> > > collected was routinely performed on each animal of

> > > all experimental groups. The results of the study show

> > > for the first time that APM, in our experimental

> > > conditions, causes: 1) an increased incidence of

> > > malignant tumor-bearing animals with a positive

> > > significant trend in males (p0.05) and in females

> > > (p0.01), in particular those females treated at

> > > 50,000 ppm (p0.01); 2) an increase in lymphomas and

> > > leukemias with a positive significant trend in both

> > > males (p0.05) and females (p0.01), in particular in

> > > females treated at doses of 100,000 (p0.01), 50,000

> > > (p0.01), 10,000 (p0.05), 2,000 (p0.05), 400

> > > (p0.01) ppm; 3) a statistically significant increased

> > > incidence, with a positive significant trend (p0.01)

> > > of transitional cell carcinomas of the renal pelvis

> > > and ureter and their precursors (dysplasias) in

> > > females treated at 100,000 (p0.01), 50,000 (p0.01),

> > > 10,000 (p0.01), 2,000 (p0.05) and 400 ppm (p0.05);

> > > and 4) an increased incidence of malignant schwannomas

> > > of peripheral nerves with a positive trend (p 0.05)

> > > in males. The results of this mega-experiment indicate

> > > that APM is a multipotential carcinogenic agent, even

> > > at a daily dose of 20 mg/kg b.w., much less than the

> > > current acceptable daily intake (ADI). On the basis of

> > > these results, a re-evaluation of the present

> > > guidelines on the use and consumption of APM is urgent

> > > and cannot be delayed.

> > >

> >

>