Guest guest Posted October 13, 2005 Report Share Posted October 13, 2005 There have been some recent discussions about protein restriction. The following report has a section dealing with this topic. Tony ====== Energy and protein requirements. A report from the World Health Organization, the Food and Agriculture Organization of the United Nations, and the United Nations University http://www.fao.org/DOCREP/003/AA040E/AA040E00.htm#TOC The section 5.2 " Adaptation to low protein intakes " : http://www.fao.org/DOCREP/003/AA040E/AA040E05.htm#ch5.2 When an adult man is transferred from a higher than customary N intake to one that is close to the physiological minimum, e.g., from 14 to 4 g N per day, a level of excretion close to a new steady state is reached in about 7 days (14), and over this period there is a cumulative N loss equivalent to about 1.5% of total body N. In similar studies on children the new steady state was reached more rapidly, with a total loss estimated at 1% of body N (15). In experimental animals the losses on passing from a customary to a lower protein intake are relatively greater. From such experiments it is known that initially most of the N is lost preferentially from the liver and gut (16, 17). Later, because of the recycling discussed above, it is the N content of muscle and skin that is mainly reduced (18). Nigerian farmers could achieve [nitrogen] balance with an intake that was apparently inadequate for North American men, several short-term balances that have been carried out since 1971 reveal no striking differences in the estimates of maintenance requirement in relation to body cell mass obtained in studies of well-nourished subjects in different countries. However, the question of long-term adaptation cannot be answered definitively without further research. Given the evidence currently available, it must be concluded that there is probably only limited scope for metabolic adaptation to N intakes below the physiological minimum for N balance found in subjects with " normal " intakes. The important question that remains is whether the degree of adaptation that does occur, consistent with the maintenance of nitrogen equilibrium, represents a metabolic adjustment without functional significance, or whether it is detrimental to health and long-term survival. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 13, 2005 Report Share Posted October 13, 2005 Hi Tony: Funny isn't it, that they were unable to consider the possibility that restricted protein might be associated with benefits! Probably it isn't, but that wording discloses a clear bias. 'More is better' is ingrained. Rodney. > The important question that remains is whether the degree of > adaptation that does occur, consistent with the maintenance of > nitrogen equilibrium, represents a metabolic adjustment without > functional significance, or whether it is detrimental to health and > long-term survival. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 13, 2005 Report Share Posted October 13, 2005 Hi Tony: Funny isn't it, that they were unable to consider the possibility that restricted protein might be associated with benefits! Probably it isn't, but that wording discloses a clear bias. 'More is better' is ingrained. Rodney. > The important question that remains is whether the degree of > adaptation that does occur, consistent with the maintenance of > nitrogen equilibrium, represents a metabolic adjustment without > functional significance, or whether it is detrimental to health and > long-term survival. Quote Link to comment Share on other sites More sharing options...
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