Re: Fruits, veggies drop pancreatic cancer risk 50%

September 16, 2005

--- T <pct35768@...> wrote:

> I notice everyone on these lists is fond of epidemiologic work. Although I am

> not, whenever they say something that makes sense mechanistically, I will

> emphasize it.

>

> Maybe they are actually starting to use their data for good, not evil.

>

> =-=-=-=-=-=-=--==-

>

http://news./s/hsn/20050915/hl_hsn/vegetablesfruitcutpancreaticcancerri\

sk;_ylt=AswEfms06Pz.Ny1kh5I8d1u3j7AB;_ylu=X3oDMTBiMW04NW9mBHNlYwMlJVRPUCUl

>

Hi All,

Here is what the prospective studies meta pdf-available paper analysis revealed:

J Natl Cancer Inst. 2005 Apr 6;97(7):518-24.

Dietary patterns and pancreatic cancer risk in men and women.

Michaud DS, Skinner HG, Wu K, Hu F, Giovannucci E, Willett WC, Colditz GA, Fuchs

CS.

PMID: 15812077

BACKGROUND: Diabetes appears to be associated with the development of pancreatic

cancer. Three large prospective cohort studies observed a statistically

significant

relation between obesity and pancreatic cancer risk. Dietary patterns have been

associated with fasting insulin levels and risk of diabetes. To determine

whether

dietary patterns are associated with pancreatic cancer risk, we analyzed data

from

two large prospective cohort studies. METHODS: We combined data for men and

women to

obtain a total of 366 cases of incident pancreatic cancer from a total of

124,672

eligible participants. Dietary data were obtained from food frequency

questionnaires

in 1986 for men and in 1984 for women. We identified two major dietary patterns,

prudent and western, by factor analysis. The prudent pattern was characterized

by

high fruit and vegetable intake; the western pattern was characterized by high

meat

and high fat intakes. Multivariable relative risks (RRs) were adjusted for

potential

confounders, including smoking and body mass index. RESULTS: In the pooled

analysis

of men and women, no associations were observed between the prudent pattern (RR

=

1.32, 95% confidence interval [CI] = 0.66 to 2.63, for highest versus lowest

quintile) or the western pattern (RR = 0.91, 95% CI = 0.57 to 1.47, for highest

versus lowest quintile) and the risk of pancreatic cancer. Stratifying by body

mass

index or physical activity did not change the associations. CONCLUSION: Dietary

patterns were not associated with the risk of pancreatic cancer in two large

cohort

studies of men and women.

Al Pater, PhD; email: old542000@...

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September 16, 2005