CR + high-carbohydrate betters high-fat?

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Hi All,

See the below abstract and citation of a not pdf-available paper that suggests

that

fat dietary intake may interfere with CR benefits via oxidation processes.

Garait B, Couturier K, Servais S, Letexier D, Perrin D, Batandier C, Rouanet JL,

Sibille B, Rey B, Leverve X, Favier R.

Fat intake reverses the beneficial effects of low caloric intake on skeletal

muscle

mitochondrial H(2)O(2) production.

Free Radic Biol Med. 2005 Nov 1;39(9):1249-1261. Epub 2005 Aug 8.

PMID: 16214040

Food restriction is the most effective modulator of oxidative stress and it is

believed that a reduction in caloric intake per se is responsible for the

reduced

generation of reactive oxygen species (ROS) by mitochondria. Hydrogen peroxide

(H(2)O(2)) generation and oxygen consumption (O(2)) by skeletal muscle

mitochondria

were determined in a peculiar strain of rats (Lou/C) characterized by a

self-low-caloric intake and a dietary preference for fat. These rats were fed

either

with a standard high-carbohydrate (HC) or a high-fat (HF) diet and the results

were

compared to those measured in Wistar rats fed a HC diet. H(2)O(2) production was

significantly reduced in Lou/C rats fed a HC diet; this effect was not due to a

lower O(2) consumption but rather to a decrease in rotenone-sensitive

NADH-ubiquinone oxidoreductase activity and increased expression of uncoupling

proteins 2 and 3. The reduced H(2)O(2) generation displayed by Lou/C rats was

accompanied by a significant inhibition of permeability transition pore (PTP)

opening. H(2)O(2) production was restored and PTP inhibition was relieved when

Lou/C

rats were allowed to eat a HF diet, suggesting that the reduced oxidative stress

provided by low caloric intake is lost when fat proportion in the diet is

increased.

Al Pater, PhD; email: old542000@...

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