CR better male benefits via high density lipoprotein?

[Guest guest]

Hi All,

It seems that, in the citation and abstract only available paper (2), male

animals

on CR benefit more than females from the CR regimen and high density lipoprotein

is

the lipid class that are affected to cause greater heart disease protection for

the

males. How this occurs seems to be shown. Regarding male-female differentially

affects of CR, males may be more behind the eight ball to begin with, since

their

high density lipoprotein levels are lower when eating ad lib.

First, (1) is a paper for which the title appears to indicate that CR can result

from a calcium channel blocker.

1. Amer A, Maher TJ.

Nasal administration of the calcium channel blocker diltiazem decreases food

intake

and attenuates weight gain in rats.

Pharmacol Biochem Behav. 2005 Oct 6; [Epub ahead of print]

PMID: 16214208

2. -Moya E, Gianotti M, Llado I, Proenza AM.

Effects of caloric restriction and gender on rat serum paraoxonase 1 activity.

J Nutr Biochem. 2005 Oct 5; [Epub ahead of print]

PMID: 16214326

Paraoxonase 1 (PON1) associates to specific high-density lipoproteins (HDLs) -

those

containing apolipoprotein A-I (apoA-I) and apolipoprotein J (apoJ) - and is

largely

responsible for their antiatherogenic properties. Caloric restriction (CR) has

been

shown to reduce major atherosclerotic risk factors. The aims of this work were

to

study PON1 activity response to CR (40% over 14 weeks) and to elucidate whether

there are adaptive differences related to gender. ... No effects of CR or gender

were observed in triglyceride, total cholesterol concentration and PON1 mRNA

levels.

HDL cholesterol was higher in female rats than in male rats and increased with

CR

only in the latter animals. Serum PON1 activities tended to be higher in female

rats

and dropped with CR, with females showing the biggest decrease. Serum PON1

content

was higher in female rats and decreased in both genders with CR, whereas apoA-I

and

apoJ contents, which were higher in female rats too, decreased only in the

former

animals, accounting for the high PON1 activity decrease observed in these

animals.

In conclusion, the short-term CR-associated reduction of serum PON1 activity and

PON1, apoA-I and apoJ levels points toward a reduced stability of HDL-PON1

complexes

and/or HDL particle levels responsible for PON1 transport and function in the

blood.

Moreover, the variations in PON1 activity and apolipoprotein levels show

gender-related differences that are indicative of a different adaptive strategy

of

male and female rats when faced with a period of food restriction.

Al Pater, PhD; email: old542000@...

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